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        <link:definition>0204 - Disclosure - Accounting for stock-based compensation</link:definition>
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        <link:definition>0202 - Disclosure - Investment in securities</link:definition>
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        <link:definition>0206 - Disclosure - State research and development credit exchange receivable</link:definition>
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        <link:definition>0207 - Disclosure - Property and equipment - net</link:definition>
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        <link:definition>0208 - Disclosure - Common and preferred stock</link:definition>
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        <link:definition>0213 - Disclosure - Income taxes</link:definition>
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