Entity Central Index Key Document and entity information. Document And Entity Information [Abstract] Document Type Document Type Amendment Flag Amendment Flag Document Period End Date Document Period End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Trading Symbol Trading Symbol Entity Registrant Name Entity Registrant Name Entity Central Index Key Current Fiscal Year End Date Current Fiscal Year End Date Entity Well-known Seasoned Issuer Entity Well Known Seasoned Issuer Entity Current Reporting Status Entity Current Reporting Status Entity Voluntary Filers Entity Voluntary Filers Entity Filer Category Entity Filer Category Entity Common Stock, Shares Outstanding Entity Common Stock Shares Outstanding Entity Public Float Entity Public Float Deferred collaborative credit current. Purchase obligation current. Accrued interest noncurrent. Purchase obligation noncurrent. Deferred collaborative credit noncurrent. Milestone rights liability and other liabilities, noncurrent. Statement Of Financial Position [Abstract] ASSETS Assets [Abstract] Current assets: Assets Current [Abstract] Cash and cash equivalents Cash And Cash Equivalents At Carrying Value Restricted cash Restricted Cash Current Accounts receivable, net Accounts Receivable Net Current Receivable from Sanofi Accounts And Other Receivables Net Current Inventory Inventory Net Asset held for sale Assets Held For Sale Not Part Of Disposal Group Current Deferred costs from commercial product sales Other Deferred Costs Net Prepaid expenses and other current assets Prepaid Expense And Other Assets Current Total current assets Assets Current Property and equipment, net Property Plant And Equipment Net Other assets Other Assets Noncurrent Total assets Assets LIABILITIES AND STOCKHOLDERS' DEFICIT Liabilities And Stockholders Equity [Abstract] Current liabilities: Liabilities Current [Abstract] Accounts payable Accounts Payable Current Accrued expenses and other current liabilities Accrued Liabilities Current Facility financing obligation Other Long Term Debt Current Deferred revenue, net Deferred Revenue Current Deferred payments from collaboration - current Deferred Collaborative Credit Current Recognized loss on purchase commitments - current Purchase Obligation Current Total current liabilities Liabilities Current Note payable to principal stockholder Notes Payable Related Parties Noncurrent Accrued interest - note payable to principal stockholder Accrued Interest Noncurrent Senior convertible notes Convertible Long Term Notes Payable Recognized loss on purchase commitments - long term Purchase Obligation Noncurrent Warrant liability Derivative Liabilities Noncurrent Deferred payments from collaboration - long term Deferred Collaborative Credit Noncurrent Milestone rights liability and other liabilities Milestone Rights Liability And Other Liabilities Noncurrent Total liabilities Liabilities Commitments and contingencies (Note 14) Commitments And Contingencies Stockholders' deficit: Stockholders Equity [Abstract] Undesignated preferred stock, $0.01 par value - 10,000,000 shares authorized; no shares issued or outstanding at December 31, 2017 and 2016 Preferred Stock Value Common stock, $0.01 par value - 280,000,000 and 140,000,000 shares authorized, 119,053,414 and 95,680,831 shares issued and outstanding at December 31, 2017 and 2016, respectively Common Stock Value Additional paid-in capital Additional Paid In Capital Common Stock Accumulated other comprehensive loss Accumulated Other Comprehensive Income Loss Net Of Tax Accumulated deficit Retained Earnings Accumulated Deficit Total stockholders' deficit Stockholders Equity Total liabilities and stockholders' deficit Liabilities And Stockholders Equity Undesignated preferred stock, par value Preferred Stock Par Or Stated Value Per Share Undesignated preferred stock, shares authorized Preferred Stock Shares Authorized Undesignated preferred stock, shares issued Preferred Stock Shares Issued Undesignated preferred stock, shares outstanding Preferred Stock Shares Outstanding Common stock, par value Common Stock Par Or Stated Value Per Share Common stock, shares authorized Common Stock Shares Authorized Common stock, shares issued Common Stock Shares Issued Common stock, shares outstanding Common Stock Shares Outstanding Net revenue from collaboration. Product costs from collaboration. Gain (loss) on purchase commitments. Change in fair value of warrant liability. Income Statement [Abstract] Revenues: Revenues [Abstract] Net revenue - commercial product sales Sales Revenue Goods Net Net revenue - collaboration Net Revenue From Collaboration Revenue - other Other Sales Revenue Net Total revenues Sales Revenue Net Expenses: Costs And Expenses [Abstract] Cost of goods sold Cost Of Goods Sold Cost of revenue - collaboration Product Costs From Collaboration Research and development Research And Development Expense Excluding Acquired In Process Cost Selling, general and administrative Selling General And Administrative Expense Property and equipment impairment Impairment Of Long Lived Assets Held For Use Loss (gain) on foreign currency translation Foreign Currency Transaction Gain Loss Realized (Gain) loss on purchase commitments Gain Loss On Purchase Commitments Total expenses Costs And Expenses (Loss) income from operations Operating Income Loss Other (expense) income: Nonoperating Income Expense [Abstract] Change in fair value of warrant liability Change In Fair Value Of Warrant Liability Interest income Investment Income Interest Interest expense on notes Interest Expense Debt Interest expense on note payable to principal stockholder Related Party Transaction Expenses From Transactions With Related Party (Loss) gain