Accounting Policies [Abstract] Accounting Policies [Abstract] Accounts and Other Receivables [Line Items] Accounts and Other Receivables [Line Items] Accounts and Other Receivables [Line Items] Accounts and Other Receivables [Table] Accounts and Other Receivables [Table] Accounts and Other Receivables [Table] Accounts Payable and Accrued Liabilities Disclosure [Text Block] Accrued expenses and other current liabilities Accounts Payable, Current Accounts payable Accrued Expenses and Other Current Liabilities [Line Items] Accrued Expenses and Other Current Liabilities [Line Items] Accrued Expenses and Other Current Liabilities [Line Items] Accrued Expenses and Other Current Liabilities [Table] Accrued Expenses and Other Current Liabilities [Table] Accrued Expenses and Other Current Liabilities [Table] Accrued interest on investments, net of amortization of discounts. Accrued Interest On Investments Net Of Amortization Of Discounts Accrued interest on investments, net of amortization of discounts Accrued Liabilities, Current Accrued expenses and other current liabilities Accrued expenses and other current liabilities Research and clinical trial costs accrued. Accrued Research And Clinical Trial Costs Research and clinical trial costs Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Less accumulated depreciation and amortization Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive loss Achievement of Product Sales Milestone [Member] Achievement of Product Sales Milestone [Member] Product Sales Milestones Additional Paid in Capital, Common Stock Additional paid-in capital Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash provided by (used in) operating activities: Aggregate Offering Price Under Each Agreement Aggregate Offering Price Under Each Agreement Offering price of common stock under agreement Agreement. Agreements [Axis] Agreements [Axis] Agreements. Agreements [Domain] Agreements [Domain] Agreement Type [Axis] Agreement Type [Axis] Agreement Type [Axis] Agreement Type [Domain] Agreement Type [Domain] Agreement Type [Domain] Allocated Share-based Compensation Expense Stock-based compensation Allocated Share Based Compensation Expense (Credit) Allocated Share Based Compensation Expense (Credit) Credit to stock compensation expense Amended Agreement [Member] Amended Agreement [Member] Amended Agreement Amendment Flag Amendment Flag Amortization of Debt Discount (Premium) Accretion expense- debt discount Debt discount Amortization of Financing Costs Accretion expense- debt issuance cost Amortization of Financing Costs and Discounts Accretion expense Accretion of debt discount and debt issuance expense Amortization period of lease hold improvements. Amortization Period Of Lease Hold Improvements Amortization period of lease hold improvements Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Antidilutive securities Arrangements and Non-arrangement Transactions [Domain] Arrangements and Non-arrangement Transactions [Domain] Assets Total Assets [Abstract] ASSETS Assets, Current Total current assets Assets, Current [Abstract] Current assets: At Market Sales Agreement [Member] At Market Sales Agreement [Member] ATM Agreements Available borrowings under the loan agreement. Available Borrowings Under Loan Agreement Additional borrowings Available-for-sale Securities, Gross Realized Gain (Loss) Loss on available-for-sale securities Available Loan Balance Cancelled Available Loan Balance Cancelled Aggregate principal amount cancelled Award Type [Axis] Award Type [Axis] Basis of Presentation. Basis Of Presentation Policy [Text Block] Basis of Presentation Building Improvements [Member] Building Improvements Building [Member] Buildings Business. Business Policy [Text Block] Business Cancellation of principal on note payable to related party. Cancellation Of Principal On Note Payable To Related Party Reduction of principal on note payable to principal stockholder upon issuance of common stock and exercise of warrants Cash and Cash Equivalents, at Carrying Value CASH AND CASH EQUIVALENTS, END OF PERIOD CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD Cash and cash equivalents Cash equivalents Cash and Cash Equivalents, Period Increase (Decrease) NET INCREASE IN CASH AND CASH EQUIVALENTS Class of Stock [Domain] Class of Stock [Domain] Class of Stock [Line Items] Class of Stock [Line Items] Collaboration and License Agreement [Member] Collaboration and License Agreement [Member] License and Collaboration Agreement with Sanofi Collaborative Arrangement Disclosure [Text Block] Collaboration arrangement Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Collection of Series C convertible preferred stock subscriptions receivable. Collection Of Convertible Preferred