<?xml version="1.0" encoding="US-ASCII"?>
<!-- DFIN New ActiveDisclosure (SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date :2024-04-05T00:44:19.1857+00:00 -->
<!-- Copyright (c) 2024 Donnelly Financial Solutions, Inc. All Rights Reserved. -->
<xsd:schema targetNamespace="http://www.mannkindcorp.com/20240405" attributeFormDefault="unqualified" elementFormDefault="qualified" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2022-03-31" xmlns:enum2="http://xbrl.org/2020/extensible-enumerations-2.0" xmlns:ecd-sub="http://xbrl.sec.gov/ecd-sub/2023" xmlns:ecd="http://xbrl.sec.gov/ecd/2023" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:us-gaap="http://fasb.org/us-gaap/2023" xmlns:dei="http://xbrl.sec.gov/dei/2023" xmlns:mnkd="http://www.mannkindcorp.com/20240405" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xlink="http://www.w3.org/1999/xlink">
  <xsd:import schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" namespace="http://www.xbrl.org/2003/instance"/>
  <xsd:import schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" namespace="http://www.xbrl.org/2003/linkbase"/>
  <xsd:import schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" namespace="http://xbrl.org/2005/xbrldt"/>
  <xsd:import schemaLocation="https://xbrl.sec.gov/dei/2023/dei-2023.xsd" namespace="http://xbrl.sec.gov/dei/2023"/>
  <xsd:import schemaLocation="https://xbrl.sec.gov/ecd/2023/ecd-sub-2023.xsd" namespace="http://xbrl.sec.gov/ecd-sub/2023"/>
  <xsd:import schemaLocation="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd" namespace="http://fasb.org/us-gaap/2023"/>
  <xsd:import schemaLocation="https://www.xbrl.org/dtr/type/2022-03-31/types.xsd" namespace="http://www.xbrl.org/dtr/type/2022-03-31"/>
  <xsd:import schemaLocation="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd" namespace="http://xbrl.sec.gov/ecd/2023"/>
  <xsd:annotation>
    <xsd:appinfo>
      <link:roleType roleURI="http://www.mannkindcorp.com/20240405/taxonomy/role/DocumentDocumentAndEntityInformation" id="DocumentDocumentAndEntityInformation">
        <link:definition>100000 - Document - Document and Entity Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:linkbase id="lnk">
        <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" xlink:type="simple"/>
        <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" xlink:type="simple"/>
        <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" xlink:type="simple"/>
        <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" xlink:type="simple"/>
        <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" xlink:type="simple"/>
        <link:roleRef roleURI="http://www.mannkindcorp.com/20240405/taxonomy/role/DocumentDocumentAndEntityInformation" xlink:href="mnkd-20240405.xsd#DocumentDocumentAndEntityInformation" xlink:type="simple"/>
        <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/PvpDisclosure" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#PvpDisclosure" xlink:type="simple"/>
        <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/PvpAdjustmentsOnly" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#PvpAdjustmentsOnly" xlink:type="simple"/>
        <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/IndividualsOnly" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#IndividualsOnly" xlink:type="simple"/>
        <link:labelLink xlink:role="http://www.xbrl.org/2003/role/link" xlink:title="labelLink" xlink:type="extended">
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMinimum" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionInitialTsrMaximum" xlink:label="mnkd_EquityValuationAssumptionInitialTsrMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionTermMaximum" xlink:label="mnkd_EquityValuationAssumptionTermMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_FairValueOfAwardsGrantedInPriorYearForfeitedMember" xlink:label="mnkd_FairValueOfAwardsGrantedInPriorYearForfeitedMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionBeginningAverageStockPriceMinimum" xlink:label="mnkd_EquityValuationAssumptionBeginningAverageStockPriceMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionExercisePriceMinimum" xlink:label="mnkd_EquityValuationAssumptionExercisePriceMinimum"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityCentralIndexKey" xlink:label="dei_EntityCentralIndexKey"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionVolatilityPeerAverageMinimum" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerAverageMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionExercisePriceMaximum" xlink:label="mnkd_EquityValuationAssumptionExercisePriceMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_ChangeInFairValueOfAwardsGrantedInPriorYearVestedMember" xlink:label="mnkd_ChangeInFairValueOfAwardsGrantedInPriorYearVestedMember"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityRegistrantName" xlink:label="dei_EntityRegistrantName"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionVolatilityPeerAverageMaximum" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerAverageMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMaximum" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_ChangeInFairValueOfOutstandingAndUnvestedStockAwardsGrantedInPriorYearsMeasuredAsOfYearEndMember" xlink:label="mnkd_ChangeInFairValueOfOutstandingAndUnvestedStockAwardsGrantedInPriorYearsMeasuredAsOfYearEndMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_ChangeInFairValueOfEquityAwardsGrantedDuringTheYearUnvestedMember" xlink:label="mnkd_ChangeInFairValueOfEquityAwardsGrantedDuringTheYearUnvestedMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionVolatilityPeerMedianMinimum" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerMedianMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMinimum" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionInitialTsrMinimum" xlink:label="mnkd_EquityValuationAssumptionInitialTsrMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_SummaryOfCompensationTableTotalMember" xlink:label="mnkd_SummaryOfCompensationTableTotalMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionValuationDateStockPriceMinimum" xlink:label="mnkd_EquityValuationAssumptionValuationDateStockPriceMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionVolatilityMannkindMaximum" xlink:label="mnkd_EquityValuationAssumptionVolatilityMannkindMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_DividendsOrOtherEarningsPaidPriorToVestingDateMember" xlink:label="mnkd_DividendsOrOtherEarningsPaidPriorToVestingDateMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_StockOptionsMember" xlink:label="mnkd_StockOptionsMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerMedian" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerMedian"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_StockAwardsMember" xlink:label="mnkd_StockAwardsMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_CastagnaMember" xlink:label="mnkd_CastagnaMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionBeginningAverageStockPriceMaximum" xlink:label="mnkd_EquityValuationAssumptionBeginningAverageStockPriceMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionRiskFreeRateMaximum" xlink:label="mnkd_EquityValuationAssumptionRiskFreeRateMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMaximum" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMaximum"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CoverAbstract" xlink:label="dei_CoverAbstract"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionTermMinimum" xlink:label="mnkd_EquityValuationAssumptionTermMinimum"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_AmendmentFlag" xlink:label="dei_AmendmentFlag"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionValuationDateStockPrice" xlink:label="mnkd_EquityValuationAssumptionValuationDateStockPrice"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionVolatilityPeerMedianMaximum" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerMedianMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionValuationDateStockPriceMaximum" xlink:label="mnkd_EquityValuationAssumptionValuationDateStockPriceMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionRiskFreeRateMinimum" xlink:label="mnkd_EquityValuationAssumptionRiskFreeRateMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionVolatilityMannkindMinimum" xlink:label="mnkd_EquityValuationAssumptionVolatilityMannkindMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_PsusMember" xlink:label="mnkd_PsusMember"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentType" xlink:label="dei_DocumentType"/>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Correlation Coefficient - MannKind, Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Difference Correlation Coefficient MannKind Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption difference correlation coefficient mannkind minimum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionInitialTsrMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Initial TSR, Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionInitialTsrMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Initial TSR Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionInitialTsrMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption initial TSR maximum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionTermMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Term (years), Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionTermMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Term Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionTermMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption term maximum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_FairValueOfAwardsGrantedInPriorYearForfeitedMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deduct: Fair Value at Prior Year End of Awards Granted during Prior FY that were Forfeited [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_FairValueOfAwardsGrantedInPriorYearForfeitedMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value of awards granted in prior year forfeited.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_FairValueOfAwardsGrantedInPriorYearForfeitedMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value of Awards Granted In Prior Year Forfeited [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionBeginningAverageStockPriceMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Beginning Average Stock Price, Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionBeginningAverageStockPriceMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Beginning Average Stock Price Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionBeginningAverageStockPriceMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption beginning average stock price minimum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionExercisePriceMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise Price, Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionExercisePriceMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Exercise Price Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionExercisePriceMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption exercise price minimum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCentralIndexKey_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Central Index Key</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCentralIndexKey_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">CIK</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerAverageMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Volatility - Peer Average, Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerAverageMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Volatility Peer Average Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerAverageMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption volatility peer average minimum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionExercisePriceMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise Price, Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionExercisePriceMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Exercise Price Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionExercisePriceMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption exercise price maximum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_ChangeInFairValueOfAwardsGrantedInPriorYearVestedMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Change in fair value of awards granted in prior year vested.