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Disclosure - State research and development credit exchange receivable link:calculationLink link:presentationLink link:definitionLink 112 - Disclosure - Inventories link:calculationLink link:presentationLink link:definitionLink 113 - Disclosure - Property and equipment link:calculationLink link:presentationLink link:definitionLink 114 - Disclosure - Accrued expenses and other current liabilities link:calculationLink link:presentationLink link:definitionLink 115 - Disclosure - Related-party arrangements link:calculationLink link:presentationLink link:definitionLink 116 - Disclosure - Senior convertible notes link:calculationLink link:presentationLink link:definitionLink 117 - Disclosure - Collaboration arrangement link:calculationLink link:presentationLink link:definitionLink 118 - Disclosure - Fair Value of Financial Instruments link:calculationLink link:presentationLink link:definitionLink 119 - Disclosure - Common and preferred stock link:calculationLink link:presentationLink link:definitionLink 120 - Disclosure - Net loss per common share link:calculationLink link:presentationLink link:definitionLink 121 - Disclosure - Stock award plans link:calculationLink link:presentationLink link:definitionLink 122 - Disclosure - Commitments and contingencies link:calculationLink link:presentationLink link:definitionLink 123 - Disclosure - Employee benefit plans link:calculationLink link:presentationLink link:definitionLink 124 - Disclosure - Income taxes link:calculationLink link:presentationLink link:definitionLink 125 - Disclosure - Facility Agreement link:calculationLink link:presentationLink link:definitionLink 126 - Disclosure - Selected quarterly financial data (unaudited) link:calculationLink link:presentationLink link:definitionLink 127 - Disclosure - Description of business and basis of presentation (Policies) link:calculationLink link:presentationLink link:definitionLink 128 - Disclosure - Inventories (Tables) link:calculationLink link:presentationLink link:definitionLink 129 - Disclosure - Property and equipment (Tables) link:calculationLink link:presentationLink link:definitionLink 130 - Disclosure - Accrued expenses and other current liabilities (Tables) link:calculationLink link:presentationLink link:definitionLink 131 - Disclosure - Senior convertible notes (Tables) link:calculationLink link:presentationLink link:definitionLink 132 - Disclosure - Fair Value of Financial Instruments (Tables) link:calculationLink link:presentationLink link:definitionLink 133 - Disclosure - Net loss per common share (Tables) link:calculationLink link:presentationLink link:definitionLink 134 - Disclosure - Stock award plans (Tables) link:calculationLink link:presentationLink link:definitionLink 135 - Disclosure - Income taxes (Tables) link:calculationLink link:presentationLink link:definitionLink 136 - Disclosure - Facility Agreement (Tables) link:calculationLink link:presentationLink link:definitionLink 137 - Disclosure - Selected quarterly financial data (unaudited) (Tables) link:calculationLink link:presentationLink link:definitionLink 138 - Disclosure - Description of Business and Basis of Presentation - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 139 - Disclosure - Summary Of Significant Accounting Policies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 140 - Disclosure - State Research and Development Credit Exchange Receivable - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 141 - Disclosure - Components of Inventories (Detail) link:calculationLink link:presentationLink link:definitionLink 142 - Disclosure - Property and Equipment (Detail) link:calculationLink link:presentationLink link:definitionLink 143 - Disclosure - Property and Equipment - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 144 - Disclosure - Accrued Expenses and Other Current Liabilities (Detail) link:calculationLink link:presentationLink link:definitionLink 145 - Disclosure - Related-Party Arrangements - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 146 - Disclosure - Summary of Senior Convertible Notes (Detail) link:calculationLink link:presentationLink link:definitionLink 147 - Disclosure - Senior Convertible Notes - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 148 - Disclosure - Collaborative Arrangement - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 149 - Disclosure - Fair Value of Financial Instruments - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 150 - Disclosure - Summary of Carrying Values and Estimated Fair Values of Notes and Facility Financing Obligation (Detail) link:calculationLink link:presentationLink link:definitionLink 151 - Disclosure - Changes in Fair Value of Level 3 Forward Purchase Contract (Detail) link:calculationLink link:presentationLink link:definitionLink 152 - 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Disclosure - Fair Value of Employee Stock Options Assumptions (Detail) link:calculationLink link:presentationLink link:definitionLink 160 - Disclosure - Summary of Stock Options Outstanding (Detail) link:calculationLink link:presentationLink link:definitionLink 161 - Disclosure - Summary of Restricted Stock Unit Activity (Detail) link:calculationLink link:presentationLink link:definitionLink 162 - Disclosure - Commitments and Contingencies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 163 - Disclosure - Employee Benefit Plans - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 164 - Disclosure - Provision for Income Taxes (Detail) link:calculationLink link:presentationLink link:definitionLink 165 - Disclosure - Components of Net Deferred Tax Asset (Detail) link:calculationLink link:presentationLink link:definitionLink 166 - Disclosure - Income Taxes - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 167 - Disclosure - Effective Income Tax Rate (Detail) link:calculationLink link:presentationLink link:definitionLink 168 - Disclosure - Facility Agreement - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 169 - Disclosure - Accretion of Debt Issuance Cost and Debt Discount in Connection with Deerfield Financing (Detail) link:calculationLink link:presentationLink link:definitionLink 170 - Disclosure - Selected Quarterly Financial Data (Detail) link:calculationLink link:presentationLink link:definitionLink