12.228
3426000
0.03
6.50
P10D
0.0575
100000000
4200000
6659000
86300000
77200000
35937500
Each unit consisting of one share of common stock and a warrant to purchase 0.6 of a share of common stock
0.6
21562500
2.40
Each unit consisting of one share of common stock and a warrant to purchase 0.6 of a share of common stock
2.256
4687500
2.40
350000000
0.0042
1.69
13100000
0.0018
0.0008
0.0257
0.25
225000
800000
2000000
289350125
50000000
50000000
5417840
2246781
350000000
31250000
264556791
216000000
0.05
0.54
0.001
8600000
2.60
125400000
350000000
107400000
119600000
2.59
350000000
107400000
0.125
0.05
2.00
-11000
10000
998000
890000
-911000
-278000
11000
1071000
1797000
-2086000
-908000
11000
1090000
2723000
-3242000
-400000
-707000
11000
1126000
4528000
-5246000
-3108000
11000
1127000
4942000
-8061000
-5481000
11000
1131000
5139000
-10631000
-7368000
17000
1718000
5526000
-12911000
3404000
43000
4254000
19603000
-16242000
-746000
46000
4496000
21129000
-21921000
31890000
93000
9249000
65613000
15000000
193000
-46582000
-2234000
151400000
0.59
0.69
0.76
235018000
123000
12305000
317117000
15000000
193000
-94827000
-2395000
90773000
165000
16464000
378010000
15000000
193000
-301092000
-1310000
111577000
200000
19975000
433141000
15000000
193000
-366971000
-228000
-1412000
50000000
-18153000
150363000
327000
32756000
592999000
-442963000
206977000
503000
50314000
763775000
-557301000
0.0375
115000000
3700000
15000000
383487000
734000
73360000
1170602000
-787849000
364100000
1014000
101381000
1444125000
-1081039000
86734000
1020000
102008000
1469497000
295000
-1384078000
-59221000
30019000
1130000
113025000
1544112000
-281000
-1604182000
-185532000
9000000
9000000
25500000
66061000
9000000
385000
700000
192000
1278000
127793000
1587858000
74000
-1774742000
2827000
3140000
284793000
473000
1620535000
689412000
230000
59848000
-313652000
1094000
250000000
8997000
168
9000000
131522945
9000000
27964000
718200000
513205000
277203000
4624000
557427000
0
8906000
4.47
1935546000
10000000
2700000
199553000
5.67
210642000
0.01
199553000
2681000
131522945
44000
4137688
20736000
25360000
10082351
1315000
0.01
8262000
5821000
689412000
91764000
193029000
28800000
32440000
5900000
2383000
45000000
9000000
609000
277203000
700000
600000
113860000
115000000
192000
61000000
1140000
96782000
100000000
2200000
60800000
3218000
1315000
131523000
1620535000
44000
-1935546000
67000
53000
114247000
8498000
54948000
5273000
83476000
5249000
13049000
2922000
4520000
21000
285210000
6630516
313000
1991379000
0.05
750151000
450000
230000
7199768
65315000
-110679000
1297000
602
550000000
10074000
5.26
4867
9000000
286035082
9000000
119600000
30928000
77400000
784600000
361993000
119635000
4555000
609471000
10025000
3.73
2104912000
10000000
61800000
251314000
3.46
97583000
0.01
251314000
125400000
4867
61840000
286035082
1100000000
17546663
-6000
3761031
25777000
144775000
18674539
2860000
0.01
4533000
66810000
1600000000
750151000
114443000
3878000
101249000
183961000
3.53
34400000
3.74
31490000
3254819
0.25
2200000
5995000
12750000
9000000
16500000
289000
2.40
8600000
12000000
119635000
700000
2777778
225000
6492056
28200000
2674003
6521347
3761031
17983708
109169
690831
60800000
114443000
0.0375
115000000
192000
22.47
81900000
557000
97583000
100000000
2200000
6.80
63200000
2417000
14700000
900000
1100000
436500
16000000
6055556
0.60
0.0016
16800000
7700000
2000000
2860000
286035000
1991379000
15000000
-6000
-2104912000
6500000
2100000
31250000
2.47
107400000
17000
114245000
12266000
54948000
5273000
81382000
5239000
11840000
13200000
11876000
2343000
12200000
7800000
107000
3700000
243033
1177300
8200000
1467500
0.50
901000
1.00
One-year London Interbank Offered Rate (LIBOR)
5000000
250000000
3942500
0.60
3892500
6700000
1.12
2014-05-01
13900000
4493509
One-year LIBOR
0.0011
0.023
19700000
44.5002
1.00
1000
0.0000
0.015
1805000
-2004000
400000
36000
1805000
-2004000
400000
175000000
170200000
4500000
17132000
300000
87300000
59700000
8360000
1000000
8.11
960000
7.35
700000
0.92
18200000
350000000
7.15
147.0859
1.00
Least 20 of the 30
1.50
1.00
1000
257
0.41
6700000
0.01
700000
0.10
6000000
3700000
250000000
13000000
350000000
92000000
40000000
1
0.75
2013-10
86300000
6000000
4500000
30000000
One-year LIBOR
40000000
40000000
annual interest rate on all outstanding principal to the one-year LIBOR rate on December 31, 2012 plus 5%, effective beginning on January 1, 2013
2014-01-01
0.50
-12800000
annual interest rate on all outstanding principal to the one-year London Interbank Offered Rate (LIBOR) on December 31, 2012 plus 5%, effective January 1, 2013
2014-01-01
350000000
2013-09-30
-403000
6189000
888000
-1175000
20000
1000
73000
887000
20000
-1175000
526000
-1156000
11000
8000
526000
400000
-1156000
-400000
384000
22000
-2815000
8000
1000
384000
22000
8000
-2815000
2000
196000
60000
135000
-2280000
12000
27000
6000
548000
2000
190000
60000
135000
-2280000
150000
12726000
1202000
25000
-3331000
215000
68000
23000
2000
1000
2253000
150000
12703000
1200000
24000
-3331000
534000
995000
-5679000
80000
2000
1000
162000
532000
994000
-5679000
1565000
239000
78030000
13000
-48245000
3900000
171154000
2949000
189000
28000
60000
1000
30000
3052000
3000
1565000
239000
78000000
13000
3900000
171154000
2949000
60000
-48245000
189000
28000
268000
251000
58815000
-206265000
151400000
84000
1421000
98000
1421000
1921000
229000
1314000
40000
3000
3922000
2000