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_ChangeInFairValueOfAwardsGrantedInPriorYearVestedMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Change in Fair Value of Awards Granted In Prior Year Vested [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_ChangeInFairValueOfAwardsGrantedInPriorYearVestedMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Add: Vesting Date Fair Value of Awards Granted during Prior FY that Vested [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityRegistrantName_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Registrant Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityRegistrantName_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Registrant Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerAverageMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Volatility - Peer Average, Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerAverageMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Volatility Peer Average Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerAverageMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption volatility peer average maximum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Correlation Coefficient - Peer Average, Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Difference Correlation Coefficient Peer Average Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption difference correlation coefficient peer average maximum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_ChangeInFairValueOfOutstandingAndUnvestedStockAwardsGrantedInPriorYearsMeasuredAsOfYearEndMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Change in fair value of outstanding and unvested stock awards granted in prior years measured as of year end.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_ChangeInFairValueOfOutstandingAndUnvestedStockAwardsGrantedInPriorYearsMeasuredAsOfYearEndMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Change In Fair Value Of Outstanding and Unvested Stock Awards Granted In Prior Years Measured As Of Year End [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_ChangeInFairValueOfOutstandingAndUnvestedStockAwardsGrantedInPriorYearsMeasuredAsOfYearEndMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Add: Year over Year Change in Fair Value of Awards Granted during Prior FY that were Outstanding and Unvested [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_ChangeInFairValueOfEquityAwardsGrantedDuringTheYearUnvestedMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value of equity awards granted during the year unvested.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_ChangeInFairValueOfEquityAwardsGrantedDuringTheYearUnvestedMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value of Equity Awards Granted During The Year Unvested [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_ChangeInFairValueOfEquityAwardsGrantedDuringTheYearUnvestedMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Add: Fair Value at Applicable FY End of Awards Granted during Applicable FY that Remain Unvested [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerMedianMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Volatility - Peer Median, Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerMedianMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Volatility Peer Median Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerMedianMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption volatility peer median minimum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Correlation Coefficient - Peer Average, Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Difference Correlation Coefficient Peer Average Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption difference correlation coefficient peer average minimum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionInitialTsrMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Initial TSR, Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionInitialTsrMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Initial TSR Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionInitialTsrMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption initial TSR minimum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_SummaryOfCompensationTableTotalMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Summary of Compensation Table Total [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_SummaryOfCompensationTableTotalMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Summary of Compensation Table Total [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_SummaryOfCompensationTableTotalMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Compensation Table Total [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionValuationDateStockPriceMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Valuation Date Stock Price, Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionValuationDateStockPriceMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Valuation Date Stock Price Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionValuationDateStockPriceMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption valuation date stock price minimum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionVolatilityMannkindMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Volatility - MannKind, Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionVolatilityMannkindMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Volatility MannKind Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionVolatilityMannkindMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption volatility mannkind maximum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_DividendsOrOtherEarningsPaidPriorToVestingDateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Add: Dividends or Other Earnings Paid during Applicable FY prior to Vesting Date [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_DividendsOrOtherEarningsPaidPriorToVestingDateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Dividends or other earnings paid prior to vesting date.