Document and Entity Information [Abstract] Statement, Equity Components [Axis] Equity Component [Domain] ASSETS Assets [Abstract] Current assets: Assets, Current [Abstract] Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value Marketable securities Available-for-sale Securities, Current State research and development credit exchange receivable - current Nontrade Receivables, Current Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Assets, Current, Total Total current assets Total current assets Property and equipment - net Property, Plant and Equipment, Net State research and development credit exchange receivable - net of current portion Nontrade Receivables, Noncurrent Other assets Other Assets, Noncurrent Assets, Total Total Total LIABILITIES AND STOCKHOLDERS' DEFICIT Liabilities and Equity [Abstract] Current liabilities: Liabilities, Current [Abstract] Accounts payable Accounts Payable, Current Accrued expenses and other current liabilities Accrued Liabilities, Current Liabilities, Current, Total Total current liabilities Total current liabilities Senior convertible notes Convertible Notes Payable, Noncurrent Note payable to related party Notes Payable, Related Parties, Noncurrent Total liabilities Liabilities, Total Total liabilities Commitments and contingencies Commitments and Contingencies Stockholders' deficit: Stockholders' Equity Attributable to Parent [Abstract] Preferred Stock, Value, Issued Undesignated preferred stock, $0.01 par value - 10,000,000 shares authorized; no shares issued or outstanding at December 31, 2010 and 2011 Common stock, $0.01 par value -200,000,000 and 250,000,000 shares authorized at December 31, 2010 and 2011, respectively; 127,793,178 and 131,522,945 shares issued and outstanding at December 31, 2010 and 2011, respectively Common Stock, Value, Issued Common Stock, Par or Stated Value Per Share Common stock, par value Common Stock, Shares Authorized Common stock, shares authorized Common Stock, Shares, Issued Common stock, shares issued Common Stock, Shares, Outstanding Common stock, shares outstanding Additional paid-in capital Additional Paid in Capital, Common Stock Accumulated other comprehensive income (loss) Accumulated Other Comprehensive Income (Loss), Net of Tax Development Stage Enterprise, Deficit Accumulated During Development Stage Deficit accumulated during the development stage Deficit accumulated during the development stage Stockholders' Equity Attributable to Parent, Total Ending balance Beginning balance Total stockholders' deficit Total stockholders' deficit Liabilities and Equity, Total Total Total Revenue Revenue, Net Operating expenses: Operating Expenses [Abstract] Research and development Research and Development Expense (Excluding Acquired in Process Cost) General and administrative General and Administrative Expense In-process research and development Research and Development in Process Goodwill impairment Goodwill, Impairment Loss Operating Expenses, Total Total operating expenses Total operating expenses Total operating expenses Operating Income (Loss) Loss from operations Loss from operations Other income (expense) Other Nonoperating Income (Expense) Related Party Transaction, Expenses from Transactions with Related Party Interest expense on note payable to related party Interest Expense, Debt Interest expense on senior convertible notes Interest income Investment Income, Interest Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Extraordinary Items, Noncontrolling Interest Loss before provision for income taxes Loss before provision for income taxes Income Tax Expense (Benefit) Income taxes Income taxes Net Income (Loss) Attributable to Parent Net loss Net loss Preferred Stock Conversions, Inducements Deemed dividend related to beneficial conversion feature of convertible preferred stock Deemed dividend related to beneficial conversion feature of convertible preferred stock Temporary Equity, Accretion to Redemption Value, Adjustment Accretion on redeemable preferred stock Accretion on redeemable convertible preferred stock Net Income (Loss) Available to Common Stockholders, Basic Net loss applicable to common stockholders Net loss applicable to common stockholders Net loss per share applicable to common stockholders - basic and diluted Earnings Per Share, Basic and Diluted Basic and Diluted Weighted Average Number of Shares Outstanding Shares used to compute basic and diluted net loss per share applicable to common stockholders Shares used to compute basic and diluted net loss per share applicable to common stockholders Statement [Table] Statement [Line Items] Common Stock Other Comprehensive Income (Loss) Stock Issued During Period, Value, Stock Options Exercised Exercise of stock options Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Stock-based compensation Issuance of Put Option by Stockholder Issuance of put option by stockholder Issuance of put option by stockholder Put Option Redemption by Stockholder Put option redemption by stockholder Put option redemption by stockholder Put Shares Sold to Majority Stockholder Put