Stock Subscriptions Receivable Collection of Series C convertible preferred stock subscriptions receivable Commitment Asset [Member] Commitment Asset [Member] Commitment Asset Commitment Assets, Market Yields Commitment Assets, Market Yields Percentage of market yield Commitments and Contingencies Commitments and contingencies Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Text Block] Commitments and contingencies Commitments and Contingencies [Line Items] Commitments and Contingencies [Line Items] Commitments and Contingencies [Line Items] Commitments and Contingencies [Table] Commitments and Contingencies [Table] Commitments and Contingencies [Table] Common and preferred stock. Common And Preferred Stock [Text Block] Common and preferred stock Common Shares Issuable upon Conversion of Convertible Debt Common Shares Issuable upon Conversion of Convertible Debt Common shares issuable upon conversion Common stock loaned under share lending agreement, shares. Common Stock Loaned Under Share Lending Agreement Shares Common stock loaned under share lending agreement, shares Common Stock, Par or Stated Value Per Share Common stock, par value Common Stock, Shares Authorized Common stock, shares authorized Common Stock, Shares, Issued Common stock, shares issued Common Stock, Shares, Outstanding Common stock, shares outstanding Common Stock, Value, Issued Common stock, $0.01 par value - 550,000,000 shares authorized at September 30, 2014 and December 31, 2013; 405,469,034 and 369,391,972 shares issued and outstanding at September 30, 2014 and December 31, 2013, respectively Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract] Other comprehensive loss: Computer equipment and software. Computer Equipment And Software [Member] Computer Equipment and Software Construction in Progress Expenditures Incurred but Not yet Paid Non-cash construction in progress and property and equipment Construction in Progress [Member] Construction in Progress Construction Payable, Current Construction in progress Contingent Liability Contingent Liability Contingent liability for milestone payments Conversion of Stock, Amount Converted Conversion of convertible preferred stock amount converted Conversion of Series A redeemable convertible preferred stock Convertible Debt [Line Items] Convertible Debt [Line Items] Convertible Debt [Line Items] Convertible Debt [Table] Convertible Debt [Table] Convertible Debt [Table] Convertible Notes Payable, Noncurrent Senior convertible notes Convertible Notes Payable, Current Senior convertible notes - current Credit Agreement [Axis] Credit Agreement [Axis] Credit Agreement [Axis] Credit Agreement [Domain] Credit Agreement [Domain] Credit Agreement [Domain] Credit Facility [Axis] Credit Facility [Axis] Credit Facility [Domain] Credit Facility [Domain] Current Fiscal Year End Date Current Fiscal Year End Date Debt Conversion, Converted Instrument, Amount Issuance of common stock upon conversion of notes payable Debt Conversion, Original Debt, Amount Amount of common shares issued upon conversion Issuance of common stock pursuant to conversion of facility financing obligation Debt Disclosure [Abstract] Debt Disclosure [Abstract] Debt Disclosure [Text Block] Facility Agreement Debt Instrument Amount Of Tranches Debt Instrument Amount Of Tranches Debt facility periodic principal amount Debt Instrument, Basis Spread on Variable Rate Interest rate (LIBOR) Long-term Debt, Gross Carrying value Net carrying amount Debt Instrument Contingent Convertible Amount Debt Instrument Contingent Convertible Amount Aggregate principal amount of convertible notes Debt Instrument, Convertible, Carrying Amount of Equity Component Principal converted to equity Debt Instrument, Convertible, Conversion Price Conversion price of shares Debt Instrument, Convertible, Conversion Ratio No of convertible shares Debt Instrument, Convertible, Threshold Consecutive Trading Days Consecutive trading days Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger Percentage of conversion price equaling stock price Debt Instrument, Convertible, Threshold Trading Days Trading days Debt Instrument, Description of Variable Rate Basis Description of variable rate interest Debt Instrument, Face Amount Principal amount Carrying value Debt facility principal amount Debt Instrument, Fair Value Disclosure Estimated fair value Debt Instrument, Interest Rate, Stated Percentage Senior notes, effective interest rate Debt Instrument [Line Items] Debt Instrument [Line Items] Debt Instrument, Maturity Date Debt instrument maturity date Promissory note maturity date Debt Instrument, Redemption Price, Percentage Percentage of repurchase price Debt Instrument, Repurchased Face Amount Principal amount of