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_DividendsOrOtherEarningsPaidPriorToVestingDateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Dividends or Other Earnings Paid Prior to Vesting Date [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_StockOptionsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stock Options [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_StockOptionsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Stock options.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerMedian_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Correlation Coefficient - Peer Median</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerMedian_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Difference Correlation Coefficient Peer Median</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerMedian_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption difference correlation coefficient peer median.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_StockAwardsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Stock awards.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_StockAwardsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stock Awards [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_CastagnaMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Castagna.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_CastagnaMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Castagna [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionBeginningAverageStockPriceMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Beginning Average Stock Price, Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionBeginningAverageStockPriceMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Beginning Average Stock Price Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionBeginningAverageStockPriceMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption beginning average stock price maximum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionRiskFreeRateMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Risk-Free Rate, Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionRiskFreeRateMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Risk-free Rate Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionRiskFreeRateMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption risk-free rate maximum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Correlation Coefficient - MannKind, Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Difference Correlation Coefficient Mannkind Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption difference correlation coefficient mannkind maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_CoverAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cover [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_CoverAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cover</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionTermMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Term (years), Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionTermMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Term Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionTermMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption term minimum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_AmendmentFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Amendment Flag</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_AmendmentFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amendment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionValuationDateStockPrice_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Valuation Date Stock Price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionValuationDateStockPrice_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Valuation Date Stock Price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionValuationDateStockPrice_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption valuation date stock price.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerMedianMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Volatility - Peer Median, Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerMedianMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Volatility Peer Median Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerMedianMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption volatility peer median maximum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionValuationDateStockPriceMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Valuation Date Stock Price, Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionValuationDateStockPriceMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Valuation Date Stock Price Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionValuationDateStockPriceMaximum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption valuation date stock price maximum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionRiskFreeRateMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Risk-Free Rate, Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionRiskFreeRateMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Risk-free Rate Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionRiskFreeRateMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption risk-free rate minimum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionVolatilityMannkindMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Volatility - MannKind, Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionVolatilityMannkindMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Valuation Assumption Volatility MannKind Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_EquityValuationAssumptionVolatilityMannkindMinimum_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity valuation assumption volatility &#8212; mannkind minimum.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_PsusMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">PSUs [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="mnkd_PsusMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">PSUs.