Entity Central Index Key
Document and entity information.
Document And Entity Information [Abstract]
Document Type
Document Type
Amendment Flag
Amendment Flag
Document Period End Date
Document Period End Date
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Trading Symbol
Trading Symbol
Entity Registrant Name
Entity Registrant Name
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Filer Category
Entity Filer Category
Entity Small Business
Entity Small Business
Entity Emerging Growth Company
Entity Emerging Growth Company
Entity Common Stock, Shares Outstanding
Entity Common Stock Shares Outstanding
Right-of-use and other assets.
Purchase obligation current.
Accrued interest noncurrent.
Purchase obligation noncurrent.
Milestone rights liabilities noncurrent.
Statement Of Financial Position [Abstract]
ASSETS
Assets [Abstract]
Current assets:
Assets Current [Abstract]
Cash and cash equivalents
Cash And Cash Equivalents At Carrying Value
Restricted cash
Restricted Cash Current
Short-term investments
Short Term Investments
Accounts receivable, net
Accounts Receivable Net Current
Inventory
Inventory Net
Prepaid expenses and other current assets
Prepaid Expense And Other Assets Current
Total current assets
Assets Current
Property and equipment, net
Property Plant And Equipment Net
Right-of-use and other assets
Right Of Use And Other Assets
Total assets
Assets
LIABILITIES AND STOCKHOLDERS' DEFICIT
Liabilities And Stockholders Equity [Abstract]
Current liabilities:
Liabilities Current [Abstract]
Accounts payable
Accounts Payable Current
Accrued expenses and other current liabilities
Accrued Liabilities Current
Facility financing obligation
Other Long Term Debt Current
Deferred revenue - current
Contract With Customer Liability Current
Recognized loss on purchase commitments - current
Purchase Obligation Current
Total current liabilities
Liabilities Current
Senior convertible notes
Convertible Long Term Notes Payable
Note payable to related party
Notes Payable Related Parties Noncurrent
Accrued interest - note payable to related party
Accrued Interest Noncurrent
Recognized loss on purchase commitments - long term
Purchase Obligation Noncurrent
Deferred revenue - long term
Contract With Customer Liability Noncurrent
Milestone rights liability
Milestone Rights Liabilities Noncurrent
Operating lease liabilities
Operating Lease Liability Noncurrent
Total liabilities
Liabilities
Commitments and contingencies
Commitments And Contingencies
Stockholders' deficit:
Stockholders Equity [Abstract]
Common stock, $0.01 par value - 280,000,000 shares authorized, 187,778,236 and 187,029,967 shares issued and outstanding at March 31, 2019 and December 31, 2018, respectively
Common Stock Value
Additional paid-in capital
Additional Paid In Capital Common Stock
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income Loss Net Of Tax
Accumulated deficit
Retained Earnings Accumulated Deficit
Total stockholders' deficit
Stockholders Equity
Total liabilities and stockholders' deficit
Liabilities And Stockholders Equity
Common stock, par value
Common Stock Par Or Stated Value Per Share
Common stock, shares authorized
Common Stock Shares Authorized
Common stock, shares issued
Common Stock Shares Issued
Common stock, shares outstanding
Common Stock Shares Outstanding
Income Statement [Abstract]
Statement [Table]
Statement [Table]
Product and Service
Product Or Service [Axis]
Product and Service
Products And Services [Domain]
Commercial product sales
Product [Member]
Collaborations and services
License And Service [Member]
Statement [Line Items]
Statement [Line Items]
Revenues:
Revenues [Abstract]
Total revenues
Revenue From Contract With Customer Excluding Assessed Tax
Expenses:
Costs And Expenses [Abstract]
Cost of goods sold
Cost Of Goods And Services Sold
Cost of revenue
Cost Of Revenue
Research and development
Research And Development Expense Excluding Acquired In Process Cost
Selling, general and administrative
Selling General And Administrative Expense
(Gain) loss on foreign currency translation
Foreign Currency Transaction Gain Loss Realized
Total expenses
Costs And Expenses
Loss from operations
Operating Income Loss
Other (expense) income:
Nonoperating Income Expense [Abstract]
Interest income
Investment Income Interest
Interest expense on notes
Interest Expense Debt
Interest expense on note payable to related party
Related Party Transaction Expenses From Transactions With Related Party
Loss on extinguishment of debt
Gains Losses On Extinguishment Of Debt
Other income (expense)
Other Nonoperating Income Expense
Total other expense
Nonoperating Income Expense
Loss before provision for income taxes
Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest
Provision for income taxes
Income Tax Expense Benefit
Net loss
Net Income Loss
Net loss per share - basic and diluted
Earnings Per Share Basic And Diluted
Shares used to compute basic and diluted net loss per share
Weighted Average Number Of Share Outstanding Basic And Diluted
Statement Of Income And Comprehensive Income [Abstract]
Net loss
Other comprehensive income (loss):
Other Comprehensive Income Loss Net Of Tax Period Increase Decrease [Abstract]
Cumulative translation gain
Other Comprehensive Income Foreign Currency Transaction And Translation Gain Loss Arising During Period Net Of Tax
Comprehensive loss
Comprehensive Income Net Of Tax
Adjustments to additional paid in capital amortization of shelf fees.
Stock issued during period shares market price stock purchase plan.
Stock issued during period value market price stock purchase plan.
