Entity Central Index Key Document and entity information. Document And Entity Information [Abstract] Document Type Document Type Amendment Flag Amendment Flag Document Period End Date Document Period End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Trading Symbol Trading Symbol Entity Registrant Name Entity Registrant Name Entity Central Index Key Current Fiscal Year End Date Current Fiscal Year End Date Entity Filer Category Entity Filer Category Entity Common Stock, Shares Outstanding Entity Common Stock Shares Outstanding Deferred collaborative credit current. Purchase obligation current. Accrued interest noncurrent. Purchase obligation noncurrent. Deferred collaborative credit noncurrent. Milestone rights liabilities noncurrent. Statement Of Financial Position [Abstract] ASSETS Assets [Abstract] Current assets: Assets Current [Abstract] Cash and cash equivalents Cash And Cash Equivalents At Carrying Value Restricted cash Restricted Cash Current Accounts receivable, net Accounts Receivable Net Current Inventory Inventory Net Deferred costs from commercial product sales Other Deferred Costs Net Prepaid expenses and other current assets Prepaid Expense And Other Assets Current Total current assets Assets Current Property and equipment, net Property Plant And Equipment Net Other assets Other Assets Noncurrent Total assets Assets LIABILITIES AND STOCKHOLDERS' DEFICIT Liabilities And Stockholders Equity [Abstract] Current liabilities: Liabilities Current [Abstract] Accounts payable Accounts Payable Current Accrued expenses and other current liabilities Accrued Liabilities Current Facility financing obligation Other Long Term Debt Current Deferred revenue, net Deferred Revenue Current Deferred payments from collaboration - current Deferred Collaborative Credit Current Recognized loss on purchase commitments - current Purchase Obligation Current Total current liabilities Liabilities Current Note payable to related party Notes Payable Related Parties Noncurrent Accrued interest - note payable to related party Accrued Interest Noncurrent Senior convertible notes Convertible Long Term Notes Payable Recognized loss on purchase commitments - long term Purchase Obligation Noncurrent Deferred payments from collaboration - long term Deferred Collaborative Credit Noncurrent Milestone rights liability Milestone Rights Liabilities Noncurrent Total liabilities Liabilities Commitments and contingencies (Note 12) Commitments And Contingencies Stockholders' deficit: Stockholders Equity [Abstract] Undesignated preferred stock, $0.01 par value - 10,000,000 shares authorized; no shares issued or outstanding at June 30, 2018 and December 31, 2017 Preferred Stock Value Common stock, $0.01 par value - 280,000,000 shares authorized, 145,619,293 and 119,053,414 shares issued and outstanding at June 30, 2018 and December 31, 2017, respectively Common Stock Value Additional paid-in capital Additional Paid In Capital Common Stock Accumulated other comprehensive loss Accumulated Other Comprehensive Income Loss Net Of Tax Accumulated deficit Retained Earnings Accumulated Deficit Total stockholders' deficit Stockholders Equity Total liabilities and stockholders' deficit Liabilities And Stockholders Equity Undesignated preferred stock, par value Preferred Stock Par Or Stated Value Per Share Undesignated preferred stock, shares authorized Preferred Stock Shares Authorized Undesignated preferred stock, shares issued Preferred Stock Shares Issued Undesignated preferred stock, shares outstanding Preferred Stock Shares Outstanding Common stock, par value Common Stock Par Or Stated Value Per Share Common stock, shares authorized Common Stock Shares Authorized Common stock, shares issued Common Stock Shares Issued Common stock, shares outstanding Common Stock Shares Outstanding Change in fair value of warrant liability. Income Statement [Abstract] Statement [Table] Statement [Table] Product and Service Product Or Service [Axis] Product and Service Products And Services [Domain] Net revenue - commercial product sales Product [Member] Net revenue - collaboration License [Member] Revenue - other Product And Service Other [Member] Statement [Line Items] Statement [Line Items] Revenues: Revenues [Abstract] Total revenues Revenue From Contract With Customer Excluding Assessed Tax Expenses: Costs And Expenses [Abstract] Cost of goods sold Cost Of Goods And Services Sold Research and development Research And Development Expense Excluding Acquired In Process Cost Selling, general and administrative Selling General And Administrative Expense Property and equipment impairment Impairment Of Long Lived Assets Held For Use (Gain) Loss on foreign currency translation Foreign Currency Transaction Gain Loss Realized Total