| BlackRock Institutional Trust Company, N.A. |
18,256,518 |
7.09 |
404,343 |
6/30/22 |
| The Vanguard Group, Inc. |
12,834,402 |
4.99 |
52,202 |
6/30/22 |
| State Street Global Advisors (US) |
12,501,186 |
4.86 |
-2,203,047 |
6/30/22 |
| Mann (Alfred E) |
9,402,854 |
3.65 |
481,207 |
3/11/22 |
| Avoro Capital Advisors LLC |
9,100,000 |
3.54 |
300,000 |
6/30/22 |
| Emerald Advisers LLC |
9,031,916 |
3.51 |
-1,001,710 |
6/30/22 |
| Fidelity Management & Research Company LLC |
6,585,994 |
2.56 |
1,284,286 |
6/30/22 |
| Geode Capital Management, L.L.C. |
4,551,176 |
1.77 |
16,671 |
6/30/22 |
| D. E. Shaw & Co., L.P. |
3,247,695 |
1.26 |
1,994,946 |
6/30/22 |
| Nuveen LLC |
2,473,594 |
0.96 |
34,223 |
6/30/22 |
| Schonfeld Strategic Advisors LLC |
2,437,629 |
0.95 |
1,067,829 |
6/30/22 |
| Polar Asset Management Partners Inc. |
2,170,233 |
0.84 |
1,557,400 |
6/30/22 |
| Northern Trust Investments, Inc. |
2,089,141 |
0.81 |
-44,078 |
6/30/22 |
| Charles Schwab Investment Management, Inc. |
1,796,310 |
0.70 |
-31,925 |
6/30/22 |
| Castagna (Michael E) |
1,710,207 |
0.66 |
-35,952 |
8/27/22 |
| Goldman Sachs & Company, Inc. |
1,633,368 |
0.63 |
442,549 |
6/30/22 |
| Morgan Stanley & Co. LLC |
1,568,528 |
0.61 |
721,931 |
6/30/22 |
| Principal Funds, Inc. |
1,441,566 |
0.56 |
-5,565 |
4/30/22 |
| 180 Wealth Advisors, L.L.C. |
1,439,864 |
0.56 |
69,960 |
6/30/22 |
| BlackRock Financial Management, Inc. |
1,434,692 |
0.56 |
-113,235 |
6/30/22 |
| Morgan Stanley Smith Barney LLC |
1,359,421 |
0.53 |
1,002,145 |
6/30/22 |
| Millennium Management LLC |
1,200,202 |
0.47 |
1,033,915 |
6/30/22 |
| Thomson (David B) |
1,045,693 |
0.41 |
-21,178 |
8/29/22 |
| Two Sigma Investments, LP |
971,766 |
0.38 |
958,852 |
6/30/22 |
| UBS Asset Management (Americas), Inc. |
955,677 |
0.37 |
-- |
7/31/22 |
| Kocinsky (Joseph) |
938,370 |
0.36 |
-12,813 |
8/27/22 |
| Tross Stuart A |
883,543 |
0.34 |
-14,178 |
8/27/22 |
| Goldman Sachs Asset Management, L.P. |
825,498 |
0.32 |
189,826 |
6/30/22 |
| BlackRock Investment Management, LLC |
810,315 |
0.31 |
4,944 |
6/30/22 |
| Parkman Healthcare Partners LLC |
764,814 |
0.30 |
89,411 |
6/30/22 |
| Susquehanna International Group, LLP |
737,629 |
0.29 |
-294,699 |
6/30/22 |
| DuPont Capital Management Corporation |
726,200 |
0.28 |
600 |
6/30/22 |
| Citadel Advisors LLC |
723,466 |
0.28 |
-466,272 |
6/30/22 |
| Renaissance Technologies LLC |
712,896 |
0.28 |
535,451 |
6/30/22 |
| Binder (Steven B) |
695,295 |
0.27 |
-14,178 |
8/27/22 |
| Scopia Capital Management LP |
694,961 |
0.27 |
-- |
6/30/22 |
| Voya Investment Management LLC |
651,952 |
0.25 |
544,749 |
6/30/22 |
| Galindo (Alejandro) |
620,568 |
0.24 |
-4,615 |
8/22/22 |
| BNY Mellon Asset Management |
573,413 |
0.22 |
39,160 |
6/30/22 |
| Schweizerische Nationalbank |
564,400 |
0.22 |
-- |
6/30/22 |
| 1492 Capital Management, LLC |
537,526 |
0.21 |
-19,525 |
6/30/22 |
| Lazard Asset Management, L.L.C. |
495,240 |
0.19 |
-136,377 |
6/30/22 |
| Walleye Capital LLC |
468,540 |
0.18 |
432,180 |
6/30/22 |
| BlackRock Investment Management (UK) Ltd. |
438,969 |
0.17 |
224,232 |
6/30/22 |
| Citi Investment Research (US) |
429,773 |
0.17 |
276,698 |
6/30/22 |
| Rafferty Asset Management LLC |
427,927 |
0.17 |
-458,624 |
6/30/22 |
| HRT Financial LP |
422,270 |
0.16 |
422,270 |
6/30/22 |
| EAM Global Investors LLC |
362,666 |
0.14 |
362,666 |
6/30/22 |
| Rhumbline Advisers Ltd. Partnership |
362,181 |
0.14 |
46,513 |
6/30/22 |
| Raymond James & Associates, Inc. |
345,114 |
0.13 |
-2,966 |
6/30/22 |