234000
268000
251000
58775000
84000
1421000
98000
1421000
1921000
-2000
-206265000
229000
1314000
4501000
253000
50000000
-65879000
1017000
1017000
70000
623000
105000
31847000
35000
3494000
17000
4501000
253000
49965000
1017000
1017000
70000
623000
225000
-65879000
3000
-225000
102000
50000000
-50000000
31847000
-1828000
495000
170234000
1951000
-114338000
-145000
245000
304000
1000
171000
58000
3000
40000
17132000
1000
24000
-1828000
494000
170063000
1948000
-146000
245000
-114338000
14667000
981000
384670000
2312000
-340000
-230548000
2694000
2074000
263000
1000
230000
86000
3000
1000
23000000
102000
339000
3000
844000
8000
100000
1000
14667000
980000
384440000
2309000
-341000
2691000
-8000
2073000
-230548000
17522000
1065000
249750000
4923000
-524000
-293190000
123000
944000
607000
1000
270000
124000
6000
2000
30000
27014000
146000
100000
1000
17522000
1064000
249480000
4917000
-526000
123000
943000
-293190000
20219000
1400000
59724000
383000
5000
-7001000
-220104000
-581000
94000
3000
84000
323000
1000
22000
8360000
2240000
20219000
1397000
59640000
382000
-7023000
5000
-581000
-220104000
1600000
-152498000
6000
-4287000
P8Y1M6D
-725000
13580000
924000
-170205000
16500000
13580000
-0.050
2000000
112279000
-1.50
17324000
0.000
87000000
-148654000
200000
10249000
-11720000
40000
1605000
1742000
11400000
14335000
9542000
36042000
40312000
-267000
16681000
1600000
-823000
287597
924000
93000
-170560000
-6000
196416000
752000
7128000
4178000
-644000
152591000
1200000
0.350
56500000
-7554000
-0.300
13580000
13662000
-3392000
30858590
-170560000
95783000
-170560000
361000
17400000
4.06
361000
17025000
30858590
10500000
113672000
16681000
3392000
1115000
161000
230000
5654000
7926000
13478000
102000
0.0074
P2Y7M6D
0.78
0.0314
P6Y1M6D
1.02
2100000
318000
3000
21000
21000
288000
3000
10000
2100000
962000
9000000
90000
13580000
1602000
14314000
16660000
921000
-3402000
71000
-6000
361000
-170560000
14100000
2100000
16700000
2100000
3271644
19826113
7760833
9700000
1400000
1400000
27800000
443000
-140539000
3000
2672000
P8Y
1541000
11204000
625000
-160834000
14600000
11204000
-0.050
3828000
93000
99959000
-1.32
15912000
0.000
53000000
-123837000
10883000
-2937000
18000
769000
250000
1600000
9540000
6858000
-63380000
40630000
-87000
11116000
1300000
-224000
1300000
282816
628000
50000
-160804000
-3000
63394000
777000
10941000
400000
140589000
766000
0.350
57200000
6045000
-0.300
11204000
17248000
-543000
34048852
-160804000
-160804000
-27000
21800000
2.04
-27000
10941000
6300000
34048852
1700000
121817000
11116000
0.01
4000
547000
830000
111000
5838000
5366000
11202000
2000
0.0010
P1Y1M6D
0.76
0.0243
P6Y1M6D
0.83
1400000
214000
3000
14000
14000
283000
2000
4000
1400000
433000
11204000
766000
9526000
11102000
626000
-547000
-3000
-27000
-160804000
11100000
1400000
1600000
4700000
50000000
4140388
19826113
10082351
126000
59000
12000
-2570000
3000
1000
126000
59000
12000
-2570000
9609000
149000
31633000
1074000
-24661000
-993000
15000000
999000
117000
241000
63000
46000
1000
4690000
9609000
149000
33945000
1073000
-993000
999000
15000000
193000
-24661000
-2358000
117000
241000
6810000
60000
430000
18153000
1079000
-75992000
19822000
83176000
46000
19822000
3000
107000
5248000
86000
36000
66000
6557000
4000
811000
4464000
22000
9000
8000
45000
891000
90000
1000
6810000
60000
430000
1079000
19822000
83110000
46000
19822000
-225000
5239000
14992000
49955000
1518000
356000
18153000
-980000
31847000
-50000000
624000
-193000
-15000000
-75992000
228000
107000
-1519000
-18153000
-31847000
18153000
24811000
900000
-315000
-303039000
-18000
295000
4000
349000
2000
30000
248000
24811000
896000
-317000
-18000
295000
-303039000
MNKD
MANNKIND CORP
Yes
false
Accelerated Filer
FY
No
2012
10-K
2012-12-31
0000899460
No
--12-31
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 4%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The
Company’s effective income tax rate differs from the
statutory federal income tax rate as follows for the years ended
December 31, 2010, 2011 and 2012:</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="82%"></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="10" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>December 31,</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2010</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Federal tax benefit
rate</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">35.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">35.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">35.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">State tax benefit, net of
federal benefit</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Permanent items</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Intercompany transfer of
intellectual property</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(5.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(5.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(4.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Valuation
allowance</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(30.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(30.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(31.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Effective income tax
rate</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">0.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">0.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">0.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
