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        <link:definition>0511 - Disclosure - Related-party arrangements (Tables)</link:definition>
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        <link:definition>06111 - Disclosure - Related-party arrangements (Details Textual)</link:definition>
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        <link:definition>06011 - Disclosure - Description of business and basis of presentation (Details 1)</link:definition>
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        <link:definition>0605 - Disclosure - Net loss per common share (Details)</link:definition>
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        <link:definition>06122 - Disclosure - Senior convertible notes (Details Textual)</link:definition>
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        <link:definition>06121 - Disclosure - Senior convertible notes (Details 1)</link:definition>
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        <link:definition>0612 - Disclosure - Senior convertible notes (Details)</link:definition>
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        <link:definition>0608 - Disclosure - Common and preferred stock (Details Textual)</link:definition>
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        <link:definition>06072 - Disclosure - Property and equipment - net (Details Textual)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>06071 - Disclosure - Property and Equipment - net (Details 1)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>0607 - Disclosure - Property and equipment - net (Details)</link:definition>
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        <link:definition>0507 - Disclosure - Property and equipment net (Tables)</link:definition>
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        <link:definition>0606 - Disclosure - State research and development credit exchange receivable (Details)</link:definition>
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        <link:definition>06042 - Disclosure - Accounting for Stock-based Compensation (Details Textual)</link:definition>
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        <link:definition>0604 - Disclosure - Accounting for Stock- based Compensation (Details)</link:definition>
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        <link:definition>0504 - Disclosure - Accounting for Stock- Based Compensation (Tables)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>0603 - Disclosure - Accrued Expenses and Other Current Liabilities (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://mannkindcorp.com/role/AccruedExpensesAndOtherCurrentLiabilitiesTables" id="AccruedExpensesAndOtherCurrentLiabilitiesTables">
        <link:definition>0503 - Disclosure - Accrued Expenses and Other Current Liabilities (Tables)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>06012 - Disclosure - Description of business and basis of presentation (Details Textual)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://mannkindcorp.com/role/DescriptionOfBusinessAndBasisOfPresentationDetails" id="DescriptionOfBusinessAndBasisOfPresentationDetails">
        <link:definition>0601 - Disclosure - Description of business and basis of presentation (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://mannkindcorp.com/role/DescriptionOfBusinessAndBasisOfPresentationTables" id="DescriptionOfBusinessAndBasisOfPresentationTables">
        <link:definition>0501 - Disclosure - Description of business and basis of presentation (Tables)</link:definition>
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        <link:definition>0141 - Statement - Condensed Consolidated Statements of Cash Flows (Parenthetical) (Unaudited)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>00 - Document - Document and Entity Information</link:definition>
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        <link:definition>0110 - Statement - Condensed Consolidated Balance Sheets (Unaudited)</link:definition>
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        <link:definition>0111 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) (Unaudited)</link:definition>
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        <link:definition>0120 - Statement - Condensed Consolidated Statements of Operations (Unaudited)</link:definition>
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        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>0140 - Statement - Condensed Consolidated Statements of Cash Flows (Unaudited)</link:definition>
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        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>0201 - Disclosure - Description of business and basis of presentation</link:definition>
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        <link:definition>0203 - Disclosure - Accrued expenses and other current liabilities</link:definition>