shares sold to majority stockholder Put shares sold to majority stockholder Put shares sold to majority stockholder Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract] Comprehensive loss: CASH FLOWS FROM OPERATING ACTIVITIES: Net Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Depreciation and amortization Depreciation, Depletion and Amortization, Nonproduction Stock-based compensation expense Share-based Compensation Stock Expense for Shares Issued Pursuant to Research Agreement Stock expense for shares issued pursuant to research agreement Stock expense for shares issued pursuant to research agreement Loss (gain) on sale, abandonment/disposal or impairment of property and equipment Gain Loss on Sale Abandonment Disposal or Impairment of Property and Equipment Loss on sale, abandonment/disposal or impairment of property and equipment Loss on sale, abandonment/disposal or impairment of property and equipment Accrued Interest on Investments Net of Amortization of Discounts Accrued interest on investments, net of amortization of premiums (discounts) Accrued interest on investments, net of amortization of premiums (discounts) Accrued interest on investments, net of amortization of premiums (discounts) Available-for-sale Securities, Gross Realized Gain (Loss) Loss on available-for-sale securities Loss on available-for-sale securities Other Noncash Income (Expense) Other, net Changes in assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] State Research and Development Credit Exchange Receivable State research and development credit exchange receivable State research and development credit exchange receivable Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other current assets Prepaid expenses and other current assets Increase (Decrease) in Other Operating Assets Other assets Other assets Accounts payable Increase (Decrease) in Accounts Payable Accrued expenses and other current liabilities Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities Other liabilities Increase (Decrease) in Other Operating Liabilities Net Cash Provided by (Used in) Operating Activities Net cash used in operating activities Net cash used in operating activities CASH FLOWS FROM INVESTING ACTIVITIES: Net Cash Provided by (Used in) Investing Activities [Abstract] Payments to Acquire Available-for-sale Securities Purchase of marketable securities Purchase of marketable securities Sales and maturities of marketable securities Proceeds from Sale and Maturity of Available-for-sale Securities Payments to Acquire Property, Plant, and Equipment Purchase of property and equipment Purchase of property and equipment Proceeds from sale of property and equipment Proceeds from Sale of Property, Plant, and Equipment Net cash used in investing activities Net Cash Provided by (Used in) Investing Activities Net cash used in investing activities CASH FLOWS FROM FINANCING ACTIVITIES: Net Cash Provided by (Used in) Financing Activities [Abstract] Proceeds from Issuance of Common Stock and Warrants Issuance of common stock and warrants Issuance of common stock and warrants Collection of Convertible Preferred Stock Subscriptions Receivable Collection of Series C convertible preferred stock subscriptions receivable Collection of Series C convertible preferred stock subscriptions receivable Issuance of Series B convertible preferred stock for cash Proceeds from Issuance of Convertible Preferred Stock Cash received for common stock to be issued Proceeds from Issuance of Common Stock Payments for Repurchase of Common Stock Repurchase of common stock Repurchase of common stock Borrowings under lines of credit Proceeds from Long-term Lines of Credit Proceeds from notes receivables Proceeds from Collection of Notes Receivable Borrowings on notes payable from related party Proceeds from Related Party Debt Repayments of Related Party Debt Principal payments on notes payable to principal stockholder Principal payments on notes payable to principal stockholder Borrowings on notes payable Proceeds from Notes Payable Repayments of Notes Payable Principal payments on notes payable Principal payments on notes payable Proceeds from senior convertible notes Proceeds from Convertible Debt Payment of Employment Taxes Related to Vested Restricted Stock Units Payment of employment taxes related to vested restricted stock units Payment of employment taxes related to vested restricted stock units Payment of employment taxes related to vested restricted stock units Net cash provided by financing activities Net Cash Provided by (Used in) Financing Activities Net cash provided by financing activities Cash and Cash Equivalents, Period Increase (Decrease) NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD CASH AND CASH EQUIVALENTS, END OF PERIOD SUPPLEMENTAL CASH FLOWS DISCLOSURES: Supplemental Cash Flow Information [Abstract] Cash paid for income taxes Income Taxes Paid Interest paid in cash, net of amounts capitalized Interest Paid Issuance of common stock upon conversion of notes payable Debt Conversion, Converted Instrument, Amount Increase in Additional Paid in