Statement Of Stockholders Equity [Abstract]
Equity Components
Statement Equity Components [Axis]
Equity Component
Equity Component [Domain]
Common Stock
Common Stock [Member]
Additional Paid-in Capital
Additional Paid In Capital [Member]
Accumulated Other Comprehensive Income (Loss)
Accumulated Other Comprehensive Income [Member]
Accumulated Deficit
Retained Earnings [Member]
Adjustments for New Accounting Pronouncements
Adjustments For New Accounting Pronouncements [Axis]
Type of Adoption
Type Of Adoption [Member]
Topic 718
Accounting Standards Update201609 [Member]
Sale of Stock
Subsidiary Sale Of Stock [Axis]
Sale of Stock
Sale Of Stock Name Of Transaction [Domain]
At-the-market placement.
At-the-market Issuance
At The Market Pacement [Member]
Debt Instrument
Debt Instrument [Axis]
Debt Instrument, Name
Debt Instrument Name [Domain]
Senior convertible notes.
Senior Convertible Notes
Senior Convertible Notes [Member]
Facility financing obligation.
Facility Financing Obligation
Facility Financing Obligation [Member]
Note payable to related party.
Related Party Notes
Note Payable To Related Party [Member]
Beginning Balance
Beginning Balance (in shares)
Shares Outstanding
Exercise of stock options
Stock Issued During Period Value Stock Options Exercised
Exercise of stock options (in shares)
Stock Issued During Period Shares Stock Options Exercised
Adjustment to adopt ASU 2016-09
New Accounting Pronouncement Or Change In Accounting Principle Effect Of Adoption Quantification
Issuance of common shares from the release of restricted stock units
Stock Issued During Period Value Restricted Stock Award Net Of Forfeitures
Issuance of common shares from the release of restricted stock units (in shares)
Stock Issued During Period Shares Restricted Stock Award Net Of Forfeitures
Issuance of common shares under Employee Stock Purchase Plan
Stock Issued During Period Value Employee Stock Purchase Plan
Issuance of common shares under Employee Stock Purchase Plan (in shares)
Stock Issued During Period Shares Employee Stock Purchase Plans
Stock-based compensation expense
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
Restricted stock unit award
Adjustments To Additional Paid In Capital Share Based Compensation Restricted Stock Units Requisite Service Period Recognition
Issuance of shares pursuant to conversion notes
Stock Issued During Period Value Conversion Of Convertible Securities
Issuance of shares pursuant to conversion notes (in shares)
Stock Issued During Period Shares Conversion Of Convertible Securities
Amortization of shelf fees
Adjustments To Additional Paid In Capital Amortization Of Shelf Fees
Issuance of at-the-market placement
Stock Issued During Period Value Market Price Stock Purchase Plan
Issuance of at-the-market placement (in shares)
Stock Issued During Period Shares Market Price Stock Purchase Plan
Issuance costs associated with at-the- market placement
Adjustments To Additional Paid In Capital Stock Issued Issuance Costs
Net loss
Ending Balance
Ending Balance (in shares)
Operating lease right of use asset amortization.
Interest on note payable to related party.
increase decrease in right of use and other assets.
Increase decrease in recognized loss on purchase commitments.
Increase decrease in operating lease payments.
Payments of note payable to related party through common stock issuance.
Debt issuance costs related to note payable to related party accrued but not yet paid.
Payment of interest on senior convertible notes through common stock issuance
Common stock issuance to settle employee stock purchase plan liability
Addition of right-of-use assets
Statement Of Cash Flows [Abstract]
At-the-market issuance.
At-the-market Issuance
At The Market Issuance [Member]
CASH FLOWS FROM OPERATING ACTIVITIES:
Net Cash Provided By Used In Operating Activities [Abstract]
Net loss
Profit Loss
Adjustments to reconcile net loss to net cash (used in) provided by operating activities:
Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract]
Depreciation, amortization and accretion
Depreciation And Amortization
Amortization of right-of-use assets
Operating Lease Right Of Use Asset Amortization
Stock-based compensation expense
Share Based Compensation
Restricted stock unit award
Restricted Stock Expense
Loss on extinguishment of debt
(Gain) Loss on foreign currency translation
Interest on note payable to related party
Interest On Note Payable To Related Party
Write-off of inventory
Production Related Impairments Or Charges
Other, net
Other Noncash Income Expense
Changes in operating assets and liabilities:
Increase Decrease In Operating Capital [Abstract]
Accounts receivable, net
Increase Decrease In Accounts Receivable
Inventory
Increase Decrease In Inventories
Prepaid expenses and other current assets
Increase Decrease In Prepaid Deferred Expense And Other Assets
Right-of-use and other assets
Increase Decrease In Right Of Use And Other Assets
Accounts payable
Increase Decrease In Accounts Payable
Accrued expenses and other current liabilities
Increase Decrease In Accrued Liabilities And Other Operating Liabilities
Deferred revenue
Increase Decrease In Contract With Customer Liability
Recognized loss on purchase commitments
Increase Decrease In Recognized Loss On Purchase Commitments
Operating lease payments
Increase Decrease In Operating Lease Payments
Net cash used in operating activities
Net Cash Provided By Used In Operating Activities
CASH FLOWS FROM INVESTING ACTIVITIES:
Net Cash Provided By Used In Investing Activities [Abstract]
Purchase of property and equipment
Payments To Acquire Property Plant And Equipment
Purchase of short-term investments
Payments To Acquire Short Term Investments
Net cash used in investing activities