notes purchased Schedule of Long-term Debt Instruments [Table] Schedule of Long-term Debt Instruments [Table] Debt Instrument, Unamortized Discount Commitment asset, debt discount Debt issuance cost. Debt Issuance Cost Issuance cost Deerfield Management Company Lp [Member] Deerfield Management Company Lp [Member] Deerfield Deferred Compensation Share-based Arrangements, Liability, Current and Noncurrent Remaining liability awards Deferred Revenue Deferred revenue Deferred Revenue, Current Deferred up-front payment from collaboration agreement Depreciation, Depletion and Amortization, Nonproduction Depreciation and accretion Depreciation and amortization expense. Depreciation And Amortization Expense Table [Text Block] Depreciation and Amortization Expense Depreciation and Other Amortization Expenses [Line Items] Depreciation and Other Amortization Expenses [Line Items] Depreciation and Other Amortization Expenses [Line Items] Depreciation and Other Amortization Expenses [Table] Depreciation and Other Amortization Expenses [Table] Depreciation and Other Amortization Expenses [Table] Depreciation, Depletion and Amortization Depreciation and amortization expense Development And Manufacturing Milestone Events [Member] Development And Manufacturing Milestone Events [Member] Development and Manufacturing Milestone Events Development Stage Enterprise, Deficit Accumulated During Development Stage Deficit accumulated during the development stage Deficit accumulated during the development stage Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Accounting for stock-based compensation Document And Entity Information [Abstract] Document And Entity Information [Abstract] Document And Entity Information [Abstract] Document Fiscal Period Focus Document Fiscal Period Focus Document Fiscal Year Focus Document Fiscal Year Focus Document Information [Line Items] Document Information [Line Items] Document Information [Table] Document Information [Table] Document Period End Date Document Period End Date Document Type Document Type Earnings Per Share [Abstract] Earnings Per Share [Abstract] Earnings Per Share, Basic and Diluted Net loss per share applicable to common stockholders - basic and diluted Earnings Per Share [Text Block] Net loss per common share Employee-related Liabilities, Current Salary and related expenses Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized Unrecognized compensation cost related to non vested stock options Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition Weighted average vesting period for unrecognized compensation cost Employee Stock Option [Member] Stock Options Entity Central Index Key Entity Central Index Key Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Entity [Domain] Entity [Domain] Entity Filer Category Entity Filer Category Entity Registrant Name Entity Registrant Name Equity [Abstract] Equity [Abstract] Estimated Amounts Credit Exchange Receivable Current Estimated Amounts Credit Exchange Receivable Current Estimated amounts receivable under program, Current Estimated Amounts Credit Exchange Receivable Noncurrent Estimated Amounts Credit Exchange Receivable Noncurrent Estimated amounts receivable under program, Long-term Facility Agreement [Member] Facility Agreement [Member] Facility Agreement Facility Financing Obligation [Member] Facility Financing Obligation [Member] Facility financing obligation Asset Class [Domain] Asset Class [Domain] Fair Value Assumptions, Expected Volatility Rate Company's longer-term historical volatility rate Asset Class [Axis] Asset Class [Axis] Fair Value, Hierarchy [Axis] Fair Value, Hierarchy [Axis] Fair Value Disclosures [Abstract] Fair Value Disclosures [Abstract] Fair Value Disclosures [Text Block] Fair value of financial instruments Fair Value Inputs, Discount Rate Market discount rate Fair Value, Inputs, Level 3 [Member] Fair Value, Inputs, Level 3 Fair Value Hierarchy [Domain] Fair Value Hierarchy [Domain] Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Transfers, Net Transfers of assets between fair value measurement Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Transfers, Net Transfers of liabilities between fair value measurement Fair Value of Financial Instruments [Line Items] Fair Value of Financial Instruments [Line Items] Fair Value of Financial Instruments [Line Items] Fair Value of Financial Instruments, Policy [Policy Text Block] Fair Value of Financial Instruments Fair Value of Financial Instruments [Table] Fair Value of Financial Instruments [Table] Fair Value of Financial Instruments [Table] Filing and Completion of Regulatory Approvals [Member] Filing and Completion of Regulatory Approvals [Member] Regulatory Approvals Finite-Lived Intangible Assets by Major Class [Axis] Finite-Lived Intangible Assets by Major Class [Axis] Finite-Lived Intangible Assets, Major Class Name [Domain] Finite-Lived Intangible Assets, Major Class Name [Domain] Forward purchase contract contribution to additional paid in capital. Forward Purchase Contract Contribution To Additional Paid In Capital Forward purchase contract contribution to APIC Furniture, fixtures and office equipment. Furniture Fixtures And Office Equipment [Member] Furniture, fixtures and office equipment Gain (Loss) on Disposition of Intangible Assets Income from sale of intellectual property (Gain) loss on sale, abandonment/disposal or impairment of property and equipment. Gain Loss On Sale Abandonment Disposal Or Impairment Of Property And Equipment (Gain) loss on sale, abandonment/disposal or impairment of property and equipment Gains (Losses) on Extinguishment of Debt Loss on debt conversion General and Administrative Expense General and administrative Goodwill, Impairment Loss Goodwill impairment Income Approach Valuation Technique [Member] Income Approach Valuation Technique Income (Loss) from Continuing Operations before Income Taxes, Extraordinary Items, Noncontrolling Interest Loss before benefit for income taxes Income Statement [Abstract] Income Statement [Abstract] Income Tax Disclosure [Abstract] Income Tax Disclosure [Abstract] Income Tax Disclosure [Text Block] Income taxes Income Taxes Paid Cash paid for income taxes Income Tax Expense (Benefit) Income tax benefit Increase (Decrease) in Accounts Payable Accounts payable Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities Accrued expenses and other current liabilities Increase (Decrease) in Deferred Compensation Increase in stock-based compensation expenses Increase (Decrease) in Deferred Revenue Deferred up-front payment from collaboration agreement Increase (Decrease) in Operating Capital [Abstract] Changes in assets and liabilities: Increase (Decrease) in Other Operating Assets Other assets Increase (Decrease) in Other Operating Liabilities Other liabilities Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other current assets Increase in additional paid-in capital resulting from merger. Increase In Additional Paid In Capital Resulting From Merger Increase in additional paid-in capital resulting from merger Intellectual Property [Member] Intellectual property Interest Expense, Debt Interest expense on notes Interest Expense Related To Milestone Payment Interest Expense Related To Milestone Payment Interest expense related to milestone payment Interest Paid Interest paid in cash, net of amounts capitalized Interest Paid, Capitalized Capitalization of interest on note payable to principal stockholder Interest Payable, Current Accrued interest Interest Payable Accrued interest Interest payable Investment Income, Interest Interest income Issuance of Series C convertible preferred stock subscriptions. Issuance Of Convertible Preferred Stock Subscriptions Issuance of Series C convertible preferred stock subscriptions Issuance of put option by stockholder. Issuance Of Put Option By Stockholder Issuance of put option by stockholder Issuance of Series A redeemable convertible preferred stock. Issuance Of Redeemable Convertible Preferred Stock Issuance of Series A redeemable convertible preferred stock Issuance of Stock and Warrants for Services or Claims Litigation settlement in stock Land [Member] Land Leasehold Improvements [Member] Leasehold Improvements Legal Entity [Axis] Legal Entity [Axis] Letter agreement. Letter Agreement [Member] Letter Agreement Liabilities Total liabilities Liabilities and Equity Total Liabilities and Equity [Abstract] LIABILITIES AND STOCKHOLDERS' DEFICIT Liabilities, Current Total current liabilities Liabilities, Current [Abstract] Current liabilities: Financial and Nonfinancial Liabilities, Fair Value Disclosure Fair value of Milestone Rights Long-term Line of Credit Principal amount outstanding under credit facility Lender Name [Axis] Lender Name [Axis] Line of Credit Facility, Lender [Domain] Line of Credit Facility, Lender [Domain] Line of Credit Facility, Maximum Borrowing Capacity Maximum sales amount under the agreement Maximum secured loan facility Line of Credit Facility, Remaining Borrowing Capacity Amount available for future borrowings Available borrowings under loan agreement Line Of Credit Facility Restricted Borrowing Capacity Line Of Credit Facility Restricted Borrowing Capacity Maximum available amount of credit facility under covenant restrictions Loan agreement with related party. Loan Agreement With Related Party Loan agreement with related party Loan arrangement. Loan Arrangement [Member] Loan Arrangement Loan Commitment Asset Loan Commitment Asset Commitment