Capital Resulting from Merger Increase in additional paid-in capital resulting from merger Increase in additional paid-in capital resulting from merger Issuance of common stock for notes receivable Stock Issued Issuance of Convertible Preferred Stock Subscriptions Issuance of Series C convertible preferred stock subscriptions Issuance of Series C convertible preferred stock subscriptions Issuance of Redeemable Convertible Preferred Stock Issuance of Series A redeemable convertible preferred stock Issuance of Series A redeemable convertible preferred stock Conversion of Series A redeemable convertible preferred stock Conversion of Stock, Amount Converted Non-cash construction in progress and property and equipment Construction in Progress Expenditures Incurred but Not yet Paid Cancellation of Principal on Note Payable to Related Party Cancellation of principal on note payable to related party Cancellation of principal on note payable to related party Description of business and basis of presentation Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] Description of business and basis of presentation [Abstract] Description of business and basis of presentation [Abstract] Summary of significant accounting policies Significant Accounting Policies [Text Block] Investment in securities Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block] Investment in securities [Abstract] Investment in securities [Abstract] State Research and Development Credit Exchange Receivable [Text Block] State research and development credit exchange receivable State research and development credit exchange receivable State research and development credit exchange receivable [Abstract] State research and development credit exchange receivable [Abstract] State research and development credit exchange receivable Property and equipment Property, Plant and Equipment Disclosure [Text Block] Property and equipment [Abstract] Property and equipment [Abstract] Accrued expenses and other current liabilities Accounts Payable and Accrued Liabilities Disclosure [Text Block] Accrued expenses and other current liabilities [Abstract] Accrued expenses and other current liabilities [Abstract] Related-party loan arrangement Related Party Transactions Disclosure [Text Block] Related-party loan arrangement/Related party transactions [Abstract] Related-party loan arrangement [Abstract] Senior convertible notes Long-term Debt [Text Block] Senior convertible notes [Abstract] Senior convertible notes [Abstract] Restructuring charges Restructuring and Related Activities Disclosure [Text Block] Restructuring charges [Abstract] Restructuring charges [Abstract] Fair Value of Financial Instruments Fair Value Disclosures [Text Block] Common and Preferred Stock [Text Block] Common and preferred stock Common and preferred stock Common and preferred stock [Abstract] Common and preferred stock [Abstract] Common and preferred stock Net loss per common share Earnings Per Share [Text Block] Net loss per common share [Abstract] Net loss per common share [Abstract] Stock award plans Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Commitments and contingencies Commitments and Contingencies Disclosure [Text Block] Commitments and contingencies [Abstract] Commitments and contingencies [Abstract] Employee benefit plans Pension and Other Postretirement Benefits Disclosure [Text Block] Income taxes Income Tax Disclosure [Text Block] Income taxes [Abstract] Income taxes [Abstract] Selected quarterly financial data (unaudited) Quarterly Financial Information [Text Block] Amendment Flag Current Fiscal Year End Date Document Period End Date Document Type Entity Central Index Key Entity Common Stock, Shares Outstanding Entity Current Reporting Status Entity Filer Category Entity Registrant Name Entity Voluntary Filers Entity Well-known Seasoned Issuer Entity Public Float Document Fiscal Period Focus Document Fiscal Year Focus Consolidated Balance Sheets [Abstract] Consolidated Statements of Operations [Abstract] Statement of Stockholders' Equity (Deficit) [Abstract] Consolidated Statements Of Cash Flows [Abstract] Shares, Outstanding Ending balance, shares Beginning balance, shares Issuance of common shares under Employee Stock Purchase Plan Stock Issued During Period, Value, Employee Stock Purchase Plan Stock Issued During Period, Shares, Employee Stock Purchase Plans Issuance of common shares under Employee Stock Purchase Plan, shares Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Exercise of stock options, shares Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive loss Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Gain (Loss) Arising During Period, Net of Tax Unrealized loss on foreign currency translation Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax Unrealized gain on available-for-sale securities Stock Issued During Period, Value, New Issues Issuance of common stock Series B Convertible Preferred Stock Member Series B convertible preferred stock member. Series B Convertible Preferred Stock Series C Convertible Preferred Stock Member Series B