Net Cash Provided By Used In Investing Activities
CASH FLOWS FROM FINANCING ACTIVITIES:
Net Cash Provided By Used In Financing Activities [Abstract]
Payment of employment taxes related to vested restricted stock units
Payments Related To Tax Withholding For Share Based Compensation
Proceeds from issuance of common stock
Proceeds From Issuance Of Common Stock
Issuance costs
Payments Of Stock Issuance Costs
Other
Proceeds From Payments For Other Financing Activities
Net cash provided by financing activities
Net Cash Provided By Used In Financing Activities
NET DECREASE IN CASH AND CASH EQUIVALENTS AND RESTRICTED CASH
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, BEGINNING OF PERIOD
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, END OF PERIOD
SUPPLEMENTAL CASH FLOWS DISCLOSURES:
Supplemental Cash Flow Information [Abstract]
Interest paid in cash, net of amounts capitalized
Interest Paid Net
NON-CASH INVESTING AND FINANCING ACTIVITIES:
Noncash Investing And Financing Items [Abstract]
Payment of note obligations through common stock issuance
Stock Issued1
Payment of note payable to related party through common stock issuance
Payments Of Note Payable To Related Party Through Common Stock Issuance
Accrued but unpaid debt issuance costs related to note payable to related party
Debt Issuance Costs Related To Note Payable To Related Party Accrued But Not Yet Paid
Payment of interest on senior convertible notes through common stock issuance
Payment Of Interest On Senior Convertible Notes Through Common Stock Issuance
Property and equipment in progress in accounts payable
Capital Expenditures Incurred But Not Yet Paid
Common stock issuance to settle employee stock purchase plan liability
Common Stock Issuance To Settle Employee Stock Purchase Plan Liability
Addition of right-of-use assets
Addition Of Right Of Use Assets
Accounting Policies [Abstract]
Description of Business and Significant Accounting Policies
Organization Consolidation And Presentation Of Financial Statements Disclosure And Significant Accounting Policies [Text Block]
Receivables [Abstract]
Accounts Receivable
Financing Receivables [Text Block]
Inventory Disclosure [Abstract]
Inventories
Inventory Disclosure [Text Block]
Property Plant And Equipment [Abstract]
Property and Equipment
Property Plant And Equipment Disclosure [Text Block]
Payables And Accruals [Abstract]
Accrued Expenses and Other Current Liabilities
Accounts Payable And Accrued Liabilities Disclosure [Text Block]
Related Party Transactions [Abstract]
Related-Party Arrangements
Related Party Transactions Disclosure [Text Block]
Debt Disclosure [Abstract]
Borrowings
Debt Disclosure [Text Block]
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Collaborations and Licensing Arrangements
Collaborative Arrangement Disclosure [Text Block]
Fair Value Disclosures [Abstract]
Fair Value of Financial Instruments
Fair Value Disclosures [Text Block]
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Stock-Based Compensation Expense
Disclosure Of Compensation Related Costs Share Based Payments [Text Block]
Commitments And Contingencies Disclosure [Abstract]
Commitments and Contingencies
Commitments And Contingencies Disclosure [Text Block]
Income Tax Disclosure [Abstract]
Income Taxes
Income Tax Disclosure [Text Block]
Business.
Business
Business Policy [Text Block]
Basis of Presentation.
Basis of Presentation
Basis Of Presentation Policy [Text Block]
Principles of Consolidation
Consolidation Policy [Text Block]
Segment Information
Segment Reporting Policy Policy [Text Block]
Revenue Recognition
Revenue Recognition Policy [Text Block]
Revenue from contract with customer from commercial product sales.
Revenue Recognition - Net Revenue - Commercial Product Sales
Revenue From Contract With Customer From Commercial Product Sales Policy [Text Block]
Revenue from contract with customer from collaborations and services.
Revenue Recognition- Net Revenue - Collaborations and Services
Revenue From Contract With Customer From Collaborations And Services Policy [Text Block]
Milestone Payments
Debt Policy [Text Block]
Cost of Goods Sold
Cost Of Sales Policy [Text Block]
Restricted Cash
Cash And Cash Equivalents Restricted Cash And Cash Equivalents Policy
Short-term Investments
Investment Policy [Text Block]
Concentration of Credit Risk
Concentration Risk Credit Risk
Accounts Receivable and Allowance for Doubtful Accounts
Receivables Trade And Other Accounts Receivable Allowance For Doubtful Accounts Policy
Inventories
Inventory Policy [Text Block]
Loss on purchase commitments.
Recognized Loss on Purchase Commitments
Loss On Purchase Commitments Policy Policy [Text Block]
Fair Value of Financial Instruments
Fair Value Of Financial Instruments Policy
Contingencies
Commitments And Contingencies Policy [Text Block]
Stock-Based Compensation
Compensation Related Costs Policy [Text Block]
Clinical Trial Expense
Clinical Trial Expenses
Clinical Trial Expense Policy [Text Block]
Net Income or (Loss) Per Share of Common Stock
Earnings Per Share Policy [Text Block]
Leases
Lessee Leases Policy [Text Block]
Recently issued accounting standards.
Recently Issued Accounting Standards
Recently Issued Accounting Standards Policy [Text Block]
Schedule of Potentially Dilutive Common Stock Equivalent Securities
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block]
Schedule of Accounts Receivable, Net
Schedule Of Accounts Notes Loans And Financing Receivable [Text Block]
Components of Inventory
Schedule Of Inventory Current Table [Text Block]
Property and Equipment, Net
Property Plant And Equipment [Text Block]
Accrued Expenses and Other Current Liabilities
Schedule Of Accrued Liabilities Table [Text Block]
Schedule of related party debt.