asset balance at December 31,2013 Loan Commitment Asset Current Portion Loan Commitment Asset Current Portion Less commitment asset portion associated with the receipt of Tranche 4 and Tranche B notes Loan Commitment Asset Fair Value Loan Commitment Asset Fair Value Tranche B commitment asset fair value Additional commitment asset Commitment asset at fair value Loan Commitment Asset Noncurrent Portion Loan Commitment Asset Noncurrent Portion Commitment asset value included in other assets London Interbank Offered Rate (LIBOR) [Member] LIBOR Long-term Debt, Percentage Bearing Fixed Interest, Percentage Rate Fixed borrowing rate Long-term Debt [Text Block] Senior convertible notes Long-term Debt, Type [Axis] Long-term Debt, Type [Axis] Long-term Debt, Type [Domain] Long-term Debt, Type [Domain] Long Term Purchase Commitment, Expiration Date Long Term Purchase Commitment, Expiration Date Supply Agreement expiration period Long-term purchase commitment, renewal time period. Long-term Purchase Commitment, Renewal Time Period Supply Agreement renewal period Machinery and Equipment [Member] Machinery and Equipment Maximum [Member] Maximum Milestone Events [Axis] Milestone Events [Axis] Milestone Events [Axis] Milestone Events [Domain] Milestone Events [Domain] Milestone Events [Domain] Milestone Rights Liability [Member] Milestone Rights Liability [Member] Milestone Rights Liability Minimum [Member] Minimum Money Market Funds, at Carrying Value Cash equivalents, money market funds Net Cash Provided by (Used in) Financing Activities, Continuing Operations Net cash provided by financing activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] CASH FLOWS FROM FINANCING ACTIVITIES: Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net cash used in investing activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] CASH FLOWS FROM INVESTING ACTIVITIES: Net Cash Provided by (Used in) Operating Activities Cash flow from operation since inception Net Cash Provided by (Used in) Operating Activities, Continuing Operations Net cash provided by (used in) operating activities Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] CASH FLOWS FROM OPERATING ACTIVITIES: Net Income (Loss) Attributable to Parent Net loss Net loss Net Income (Loss) Available to Common Stockholders, Basic Net loss applicable to common stockholders Net Income Loss Per Common Share [Line Items] Net Income Loss Per Common Share [Line Items] Net Income Loss Per Common Share [Line Items] Net Income Loss Per Common Share [Table] Net Income Loss Per Common Share [Table] Net Income Loss Per Common Share [Table] Nominal lending fee. Nominal Lending Fee Nominal lending fee Non Cash Financing Activities Loan Commitment Asset. Non Cash Financing Activities Loan Commitment Asset Tranche B Commitment Asset Non Employee Director Stock Options [Member] Non Employee Director Stock Options [Member] Non Employee Director Stock Options Nontrade Receivables, Current State research and development tax credit exchange receivable - current Nontrade Receivables, Noncurrent State research and development credit exchange receivable Notes Issued in Four Equal Tranches [Member] Notes Issued in Four Equal Tranches [Member] Notes Issued in Four Equal Tranches Notes Payable, Related Parties, Noncurrent Note payable to principal stockholder Number of Employees With Modified Equity Based Compensation Awards Number of Employees With Modified Equity Based Compensation Awards Number of employees under modified performance grants Number Of Equal Tranches Number Of Equal Tranches Number of equal tranches Number of months advances outstanding. Number Of Months Advances Outstanding Number of months advances outstanding Operating Expenses Total operating expenses Operating Expenses [Abstract] Operating expenses: Operating Income (Loss) Loss from operations Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] Organization, Consolidation and Presentation of Financial Statements Disclosure [Table] Organization, Consolidation and Presentation of Financial Statements Disclosure [Table] Organization, Consolidation and Presentation of Financial Statements Disclosure [Table] Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] Description of business and basis of presentation Other Accrued Liabilities, Current Other Other Assets, Noncurrent Other assets Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax [Abstract] Unrealized gain (loss) on investments: Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Gain (Loss) Arising During Period, Net of Tax Cumulative translation (loss) gain Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax Net unrealized gain on investments Other Comprehensive Income (Loss), Net of Tax Other comprehensive loss Other Comprehensive Income (Loss), Reclassification Adjustment from AOCI for Sale of Securities, Net of Tax Less: reclassification adjustment for gains (losses) included in net loss Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax Unrealized holding gain (loss) during the period Other Liabilities, Noncurrent Other liabilities Other Long-term Debt, Current Facility financing obligation Short term liability Other Long-term Debt, Noncurrent Net carrying value of facility financing obligation Facility financing obligation Long term liability Other Noncash Income (Expense) Other, net Other Nonoperating Income (Expense) Other income (expense) Own-share Lending Arrangement, Shares, Issued Shares loaned under the share lending arrangement Own-share Lending Arrangement, Shares, Outstanding Companies common stock share outstanding Payables and Accruals [Abstract] Payables and Accruals [Abstract] Payment For Contingent Liabilities Payment For Contingent Liabilities Required payment pursuant to the terms of the Milestone Agreement Payments for Repurchase of Common Stock Repurchase of common stock Payments of Debt Issuance Costs Facility financing obligation & milestone rights issuance costs Payments Related to Tax Withholding for Share-based Compensation Payment of employment taxes related to vested restricted stock units Payments to Acquire Available-for-sale Securities Purchase of marketable securities Payments to Acquire Property, Plant, and Equipment Purchase of property and equipment Percentage of credit exchange receivable. Percentage Of Credit Exchange Receivable Percentage of credit exchange receivable Percentage of Net Proceed From Sale of Notes Percentage of Net Proceed From Sale of Notes Prepayment of loan percentage of net cash proceeds sale Performance Based Restricted Stock Units [Member] Performance Based Restricted Stock Units [Member] Performance Based Restricted Stock Units Performance Based Stock Options [Member] Performance Based Stock Options [Member] Performance Based Stock Options Potential Milestone Payments Potential Milestone Payments Potential milestone payment Potential Proceeds from Warrant Exercises Potential Proceeds from Warrant Exercises Potential proceeds from the exercise of warrants from February 2012 public offering Preferred Stock Conversions, Inducements Deemed dividend related to beneficial conversion feature of convertible preferred stock Preferred Stock, Par or Stated Value Per Share Undesignated preferred stock, par value Preferred Stock, Shares Authorized Undesignated preferred stock, shares authorized Preferred Stock, Shares Issued Undesignated preferred stock, shares issued Preferred Stock, Shares Outstanding Undesignated preferred stock, shares outstanding Preferred Stock, Shares Undesignated Preferred Stock, Shares Undesignated Undesignated preferred stock, shares authorized Preferred Stock, Value, Issued Undesignated preferred stock, $0.01 par value - 10,000,000 shares authorized; no shares issued or outstanding at September 30, 2014 and December 31, 2013 Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Prepaid Expense, Current Prepayment of prepaid insurance, and prepaid clinical trial expenses Prepaid Expenses And Other Current Assets Policy [Text Block] Prepaid Expenses And Other Current Assets Policy [Text Block] Prepaid expenses and other current assets Principal amount per share. Principal Amount Per Share Principal amount per share Principal Owner [Member] Principal stockholder Proceeds from Collection of Notes Receivable Proceeds from notes receivables Proceeds from Convertible Debt Proceeds from senior convertible notes Proceeds from Issuance of Common Stock Cash received for common stock to be issued The cash inflow from the additional capital contribution to the entity including any warrants issued. Proceeds are net of cash outflows for issuance costs related to the transaction. Proceeds From Issuance Of Common Stock And Warrants Net Issuance of common stock and warrants, net of issuance costs Proceeds from Issuance of Convertible Preferred Stock Issuance of Series B convertible preferred stock for cash Proceeds from Issuance of Debt Additional sales of notes Proceeds from issuance of facility financing obligation & milestone rights Proceeds from Issuance of Long-term Debt Proceeds from issuance of Tranche B of the facility financing obligation Proceeds from Long-term Lines of Credit Borrowings under lines of credit Proceeds from Notes Payable Borrowings on notes payable Proceeds from Related Party Debt Borrowings on notes payable to principal stockholder Proceeds from Sale and Maturity of Available-for-sale Securities Sales and maturities of marketable securities Proceeds from Sale of Intangible Assets Proceeds