convertible preferred stock member. Series C Convertible Preferred Stock Series C Convertible Preferred Stock Issuable Member Series C convertible preferred stock issuable member. Series C Convertible Preferred Stock Issuable Series C Convertible Preferred Stock Subscriptions Receivable Member Series C convertible preferred stock subscriptions receivable member. Series C Convertible Preferred Stock Subscriptions Receivable Notes Receivable From Stockholders Member Notes receivable from stockholders member. Notes Receivable from Stockholders Notes Receivable from Officers Member Notes receivable from officers member. Notes Receivable from Officers Deficit Accumulated During The Development Stage Member Deficit Accumulated During the Development Stage Deficit accumulated during the development stage member. Additional Paid In Capital Member Additional Paid-In Capital Preferred Stock, Par or Stated Value Per Share Undesignated preferred stock, par value Preferred Stock, Shares Authorized Undesignated preferred stock, shares authorized Preferred Stock, Shares Issued Preferred Stock, Shares Issued, Total Undesignated preferred stock, shares issued Preferred Stock, Shares Outstanding Preferred Stock, Shares Outstanding, Ending Balance Preferred Stock, Shares Outstanding, Beginning Balance Undesignated preferred stock, shares outstanding Class of Stock [Axis] Class of Stock [Domain] Series B Preferred Stock [Member] Series B Convertible Preferred Stock Series C Preferred Stock [Member] Series C Convertible Preferred Stock Capital contribution Adjustments To Additional Paid In Capital Contribution Adjustments to additional paid in capital contribution. Stock Issued During Period Value Notes Receivable Issuance of stock for notes receivable Stock issued during period value notes receivable. Stock Issued During Period Shares Notes Receivable Issuance of stock for notes receivable, shares Stock issued during period shares notes receivable. Notes Receivable From Stockholders Collection Of Stock Subscription Collection of stock subscription Notes receivable from stockholders collection of stock subscription. Stock Issued During Period, Value, Conversion of Convertible Securities Conversion of notes payable Stock Issued During Period, Shares, Conversion of Convertible Securities Conversion of notes payable, shares Notes Receivable From Stockholders Discount On Notes Below Market Rate Discount on notes below market rate Notes receivable from stockholders discount on notes below market rate. Notes Receivable From Stockholders Accrued Interest On Notes Accrued interest on notes Notes receivable from stockholders accrued interest on notes. Adjustments to Additional Paid in Capital, Convertible Debt with Conversion Feature Beneficial conversion feature of Series A/B convertible preferred stock Adjustments To Additional Paid In Capital Amount In Excess Of Redemption Obligation Amount in excess of redemption obligation Adjustments to additional paid in capital amount in excess of redemption obligation. Adjustments to Additional Paid in Capital, Increase in Carrying Amount of Redeemable Preferred Stock Accretion to redemption value on Series A redeemable convertible preferred stock Adjustments To Additional Paid In Capital Cash Received From Common Stock Cash received for common stock issuable Adjustments to additional paid in capital cash received from common stock. Notes Receivable From Stockholders Payments Payments on notes receivable Notes receivable from stockholders payments. Adjustments To Additional Paid In Capital Put Option Issue Issuance of put option by stockholder Adjustments to additional paid in capital put option issue. Adjustments To Additional Paid In Capital Merger Record merger of entities Adjustments to additional paid in capital merger. Issuance of common stock for cash already received Stock Issued During Period Value Cash Stock issued during period value cash. Stock Issued During Period Shares Cash Issuance of common stock for cash already received, shares Stock issued during period shares cash. Issuance of stock award to employee/consultants Stock Issued During Period, Value, Share-based Compensation, Net of Forfeitures Stock Issued During Period, Value, Share-based Compensation, Net of Forfeitures, Total Stock Issued During Period, Shares, Share-based Compensation, Net of Forfeitures Stock Issued During Period, Shares, Share-based Compensation, Net of Forfeitures, Total Issuance of stock award to employee/consultants, shares Adjustments To Additional Paid In Capital Convertible Debt With Conversion Feature Deemed Dividend Deemed dividend related to beneficial conversion feature of Series B convertible preferred stock Adjustments to additional paid in capital convertible debt with conversion feature deemed dividend. Put option redemption by stockholder Adjustments To Additional Paid In Capital Put Option Redemption Adjustments to additional paid in capital put option redemption. Adjustments To Additional Paid In Capital Non Cash Compensation Non-cash compensation expense of officer resulting from stockholder