Related Party
Related Party Transactions By Related Party [Axis]
Related Party
Related Party [Domain]
Related party debt.
Related Party Notes
Related Party Debt [Member]
Schedule of Related Party Debt
Schedule Of Related Party Debt Table [Text Block]
Schedule of Interest Expense on Note Payable to Related Party
Schedule Of Related Party Transactions Table [Text Block]
Schedule of amortization of debt issuance cost and debt discount.
Schedule of Amortization of Premium and Accretion of Debt Issuance Costs
Schedule Of Amortization Of Debt Issuance Cost And Debt Discount Table [Text Block]
Summary of Borrowings
Schedule Of Debt Table [Text Block]
Schedule of principal payment settlement in cash or exchange for issuance of shares.
Schedule of Principal Payment Settlement in Cash or Exchange for Issuance of Shares
Schedule Of Principal Payment Settlement In Cash Or Exchange For Issuance Of Shares Table [Text Block]
Accretion of Debt Issuance Cost and Debt Discount
Schedule Of Other Assets And Other Liabilities Table [Text Block]
Schedule of Revenue from Collaboration and Services
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions Table [Text Block]
Fair Value of Financial Instruments
Schedule Of Fair Value Assets And Liabilities Measured On Recurring Basis Table [Text Block]
Stock Based Compensation Expense Recognized in Accompanying Condensed Consolidated Statements of Operations
Schedule Of Share Based Compensation Activity Table [Text Block]
Annual Purchase Requirements under Contract
Long Term Purchase Commitment [Text Block]
Schedule of Future Minimum Office And Vehicle Lease Payments
Lessee Operating Lease Liability Maturity Table [Text Block]
Organization, consolidation and presentation of financial statements disclosure.
Organization, Consolidation and Presentation of Financial Statements Disclosure [Table]
Organization Consolidation And Presentation Of Financial Statements Disclosure [Table]
Organization Consolidation And Presentation Of Financial Statements Disclosure [Table]
Legal Entity
Legal Entity [Axis]
Entity
Entity [Domain]
Deerfield Management Company L.P.
Deerfield
Deerfield Management Company Lp [Member]
Two thousand nineteen notes.
2019 notes
Two Thousand Nineteen Notes [Member]
Eight point seven five senior convertible notes due two thousand nineteen.
Tranche B notes
Eight Point Seven Five Senior Convertible Notes Due Two Thousand Nineteen [Member]
Range
Range [Axis]
Range
Range [Member]
Minimum
Minimum [Member]
Maximum [Member]
Maximum [Member]
Maximum
AFREZZA product sales
Investment Type
Investment Type [Axis]
Investments
Investment Type Categorization [Member]
Short-term Investments
Short Term Investments [Member]
Insulin.
Insulin
Insulin [Member]
(“ASC”) Topic 842 – Leases
Accounting Standards Update201602 [Member]
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items]
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Line of credit facility restricted borrowing capacity for each quarter end after current fiscal year.
Available amount of credit facility under covenant restrictions for each quarter end after current fiscal
Line Of Credit Facility Restricted Borrowing Capacity For Each Quarter End After Current Fiscal Year
Senior notes, effective interest rate
Debt Instrument Interest Rate Stated Percentage
Principal amount of outstanding borrowings
Debt Instrument Face Amount
Sales return period.
Percentage of estimated products returns.
Sales return right following product expiration in months
Sales Return Period
Percentage of estimated products returned
Percentage Of Estimated Products Returns
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date
Revenue Remaining Performance Obligation Expected Timing Of Satisfaction Start Date [Axis]
Remaining performance obligation, Expected timing of satisfaction, period
Revenue Remaining Performance Obligation Expected Timing Of Satisfaction Period1
Gain (loss) on investments
Gain Loss On Investments
Loss on purchase commitments number of contracts recognized.
Loss on purchase commitments
Purchase Obligation
Loss on purchase commitments, number of new contracts recognized
Loss On Purchase Commitments Number Of Contracts Recognized
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Antidilutive Securities
Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis]
Antidilutive Securities, Name
Antidilutive Securities Name [Domain]
Vesting of Restricted Stock Units
Restricted Stock [Member]
Conversion of Convertible Notes into Common Stock
Convertible Debt Securities [Member]
Conversion of convertible related party notes into common stock.
Conversion of Convertible Related Party Notes into Common Stock
Conversion Of Convertible Related Party Notes Into Common Stock [Member]
Exercise of Common Stock Warrants
Warrant [Member]
Employee stock purchase plan.
Employee Stock Purchase Plan
Employee Stock Purchase Plan [Member]
Exercise of Common Stock Options
Employee Stock Option [Member]
Exercise of warrants associated with public offering.
Exercise of Warrants Associated with Public Offering
Exercise Of Warrants Associated With Public Offering [Member]
Exercise of warrants associated with direct placement.
Exercise of Warrants Associated with Direct Placement
Exercise Of Warrants Associated With Direct Placement [Member]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Anti-dilutive securities excluded from computation of earnings per share
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
New accounting pronouncement or change in accounting principle, cumulative effect of change on net assets liabilities.
Increase in total assets and total liabilities
New Accounting Pronouncement Or Change In Accounting Principle Cumulative Effect Of Change On Net Assets Liabilities
Wholesaler distribution fees and prompt pay discounts.
Reserve for returns.
