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<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2020-02-25T01:34:05.6852544+00:00 -->
<!-- Version            : 5.0.1.321 -->
<!-- Package ID         : 31edfd94c77e4b8f8bb5bc10e1daf5de -->
<!-- Copyright (c) 2020 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="mnkd_CommonStockIssuedInDirectPlacementShares" name="CommonStockIssuedInDirectPlacementShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_CommonStockIssuedInDirectPlacementValue" name="CommonStockIssuedInDirectPlacementValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_AdjustmentsToAdditionalPaidInCapitalDirectPlacementIssuanceCosts" name="AdjustmentsToAdditionalPaidInCapitalDirectPlacementIssuanceCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_AdjustmentsToAdditionalPaidInCapitalSharesIssuedPublicOfferingIssuanceCost" name="AdjustmentsToAdditionalPaidInCapitalSharesIssuedPublicOfferingIssuanceCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_StockIssuedDuringPeriodSharesMarketPriceStockPurchasePlan" name="StockIssuedDuringPeriodSharesMarketPriceStockPurchasePlan" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_StockIssuedDuringPeriodValueMarketPriceStockPurchasePlan" name="StockIssuedDuringPeriodValueMarketPriceStockPurchasePlan" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_AdjustmentsToAdditionalPaidInCapitalAmortizationOfShelfFees" name="AdjustmentsToAdditionalPaidInCapitalAmortizationOfShelfFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_AdjustmentsToAdditionalPaidInCapitalIssuanceOfWarrantsPursuantToCreditFacility" name="AdjustmentsToAdditionalPaidInCapitalIssuanceOfWarrantsPursuantToCreditFacility" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_StockIssuedDuringPeriodSharesExerciseOfWarrants" name="StockIssuedDuringPeriodSharesExerciseOfWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_StockIssuedDuringPeriodValueExerciseOfWarrants" name="StockIssuedDuringPeriodValueExerciseOfWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_AdjustmentsToAdditionalPaidInCapitalWarrantModification" name="AdjustmentsToAdditionalPaidInCapitalWarrantModification" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_AdjustmentsToAdditionalPaidInCapitalRepurchasedWarrant" name="AdjustmentsToAdditionalPaidInCapitalRepurchasedWarrant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_NotePayableToRelatedPartyMember" name="NotePayableToRelatedPartyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_SeniorConvertibleNotesMember" name="SeniorConvertibleNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_FacilityFinancingObligationMember" name="FacilityFinancingObligationMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_PromissoryNotesMember" name="PromissoryNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AtTheMarketOfferingMember" name="AtTheMarketOfferingMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AtTheMarketPlacementMember" name="AtTheMarketPlacementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_MannGroupMember" name="MannGroupMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_PaymentInKindInterestOnPromissoryNotes" name="PaymentInKindInterestOnPromissoryNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_InterestExpenseOnPromissoryNotes" name="InterestExpenseOnPromissoryNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_OperatingLeaseRightOfUseAssetAmortization" name="OperatingLeaseRightOfUseAssetAmortization" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_GainLossOnWarrantTransactions" name="GainLossOnWarrantTransactions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_IncreaseDecreaseInRecognizedLossOnPurchaseCommitments" name="IncreaseDecreaseInRecognizedLossOnPurchaseCommitments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_IncreaseDecreaseInOperatingLeaseLiabilities" name="IncreaseDecreaseInOperatingLeaseLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_IncreaseDecreaseInAccruedInterestOnPromissoryNotes" name="IncreaseDecreaseInAccruedInterestOnPromissoryNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_MilestonePayments" name="MilestonePayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_RepaymentOfIssuanceOfCreditFacility" name="RepaymentOfIssuanceOfCreditFacility" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_RepaymentsOfIssuancePromissoryNotes" name="RepaymentsOfIssuancePromissoryNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_AdditionOfRightOfUseAssets" name="AdditionOfRightOfUseAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_PaymentOfFacilityObligationThroughCommonStockIssuance" name="PaymentOfFacilityObligationThroughCommonStockIssuance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PaymentOfInterestOnSeniorConvertibleNotesThroughCommonStockIssuance" name="PaymentOfInterestOnSeniorConvertibleNotesThroughCommonStockIssuance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_CommonStockIssuanceToSettleEmployeeStockPurchasePlanLiability" name="CommonStockIssuanceToSettleEmployeeStockPurchasePlanLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_IssuanceOfWarrantsAssociatedWithCreditFacility" name="IssuanceOfWarrantsAssociatedWithCreditFacility" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PublicOfferingMember" name="PublicOfferingMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AtTheMarketIssuanceMember" name="AtTheMarketIssuanceMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_BusinessPolicyTextBlock" name="BusinessPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_BasisOfPresentationPolicyTextBlock" name="BasisOfPresentationPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_RevenueFromContractWithCustomerFromCommercialProductSalesPolicyTextBlock" name="RevenueFromContractWithCustomerFromCommercialProductSalesPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_RevenueFromContractWithCustomerFromCollaborationsAndServicesPolicyTextBlock" name="RevenueFromContractWithCustomerFromCollaborationsAndServicesPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PreLaunchInventoryPolicyTextBlock" name="PreLaunchInventoryPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_LossOnPurchaseCommitmentsPolicyPolicyTextBlock" name="LossOnPurchaseCommitmentsPolicyPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_MilestoneRightsLiabilityPolicyTextBlock" name="MilestoneRightsLiabilityPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ClinicalTrialExpensePolicyTextBlock" name="ClinicalTrialExpensePolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_RecentlyIssuedAccountingStandardsPolicyTextBlock" name="RecentlyIssuedAccountingStandardsPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ContractWithCustomerLiabilityTableTextBlock" name="ContractWithCustomerLiabilityTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ScheduleOfAmortizationOfDebtIssuanceCostAndDebtDiscountTableTextBlock" name="ScheduleOfAmortizationOfDebtIssuanceCostAndDebtDiscountTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems" name="OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable" name="OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_MidCapCreditFacilityMember" name="MidCapCreditFacilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TrancheTwoMember" name="TrancheTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TrancheThreeMember" name="TrancheThreeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DeerfieldManagementCompanyLpMember" name="DeerfieldManagementCompanyLpMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TheMannGroupLLCMember" name="TheMannGroupLLCMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NewLoanArrangementMember" name="NewLoanArrangementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ConvertiblePromissoryNoteMember" name="ConvertiblePromissoryNoteMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NonConvertiblePromissoryNoteMember" name="NonConvertiblePromissoryNoteMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_SeniorSubordinatedExchangeConvertibleNotesDueTwoThousandTwentyOneMember" name="SeniorSubordinatedExchangeConvertibleNotesDueTwoThousandTwentyOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_JuneTwoThousandTwentyPromissoryNoteMember" name="JuneTwoThousandTwentyPromissoryNoteMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DecemberTwoThousandTwentyPromissoryNoteMember" name="DecemberTwoThousandTwentyPromissoryNoteMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_SeniorSubordinatedExchangeConvertibleNotesDueNovemberTwoThousandTwentyFourMember" name="SeniorSubordinatedExchangeConvertibleNotesDueNovemberTwoThousandTwentyFourMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DebtInstrumentCovenantMinimumTargetNetRevenue" name="DebtInstrumentCovenantMinimumTargetNetRevenue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_DebtInstrumentMinimumCashCovenant" name="DebtInstrumentMinimumCashCovenant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_DebtInstrumentMaturityMonthAndYear" name="DebtInstrumentMaturityMonthAndYear" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_SummaryOfSignificantAccountingPoliciesLineItems" name="SummaryOfSignificantAccountingPoliciesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_SummaryOfSignificantAccountingPoliciesTable" name="SummaryOfSignificantAccountingPoliciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_SalesReturnPeriod" name="SalesReturnPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_InsulinMember" name="InsulinMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_MilestoneRightsLiabilityMember" name="MilestoneRightsLiabilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ContractWithCustomerLiabilityUpfrontAndMilestonePayments" name="ContractWithCustomerLiabilityUpfrontAndMilestonePayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_ContractWithCustomerLiabilityPassThroughPayments" name="ContractWithCustomerLiabilityPassThroughPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_LongTermPurchaseCommitmentAmendmentFee" name="LongTermPurchaseCommitmentAmendmentFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_WholesalerDistributionFeesAndPromptPayDiscounts" name="WholesalerDistributionFeesAndPromptPayDiscounts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_ReserveForReturns" name="ReserveForReturns" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_NumberOfWholesaleDistributors" name="NumberOfWholesaleDistributors" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PercentageOfSalesFromMajorCustomers" name="PercentageOfSalesFromMajorCustomers" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ContingentLiability" name="ContingentLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_ContingentLiabilityRemainingPayableAmount" name="ContingentLiabilityRemainingPayableAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_MilestoneRightsLiabilitiesCurrentAndNoncurrent" name="MilestoneRightsLiabilitiesCurrentAndNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_NewAccountingPronouncementOrChangeInAccountingPrincipleCumulativeEffectOfChangeOnNetAssetsLiabilities" name="NewAccountingPronouncementOrChangeInAccountingPrincipleCumulativeEffectOfChangeOnNetAssetsLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PercentageOfMaterialReceived" name="PercentageOfMaterialReceived" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PreLaunchInventoryMember" name="PreLaunchInventoryMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_FurnitureFixturesAndOfficeEquipmentMember" name="FurnitureFixturesAndOfficeEquipmentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ComputerEquipmentAndSoftwareMember" name="ComputerEquipmentAndSoftwareMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_FurnitureAndFixturesManufacturingEquipmentAndLabratoryEquipmentMember" name="FurnitureAndFixturesManufacturingEquipmentAndLabratoryEquipmentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ManufacturingEquipmentAndComputerHardwareMember" name="ManufacturingEquipmentAndComputerHardwareMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CustomerDiscountsAndAllowances" name="CustomerDiscountsAndAllowances" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_SalesAndMarketingRelatedExpensesAccrued" name="SalesAndMarketingRelatedExpensesAccrued" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_CurrentPortionOfMilestoneRightLiability" name="CurrentPortionOfMilestoneRightLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_AccruedExpensesAndOtherCurrentLiabilitiesAbstract" name="AccruedExpensesAndOtherCurrentLiabilitiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_PercentageOfBeneficialInterestOwned" name="PercentageOfBeneficialInterestOwned" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_TrusteeSubstantialPortionDisposedTerm" name="TrusteeSubstantialPortionDisposedTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PercentageOfCommonStockSharesOutstanding" name="PercentageOfCommonStockSharesOutstanding" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mnkd_AdditionalCommonStockSharesReservedForIssuance" name="AdditionalCommonStockSharesReservedForIssuance" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PercentageOfBeneficiallyOwnInExcess" name="PercentageOfBeneficiallyOwnInExcess" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_WrittenNoticePeriodFromRelatedParty" name="WrittenNoticePeriodFromRelatedParty" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_LoanArrangementMember" name="LoanArrangementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DeerfieldCreditFacilityMember" name="DeerfieldCreditFacilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AccruedPaidInKindInterest" name="AccruedPaidInKindInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_FivePointSevenFivePercentTwoThousandTwentyFourConvertibleNotesMember" name="FivePointSevenFivePercentTwoThousandTwentyFourConvertibleNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CreditFacilityDueJulyTwoThousandNineteenMember" name="CreditFacilityDueJulyTwoThousandNineteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CreditFacilityDueAugustTwoThousandNineteenMember" name="CreditFacilityDueAugustTwoThousandNineteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CreditFacilityDueMayTwoThousandNineteenMember" name="CreditFacilityDueMayTwoThousandNineteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DebtInstrumentFloorRate" name="DebtInstrumentFloorRate" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentAdditionalBorrowingCapacity" name="DebtInstrumentAdditionalBorrowingCapacity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_TwoThousandNineteenNotesMember" name="TwoThousandNineteenNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_EightPointSevenFiveSeniorConvertibleNotesDueTwoThousandNineteenMember" name="EightPointSevenFiveSeniorConvertibleNotesDueTwoThousandNineteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DeerfieldFacilityFinancingObligationMember" name="DeerfieldFacilityFinancingObligationMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TwoThousandNineteenNotesTrancheOneMember" name="TwoThousandNineteenNotesTrancheOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_PaymentForMilestoneRightsLiabilities" name="PaymentForMilestoneRightsLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_MilestoneRightsLiabilitiesCurrent" name="MilestoneRightsLiabilitiesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_MilestoneInterestExpense" name="MilestoneInterestExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_TrancheOneMember" name="TrancheOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TrancheOneAndTrancheTwoMember" name="TrancheOneAndTrancheTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TrancheTwoAndThreeMember" name="TrancheTwoAndThreeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DebtInstrumentExitFeePercentage" name="DebtInstrumentExitFeePercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentPaymentNumberOfEqualMonthlyInstallments" name="DebtInstrumentPaymentNumberOfEqualMonthlyInstallments" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_EarlyTerminationFeesPercentage" name="EarlyTerminationFeesPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_TermLoanAdvancePercentageOfAmountDrawdown" name="TermLoanAdvancePercentageOfAmountDrawdown" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_SeniorNotesDueTwoThousandTwentyOneMember" name="SeniorNotesDueTwoThousandTwentyOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TwoThousandTwentyFourConvertibleNotesMember" name="TwoThousandTwentyFourConvertibleNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_PrivatelyNegotiatedExchangeAgreementMember" name="PrivatelyNegotiatedExchangeAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_BruceAndCoIncMember" name="BruceAndCoIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_PrincipalAmountPerShare" name="PrincipalAmountPerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentConvertibleThresholdConsecutiveTradingDay" name="DebtInstrumentConvertibleThresholdConsecutiveTradingDay" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_AmortizationOfDebtPremium" name="AmortizationOfDebtPremium" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_AmortizationOfDebtDiscount" name="AmortizationOfDebtDiscount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_LicenseAgreementMember" name="LicenseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ResearchAgreementMember" name="ResearchAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CollaborationAndLicenseAgreementMember" name="CollaborationAndLicenseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DistributionAgreementMember" name="DistributionAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_UnitedTherapeuticsCorporationMember" name="UnitedTherapeuticsCorporationMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ReceptorLifeScienceIncMember" name="ReceptorLifeScienceIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CiplaLtdMember" name="CiplaLtdMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_BiommSAMember" name="BiommSAMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_UpfrontPaymentReceived" name="UpfrontPaymentReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_MilestonePaymentReceived" name="MilestonePaymentReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_PotentialMilestonePaymentsToBeReceived" name="PotentialMilestonePaymentsToBeReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_AdditionalOptionExerciseAndDevelopmentMilestonePaymentsToBeReceived" name="AdditionalOptionExerciseAndDevelopmentMilestonePaymentsToBeReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_EngineeringConsultingServicesMember" name="EngineeringConsultingServicesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ProductPrototypeMember" name="ProductPrototypeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_SupplyAndDistributionAgreementMember" name="SupplyAndDistributionAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_LicenseAndDistributionAgreementMember" name="LicenseAndDistributionAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DateOfAgreementInitiationForMarketingAndDistribution" name="DateOfAgreementInitiationForMarketingAndDistribution" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_FairValueOfFinancialInstrumentsLineItems" name="FairValueOfFinancialInstrumentsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_FairValueOfFinancialInstrumentsTable" name="FairValueOfFinancialInstrumentsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_FairValueOfDebtInstrumentsToRelatedPartyDescription" name="FairValueOfDebtInstrumentsToRelatedPartyDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ChangeInFairValueOfNotePayableValueDueToChangeInInterestRatePercentage" name="ChangeInFairValueOfNotePayableValueDueToChangeInInterestRatePercentage" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