on extinguishment of debt Gains Losses On Extinguishment Of Debt Other income (expense) Other Nonoperating Income Expense Total other (expense) income Nonoperating Income Expense (Loss) income before income tax expense Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest Provision for income taxes Income Tax Expense Benefit Net (loss) income Net Income Loss Net (loss) income per share - basic Earnings Per Share Basic Net (loss) income per share - diluted Earnings Per Share Diluted Shares used to compute basic net (loss) income per share Weighted Average Number Of Shares Outstanding Basic Shares used to compute diluted net (loss) income per share Weighted Average Number Of Diluted Shares Outstanding Statement Of Income And Comprehensive Income [Abstract] Net (loss) income Other comprehensive income (loss): Other Comprehensive Income Loss Net Of Tax Period Increase Decrease [Abstract] Cumulative translation gain (loss) Other Comprehensive Income Foreign Currency Transaction And Translation Gain Loss Arising During Period Net Of Tax Comprehensive (loss) income Comprehensive Income Net Of Tax Stock Issued During Period Shares Warrant Exercises Stock Issued During Period Value Warrant Exercises Stock issued during period shares share lending agreement. Stock issued during period value share lending agreement. Adjustments To Additional Paid In Capital Stock Option Issued Upon Debt Conversion Common stock loaned under share lending agreement, shares. Common Stock Loaned Under Share Lending Agreement Value Adjustments to additional paid in capital reclassification of warrants from liability to equity shares. Adjustments To Additional Paid In Capital Reclassification Of Warrants From Liability To Equity Common Stock and Warrants Issued in Direct Placement Shares Common Stock and Warrants Issued in Direct Placement Value Adjustments To Additional Paid In Capital Shares Issued In Private Placement Common stock issued in direct placement shares. Common stock issued in direct placement value. Adjustments to additional paid in capital amortization of shelf fees. Statement Of Stockholders Equity [Abstract] Statement [Table] Statement [Table] Additional Paid-in Capital Statement Equity Components [Axis] Equity Component Equity Component [Domain] Common Stock Common Stock [Member] Additional Paid-in Capital Additional Paid In Capital [Member] Accumulated Other Comprehensive Income (Loss) Accumulated Other Comprehensive Income [Member] Deficit accumulated during the development stage member. Deficit Accumulated During Development Stage Deficit Accumulated During Development Stage [Member] Entity Listings, Exchange Entity Listings Exchange [Axis] Exchange Exchange [Domain] TEL AVIV STOCK EXCHANGE X T A E Statement [Line Items] Statement [Line Items] Beginning Balance Beginning Balance (in shares) Shares Outstanding Exercise of stock options Stock Issued During Period Value Stock Options Exercised Exercise of stock options (in shares) Stock Issued During Period Shares Stock Options Exercised Issuance of common shares from the release of restricted stock units Stock Issued During Period Value Restricted Stock Award Net Of Forfeitures Issuance of common shares from the release of restricted stock units (in shares) Stock Issued During Period Shares Restricted Stock Award Net Of Forfeitures Issuance of common shares pursuant to warrant exercises Stock Issued During Period Value Warrant Exercises Issuance of common shares pursuant to warrant exercises (in shares) Stock Issued During Period Shares Warrant Exercises Issuance of common shares under Employee Stock Purchase Plan Stock Issued During Period Value Employee Stock Purchase Plan Issuance of common shares under Employee Stock Purchase Plan (in shares) Stock Issued During Period Shares Employee Stock Purchase Plans Stock-based compensation expense Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value Restricted stock units taxes paid in cash Adjustments To Additional Paid In Capital Share Based Compensation Restricted Stock Units Requisite Service Period Recognition Capital contribution Partners Capital Account Contributions Issuance of common shares pursuant to conversions of certain notes Stock Issued During Period Value Conversion Of Convertible Securities Issuance of common shares pursuant to conversions of certain notes (in shares) Stock Issued During Period Shares Conversion Of Convertible Securities Issuance of direct placement - common stock and warrants (value) Common Stock And Warrants Issued In Direct Placement Value Issuance of direct placement - common stock and warrants (shares) Common Stock And Warrants Issued In Direct Placement Shares Issuance of direct placement — common stock Common Stock Issued In Direct Placement Value Issuance of direct placement — common stock (shares) Common Stock Issued In Direct Placement Shares Issuance costs associated with direct placement Adjustments To Additional Paid In Capital Shares Issued In Private Placement Issuance of common stock for lender financing fees Stock Issued During Period Value Share Lending Agreement Issuance of common stock for lender financing fees (in shares) Stock Issued During Period Shares Share Lending Agreement Discount on notes-for-stock exchange Adjustments To Additional Paid In Capital Stock Option Issued Upon Debt Conversion Issuance of common stock Stock Issued During Period Value New Issues Issuance of common stock (Shares) Stock Issued During Period Shares New Issues Return of loaned common stock Common Stock Loaned Under Share Lending Agreement Value Return of loaned common stock (in shares) Common Stock Loaned Under Share Lending Agreement Shares Issuance of warrant liability Adjustments To Additional Paid In Capital Warrant Issued Issuance costs associated with ATM placement Adjustments To Additional Paid In Capital Stock Issued Issuance Costs Reclassification of warrant liability to equity Adjustments To Additional Paid In Capital Reclassification Of Warrants From Liability To Equity Reclassification of warrant liability to equity (in shares) Adjustments To Additional Paid In Capital Reclassification Of Warrants From Liability To Equity Shares Amortization of shelf fees Adjustments To Additional Paid In Capital Amortization Of Shelf Fees Cumulative translation loss Ending Balance Ending Balance (in shares) Interest on note payable to principal stockholder. Warrant issuance costs. Increase (decrease) in other deferred charges. Increase (decrease) in deferred collaborative revenue. Increase (decrease) in purchase commitment loss. The cash inflow from the additional capital contribution to the entity including any warrants issued. Proceeds are net of cash outflows for issuance costs related to the transaction. Milestone payments. Reclassification of property plant and equipment to assets held for sale noncash. Statement Of Cash Flows [Abstract] CASH FLOWS FROM OPERATING ACTIVITIES: Net Cash Provided By Used In Operating Activities Continuing Operations [Abstract] Adjustments to reconcile net (loss) income to net cash used in operating activities: Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract] Depreciation, amortization and accretion Depreciation And Amortization Stock-based compensation expense Share Based Compensation Change in fair value of warrant liability Loss (gain) on extinguishment of debt Interest incurred through borrowings under Sanofi Loan Facility Paid In Kind Interest Interest on note payable to principal stockholder Interest On Note Payable To Principal Stockholder Series A warrant issuance cost Warrant Issuance Costs Other, net Other Noncash Income Expense (Gain) loss on sale, abandonment/disposal or impairment of property and equipment Gain Loss On Disposition Of Assets (Gain) loss on purchase commitments Write-off of inventory Production Related Impairments Or Charges Changes in operating assets and liabilities: Increase Decrease In Operating Capital [Abstract] Accounts receivable, net Increase Decrease In Accounts Receivable Receivable from Sanofi Increase Decrease In Accounts And Notes Receivable Inventory Increase Decrease In Inventories Receivable from collaboration Increase Decrease In Accounts And Other Receivables Deferred costs from commercial product sales Increase Decrease In Other Deferred Charges Deferred costs from collaboration Increase Decrease In Deferred Charges Prepaid expenses and other current assets Increase Decrease In Prepaid Deferred Expense And Other Assets Other assets Increase Decrease In Other Operating Assets Accounts payable Increase Decrease In Accounts Payable Accrued expenses and other current liabilities Increase Decrease In Accrued Liabilities And Other Operating Liabilities Deferred revenue Increase Decrease In Deferred Revenue Deferred payments from collaboration Increase Decrease In Customer Advances And Deposits Deferred sales from collaboration Increase Decrease In Deferred Collaborative Revenue Recognized loss on purchase commitments Increase Decrease In Purchase Commitment Loss Milestone rights liability and other liabilities Increase Decrease In Other Operating Liabilities Net cash used in operating activities Net Cash Provided By Used In Operating Activities Continuing Operations CASH FLOWS FROM INVESTING ACTIVITIES: Net Cash Provided By Used In Investing Activities Continuing Operations [Abstract] Purchase of property and equipment Payments To Acquire Property Plant And Equipment Net proceeds from sale of asset held for sale Proceeds From Sale Of Productive Assets Proceeds from sale of property and equipment Proceeds From Sale Of Property Plant And Equipment Net cash provided by (used in) investing activities Net Cash Provided By Used In Investing Activities Continuing Operations CASH FLOWS FROM FINANCING ACTIVITIES: Net Cash Provided By Used In Financing Activities Continuing Operations [Abstract] Proceeds from direct placement of common stock Proceeds From Issuance Of Private Placement Issuance cost associated with direct placement Payment Of Financing And Stock Issuance Costs Principal payments on facility financing obligation Repayments Of Lines Of Credit Payment of employment taxes related to vested restricted stock units Payments Related To Tax Withholding For Share Based Compensation Proceeds from issuance of common stock Proceeds From Issuance Of Common Stock And Warrants Net Exercise of warrants for common stock Proceeds From Warrant Exercises Payment of senior convertible notes Repayments Of Senior Debt Payment of debt issuance costs on senior convertible notes Payments Of Debt Issuance Costs Borrowings on note payable to principal stockholder Proceeds From Related Party Debt Milestone payment Milestone Payments Proceeds from issuance of common stock pursuant to at-the-market issuance Proceeds From Issuance Of Common Stock Issuance costs Payments Of Stock Issuance Costs Other Proceeds From Payments For Other Financing Activities Net cash provided by financing activities Net Cash Provided By Used In Financing Activities Continuing Operations NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS AND RESTRICTED CASH Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Excluding Exchange Rate Effect CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, BEGINNING OF PERIOD Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, END OF PERIOD SUPPLEMENTAL CASH FLOWS DISCLOSURES: Supplemental Cash Flow Information [Abstract]