</div>
<div>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: Times New Roman" size="2"><b>8. Restructuring
charges</b></font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">On
February 10, 2011, the Company announced that following
receipt of the Complete Response letter from the United States Food
and Drug Administration (“FDA”) regarding the new drug
application (“NDA”) for AFREZZA, it implemented a
restructuring to streamline operations, reduce operating expenses,
extend the cash runway and focus its resources on securing the
FDA’s approval of the NDA for AFREZZA. In connection with the
restructuring, the Company reduced its total workforce by
approximately 41% to 257 employees. The Company recorded charges of
approximately $6.7 million for employee severance and other related
termination benefits and recognized an initial liability of $6.7
million in February 2011, which approximated fair value.</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="90%"></td>
<td valign="bottom" width="6%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Workforce<br />
Reduction</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Restructuring Balance,
February 10, 2011</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">6,659</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Cash payments</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(6,189</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Adjustment</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(403</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Restructuring Balance,
December 31, 2011</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">67</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Adjustment</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(67</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Restructuring Balance,
December 31, 2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">During the year
ended December 31, 2011, the Company adjusted the
restructuring balance based on the election of certain termination
benefits by a portion of the terminated employees.</font></p>
<p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px; FONT-SIZE: 1px">
 </p>
<p style="MARGIN-TOP: 0px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The remaining
restructuring balance as of December 31, 2011 consists of
severance and related termination benefits for employees still to
be terminated.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The net $6.3
million of costs associated with the restructuring are included in
“Research and development” and “General and
administrative” operating expenses in the consolidated
statements of operations as $4.7 million and $1.6 million,
respectively, for the year ended December 31, 2011.</font></p>
</div>
1000
-146960000
2000
14219000
44000
P6Y6M
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Stock-Based
Compensation</i> — As of December 31, 2012, the Company
had three active stock-based compensation plans, which are
described more fully in Note 12. The Company accounts for all
share-based payments to employees, including grants of stock awards
and the compensatory elements of the employee stock purchase plan
in accordance with ASC 718 <i>Compensation- Stock Compensation</i>
(“ASC 718”)<i>.</i> ASC 718 requires all share-based
payments to employees, including grants of stock options,
restricted stock units, performance-based awards and the
compensatory elements of employee stock purchase plans, to be
recognized in the income statement based upon the fair value of the
awards at the grant date. The Company uses the Black-Scholes option
valuation model to estimate the grant date fair value of employee
stock options and the compensatory elements of employee stock
purchase plans. Restricted stock units are valued based on the
market price on the grant date. The Company evaluates stock awards
with performance conditions as to the probability that the
performance conditions will be met and estimates the date at which
the performance conditions will be met in order to properly
recognize stock-based compensation expense over the requisite
service period.</font></p>
</div>
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Segment
Information</i> — In accordance with Accounting Standards
Codification (“ASC”) 280-10-50 <i>Segment
Reporting</i>, operating segments are identified as components of
an enterprise about which separate discrete financial information
is available for evaluation by the chief operating decision-maker
in making decisions regarding resource allocation and assessing
performance. To date, the Company has viewed its operations and
manages its business as one segment operating primarily in the
United States of America.</font></p>
</div>
-1191000
13292000
9200
-169416000
15.17
1371455
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Property and
Equipment</i> — Property and equipment are recorded at cost
and depreciated using the straight-line method over the estimated
useful lives of the related assets. Leasehold improvements are
amortized over the term of the lease or the service lives of the
improvements, whichever is shorter. Assets under construction are
not depreciated until placed into service.</font></p>
</div>