contribution Adjustments to additional paid in capital non cash compensation. Notes Receivable From Officers Issue Notes receivable by stockholder issued to officers Notes receivable from officers issue. Adjustments To Additional Paid In Capital Put Option Sales Put shares sold to majority stockholder Adjustments to additional paid in capital put option sales. Stock Issued During Period Value Warrants Exercised Exercise of warrants Stock issued during period value warrants exercised. Stock Issued During Period Shares Warrants Exercised Exercise of warrants, shares Stock issued during period shares warrants exercised. Notes Receivable From Officers Repayment Repayment of notes receivable by stockholder issued to officers Notes receivable from officers repayment. Stock Repaid During Period Value Notes Receivable Repayment of stock note receivable Stock repaid during period value notes receivable. Stock Repaid During Period Shares Notes Receivable Repayment of stock note receivable, shares Stock repaid during period shares notes receivable. Stock Issued During Period Value Conversion Of Convertible Securities Series B Conversion of Series B convertible preferred stock to common stock Stock issued during period value conversion of convertible securities series B. Stock Issued During Period Shares Conversion Of Convertible Securities Series B Conversion of Series B convertible preferred stock to common stock, shares Stock issued during period shares conversion of convertible securities series B. Stock Issued During Period Value Conversion Of Convertible Securities Series C Conversion of Series C convertible preferred stock to common stock Stock issued during period value conversion of convertible securities series C. Stock Issued During Period Shares Conversion Of Convertible Securities Series C Conversion of Series C convertible preferred stock to common stock, shares Stock issued during period shares conversion of convertible securities series C. Stock Issued During Period Value Conversion Of Convertible Securities Series A Conversion of Series A convertible preferred stock to common stock Stock issued during period value conversion of convertible securities series A. Stock Issued During Period Shares Conversion Of Convertible Securities Series A Conversion of Series A convertible preferred stock to common stock, shares Stock issued during period shares conversion of convertible securities series A. Stock Issued During Period Shares Exchange Of Warrants Issuance of common shares in exchange for warrants Stock issued during period shares exchange of warrants. Stock Issued During Period Value Exchange Of Warrants Issuance of common shares in exchange for warrants Stock issued during period value exchange of warrants. Stock Cancelled During Period Value Notes Receivable Cancellation of common shares for stock notes receivable Stock cancelled during period value notes receivable. Stock Cancelled During Period Shares Notes Receivable Cancellation of common shares for stock notes receivable, shares Stock cancelled during period shares notes receivable. Issuance of common shares from the release of restricted stock units Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures, Total Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures, Total Issuance of common shares from the release of restricted stock units, shares Stock Issued During Period Value Research Agreement Issuance of common shares pursuant to research agreement Stock issued during period value research agreement. Stock Issued During Period Shares Research Agreement Issuance of common shares pursuant to research agreement, shares Stock issued during period shares research agreement. Stock Issued During Period Value Share Lending Agreement Issuance of stock under share lending agreement Stock issued during period value share lending agreement. Stock Issued During Period Shares Share Lending Agreement Issuance of stock under share lending agreement, shares Stock issued during period shares share lending agreement. Summary of significant accounting policies [Abstract] Fair Value of Financial Instruments [Abstract] Stock award plans [Abstract] Employee benefit plans [Abstract] Related Party Transaction Disclosure Text Block Related party transactions Related party transaction disclosure. Selected quarterly financial data (unaudited) [Abstract] Subsequent Events [Text Block] Subsequent events Subsequent Events [Abstract] Stock Issued During Period Value Issuance of Series B preferred stock for cash Stock issued during period value. Stock Issued During Period Shares Issuance of Series B preferred stock for cash, shares Stock issued during period shares. Stock Issued During Period Value Services Issuance of common stock for services Stock issued during period value services. Stock Issued During Period Shares Services Issuance of common stock for services, shares Stock issued during period shares services. Stock Issued During Period, Shares, New Issues Issuance of common stock, shares Converted To Common Stock Converted to Common Stock Converted to common stock.