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentType_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Type</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentType_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Type</link:label>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMinimum" xlink:to="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMinimum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionInitialTsrMaximum" xlink:to="mnkd_EquityValuationAssumptionInitialTsrMaximum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionTermMaximum" xlink:to="mnkd_EquityValuationAssumptionTermMaximum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_FairValueOfAwardsGrantedInPriorYearForfeitedMember" xlink:to="mnkd_FairValueOfAwardsGrantedInPriorYearForfeitedMember_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionBeginningAverageStockPriceMinimum" xlink:to="mnkd_EquityValuationAssumptionBeginningAverageStockPriceMinimum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionExercisePriceMinimum" xlink:to="mnkd_EquityValuationAssumptionExercisePriceMinimum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityCentralIndexKey" xlink:to="dei_EntityCentralIndexKey_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionVolatilityPeerAverageMinimum" xlink:to="mnkd_EquityValuationAssumptionVolatilityPeerAverageMinimum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionExercisePriceMaximum" xlink:to="mnkd_EquityValuationAssumptionExercisePriceMaximum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_ChangeInFairValueOfAwardsGrantedInPriorYearVestedMember" xlink:to="mnkd_ChangeInFairValueOfAwardsGrantedInPriorYearVestedMember_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityRegistrantName" xlink:to="dei_EntityRegistrantName_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionVolatilityPeerAverageMaximum" xlink:to="mnkd_EquityValuationAssumptionVolatilityPeerAverageMaximum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMaximum" xlink:to="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMaximum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_ChangeInFairValueOfOutstandingAndUnvestedStockAwardsGrantedInPriorYearsMeasuredAsOfYearEndMember" xlink:to="mnkd_ChangeInFairValueOfOutstandingAndUnvestedStockAwardsGrantedInPriorYearsMeasuredAsOfYearEndMember_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_ChangeInFairValueOfEquityAwardsGrantedDuringTheYearUnvestedMember" xlink:to="mnkd_ChangeInFairValueOfEquityAwardsGrantedDuringTheYearUnvestedMember_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionVolatilityPeerMedianMinimum" xlink:to="mnkd_EquityValuationAssumptionVolatilityPeerMedianMinimum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMinimum" xlink:to="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMinimum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionInitialTsrMinimum" xlink:to="mnkd_EquityValuationAssumptionInitialTsrMinimum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_SummaryOfCompensationTableTotalMember" xlink:to="mnkd_SummaryOfCompensationTableTotalMember_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionValuationDateStockPriceMinimum" xlink:to="mnkd_EquityValuationAssumptionValuationDateStockPriceMinimum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionVolatilityMannkindMaximum" xlink:to="mnkd_EquityValuationAssumptionVolatilityMannkindMaximum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_DividendsOrOtherEarningsPaidPriorToVestingDateMember" xlink:to="mnkd_DividendsOrOtherEarningsPaidPriorToVestingDateMember_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_StockOptionsMember" xlink:to="mnkd_StockOptionsMember_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerMedian" xlink:to="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerMedian_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_StockAwardsMember" xlink:to="mnkd_StockAwardsMember_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_CastagnaMember" xlink:to="mnkd_CastagnaMember_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionBeginningAverageStockPriceMaximum" xlink:to="mnkd_EquityValuationAssumptionBeginningAverageStockPriceMaximum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionRiskFreeRateMaximum" xlink:to="mnkd_EquityValuationAssumptionRiskFreeRateMaximum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMaximum" xlink:to="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMaximum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_CoverAbstract" xlink:to="dei_CoverAbstract_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionTermMinimum" xlink:to="mnkd_EquityValuationAssumptionTermMinimum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_AmendmentFlag" xlink:to="dei_AmendmentFlag_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionValuationDateStockPrice" xlink:to="mnkd_EquityValuationAssumptionValuationDateStockPrice_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionVolatilityPeerMedianMaximum" xlink:to="mnkd_EquityValuationAssumptionVolatilityPeerMedianMaximum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionValuationDateStockPriceMaximum" xlink:to="mnkd_EquityValuationAssumptionValuationDateStockPriceMaximum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionRiskFreeRateMinimum" xlink:to="mnkd_EquityValuationAssumptionRiskFreeRateMinimum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_EquityValuationAssumptionVolatilityMannkindMinimum" xlink:to="mnkd_EquityValuationAssumptionVolatilityMannkindMinimum_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mnkd_PsusMember" xlink:to="mnkd_PsusMember_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_DocumentType" xlink:to="dei_DocumentType_lbl"/>
        </link:labelLink>
        <link:presentationLink xlink:role="http://www.mannkindcorp.com/20240405/taxonomy/role/DocumentDocumentAndEntityInformation" xlink:title="presentationLink" xlink:type="extended">
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CoverAbstract" xlink:label="dei_CoverAbstract"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityCentralIndexKey" xlink:label="dei_EntityCentralIndexKey"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_AmendmentFlag" xlink:label="dei_AmendmentFlag"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentType" xlink:label="dei_DocumentType"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityRegistrantName" xlink:label="dei_EntityRegistrantName"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_CoverAbstract" xlink:to="dei_EntityCentralIndexKey" order="49.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/label"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_CoverAbstract" xlink:to="dei_AmendmentFlag" order="50.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/label"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_CoverAbstract" xlink:to="dei_DocumentType" order="51.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/label"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_CoverAbstract" xlink:to="dei_EntityRegistrantName" order="52.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/label"/>