Accounts receivable, gross
Accounts Receivable Gross Current
Wholesaler distribution fees and prompt pay discounts
Wholesaler Distribution Fees And Prompt Pay Discounts
Reserve for returns
Reserve For Returns
Accounts receivable, net
Number of wholesale distributors.
Percentage of accounts receivable from major customers.
Number of wholesale distributors
Number Of Wholesale Distributors
Percentage of accounts receivable from major wholesale distributors
Percentage Of Accounts Receivable From Major Customers
Raw materials
Inventory Raw Materials Net Of Reserves
Work-in-process
Inventory Work In Process Net Of Reserves
Finished goods
Inventory Finished Goods Net Of Reserves
Total inventory
Schedule Of Property Plant And Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Property, Plant and Equipment, Type
Property Plant And Equipment By Type [Axis]
Property, Plant and Equipment, Type
Property Plant And Equipment Type [Domain]
Land
Land [Member]
Buildings
Building [Member]
Building Improvements
Building Improvements [Member]
Machinery and Equipment
Machinery And Equipment [Member]
Furniture, fixtures and office equipment.
Furniture, fixtures and office equipment
Furniture Fixtures And Office Equipment [Member]
Computer equipment and software.
Computer Equipment and Software
Computer Equipment And Software [Member]
Construction in Progress
Construction In Progress [Member]
Property Plant And Equipment [Line Items]
Property Plant And Equipment [Line Items]
Property and equipment - gross
Property Plant And Equipment Gross
Less accumulated depreciation
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
Total property and equipment, net
Estimated Useful Life (Years)
Property Plant And Equipment Useful Life
Depreciation expense
Depreciation
Current portion of milestone right liability.
Customer Discounts And Allowances
Sales And Marketing Related Expenses Accrued
Accrued expenses and other current liabilities.
Accrued Expenses And Other Current Liabilities [Abstract]
Salary and related expenses
Employee Related Liabilities Current
Current portion of milestone rights liability
Current Portion Of Milestone Right Liability
Professional fees
Accrued Professional Fees Current
Discounts and allowances for commercial product sales
Customer Discounts And Allowances
Sales and marketing services
Sales And Marketing Related Expenses Accrued
Accrued interest
Interest Payable Current
Deferred Lease Liability
Direct Financing Lease Deferred Selling Profit
Other
Other Accrued Liabilities Current
Total accrued expenses and other current liabilities
Schedule Of Related Party Transactions By Related Party [Table]
Schedule Of Related Party Transactions By Related Party [Table]
Related Party Debt
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Principal amount
Unamortized premium
Debt Instrument Unamortized Premium
Unaccreted debt issuance costs
Unamortized Debt Issuance Expense
Net carrying amount
Principal amount per share.
The mann group llc.
The Mann Group LLC
The Mann Group L L C [Member]
Related Party Transaction
Related Party Transaction [Axis]
Related Party Transaction
Related Party Transaction [Domain]
Amended and restated loan arrangement.
Amended and Restated Loan Arrangement
Amended And Restated Loan Arrangement [Member]
Loan arrangement.
Loan Arrangement
Loan Arrangement [Member]
Letter agreement.
Letter Agreement
Letter Of Agreement [Member]
Variable Rate
Variable Rate [Axis]
Variable Rate
Variable Rate [Domain]
LIBOR
London Interbank Offered Rate L I B O R [Member]
Maturity date
Debt Instrument Maturity Date
No of convertible shares
Debt Instrument Convertible Conversion Ratio1
Principal amount per share
Principal Amount Per Share
Conversion price of shares
Debt Instrument Convertible Conversion Price1
Loss on extinguishment of debt
Debt issuance costs
Debt instrument principal amounts cancelled.
Principal balance cancelled amount
Debt Instrument Principal Amounts Cancelled
Related party transaction debt instrument prepayment.
Number of months advances outstanding.
Related party transaction prepayment period.
Available loan balance cancelled.
Fixed borrowing rate
Long Term Debt Percentage Bearing Fixed Interest Rate
Amount prepaid for cancellation of indebtedness
Related Party Transaction Debt Instrument Prepayment
Number of months advances outstanding
Number Of Months Advances Outstanding
Related party transaction prepayment period
Related Party Transaction Prepayment Period
Aggregate principal amount cancelled
Available Loan Balance Cancelled
Interest rate (LIBOR)
Debt Instrument Basis Spread On Variable Rate1
Description of variable rate interest
Debt Instrument Description Of Variable Rate Basis
Accrued interest of related party debt.
Accrued interest of related party debt
Accrued Interest Of Related Party Debt
Amount available for future borrowings
Line Of Credit Facility Remaining Borrowing Capacity
Interest expense on note payable to related party
Interest Expense Related Party
Amortization of debt premium
Amortization Of Debt Discount Premium
Accretion expense - debt issuance cost
Amortization Of Financing Costs And Discounts
Debt Instrument [Table]
Debt Instrument [Table]
Nine point Seven five senior convertible notes due two thousand nineteen and eight point seven five senior convertible notes due two thousand nineteen.
2019 Notes and Tranche B Notes
Nine Point Seven Five Senior Convertible Notes Due Two Thousand Nineteen And Eight Point Seven Five Senior Convertible Notes Due Two Thousand Nineteen [Member]
Senior convertible notes due two thousand twenty one.