from sale of intellectual property Proceeds from Sale of Property, Plant, and Equipment Proceeds from sale of property and equipment Profit Loss Sharing Agreement Allocation Percentage Profit Loss Sharing Agreement Allocation Percentage Profits and losses sharing percentage Property, Plant and Equipment [Abstract] Property, Plant and Equipment [Abstract] Property, Plant and Equipment, Type [Axis] Property, Plant and Equipment, Type [Axis] Property, Plant and Equipment Disclosure [Text Block] Property and equipment Property, Plant and Equipment, Gross Property and equipment - gross Property, Plant and Equipment [Line Items] Property, Plant and Equipment [Line Items] Property, Plant and Equipment, Net Property and equipment - net Property and equipment - net Property, Plant and Equipment [Table Text Block] Property and Equipment Property, Plant and Equipment, Type [Domain] Property, Plant and Equipment, Type [Domain] Property, Plant and Equipment, Useful Life Estimated Useful Life (Years) Purchase Commitment, Remaining Minimum Amount Committed Remaining minimum amount committed in calendar years 2015 through 2019 Put option redemption by stockholder. Put Option Redemption By Stockholder Put option redemption by stockholder Put shares sold to majority stockholder. Put Shares Sold To Majority Stockholder Put shares sold to majority stockholder Range [Axis] Range [Axis] Range [Domain] Range [Domain] Recently issued accounting standards. Recently Issued Accounting Standards [Policy Text Block] Recently Issued Accounting Standards Reclassification of forward purchase contract to additional paid in capital. Reclassification Of Forward Purchase Contract To Additional Paid In Capital Reclassification of forward purchase contract to APIC Reclassification of Share Based Awards to Liability Reclassification of Share Based Awards to Liability Reclassification of share-based awards to liability Recognition of Deferred Revenue Collaboration revenue recognized Related party debt. Related Party Debt [Member] Related Party Debt Related Party [Domain] Related Party [Domain] Related Party Transaction, Amounts of Transaction Offset expense associated with intellectual property Related Party Transaction [Axis] Related Party Transaction [Axis] Related Party Transaction Debt Instrument Prepayment Related Party Transaction Debt Instrument Prepayment Amount prepaid for cancellation of indebtedness Related Party Transaction [Domain] Related Party Transaction [Domain] Related Party Transaction, Expenses from Transactions with Related Party Interest expense on note payable to principal stockholder Related Party Transaction [Line Items] Related Party Transaction [Line Items] Related party transaction prepayment period. Related Party Transaction Prepayment Period Related party transaction prepayment period Related Party Transactions [Abstract] Related Party Transactions [Abstract] Related Party [Axis] Related Party [Axis] Related Party Transactions Disclosure [Text Block] Related-party arrangements Repayment As Percentage Of Principal Amount Repayment As Percentage Of Principal Amount Repayment as a percentage of original principal amount Repayments of Notes Payable Principal payments on notes payable Repayments of Related Party Debt Principal payments on notes payable to principal stockholder Repayments of Senior Debt Payment of 2013 notes Research and Development Expense (Excluding Acquired in Process Cost) Research and development Research and Development in Process In-process research and development In-process research and development costs Restricted Stock Units (RSUs) [Member] Restricted Stock Units (RSUs) Sale of intellectual property [Policy Text Block] Sale of Intellectual Property [Policy Text Block] Sale of intellectual property Revenue, Net Revenue Sanofi Aventis [Member] Sanofi Aventis [Member] Sanofi-Aventis Deutschland GmbH Schedule of Accrued Liabilities [Table Text Block] Accrued Expenses and Other Current Liabilities Schedule of amortization of debt issuance expense. Schedule Of Amortization Of Debt Issuance Expense Table [Text Block] Accretion of Debt Issuance Expense Schedule of Carrying Values and Estimated Fair Values of Debt Instruments [Table Text Block] Summary of Carrying Values and Estimated Fair Values of Notes and Facility Financing Obligation Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] Schedule of Long-term Debt Instruments [Table Text Block] Summary of Senior Convertible Notes Schedule of Debt [Table Text Block] Components of Facility Financing Agreement Schedule of Other Assets and Other Liabilities [Table Text Block] Accretion of Debt Issuance Cost and Debt Discount Property, Plant and Equipment [Table] Property, Plant and Equipment [Table] Schedule