        </link:presentationLink>
        <link:presentationLink xlink:role="http://xbrl.sec.gov/ecd/role/PvpDisclosure" xlink:title="presentationLink" xlink:type="extended">
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AllAdjToCompMember" xlink:label="ecd_AllAdjToCompMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_SummaryOfCompensationTableTotalMember" xlink:label="mnkd_SummaryOfCompensationTableTotalMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_StockAwardsMember" xlink:label="mnkd_StockAwardsMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_ChangeInFairValueOfEquityAwardsGrantedDuringTheYearUnvestedMember" xlink:label="mnkd_ChangeInFairValueOfEquityAwardsGrantedDuringTheYearUnvestedMember"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AllIndividualsMember" xlink:label="ecd_AllIndividualsMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_CastagnaMember" xlink:label="mnkd_CastagnaMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_ChangeInFairValueOfOutstandingAndUnvestedStockAwardsGrantedInPriorYearsMeasuredAsOfYearEndMember" xlink:label="mnkd_ChangeInFairValueOfOutstandingAndUnvestedStockAwardsGrantedInPriorYearsMeasuredAsOfYearEndMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_ChangeInFairValueOfAwardsGrantedInPriorYearVestedMember" xlink:label="mnkd_ChangeInFairValueOfAwardsGrantedInPriorYearVestedMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_PsusMember" xlink:label="mnkd_PsusMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_StockOptionsMember" xlink:label="mnkd_StockOptionsMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_FairValueOfAwardsGrantedInPriorYearForfeitedMember" xlink:label="mnkd_FairValueOfAwardsGrantedInPriorYearForfeitedMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_DividendsOrOtherEarningsPaidPriorToVestingDateMember" xlink:label="mnkd_DividendsOrOtherEarningsPaidPriorToVestingDateMember"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_PayVsPerformanceDisclosureLineItems" xlink:label="ecd_PayVsPerformanceDisclosureLineItems"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionTermMinimum" xlink:label="mnkd_EquityValuationAssumptionTermMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionTermMaximum" xlink:label="mnkd_EquityValuationAssumptionTermMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMinimum" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMaximum" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMinimum" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMaximum" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerMedian" xlink:label="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerMedian"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionBeginningAverageStockPriceMinimum" xlink:label="mnkd_EquityValuationAssumptionBeginningAverageStockPriceMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionBeginningAverageStockPriceMaximum" xlink:label="mnkd_EquityValuationAssumptionBeginningAverageStockPriceMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionValuationDateStockPrice" xlink:label="mnkd_EquityValuationAssumptionValuationDateStockPrice"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionValuationDateStockPriceMinimum" xlink:label="mnkd_EquityValuationAssumptionValuationDateStockPriceMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionValuationDateStockPriceMaximum" xlink:label="mnkd_EquityValuationAssumptionValuationDateStockPriceMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionInitialTsrMinimum" xlink:label="mnkd_EquityValuationAssumptionInitialTsrMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionInitialTsrMaximum" xlink:label="mnkd_EquityValuationAssumptionInitialTsrMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionRiskFreeRateMinimum" xlink:label="mnkd_EquityValuationAssumptionRiskFreeRateMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionRiskFreeRateMaximum" xlink:label="mnkd_EquityValuationAssumptionRiskFreeRateMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionVolatilityMannkindMinimum" xlink:label="mnkd_EquityValuationAssumptionVolatilityMannkindMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionVolatilityMannkindMaximum" xlink:label="mnkd_EquityValuationAssumptionVolatilityMannkindMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionVolatilityPeerAverageMinimum" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerAverageMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionVolatilityPeerAverageMaximum" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerAverageMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionVolatilityPeerMedianMinimum" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerMedianMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionVolatilityPeerMedianMaximum" xlink:label="mnkd_EquityValuationAssumptionVolatilityPeerMedianMaximum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionExercisePriceMinimum" xlink:label="mnkd_EquityValuationAssumptionExercisePriceMinimum"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_EquityValuationAssumptionExercisePriceMaximum" xlink:label="mnkd_EquityValuationAssumptionExercisePriceMaximum"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_AllAdjToCompMember" xlink:to="mnkd_SummaryOfCompensationTableTotalMember" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_AllAdjToCompMember" xlink:to="mnkd_StockAwardsMember" order="1" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/label"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_AllAdjToCompMember" xlink:to="mnkd_ChangeInFairValueOfEquityAwardsGrantedDuringTheYearUnvestedMember" order="2" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_AllIndividualsMember" xlink:to="mnkd_CastagnaMember" order="2.