expenses Costs And Expenses Loss from operations Operating Income Loss Other (expense) income: Nonoperating Income Expense [Abstract] Change in fair value of warrant liability Change In Fair Value Of Warrant Liability Interest income Investment Income Interest Interest expense on notes Interest Expense Debt Interest expense on note payable to related party Related Party Transaction Expenses From Transactions With Related Party Gain (Loss) on extinguishment of debt Gains Losses On Extinguishment Of Debt Other income Other Nonoperating Income Expense Total other (expense) Nonoperating Income Expense Loss before provision for income taxes Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest Income tax expense Income Tax Expense Benefit Net loss Net Income Loss Net loss per share - basic and diluted Earnings Per Share Basic And Diluted Shares used to compute basic and diluted net loss per share Weighted Average Number Of Share Outstanding Basic And Diluted Statement Of Income And Comprehensive Income [Abstract] Net loss Other comprehensive income: Other Comprehensive Income Loss Net Of Tax Period Increase Decrease [Abstract] Cumulative translation (loss) gain Other Comprehensive Income Foreign Currency Transaction And Translation Gain Loss Arising During Period Net Of Tax Comprehensive loss Comprehensive Income Net Of Tax Interest on note payable to related party. Increase (decrease) in other deferred charges. Increase (decrease) in purchase commitment loss. Payments of note payable to related party through common stock issuance. Debt Iissuance costs accrued but not yet paid. Statement Of Cash Flows [Abstract] CASH FLOWS FROM OPERATING ACTIVITIES: Net Cash Provided By Used In Operating Activities [Abstract] Net loss Profit Loss Adjustments to reconcile net loss to net cash (used in) provided by operating activities: Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract] Depreciation, amortization and accretion Depreciation And Amortization Stock-based compensation expense Share Based Compensation Loss on extinguishment of debt, net Loss on sale, abandonment/disposal or impairment of property and equipment Gain Loss On Disposition Of Assets Interest on note payable to related party Interest On Note Payable To Related Party Change in fair value of warrant liability Write-off of inventory Production Related Impairments Or Charges Other, net Other Noncash Income Expense Changes in operating assets and liabilities: Increase Decrease In Operating Capital [Abstract] Accounts receivable, net Increase Decrease In Accounts Receivable Receivable from Sanofi Increase Decrease In Accounts And Notes Receivable Inventory Increase Decrease In Inventories Deferred costs from commercial product sales Increase Decrease In Other Deferred Charges Prepaid expenses and other current assets Increase Decrease In Prepaid Deferred Expense And Other Assets Other assets Increase Decrease In Other Operating Assets Accounts payable Increase Decrease In Accounts Payable Accrued expenses and other current liabilities Increase Decrease In Accrued Liabilities And Other Operating Liabilities Deferred revenue Increase Decrease In Deferred Revenue Deferred payments from collaboration Increase Decrease In Customer Advances And Deposits Recognized loss on purchase commitments Increase Decrease In Purchase Commitment Loss Net cash used in operating activities Net Cash Provided By Used In Operating Activities CASH FLOWS FROM INVESTING ACTIVITIES: Net Cash Provided By Used In Investing Activities [Abstract] Net proceeds from sale of asset held for sale Proceeds From Sale Of Productive Assets Proceeds from sale of property and equipment Proceeds From Sale Of Property Plant And Equipment Net cash provided by investing activities Net Cash Provided By Used In Investing Activities CASH FLOWS FROM FINANCING ACTIVITIES: Net Cash Provided By Used In Financing Activities [Abstract] Proceeds from direct placement of common stock Proceeds From Issuance Of Private Placement Issuance cost associated with direct placement Payment Of Financing And Stock Issuance Costs Principal payments on facility financing obligation Repayments Of Lines Of Credit Borrowings on note payable to related party Proceeds From Related Party Debt Payment of employment taxes related to vested restricted stock units Payments Related To Tax Withholding For Share Based Compensation Proceeds from issuance of common stock pursuant to at-the-market issuance Proceeds From Issuance Of Common Stock Issuance cost of at-the-market transactions Payments Of Stock Issuance Costs Proceeds from executive stock purchase plan Proceeds From Stock Plans Net cash provided by financing activities Net Cash Provided By Used In Financing Activities NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS AND RESTRICTED CASH Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, BEGINNING OF PERIOD Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, END OF PERIOD SUPPLEMENTAL CASH FLOWS DISCLOSURES: Supplemental Cash Flow Information [Abstract] Interest paid in cash, net of amounts capitalized Interest Paid Net NON-CASH INVESTING AND FINANCING ACTIVITIES: Noncash Investing And Financing Items [Abstract] Payment of note obligations through common stock issuance, net of issuance costs Stock Issued1 Payment of note payable to related party through common stock issuance Payments Of Note Payable To Related Party Through Common Stock Issuance Capitalization of interest on note payable to related party Interest Paid Capitalized Accrued but unpaid debt issuance costs Debt Issuance Costs Accrued But Not Yet Paid Accounting Policies [Abstract] Description of Business and Significant Accounting Policies Organization Consolidation And Presentation Of Financial Statements Disclosure And Significant Accounting Policies [Text Block] Receivables [Abstract] Accounts Receivable Financing Receivables [Text Block] Inventory Disclosure [Abstract] Inventories Inventory Disclosure [Text Block] Property Plant And Equipment [Abstract] Property and Equipment Property Plant And Equipment Disclosure [Text Block] Payables And Accruals [Abstract] Accrued Expenses and Other Current Liabilities Accounts Payable And Accrued Liabilities Disclosure [Text Block] Related Party Transactions [Abstract] Related-Party Arrangements Related Party Transactions Disclosure [Text Block] Debt Disclosure [Abstract] Borrowings Debt Disclosure [Text Block] Organization Consolidation And Presentation Of Financial Statements [Abstract] Collaboration Arrangements Collaborative Arrangement Disclosure [Text Block] Goodwill And Intangible Assets Disclosure [Abstract] Sale of Intellectual Property Intangible Assets Disclosure [Text Block] Fair Value Disclosures [Abstract] Fair Value of Financial Instruments Fair Value Disclosures [Text Block] Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] Stock-Based Compensation Expense Disclosure Of Compensation Related Costs Share Based Payments [Text Block] Commitments And Contingencies Disclosure [Abstract] Commitments and Contingencies Commitments And Contingencies Disclosure [Text Block] Income Tax Disclosure [Abstract] Income Taxes Income Tax Disclosure [Text Block] Restructuring And Related Activities [Abstract] Restructuring Charges Restructuring And Related Activities Disclosure [Text Block] Subsequent Events [Abstract] Subsequent Event Subsequent Events [Text Block] Business. Business Business Policy [Text Block] Basis of Presentation. Basis of Presentation Basis Of Presentation Policy [Text Block] Reverse stock split. Reverse Stock-Split Reverse Stock Split Policy [Text Block] Principles of Consolidation Consolidation Policy [Text Block] Segment Information Segment Reporting Policy Policy [Text Block] Revenue Recognition Revenue Recognition Policy [Text Block] Revenue Recognition - Net Revenue - Commercial Product Sales Revenue Recognition Sales Of Goods Revenue Recognition- Net Revenue - Collaborations Revenue Recognition Multiple Element Arrangements License of intellectual property. Licenses of Intellectual Property License Of Intellectual Property Policy [Text Block] Milestone Payments Debt Policy [Text Block] Manufacturing Supply Services Revenue Recognition Sales Of Services Royalties Revenue Recognition Services Royalty Fees Revenue recognition, bulk sales. Revenue Recognition - Revenue - Other Revenue Recognition Bulk Sales Policy [Text Block] Cost of Goods Sold Cost Of Sales Policy [Text Block] Restricted Cash Cash And Cash Equivalents Restricted Cash And Cash Equivalents Policy Accounts Receivable and Allowance for Doubtful Accounts Receivables Trade And Other Accounts Receivable Allowance For Doubtful Accounts Policy Inventories Inventory Policy [Text Block] Leases Lessee Leases Policy [Text Block] Loss on purchase commitments. Recognized Loss on Purchase Commitments Loss On Purchase Commitments Policy Policy [Text Block] Fair Value of Financial Instruments Fair Value Of Financial Instruments Policy Contingencies Commitments And Contingencies Policy [Text Block] Stock-Based Compensation Compensation Related Costs Policy [Text Block] Clinical Trial Expense Clinical Trial Expenses Clinical Trial Expense Policy [Text Block] Net Income or (Loss) Per Share of Common Stock Earnings Per Share Policy [Text Block] Impact of Adoption of the New Revenue Guidance New Accounting Pronouncements Policy Policy [Text Block] Recently issued accounting standards. Recently Issued Accounting Standards Recently Issued Accounting Standards Policy [Text Block]