2021 Notes
Senior Convertible Notes Due Two Thousand Twenty One [Member]
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Unamortized debt issuance costs and debt discount
Debt Instrument Unamortized Discount Premium And Debt Issuance Costs Net
Net carrying amount
Debt Instrument Carrying Amount
Note payable to related party - net carrying amount
Total debt - net carrying amount
Long Term Debt
Facility Financing Obligation
Debt instrument maturity month and year.
Maturity date
Debt Instrument Maturity Month And Year
Debt instrument additional borrowing capacity.
Balance Sheet Location
Balance Sheet Location [Axis]
Balance Sheet Location
Balance Sheet Location [Domain]
Accrued expenses and other current liabilities.
Accrued Expenses and Other Current Liabilities
Accrued Expenses And Other Current Liabilities [Member]
Scenario
Statement Scenario [Axis]
Scenario, Unspecified
Scenario Unspecified [Domain]
Scenario Forecast
Scenario Forecast [Member]
Conversion of notes to common shares, value
Debt Conversion Converted Instrument Amount1
Debt instument additional borrowing capacity
Debt Instrument Additional Borrowing Capacity
Debt instrument, remaining borrowing capacity
Debt Instrument Unused Borrowing Capacity Amount
Debt Instrument, Redemption, Period
Debt Instrument Redemption Period [Axis]
Debt Instrument, Redemption, Period
Debt Instrument Redemption Period [Domain]
Notes due and payable on July two thousand and sixteen.
Notes Due and Payable on July, 2016
Notes Due And Payable On July Two Thousand And Sixteen [Member]
Notes due and payable on April two thousand and seventeen.
Notes Due and Payable on April, 2017
Notes Due And Payable On April Two Thousand And Seventeen [Member]
Notes due and payable on June two thousand and seventeen.
Notes Due and Payable on June, 2017
Notes Due And Payable On June Two Thousand And Seventeen [Member]
Notes due and payable on November two thousand and seventeen.
Notes Due and Payable on November, 2017
Notes Due And Payable On November Two Thousand And Seventeen [Member]
Notes due and payable on January two thousand and eighteen.
Notes Due and Payable on January, 2018
Notes Due And Payable On January Two Thousand And Eighteen [Member]
notes due and payable on March two thousand and eighteen.
Notes Due and Payable on March, 2018
Notes Due And Payable On March Two Thousand And Eighteen [Member]
Notes due and payable on June two thousand and eighteen.
Notes Due and Payable on June, 2018
Notes Due And Payable On June Two Thousand And Eighteen [Member]
Notes due and payable on July two thousand and eighteen
Notes Due and Payable on July, 2018
Notes Due And Payable On July Two Thousand And Eighteen [Member]
Notes due and payable on September two thousand and eighteen.
Notes Due and Payable on September, 2018
Notes Due And Payable On September Two Thousand And Eighteen [Member]
Notes due and payable on October two thousand and eighteen.
Notes Due and Payable on October, 2018
Notes Due And Payable On October Two Thousand And Eighteen [Member]
Cash repayment of senior notes under exchange agreement
Repayments Of Senior Debt
Milestone rights liabilities current and noncurrent.
Milestone rights liabilities current.
Payment for milestone rights liabilities.
Remaining milestone rights liability
Milestone Rights Liabilities Current And Noncurrent
Required payment for milestone liability
Payment For Milestone Rights Liabilities
Milestone rights liability, current
Milestone Rights Liabilities Current
Accretion expense - debt issuance cost
Amortization Of Financing Costs
Accretion expense - debt discount
Senior convertible notes due two thousand eighteen.
5.75% Senior convertible notes due August 15, 2018
Senior Convertible Notes Due Two Thousand Eighteen [Member]
Type of Arrangement and Non-arrangement Transactions
Type Of Arrangement [Axis]
Arrangements and Non-arrangement Transactions
Arrangements And Nonarrangement Transactions [Member]
Privately-negotiated exchange agreement.
Privately Negotiated Exchange Agreement
Privately Negotiated Exchange Agreement [Member]
Number of shares sold in underwritten public offering
Stock Issued During Period Shares New Issues
Gain (loss) on extinguishment of debt
Unamortized debt issuance costs
Debt instrument exchange completion date.
Conversion of notes to common shares, value
Exchange price per share
Shares Issued Price Per Share
Exchange completion date
Debt Instrument Exchange Completion Date
Percentage of repurchase price
Debt Instrument Redemption Price Percentage
Debt instrument convertible threshold consecutive trading day.
Debt Instrument, redemption description
Debt Instrument Redemption Description
Percentage of conversion price equaling stock price
Debt Instrument Convertible Threshold Percentage Of Stock Price Trigger
Number of trading days
Debt Instrument Convertible Threshold Trading Days
Consecutive trading days
Debt Instrument Convertible Threshold Consecutive Trading Day
Debt Issuance Cost
Deferred Finance Costs Gross
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
License agreement.
License Agreement
License Agreement [Member]
Research agreement.
Research Agreement
Research Agreement [Member]
Collaboration and license agreement.
Collaboration and License Agreement
Collaboration And License Agreement [Member]
License and Distribution Agreement
License And Distribution Agreement [Member]
United Therapeutics Corporation.
United Therapeutics Corporation
United Therapeutics Corporation [Member]
Counterparty Name
Counterparty Name [Axis]
Counterparty Name
Repurchase Agreement Counterparty Name [Domain]
Receptor Life Science Inc.
Receptor
Receptor Life Science Inc [Member]
Cipla Ltd.
Cipla Ltd
Cipla Ltd [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Upfront payment received.
Milestone payment received.