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/label"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_AllAdjToCompMember" xlink:to="mnkd_ChangeInFairValueOfOutstandingAndUnvestedStockAwardsGrantedInPriorYearsMeasuredAsOfYearEndMember" order="3" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_AllAdjToCompMember" xlink:to="mnkd_ChangeInFairValueOfAwardsGrantedInPriorYearVestedMember" order="4" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_AllAdjToCompMember" xlink:to="mnkd_PsusMember" order="5" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/label"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_AllAdjToCompMember" xlink:to="mnkd_StockOptionsMember" order="6" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/label"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_AllAdjToCompMember" xlink:to="mnkd_FairValueOfAwardsGrantedInPriorYearForfeitedMember" order="7" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_AllAdjToCompMember" xlink:to="mnkd_DividendsOrOtherEarningsPaidPriorToVestingDateMember" order="8" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionTermMinimum" order="30.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionTermMaximum" order="31.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMinimum" order="32.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMaximum" order="33.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMinimum" order="34.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMaximum" order="35.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerMedian" order="36.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionBeginningAverageStockPriceMinimum" order="37.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionBeginningAverageStockPriceMaximum" order="38.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionValuationDateStockPrice" order="39.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionValuationDateStockPriceMinimum" order="40.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionValuationDateStockPriceMaximum" order="41.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionInitialTsrMinimum" order="42.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionInitialTsrMaximum" order="43.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionRiskFreeRateMinimum" order="44.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionRiskFreeRateMaximum" order="45.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionVolatilityMannkindMinimum" order="46.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionVolatilityMannkindMaximum" order="47.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionVolatilityPeerAverageMinimum" order="48.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionVolatilityPeerAverageMaximum" order="49.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionVolatilityPeerMedianMinimum" order="50.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionVolatilityPeerMedianMaximum" order="51.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionExercisePriceMinimum" order="52.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="mnkd_EquityValuationAssumptionExercisePriceMaximum" order="53.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
        </link:presentationLink>
        <link:definitionLink xlink:type="extended" xlink:role="http://xbrl.sec.gov/ecd/role/PvpAdjustmentsOnly">
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AllAdjToCompMember" xlink:label="ecd_AllAdjToCompMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_SummaryOfCompensationTableTotalMember" xlink:label="mnkd_SummaryOfCompensationTableTotalMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_StockAwardsMember" xlink:label="mnkd_StockAwardsMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_ChangeInFairValueOfEquityAwardsGrantedDuringTheYearUnvestedMember" xlink:label="mnkd_ChangeInFairValueOfEquityAwardsGrantedDuringTheYearUnvestedMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_ChangeInFairValueOfOutstandingAndUnvestedStockAwardsGrantedInPriorYearsMeasuredAsOfYearEndMember" xlink:label="mnkd_ChangeInFairValueOfOutstandingAndUnvestedStockAwardsGrantedInPriorYearsMeasuredAsOfYearEndMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_ChangeInFairValueOfAwardsGrantedInPriorYearVestedMember" xlink:label="mnkd_ChangeInFairValueOfAwardsGrantedInPriorYearVestedMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_PsusMember" xlink:label="mnkd_PsusMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_StockOptionsMember" xlink:label="mnkd_StockOptionsMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_FairValueOfAwardsGrantedInPriorYearForfeitedMember" xlink:label="mnkd_FairValueOfAwardsGrantedInPriorYearForfeitedMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_DividendsOrOtherEarningsPaidPriorToVestingDateMember" xlink:label="mnkd_DividendsOrOtherEarningsPaidPriorToVestingDateMember"/>
          <link:definitionArc xlink:type="arc" order="0" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="mnkd_SummaryOfCompensationTableTotalMember" priority="2" use="optional"/>
          <link:definitionArc xlink:type="arc" order="1" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="mnkd_StockAwardsMember" priority="2" use="optional"/>
          <link:definitionArc xlink:type="arc" order="2" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="mnkd_ChangeInFairValueOfEquityAwardsGrantedDuringTheYearUnvestedMember" priority="2" use="optional"/>
          <link:definitionArc xlink:type="arc" order="3" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="mnkd_ChangeInFairValueOfOutstandingAndUnvestedStockAwardsGrantedInPriorYearsMeasuredAsOfYearEndMember" priority="2" use="optional"/>
          <link:definitionArc xlink:type="arc" order="4" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="mnkd_ChangeInFairValueOfAwardsGrantedInPriorYearVestedMember" priority="2" use="optional"/>
          <link:definitionArc xlink:type="arc" order="5" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="mnkd_PsusMember" priority="2" use="optional"/>
          <link:definitionArc xlink:type="arc" order="6" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="mnkd_StockOptionsMember" priority="2" use="optional"/>