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        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>0204 - Disclosure - Accounting for stock-based compensation</link:definition>
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        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>0205 - Disclosure - Net loss per common share</link:definition>
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        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType roleURI="http://mannkindcorp.com/role/StateResearchAndDevelopmentCreditExchangeReceivable" id="StateResearchAndDevelopmentCreditExchangeReceivable">
        <link:definition>0206 - Disclosure - State research and development credit exchange receivable</link:definition>
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        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>0207 - Disclosure - Property and equipment - net</link:definition>
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        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>0208 - Disclosure - Common and preferred stock</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>0210 - Disclosure - Commitments and contingencies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>0211 - Disclosure - Related-party arrangements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>0212 - Disclosure - Senior convertible notes</link:definition>
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        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>0213 - Disclosure - Income taxes</link:definition>
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        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
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  <import namespace="http://fasb.org/us-types/2012-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2012/elts/us-types-2012-01-31.xsd" />
  <import namespace="http://fasb.org/us-gaap/2012-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd" />
  <import namespace="http://xbrl.sec.gov/dei/2012-01-31" schemaLocation="http://xbrl.sec.gov/dei/2012/dei-2012-01-31.xsd" />
  <import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <import namespace="http://xbrl.sec.gov/exch/2012-01-31" schemaLocation="http://xbrl.sec.gov/exch/2012/exch-2012-01-31.xsd" />
  <import namespace="http://xbrl.sec.gov/country/2012-01-31" schemaLocation="http://xbrl.sec.gov/country/2012/country-2012-01-31.xsd" />
  <import namespace="http://xbrl.sec.gov/currency/2012-01-31" schemaLocation="http://xbrl.sec.gov/currency/2012/currency-2012-01-31.xsd" />
  <import namespace="http://xbrl.sec.gov/naics/2011-01-31" schemaLocation="http://xbrl.sec.gov/naics/2011/naics-2011-01-31.xsd" />
  <import namespace="http://xbrl.sec.gov/sic/2011-01-31" schemaLocation="http://xbrl.sec.gov/sic/2011/sic-2011-01-31.xsd" />
  <import namespace="http://xbrl.sec.gov/stpr/2011-01-31" schemaLocation="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd" />
  <!-- elements -->
  <element name="DocumentAndEntityInformationAbstract" id="mnkd_DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="true" nillable="true" />
  <element id="mnkd_BasicAndDilutedWeightedAverageNumberOfSharesOutstanding" name="BasicAndDilutedWeightedAverageNumberOfSharesOutstanding" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_StockExpenseForSharesIssuedPursuantToResearchAgreement" name="StockExpenseForSharesIssuedPursuantToResearchAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="mnkd_GainLossOnSaleAbandonmentDisposalOrImpairmentOfPropertyAndEquipment" name="GainLossOnSaleAbandonmentDisposalOrImpairmentOfPropertyAndEquipment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="mnkd_AccruedInterestOnInvestmentsNetOfAmortizationOfDiscounts" name="AccruedInterestOnInvestmentsNetOfAmortizationOfDiscounts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="mnkd_StateResearchAndDevelopmentCreditExchangeReceivable" name="StateResearchAndDevelopmentCreditExchangeReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="mnkd_ProceedsFromIssuanceOfCommonStockAndWarrants" name="ProceedsFromIssuanceOfCommonStockAndWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="mnkd_CollectionOfConvertiblePreferredStockSubscriptionsReceivable" name="CollectionOfConvertiblePreferredStockSubscriptionsReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="mnkd_PutSharesSoldToMajorityStockholder" name="PutSharesSoldToMajorityStockholder" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="mnkd_PaymentOfEmploymentTaxesRelatedToVestedRestrictedStockUnits" name="PaymentOfEmploymentTaxesRelatedToVestedRestrictedStockUnits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="mnkd_IncreaseInAdditionalPaidInCapitalResultingFromMerger" name="IncreaseInAdditionalPaidInCapitalResultingFromMerger" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="mnkd_IssuanceOfPutOptionByStockholder" name="IssuanceOfPutOptionByStockholder" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="mnkd_PutOptionRedemptionByStockholder" name="PutOptionRedemptionByStockholder" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="mnkd_IssuanceOfConvertiblePreferredStockSubscriptions" name="IssuanceOfConvertiblePreferredStockSubscriptions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="mnkd_IssuanceOfRedeemableConvertiblePreferredStock" name="IssuanceOfRedeemableConvertiblePreferredStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="mnkd_CancellationOfPrincipalOnNotePayableToRelatedParty" name="CancellationOfPrincipalOnNotePayableToRelatedParty" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="mnkd_StateResearchAndDevelopmentCreditExchangeReceivableTextBlock" name="StateResearchAndDevelopmentCreditExchangeReceivableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_StateResearchAndDevelopmentCreditExchangeReceivableAbstract" name="StateResearchAndDevelopmentCreditExchangeReceivableAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_CommonAndPreferredStockTextBlock" name="CommonAndPreferredStockTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_CommonAndPreferredStockAbstract" name="CommonAndPreferredStockAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_ConversionOfConvertiblePreferredStockAmountConverted" name="ConversionOfConvertiblePreferredStockAmountConverted" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_BasisOfPresentationPolicyTextBlock" name="BasisOfPresentationPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_RecentlyIssuedAccountingStandardsPolicyTextBlock" name="RecentlyIssuedAccountingStandardsPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_DescriptionOfBusinessAndBasisOfPresentationTextualAbstract" name="DescriptionOfBusinessAndBasisOfPresentationTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_BorrowingsUnderLoanAgreement" name="BorrowingsUnderLoanAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="mnkd_MaturityPeriodOfCashEquivalents" name="MaturityPeriodOfCashEquivalents" type="us-types:durationStringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_MaturityPeriodOfMarketableSecurities" name="MaturityPeriodOfMarketableSecurities" type="us-types:durationStringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_AccruedResearchAndClinicalTrialCosts" name="AccruedResearchAndClinicalTrialCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="mnkd_ScheduleOfCarryingValueAndEstimatedFairValueOfSeniorNotesTableTextBlock" name="ScheduleOfCarryingValueAndEstimatedFairValueOfSeniorNotesTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_PercentageOfCreditExchangeReceivable" name="PercentageOfCreditExchangeReceivable" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_EstimatedAmountsCreditExchangeReceivable" name="EstimatedAmountsCreditExchangeReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" />
  <element id="mnkd_FurnitureFixturesAndOfficeEquipmentMember" name="FurnitureFixturesAndOfficeEquipmentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_ComputerEquipmentAndSoftwareMember" name="ComputerEquipmentAndSoftwareMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_DepreciationAndAmortizationExpenseTableTextBlock" name="DepreciationAndAmortizationExpenseTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_CommonStockLoanedUnderShareLendingAgreementShares" name="CommonStockLoanedUnderShareLendingAgreementShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element id="mnkd_NominalLendingFee" name="NominalLendingFee" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_MannGroupMember" name="MannGroupMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_RelatedPartyArrangementsTextualAbstract" name="RelatedPartyArrangementsTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_AvailableBorrowingsUnderLoanAgreement" name="AvailableBorrowingsUnderLoanAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="mnkd_PrincipalAmountPerShare" name="PrincipalAmountPerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_PercentageOfRepurchasePrice" name="PercentageOfRepurchasePrice" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_PercentageOfRedemptionPrice" name="PercentageOfRedemptionPrice" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_PercentageOfConversionPriceEqualingStockPrice" name="PercentageOfConversionPriceEqualingStockPrice" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_IncomeTaxesRecognitionPolicyTextBlock" name="IncomeTaxesRecognitionPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_AmortizationPeriodOfLeaseHoldImprovements" name="AmortizationPeriodOfLeaseHoldImprovements" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_TimeRequiredForReturningSharesAfterPaymentOfEntireDebt" name="TimeRequiredForReturningSharesAfterPaymentOfEntireDebt" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_LoanAgreementWithRelatedParty" name="LoanAgreementWithRelatedParty" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="mnkd_RelatedPartyDebtMember" name="RelatedPartyDebtMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_BorrowingRate" name="BorrowingRate" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_RelatedPartyTransactionDebtInstrumentPrepaymentMinimum" name="RelatedPartyTransactionDebtInstrumentPrepaymentMinimum" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="mnkd_RelatedPartyTransactionPrepaymentPeriod" name="RelatedPartyTransactionPrepaymentPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_RelatedPartyTransactionMaximumLimitOfBorrowings" name="RelatedPartyTransactionMaximumLimitOfBorrowings" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="mnkd_RelatedPartyTransactionPrincipalAmountOutstandingUnderLoanArrangement" name="RelatedPartyTransactionPrincipalAmountOutstandingUnderLoanArrangement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="mnkd_AccruedInterestOfRelatedPartyDebt" name="AccruedInterestOfRelatedPartyDebt" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="mnkd_DebtInstrumentBasisSpreadOnVariableRateIncaseOfDefault" name="DebtInstrumentBasisSpreadOnVariableRateIncaseOfDefault" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_ScheduleOfAmortizationOfDebtIssuanceExpenseTableTextBlock" name="ScheduleOfAmortizationOfDebtIssuanceExpenseTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_DebtIssuanceCost" name="DebtIssuanceCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="mnkd_DebtConversionBasisForDeterminingConversionPrice" name="DebtConversionBasisForDeterminingConversionPrice" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_SeniorConvertibleNotesTextualAbstract" name="SeniorConvertibleNotesTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_BusinessPolicyTextBlock" name="BusinessPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_WarrantLiabilityMember" name="WarrantLiabilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_PerformanceOptionsMember" name="PerformanceOptionsMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_FairValueAssumptionRiskFreeInterestRate" name="FairValueAssumptionRiskFreeInterestRate" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element id="mnkd_FairValueInputDiscountForLackOfMarketability" name="FairValueInputDiscountForLackOfMarketability" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element id="mnkd_WarrantLiabilityTextualAbstract" name="WarrantLiabilityTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_WarrantLiabilityAdditionalTextualAbstract" name="WarrantLiabilityAdditionalTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_FairValueAssumptionExpectedVolatilityRate" name="FairValueAssumptionExpectedVolatilityRate" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element id="mnkd_ForwardPurchaseContractsMember" name="ForwardPurchaseContractsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_EmployeeServiceShareBasedCompensationNonvestedAwardsAggregateCompensationCostNotYetRecognizedNotConsideredProbableOfAchievement" name="EmployeeServiceShareBasedCompensationNonvestedAwardsAggregateCompensationCostNotYetRecognizedNotConsideredProbableOfAchievement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" />
  <element id="mnkd_AccountingForStockBasedCompensationTextualAbstract" name="AccountingForStockBasedCompensationTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_NetLossPerCommonShareTextualAbstract" name="NetLossPerCommonShareTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_StateResearchAndDevelopmentCreditExchangeReceivableTextualAbstract" name="StateResearchAndDevelopmentCreditExchangeReceivableTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_PropertyAndEquipmentNetTextualAbstract" name="PropertyAndEquipmentNetTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_CommonStockIssuedToByPartyAxis" name="CommonStockIssuedToByPartyAxis" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_CommonStockIssuedToByPartyDomain" name="CommonStockIssuedToByPartyDomain" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_UnderwritersMember" name="UnderwritersMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_UnitsSoldUnderPublicOfferUnderwritten" name="UnitsSoldUnderPublicOfferUnderwritten" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element id="mnkd_UnitsSoldUnderPublicOfferUnderwrittenCompositionDescription" name="UnitsSoldUnderPublicOfferUnderwrittenCompositionDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element id="mnkd_UnitsSoldWarrantPortionConvertibleIntoCommonStock" name="UnitsSoldWarrantPortionConvertibleIntoCommonStock" type="us-types:perUnitItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element id="mnkd_UnitsSoldByUnderwritingPrice" name="UnitsSoldByUnderwritingPrice" type="us-types:perUnitItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element id="mnkd_PublicMember" name="PublicMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_WarrantsExercisableExpirationPeriod" name="WarrantsExercisableExpirationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_RestrictedStockAgreedToBePurchasedByLender" name="RestrictedStockAgreedToBePurchasedByLender" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="mnkd_DerivativeFairValueLiabilitySharesIssuableToLender" name="DerivativeFairValueLiabilitySharesIssuableToLender" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element