of Related Party Transactions, by Related Party [Table] Schedule of Related Party Transactions, by Related Party [Table] Schedule of Share-based Compensation, Activity [Table Text Block] Stock-Based Compensation Expense Recognized in Condensed Consolidated Statements of Operations Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Stock by Class [Table] Schedule of Stock by Class [Table] Second Amendment Agreement [Member] Second Amendment Agreement [Member] Second Amendment Facility Agreement Securities Financing Transaction [Line Items] Securities Financing Transaction [Line Items] Securities Financing Transaction [Table] Securities Financing Transaction [Table] Senior convertible notes due two thousand fifteen. Senior Convertible Notes Due Two Thousand Fifteen [Member] Senior convertible notes due August 15, 2015 Series B Preferred Stock [Member] Series B Preferred Stock Series C Preferred Stock [Member] Series C Preferred Stock Share-based Compensation Stock-based compensation expense Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period Share based payment award , vesting period Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Weighted average grant date fair value of restricted stock units Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Weighted average grant date fair value of the stock options granted Equity Award [Domain] Equity Award [Domain] Class of Stock [Axis] Class of Stock [Axis] Statement [Line Items] Statement [Line Items] Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Statement of Comprehensive Income [Abstract] Statement of Comprehensive Income [Abstract] Statement [Table] Statement [Table] State research and development credit exchange receivable. State Research And Development Credit Exchange Receivable State research and development credit exchange receivable State research and development credit exchange receivable. State Research And Development Credit Exchange Receivable [Text Block] State research and development credit exchange receivable Stock expense for shares issued pursuant to research agreement. Stock Expense For Shares Issued Pursuant To Research Agreement Stock expense for shares issued pursuant to research agreement Stockholders' Equity Attributable to Parent Total stockholders' deficit Stockholders' Equity Attributable to Parent [Abstract] Stockholders' deficit: Stock Issued Issuance of common stock for notes receivable Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Number of restricted stock units issued Stock Issued During Period, Shares, Share-based Compensation, Net of Forfeitures Number of stock options issued Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures Fair value of Restricted stock options granted , value Stock Issued During Period, Value, Share-based Compensation, Net of Forfeitures Fair value of the stock options granted , value Supplemental Cash Flow Information [Abstract] SUPPLEMENTAL CASH FLOWS DISCLOSURES: Temporary Equity, Accretion to Redemption Value, Adjustment Accretion on redeemable convertible preferred stock Accretion on redeemable preferred stock Text Block [Abstract] Text Block [Abstract] Total Consideration Received Total Consideration Received Consideration received Trading Symbol Trading Symbol Tranche B [Member] Tranche B [Member] Tranche B notes Tranche Four And TrancheB [Member] Tranche Four And TrancheB [Member] Tranche 4 and Tranche B Tranche Four [Member] Tranche Four [Member] Fourth tranche Tranche One And Tranche Four [Member] Tranche One And Tranche Four [Member] Tranche One and Tranche Four Notes Tranche One and Tranche Three [Member] Tranche One and Tranche Three [Member] Tranche One and Tranche Three Tranche One [Member] Tranche One [Member] Tranche One Tranche Three [Member] Tranche Three [Member] Tranche Three Two Thousand Nineteen Notes [Member] Two Thousand Nineteen Notes [Member] Senior convertible notes due December 31, 2019 Type of Arrangement and Non-arrangement Transactions [Axis] Type of Arrangement and Non-arrangement Transactions [Axis] Unamortized Debt Issuance Expense Unaccreted debt issuance expense Uncategorized [Abstract] Uncategorized [Abstract] Uncategorized [Abstract] Unrealized Gain (Loss) on Derivatives Fair value of forward purchase contract Upfront Fee Upfront Fee Up-front fee Valuation Technique [Axis] Valuation Technique [Axis] Valuation Technique [Domain] Valuation Technique [Domain] Variable Rate [Axis] Variable Rate [Axis] Variable Rate [Domain] Variable Rate [Domain] Weighted Average Number of Shares Outstanding, Basic and Diluted Shares used to compute basic and diluted net loss per share applicable to common stockholders Write Off of Derivative Liability Write Off of Derivative Liability Write-off of derivative liability