          <link:definitionArc xlink:type="arc" order="7" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="mnkd_FairValueOfAwardsGrantedInPriorYearForfeitedMember" priority="2" use="optional"/>
          <link:definitionArc xlink:type="arc" order="8" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="mnkd_DividendsOrOtherEarningsPaidPriorToVestingDateMember" priority="2" use="optional"/>
        </link:definitionLink>
        <link:definitionLink xlink:type="extended" xlink:role="http://xbrl.sec.gov/ecd/role/IndividualsOnly">
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AllIndividualsMember" xlink:label="ecd_AllIndividualsMember"/>
          <link:loc xlink:type="locator" xlink:href="mnkd-20240405.xsd#mnkd_CastagnaMember" xlink:label="mnkd_CastagnaMember"/>
          <link:definitionArc xlink:type="arc" order="0" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllIndividualsMember" xlink:to="mnkd_CastagnaMember" priority="2" use="optional"/>
        </link:definitionLink>
      </link:linkbase>
    </xsd:appinfo>
  </xsd:annotation>
  <xsd:element id="mnkd_EquityValuationAssumptionRiskFreeRateMinimum" name="EquityValuationAssumptionRiskFreeRateMinimum" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_EquityValuationAssumptionRiskFreeRateMaximum" name="EquityValuationAssumptionRiskFreeRateMaximum" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_EquityValuationAssumptionTermMaximum" name="EquityValuationAssumptionTermMaximum" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMinimum" name="EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMinimum" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_DividendsOrOtherEarningsPaidPriorToVestingDateMember" name="DividendsOrOtherEarningsPaidPriorToVestingDateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="mnkd_EquityValuationAssumptionVolatilityPeerMedianMinimum" name="EquityValuationAssumptionVolatilityPeerMedianMinimum" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_FairValueOfAwardsGrantedInPriorYearForfeitedMember" name="FairValueOfAwardsGrantedInPriorYearForfeitedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="mnkd_CastagnaMember" name="CastagnaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="mnkd_StockAwardsMember" name="StockAwardsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="mnkd_EquityValuationAssumptionVolatilityMannkindMaximum" name="EquityValuationAssumptionVolatilityMannkindMaximum" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_ChangeInFairValueOfOutstandingAndUnvestedStockAwardsGrantedInPriorYearsMeasuredAsOfYearEndMember" name="ChangeInFairValueOfOutstandingAndUnvestedStockAwardsGrantedInPriorYearsMeasuredAsOfYearEndMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="mnkd_ChangeInFairValueOfAwardsGrantedInPriorYearVestedMember" name="ChangeInFairValueOfAwardsGrantedInPriorYearVestedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="mnkd_EquityValuationAssumptionExercisePriceMinimum" name="EquityValuationAssumptionExercisePriceMinimum" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_EquityValuationAssumptionBeginningAverageStockPriceMaximum" name="EquityValuationAssumptionBeginningAverageStockPriceMaximum" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMinimum" name="EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMinimum" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_SummaryOfCompensationTableTotalMember" name="SummaryOfCompensationTableTotalMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="mnkd_EquityValuationAssumptionValuationDateStockPriceMaximum" name="EquityValuationAssumptionValuationDateStockPriceMaximum" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMaximum" name="EquityValuationAssumptionDifferenceCorrelationCoefficientPeerAverageMaximum" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_EquityValuationAssumptionVolatilityPeerAverageMinimum" name="EquityValuationAssumptionVolatilityPeerAverageMinimum" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_EquityValuationAssumptionVolatilityMannkindMinimum" name="EquityValuationAssumptionVolatilityMannkindMinimum" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_EquityValuationAssumptionBeginningAverageStockPriceMinimum" name="EquityValuationAssumptionBeginningAverageStockPriceMinimum" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_EquityValuationAssumptionInitialTsrMinimum" name="EquityValuationAssumptionInitialTsrMinimum" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_EquityValuationAssumptionVolatilityPeerAverageMaximum" name="EquityValuationAssumptionVolatilityPeerAverageMaximum" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_PsusMember" name="PsusMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="mnkd_EquityValuationAssumptionTermMinimum" name="EquityValuationAssumptionTermMinimum" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_ChangeInFairValueOfEquityAwardsGrantedDuringTheYearUnvestedMember" name="ChangeInFairValueOfEquityAwardsGrantedDuringTheYearUnvestedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="mnkd_EquityValuationAssumptionValuationDateStockPriceMinimum" name="EquityValuationAssumptionValuationDateStockPriceMinimum" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_EquityValuationAssumptionExercisePriceMaximum" name="EquityValuationAssumptionExercisePriceMaximum" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_EquityValuationAssumptionInitialTsrMaximum" name="EquityValuationAssumptionInitialTsrMaximum" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_EquityValuationAssumptionValuationDateStockPrice" name="EquityValuationAssumptionValuationDateStockPrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMaximum" name="EquityValuationAssumptionDifferenceCorrelationCoefficientMannkindMaximum" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_EquityValuationAssumptionVolatilityPeerMedianMaximum" name="EquityValuationAssumptionVolatilityPeerMedianMaximum" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_EquityValuationAssumptionDifferenceCorrelationCoefficientPeerMedian" name="EquityValuationAssumptionDifferenceCorrelationCoefficientPeerMedian" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnkd_StockOptionsMember" name="StockOptionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
</xsd:schema>