_NotePayablePercentageOfInterestRateChange" name="NotePayablePercentageOfInterestRateChange" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ChangeInFairValueOfNotePayablePercentageDueToChangeInInterestRatePercentage" name="ChangeInFairValueOfNotePayablePercentageDueToChangeInInterestRatePercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_MannGroupPromissoryNotesMember" name="MannGroupPromissoryNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NotePayableYieldChangesOneMember" name="NotePayableYieldChangesOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NotePayableYieldChangesTwoMember" name="NotePayableYieldChangesTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NotePayableYieldChangesThreeMember" name="NotePayableYieldChangesThreeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NotePayableYieldChangesFourMember" name="NotePayableYieldChangesFourMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ContolledEquityOfferingSalesAgreementMember" name="ContolledEquityOfferingSalesAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AtMarketIssuanceSalesAgreementMember" name="AtMarketIssuanceSalesAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_PurchasersMember" name="PurchasersMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CantorFitzgeraldMember" name="CantorFitzgeraldMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_UnderwritingAgreementMember" name="UnderwritingAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ClassOfWarrantsOrRightsExpirationDate" name="ClassOfWarrantsOrRightsExpirationDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ClosingOfOfferingDate" name="ClosingOfOfferingDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ClassOfWarrantOrRightModified" name="ClassOfWarrantOrRightModified" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ClassOfWarrantOrRightExercised" name="ClassOfWarrantOrRightExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ClassOfWarrantOrRightExpiredUnexercised" name="ClassOfWarrantOrRightExpiredUnexercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_RemainingWarrantsAvailableForPurchase" name="RemainingWarrantsAvailableForPurchase" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ConversionOfConvertibleNotesPayableToFormerRelatedPartyIntoCommonStockMember" name="ConversionOfConvertibleNotesPayableToFormerRelatedPartyIntoCommonStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ExerciseOfWarrantsAssociatedWithPublicOfferingMember" name="ExerciseOfWarrantsAssociatedWithPublicOfferingMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ExerciseOfWarrantsAssociatedWithMidcapCreditFacilityMember" name="ExerciseOfWarrantsAssociatedWithMidcapCreditFacilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ConversionOfConvertibleNotesIntoCommonStockMember" name="ConversionOfConvertibleNotesIntoCommonStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_EmployeeStockPurchasePlanMember" name="EmployeeStockPurchasePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ExerciseOfWarrantsAssociatedWithDirectPlacementMember" name="ExerciseOfWarrantsAssociatedWithDirectPlacementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_EquityIncentivePlanTwentyEighteenMember" name="EquityIncentivePlanTwentyEighteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_EmployeeStockOptionsAndPerformanceBasedOptionsMember" name="EmployeeStockOptionsAndPerformanceBasedOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TwoThousandFourEquityIncentivePlanMember" name="TwoThousandFourEquityIncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_EquityIncentivePlanTwentyThirteenMember" name="EquityIncentivePlanTwentyThirteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TwoThousandFourNonEmployeeDirectorsStockOptionPlanMember" name="TwoThousandFourNonEmployeeDirectorsStockOptionPlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CostOfRevenueCollaborationsAndServicesMember" name="CostOfRevenueCollaborationsAndServicesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TransfersFromToParentAbstract" name="TransfersFromToParentAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsInPeriodGrantDateFairValueOutstanding" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsInPeriodGrantDateFairValueOutstanding" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_CommitmentsAndContingenciesLineItems" name="CommitmentsAndContingenciesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CommitmentsAndContingenciesTable" name="CommitmentsAndContingenciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_LeaseAgreementWithEnterpriseMember" name="LeaseAgreementWithEnterpriseMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_OfficeMember" name="OfficeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_RussellRanchRoadIILLCMember" name="RussellRanchRoadIILLCMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_PurchaseObligationExtendedTerm" name="PurchaseObligationExtendedTerm" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PurchaseObligationDueInSixthYear" name="PurchaseObligationDueInSixthYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PurchaseObligationDueInSeventhYear" name="PurchaseObligationDueInSeventhYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PaymentOfLongTermPurchaseCommitmentAmendmentFee" name="PaymentOfLongTermPurchaseCommitmentAmendmentFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_LongTermPurchaseCommitmentExpirationDate" name="LongTermPurchaseCommitmentExpirationDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_LongtermPurchaseCommitmentRenewalTimePeriod" name="LongtermPurchaseCommitmentRenewalTimePeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ForeignCurrencyHedgingTransactionPeriod" name="ForeignCurrencyHedgingTransactionPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ClassOfWarrantOrRightExercisable" name="ClassOfWarrantOrRightExercisable" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_NumberOfVehicleLeases" name="NumberOfVehicleLeases" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_NumberOfVehicleLeasesRemoved" name="NumberOfVehicleLeasesRemoved" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_OperatingLeaseReductionInRightOfUseAsset" name="OperatingLeaseReductionInRightOfUseAsset" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_ReductionInOperatingLeaseLiability" name="ReductionInOperatingLeaseLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_OperatingLeaseOtherNonCurrentAssets" name="OperatingLeaseOtherNonCurrentAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_OperatingLeaseOtherLiabilitiesCurrent" name="OperatingLeaseOtherLiabilitiesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_OperatingLeasesAnnualIncreaseInRentExpense" name="OperatingLeasesAnnualIncreaseInRentExpense" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ReimbursementAmountReceivedForTenantImprovements" name="ReimbursementAmountReceivedForTenantImprovements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_OfficeAndVehicleMember" name="OfficeAndVehicleMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_IncomeTaxesLineItems" name="IncomeTaxesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_IncomeTaxesTable" name="IncomeTaxesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ConnecticutTaxAuthorityMember" name="ConnecticutTaxAuthorityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DeferredTaxAssetsCapitalizedResearchExpenses" name="DeferredTaxAssetsCapitalizedResearchExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DeferredTaxAssetsMilestoneRights" name="DeferredTaxAssetsMilestoneRights" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DeferredTaxAssetsTaxDeferredExpenseAccrualAdjustment" name="DeferredTaxAssetsTaxDeferredExpenseAccrualAdjustment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DeferredTaxAssetsLossOnPurchaseCommitment" name="DeferredTaxAssetsLossOnPurchaseCommitment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DeferredTaxAssetsCapitalizedCosts" name="DeferredTaxAssetsCapitalizedCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DeferredTaxAssetsLeaseLiabilities" name="DeferredTaxAssetsLeaseLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DeferredTaxAssetsInterestExpenseLimitation" name="DeferredTaxAssetsInterestExpenseLimitation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DeferredTaxAssetsProductRevenueAndCosts" name="DeferredTaxAssetsProductRevenueAndCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DeferredTaxLiabilitiesRightOfUseAsset" name="DeferredTaxLiabilitiesRightOfUseAsset" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_EffectiveIncomeTaxRateReconciliationPermanentItems" name="EffectiveIncomeTaxRateReconciliationPermanentItems" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_EffectiveIncomeTaxRateReconciliationEffectOfTaxLawChanges" name="EffectiveIncomeTaxRateReconciliationEffectOfTaxLawChanges" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_EffectiveIncomeTaxRateReconciliationExpirationsOfAttribute" name="EffectiveIncomeTaxRateReconciliationExpirationsOfAttribute" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_EffectiveIncomeTaxRateReconciliationForeignWithholdingTax" name="EffectiveIncomeTaxRateReconciliationForeignWithholdingTax" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_OperatingLossCarryforwardsSubjectToLimitation" name="OperatingLossCarryforwardsSubjectToLimitation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_NetOperatingLossCarryforwardAnnualLimitation" name="NetOperatingLossCarryforwardAnnualLimitation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ResearchAndDevelopmentCreditsBeginToExpire" name="ResearchAndDevelopmentCreditsBeginToExpire" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DeferredTaxAssetsTaxCreditCarryforwardsResearchNotExpire" name="DeferredTaxAssetsTaxCreditCarryforwardsResearchNotExpire" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
</xsd:schema>
