<?xml version="1.0" encoding="us-ascii"?>
<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2019-11-08T00:22:49.1933335+00:00 -->
<!-- Version            : 5.0.0.208 -->
<!-- Package ID         : 3d469d95e0a149b6b408e38bf9233fcb -->
<!-- Copyright (c) 2019 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="mnkd_ScheduleOfAmortizationOfDebtIssuanceCostAndDebtDiscountTableTextBlock" name="ScheduleOfAmortizationOfDebtIssuanceCostAndDebtDiscountTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems" name="OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable" name="OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_MidCapCreditFacilityMember" name="MidCapCreditFacilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TrancheTwoMember" name="TrancheTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TrancheThreeMember" name="TrancheThreeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DeerfieldManagementCompanyLpMember" name="DeerfieldManagementCompanyLpMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TheMannGroupLLCMember" name="TheMannGroupLLCMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ConvertiblePromissoryNoteMember" name="ConvertiblePromissoryNoteMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NonConvertiblePromissoryNoteMember" name="NonConvertiblePromissoryNoteMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NewLoanArrangementMember" name="NewLoanArrangementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_SeniorConvertibleNotesDueTwoThousandTwentyOneMember" name="SeniorConvertibleNotesDueTwoThousandTwentyOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_JuneTwoThousandTwentyPromissoryNoteMember" name="JuneTwoThousandTwentyPromissoryNoteMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DecemberTwoThousandTwentyPromissoryNoteMember" name="DecemberTwoThousandTwentyPromissoryNoteMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TwoThousandTwentyFourConvertibleNotesMember" name="TwoThousandTwentyFourConvertibleNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_InsulinMember" name="InsulinMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DebtInstrumentCovenantMinimumTargetNetRevenue" name="DebtInstrumentCovenantMinimumTargetNetRevenue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_DebtInstrumentMinimumCashCovenant" name="DebtInstrumentMinimumCashCovenant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_DebtInstrumentMaturityMonthAndYear" name="DebtInstrumentMaturityMonthAndYear" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_SalesReturnPeriod" name="SalesReturnPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PercentageOfEstimatedProductsReturns" name="PercentageOfEstimatedProductsReturns" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mnkd_LossOnPurchaseCommitmentsNumberOfContractsRecognized" name="LossOnPurchaseCommitmentsNumberOfContractsRecognized" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ConversionOfSeniorConvertibleNotesIntoCommonStockMember" name="ConversionOfSeniorConvertibleNotesIntoCommonStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ConversionOfPromissoryNotesIntoCommonStockMember" name="ConversionOfPromissoryNotesIntoCommonStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_EmployeeStockPurchasePlanMember" name="EmployeeStockPurchasePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ExerciseOfWarrantsAssociatedWithMidcapCreditFacilityMember" name="ExerciseOfWarrantsAssociatedWithMidcapCreditFacilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ExerciseOfWarrantsAssociatedWithPublicOfferingMember" name="ExerciseOfWarrantsAssociatedWithPublicOfferingMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ExerciseOfWarrantsAssociatedWithDirectPlacementMember" name="ExerciseOfWarrantsAssociatedWithDirectPlacementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NewAccountingPronouncementOrChangeInAccountingPrincipleCumulativeEffectOfChangeOnNetAssetsLiabilities" name="NewAccountingPronouncementOrChangeInAccountingPrincipleCumulativeEffectOfChangeOnNetAssetsLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_WholesalerDistributionFeesAndPromptPayDiscounts" name="WholesalerDistributionFeesAndPromptPayDiscounts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_ReserveForReturns" name="ReserveForReturns" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_NumberOfWholesaleDistributors" name="NumberOfWholesaleDistributors" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PercentageOfAccountsReceivableFromMajorCustomers" name="PercentageOfAccountsReceivableFromMajorCustomers" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mnkd_FurnitureFixturesAndOfficeEquipmentMember" name="FurnitureFixturesAndOfficeEquipmentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ComputerEquipmentAndSoftwareMember" name="ComputerEquipmentAndSoftwareMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CustomerDiscountsAndAllowances" name="CustomerDiscountsAndAllowances" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_CurrentPortionOfMilestoneRightLiability" name="CurrentPortionOfMilestoneRightLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_AccruedRepairsAndMaintenance" name="AccruedRepairsAndMaintenance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_SalesAndMarketingRelatedExpensesAccrued" name="SalesAndMarketingRelatedExpensesAccrued" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_AccruedExpensesAndOtherCurrentLiabilitiesAbstract" name="AccruedExpensesAndOtherCurrentLiabilitiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AdditionalCommonStockSharesReservedForIssuance" name="AdditionalCommonStockSharesReservedForIssuance" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PercentageOfBeneficiallyOwnInExcess" name="PercentageOfBeneficiallyOwnInExcess" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_WrittenNoticePeriodFromRelatedParty" name="WrittenNoticePeriodFromRelatedParty" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PercentageOfBeneficialInterestOwned" name="PercentageOfBeneficialInterestOwned" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_TrusteeSubstantialPortionDisposedTerm" name="TrusteeSubstantialPortionDisposedTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PercentageOfCommonStockSharesOutstanding" name="PercentageOfCommonStockSharesOutstanding" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mnkd_LoanArrangementMember" name="LoanArrangementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AccruedInterestNoncurrent" name="AccruedInterestNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_DeerfieldCreditFacilityMember" name="DeerfieldCreditFacilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CreditFacilityDueJulyTwoThousandNineteenMember" name="CreditFacilityDueJulyTwoThousandNineteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CreditFacilityDueAugustTwoThousandNineteenMember" name="CreditFacilityDueAugustTwoThousandNineteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_FivePointSevenFivePercentSeniorConvertibleNotesMember" name="FivePointSevenFivePercentSeniorConvertibleNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DebtInstrumentFloorRate" name="DebtInstrumentFloorRate" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentAdditionalBorrowingCapacity" name="DebtInstrumentAdditionalBorrowingCapacity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_TwoThousandNineteenNotesMember" name="TwoThousandNineteenNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_EightPointSevenFiveSeniorConvertibleNotesDueTwoThousandNineteenMember" name="EightPointSevenFiveSeniorConvertibleNotesDueTwoThousandNineteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DeerfieldFacilityFinancingObligationMember" name="DeerfieldFacilityFinancingObligationMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TwoThousandNineteenNotesTrancheOneMember" name="TwoThousandNineteenNotesTrancheOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ContingentLiability" name="ContingentLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_ContingentLiabilityRemainingPayableAmount" name="ContingentLiabilityRemainingPayableAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_MilestoneRightsLiabilityMember" name="MilestoneRightsLiabilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AccruedExpensesAndOtherCurrentLiabilitiesMember" name="AccruedExpensesAndOtherCurrentLiabilitiesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_MilestoneRightsLiabilitiesCurrentAndNoncurrent" name="MilestoneRightsLiabilitiesCurrentAndNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PaymentForMilestoneRightsLiabilities" name="PaymentForMilestoneRightsLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_MilestoneRightsLiabilitiesCurrent" name="MilestoneRightsLiabilitiesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_MilestoneInterestExpense" name="MilestoneInterestExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_TrancheOneMember" name="TrancheOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TrancheOneAndTrancheTwoMember" name="TrancheOneAndTrancheTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TrancheOneWarrantsMember" name="TrancheOneWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DebtInstrumentPaymentNumberOfEqualMonthlyInstallments" name="DebtInstrumentPaymentNumberOfEqualMonthlyInstallments" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_EarlyTerminationFeesPercentage" name="EarlyTerminationFeesPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentExitFeePercentage" name="DebtInstrumentExitFeePercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_TermLoanAdvancePercentageOfAmountDrawdown" name="TermLoanAdvancePercentageOfAmountDrawdown" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PrivatelyNegotiatedExchangeAgreementMember" name="PrivatelyNegotiatedExchangeAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_BruceAndCoIncMember" name="BruceAndCoIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NumberOfNonInterestBearingPromissoryNotes" name="NumberOfNonInterestBearingPromissoryNotes" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PrincipalAmountPerShare" name="PrincipalAmountPerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentConvertibleThresholdConsecutiveTradingDay" name="DebtInstrumentConvertibleThresholdConsecutiveTradingDay" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_AccruedPaidInKindInterest" name="AccruedPaidInKindInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_AmortizationOfDebtPremium" name="AmortizationOfDebtPremium" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_AmortizationOfDebtDiscount" name="AmortizationOfDebtDiscount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_LicenseAgreementMember" name="LicenseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ResearchAgreementMember" name="ResearchAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CollaborationAndLicenseAgreementMember" name="CollaborationAndLicenseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_SupplyAndDistributionAgreementMember" name="SupplyAndDistributionAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_LicenseAndDistributionAgreementMember" name="LicenseAndDistributionAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_UnitedTherapeuticsCorporationMember" name="UnitedTherapeuticsCorporationMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ReceptorLifeScienceIncMember" name="ReceptorLifeScienceIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_BiommSAMember" name="BiommSAMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CiplaLtdMember" name="CiplaLtdMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_UpfrontPaymentReceived" name="UpfrontPaymentReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_MilestonePaymentReceived" name="MilestonePaymentReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_PotentialMilestonePaymentsToBeReceived" name="PotentialMilestonePaymentsToBeReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_AdditionalOptionExerciseAndDevelopmentMilestonePaymentsToBeReceived" name="AdditionalOptionExerciseAndDevelopmentMilestonePaymentsToBeReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_ProductPrototypeMember" name="ProductPrototypeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_EngineeringConsultingServicesMember" name="EngineeringConsultingServicesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ProceedsFromSigningFeesAndUpfrontLicenseFees" name="ProceedsFromSigningFeesAndUpfrontLicenseFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DateOfAgreementInitiationForMarketingAndDistribution" name="DateOfAgreementInitiationForMarketingAndDistribution" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_FairValueOfFinancialInstrumentsLineItems" name="FairValueOfFinancialInstrumentsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_FairValueOfFinancialInstrumentsTable" name="FairValueOfFinancialInstrumentsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NotePayableYieldChangesOneMember" name="NotePayableYieldChangesOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NotePayableYieldChangesTwoMember" name="NotePayableYieldChangesTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NotePayableYieldChangesThreeMember" name="NotePayableYieldChangesThreeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NotePayableYieldChangesFourMember" name="NotePayableYieldChangesFourMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_MannGroupNotesMember" name="MannGroupNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_FairValueOfDebtInstrumentsToRelatedPartyDescription" name="FairValueOfDebtInstrumentsToRelatedPartyDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_FairValueOfNotePayableToRelatedPartyDescription" name="FairValueOfNotePayableToRelatedPartyDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_NotePayablePercentageOfInterestRateChange" name="NotePayablePercentageOfInterestRateChange" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ChangeInFairValueOfNotePayableValueDueToChangeInInterestRatePercentage" name="ChangeInFairValueOfNotePayableValueDueToChangeInInterestRatePercentage" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_ChangeInFairValueOfNotePayablePercentageDueToChangeInInterestRatePercentage" name="ChangeInFairValueOfNotePayablePercentageDueToChangeInInterestRatePercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_RestrictedStockUnitsRSUAndTimeBasedOptionsMember" name="RestrictedStockUnitsRSUAndTimeBasedOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CommitmentsAndContingenciesLineItems" name="CommitmentsAndContingenciesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CommitmentsAndContingenciesTable" name="CommitmentsAndContingenciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_UnderwritingAgreementMember" name="UnderwritingAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_LeaseAgreementWithEnterpriseMember" name="LeaseAgreementWithEnterpriseMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_OfficeMember" name="OfficeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_RussellRanchRoadIILLCMember" name="RussellRanchRoadIILLCMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_PurchaseObligationExtendedTerm" name="PurchaseObligationExtendedTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PurchaseObligationDueInSixthYear" name="PurchaseObligationDueInSixthYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PurchaseObligationDueInSeventhYear" name="PurchaseObligationDueInSeventhYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PurchaseObligationDueInEighthYear" name="PurchaseObligationDueInEighthYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_LongTermPurchaseCommitmentAmendmentFee" name="LongTermPurchaseCommitmentAmendmentFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_PaymentOfLongTermPurchaseCommitmentAmendmentFee" name="PaymentOfLongTermPurchaseCommitmentAmendmentFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_LongTermPurchaseCommitmentExpirationDate" name="LongTermPurchaseCommitmentExpirationDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_LongtermPurchaseCommitmentRenewalTimePeriod" name="LongtermPurchaseCommitmentRenewalTimePeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PurchaseObligationDueInRemainderOfFiscalYear" name="PurchaseObligationDueInRemainderOfFiscalYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_ForeignCurrencyHedgingTransactionPeriod" name="ForeignCurrencyHedgingTransactionPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ClassOfWarrantOrRightsExpirationDate" name="ClassOfWarrantOrRightsExpirationDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_NumberOfVehicleLeases" name="NumberOfVehicleLeases" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_NumberOfVehicleLeasesRemoved" name="NumberOfVehicleLeasesRemoved" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_OperatingLeaseReductionInRightOfUseAsset" name="OperatingLeaseReductionInRightOfUseAsset" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_ReductionInOperatingLeaseLiability" name="ReductionInOperatingLeaseLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_OperatingLeaseOtherNonCurrentAssets" name="OperatingLeaseOtherNonCurrentAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_OperatingLeaseOtherLiabilitiesCurrent" name="OperatingLeaseOtherLiabilitiesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_OperatingLeasesAnnualIncreaseInRentExpense" name="OperatingLeasesAnnualIncreaseInRentExpense" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ReimbursementAmountReceivedForTenantImprovements" name="ReimbursementAmountReceivedForTenantImprovements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_OfficeAndVehicleMember" name="OfficeAndVehicleMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
</xsd:schema>