id="mnkd_EquityComponentMember" name="EquityComponentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_OtherThanEquityMember" name="OtherThanEquityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_WarrantEquityComponentMember" name="WarrantEquityComponentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_WarrantLiabilityComponentMember" name="WarrantLiabilityComponentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_UnitsSoldWarrantsExercised" name="UnitsSoldWarrantsExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element id="mnkd_IssuanceOfCommonStockAndWarrantsGrossValue" name="IssuanceOfCommonStockAndWarrantsGrossValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="mnkd_NumberOfMonthsAdvancesOutstanding" name="NumberOfMonthsAdvancesOutstanding" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_CommonAndPreferredStockTextualAbstract" name="CommonAndPreferredStockTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_ClosingBidPriceOfCommonStock" name="ClosingBidPriceOfCommonStock" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_CommitmentsAndContingenciesAdditionalTextualAbstract" name="CommitmentsAndContingenciesAdditionalTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_PrincipalAmountOutstandingUnderLoanArrangementSequentToCompletionOfCommonStockPurchaseAgreementAbstract" name="PrincipalAmountOutstandingUnderLoanArrangementSequentToCompletionOfCommonStockPurchaseAgreementAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_ScheduleOfPrincipalAmountOutstandingUnderLoanArrangementTableTextBlock" name="ScheduleOfPrincipalAmountOutstandingUnderLoanArrangementTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_DerivativeActionsMember" name="DerivativeActionsMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_SecuritiesActionMember" name="SecuritiesActionMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_RequiredPaymentToClassMembersAndAttorneys" name="RequiredPaymentToClassMembersAndAttorneys" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" />
  <element id="mnkd_NumberOfCommonStockToBeIssuedToClassMembersAndAttorneys" name="NumberOfCommonStockToBeIssuedToClassMembersAndAttorneys" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_AdditionalNumberOfCommonStockToBeIssuedToClassMembersAndAttorneys" name="AdditionalNumberOfCommonStockToBeIssuedToClassMembersAndAttorneys" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="mnkd_RequiredPaymentByInsurerToPlaintiff" name="RequiredPaymentByInsurerToPlaintiff" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="mnkd_AdditionalNumberOfCommonStockToBeIssuedToPlaintiffAttorneys" name="AdditionalNumberOfCommonStockToBeIssuedToPlaintiffAttorneys" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element id="mnkd_LossContingencySettlementAgreementCashConsideration" name="LossContingencySettlementAgreementCashConsideration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="mnkd_LossContingencySettlementAgreementStockConsideration" name="LossContingencySettlementAgreementStockConsideration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" />
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  <element id="mnkd_SecuritiesAndDerivativeLawsuitsMember" name="SecuritiesAndDerivativeLawsuitsMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
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  <element id="mnkd_AvailableForSaleSecuritiesAndCertificateOfDepositTextualAbstract" name="AvailableForSaleSecuritiesAndCertificateOfDepositTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
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  <element id="mnkd_AggregateAdjustmentOfForwardPurchaseContractToFairValue" name="AggregateAdjustmentOfForwardPurchaseContractToFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" />
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  <element id="mnkd_DerivativesFairValueLiabilitySharesIssuableToLender" name="DerivativesFairValueLiabilitySharesIssuableToLender" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element id="mnkd_ForwardPurchaseContractContributionToAdditionalPaidInCapital" name="ForwardPurchaseContractContributionToAdditionalPaidInCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
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  <element id="mnkd_SeniorConvertibleNotesDueTwoThousandThirteenMember" name="SeniorConvertibleNotesDueTwoThousandThirteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
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  <element id="mnkd_WarrantsTextBlock" name="WarrantsTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
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  <element id="mnkd_PrepaidAndOtherCurrentAssetsUnderCreditExchangeProgram" name="PrepaidAndOtherCurrentAssetsUnderCreditExchangeProgram" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" />
</schema>
</XBRL>