Potential milestone payments to be received.
Additional option exercise and development milestone payments to be received.
Product prototype.
Product Prototype
Product Prototype [Member]
Engineering consulting services.
Engineering Consulting Services
Engineering Consulting Services [Member]
Income Tax Authority
Income Tax Authority [Axis]
Income Tax Authority
Income Tax Authority [Domain]
Foreign Country
Foreign Country [Member]
Income Tax Authority, Name
Income Tax Authority Name [Axis]
Income Tax Authority, Name
Income Tax Authority Name [Domain]
India Tax Authority
Ministry Of Finance India [Member]
Upfront payment received
Upfront Payment Received
Milestone Payment Received
Milestone Payment Received
Potential milestone payments to be receive
Potential Milestone Payments To Be Received
Additional option exercise and development milestone payments to be receive
Additional Option Exercise And Development Milestone Payments To Be Received
Revenue recognized from collaborations and services
Deferred revenue
Contract With Customer Liability
Total transaction price
Revenue Remaining Performance Obligation
Revenue performance obligation, method used
Revenue Performance Obligation Satisfied Over Time Method Used Description
Proceeds from option exercise and license fees received.
Nonrefundable option exercise and license fee
Proceeds From Option Exercise And License Fees Received
Deferred revenue - nonrefundable license fee
Deferred revenue recognition period
Date of agreement initiation for marketing and distribution.
Marketing and distribution agreement date
Date Of Agreement Initiation For Marketing And Distribution
Income Taxes Paid
Income Taxes Paid
Fair value of financial instruments.
Fair Value of Financial Instruments [Table]
Fair Value Of Financial Instruments [Table]
Fair Value Of Financial Instruments [Table]
Cash and Cash Equivalents
Cash And Cash Equivalents [Axis]
Cash and Cash Equivalents
Restricted Cash And Cash Equivalents Cash And Cash Equivalents [Member]
Money Market Funds
Money Market Funds [Member]
U.S. Treasury bills or notes.
U S Treasury Securities [Member]
Measurement Input Type
Measurement Input Type [Axis]
Measurement Input Type
Measurement Input Type [Domain]
Note payable yield changes one.
Note Payable Yield Changes 1
Note Payable Yield Changes One [Member]
Note payable yield changes two.
Note Payable Yield Changes 2
Note Payable Yield Changes Two [Member]
Note payable yield changes three.
Note Payable Yield Changes 3
Note Payable Yield Changes Three [Member]
Note payable yield changes four.
Note Payable Yield Changes 4
Note Payable Yield Changes Four [Member]
Fair Value of Financial Instruments [Line Items]
Fair Value Of Financial Instruments [Line Items]
Fair value of note payable to related party description.
Note payable, percentage of interest rate change.
Change in fair value of note payable value due to change in interest rate percentage.
Change in fair value of note payable percentage due to change in interest rate percentage.
Note payable, percentage of interest rate increases (decreases)
Note Payable Percentage Of Interest Rate Change
Fair value of note payable to related party, description
Fair Value Of Note Payable To Related Party Description
Note payable, percentage of yield
Debt Instrument Measurement Input
Note payable to related party, fair value
Notes Payable Fair Value Disclosure
Change in fair value of note payable value due to change in interest rate percentage
Change In Fair Value Of Note Payable Value Due To Change In Interest Rate Percentage
Increase (decrease) in fair value of note payable percentage due to increases (decreases) in interest rate percentage
Change In Fair Value Of Note Payable Percentage Due To Change In Interest Rate Percentage
Fair Value By Balance Sheet Grouping [Table]
Fair Value By Balance Sheet Grouping [Table]
Facility Financing Obligation
Note Payable to Related Party
Milestone Rights Liability
Milestone Rights Liability
Milestone Rights Liability [Member]
Measurement Basis
Fair Value By Measurement Basis [Axis]
Fair Value Disclosure Item Amounts [Default]
Portion At Fair Value Fair Value Disclosure [Member]
Fair Value Measurement
Fair Value Disclosure Item Amounts [Domain]
Carrying Value
Carrying Reported Amount Fair Value Disclosure [Member]
Estimate of Fair Value Measurement
Estimate Of Fair Value Fair Value Disclosure [Member]
Fair Value Hierarchy and NAV
Fair Value By Fair Value Hierarchy Level [Axis]
Fair Value Hierarchy and NAV
Fair Value Measurements Fair Value Hierarchy [Domain]
Fair Value, Inputs, Level 3
Fair Value Inputs Level3 [Member]
Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items]
Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items]
Financial liabilities:
Financial Liabilities Fair Value Disclosure [Abstract]
Financial liabilities fair value
Financial Liabilities Fair Value Disclosure
Fair value of liability, percentage decrease.
Probabilities of meeting milestones amount.
Probabilities of meeting milestones, percentage decrease.
Fair value of liability percentage decrease if probabilities of meeting milestones percentage decrease.
Fair value of the liability, percentage decrease
Fair Value Of Liability Percentage Decrease
Probabilities of meeting the milestones, amount
Probabilities Of Meeting Milestones Amount
Probabilities of meeting the milestones, percentage decrease
Probabilities Of Meeting Milestones Percentage Decrease
Fair value of the liability, percentage decrease
Fair Value Of Liability Percentage Decrease If Probabilities Of Meeting Milestones Percentage Decrease
Stock-based compensation
Allocated Share Based Compensation Expense
Share based compensation arrangement by share based payment award award vesting month year.
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Award Type
Award Type [Axis]
Equity Award
Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain]
Restricted Stock Units
Restricted Stock Units R S U [Member]
Stock Options
Restricted stock units RSU and time based options.
Options vest over vesting period
Restricted Stock Units R S U And Time Based Options [Member]
Performance-based Stock Options
Performance Shares [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of restricted stock units issued
Vesting period
Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Month Year
Fair value of Restricted stock options granted
Weighted average grant date fair value of the stock options granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Grant Date Fair Value
Aggregate number of shares granted to awards, share-based compensation arrangements
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
Weighted average exercise price of the stock options granted
Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
Vesting period
Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1
Fair value of stock granted, share-based compensation arrangements
Stock Granted During Period Value Sharebased Compensation Gross
Weighted average grant date fair value of the stock options granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
Unrecognized compensation expense related to options
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Stock Options
Contingent Liability
Commitments and Contingencies [Line Items]
Commitments and Contingencies [Table]
Commitments And Contingencies [Table]
Commitments And Contingencies [Table]
Credit Facility
Credit Facility [Axis]
Credit Facility
Credit Facility [Domain]
Purchasers.
Purchase Agreements
Purchasers [Member]
Underwriting agreement.
Underwriting Agreement
Underwriting Agreement [Member]
Leerink partners llc.
Leerink Partners LLC
Leerink Partners L L C [Member]
Warrants
Vehicle Leases
Vehicles [Member]
Office.
Office Lease
Office [Member]
Russell Ranch Road II LLC.
Russell Ranch Road II LLC
Russell Ranch Road I I L L C [Member]
Lease agreement with enterprise.
Lease Agreement with Enterprise
Lease Agreement With Enterprise [Member]
Commitments And Contingencies [Line Items]
Commitments And Contingencies [Line Items]
Contingent liability for milestone payments
Contingent Liability
Purchase commitment amount under insulin supply agreement
Long Term Purchase Commitment Amount
Long term purchase commitment remaining amount
Purchase Obligation Due In Sixth Year
Purchase Obligation Fiscal Year Maturity [Abstract]
2019
Purchase Obligation Future Minimum Payments Remainder Of Fiscal Year
2020
Purchase Obligation Due In Second Year
2021
Purchase Obligation Due In Third Year
2022
Purchase Obligation Due In Fourth Year
2023
Purchase Obligation Due In Fifth Year
2024
Purchase Obligation Due In Sixth Year
Long Term Purchase Commitment, Expiration Date
Long-term purchase commitment, renewal time period.
Supply Agreement expiration period
Long Term Purchase Commitment Expiration Date
Supply Agreement renewal period
Longterm Purchase Commitment Renewal Time Period
Number of shares sold in underwritten public offering
Warrants to purchase of common stock
Class Of Warrant Or Right Number Of Securities Called By Each Warrant Or Right
Amount of net proceeds from issuance of securities
Exchange price per share
Exercise price of warrants
Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1
Stock purchase agreements date
Sale Of Stock Transaction Date
Warrant expiration date
Investment Warrants Expiration Date
Number of vehicle leases.
Operating leases annual increase in rent expense.
Other non current assets.
Operating lease other liabilities current.
Number of vehicle leases
Number Of Vehicle Leases
Operating lease rent expenses
Operating Lease Expense
Lease expiration date
Lessee Operating Lease Lease Not Yet Commenced Term Of Contract1
Operating lease right-of-use assets
Operating Lease Right Of Use Asset
Operating lease liabilities
Operating Lease Liability
Operating lease, current assets
Operating Lease Other Non Current Assets
Operating lease, other current liabilities
Operating Lease Other Liabilities Current
Percentage of annual increase in lease payment
Operating Leases Annual Increase In Rent Expense
Lease expiration date
Lease Expiration Date1
Lease renewal option
Lessee Operating Lease Renewal Term
Maximum reimbursable amount for tenant improvements.
Reimbursable amount for maintenance fees.
Maximum reimbursable amount for tenant improvements
Maximum Reimbursable Amount For Tenant Improvements
Maintenance fee of common area
Reimbursable Amount For Maintenance Fees
Operating lease, current liabilities
Operating Lease Liability Current
Operating lease rent expenses
Operating Leases Rent Expense Net
Operating lease, non-current liabilities
Operating lease costs
Operating Lease Cost
Operating lease, cash paid
Operating Lease Payments
Variable lease costs
Variable Lease Cost
Operating lease, weighted average discount rate
Operating Lease Weighted Average Discount Rate Percent
Operating lease, weighted-average remaining lease term
Operating Lease Weighted Average Remaining Lease Term1
Operating Lease Liabilities Payments Due [Abstract]
Office and vehicle.
office and vehicle
Office And Vehicle [Member]
2019
Lessee Operating Lease Liability Payments Remainder Of Fiscal Year
2020
Lessee Operating Lease Liability Payments Due Year Two
2021
Lessee Operating Lease Liability Payments Due Year Three
2022
Lessee Operating Lease Liability Payments Due Year Four
2023
Lessee Operating Lease Liability Payments Due Year Five
Total
Lessee Operating Lease Liability Payments Due
2019
Operating Leases Future Minimum Payments Due Current
2020
Operating Leases Future Minimum Payments Due In Two Years
2021
Operating Leases Future Minimum Payments Due In Three Years
2022
Operating Leases Future Minimum Payments Due In Four Years
2023
Operating Leases Future Minimum Payments Due In Five Years
Total
Operating Leases Future Minimum Payments Due