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Cash and
Cash Equivalents</i> — The Company considers all highly
liquid investments with original or remaining maturities of 90 days
or less at the time of purchase, that are readily convertible into
cash to be cash equivalents.</font></p>
</div>
13000000
<div>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 12px; TEXT-INDENT: 0px; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><b><font style="FONT-FAMILY: 'Times New Roman'" size="2"><b>11. Net loss per
common share</b></font></b></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Basic net loss per share
excludes dilution for potentially dilutive securities and is
computed by dividing loss applicable to common stockholders by the
weighted average number of common shares outstanding during the
period excluding the shares loaned under the share lending
arrangement (see Note 10). As of December 31, 2010, 2011 and
2012, 9,000,000 shares of the Company’s common stock, which
were loaned to a share borrower pursuant to the terms of a share
lending agreement, as described in Note 10, were issued and
are outstanding, and holders of the borrowed shares have all the
rights of a holder of the Company’s common stock. However,
because the share borrower must return all borrowed shares to the
Company (or, in certain circumstances, the cash value thereof), the
borrowed shares are not considered outstanding for the purpose of
computing and reporting basic or diluted earnings (loss) per share.
Diluted net loss per share reflects the potential dilution that
could occur if securities or other contracts to issue common stock
were exercised or converted into common stock. Potentially dilutive
securities are excluded from the computation of diluted net loss
per share for all of the periods presented in the accompanying
statements of operations because the reported net loss in each of
these periods results in their inclusion being antidilutive.
Antidilutive securities, which consist of stock options, restricted
stock units, warrants, and shares that could be issued upon
conversion of the senior convertible notes, that are not included
in the diluted net loss per share calculation consisted of an
aggregate of 30,858,590 shares, 34,048,852 and 128,324,123 shares
of the Company’s common stock as of December 31 2010,
2011 and 2012, respectively, and exclude the 9,000,000 shares of
the Company’s common stock loaned under the share lending
arrangement as of December 31, 2011 and
2012.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Potentially dilutive
securities outstanding are summarized as follows:</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 0px; FONT: 6px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"></p>
<table style="TEXT-TRANSFORM: none; TEXT-INDENT: 0px; BORDER-COLLAPSE: collapse; FONT-FAMILY: 'Times New Roman'; LETTER-SPACING: normal; WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="66%"></td>
<td valign="bottom" width="2%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="2%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="2%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="10" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>December 31,</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>2010</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Exercise of common stock
options</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">7,760,833</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">10,082,351</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">18,674,539</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Conversion of senior
convertible notes into common stock</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">19,826,113</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">19,826,113</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">19,826,113</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Exercise of common stock
warrants</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">86,062,440</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Vesting of restricted
stock units</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">3,271,644</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">4,140,388</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">3,761,031</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top"></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">30,858,590</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">34,048,852</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">128,324,123</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
<font style="FONT-FAMILY: Times New Roman" size="2"><br class="Apple-interchange-newline" /></font></div>
13292000
1.81
-0.040
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The following
is a summary of the carrying values and estimated fair values of
the Company’s senior convertible notes due in 2013 and 2015
(in millions).</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="66%"></td>
<td valign="bottom" width="5%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="5%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="5%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="5%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="6" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>December 31,
2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="6" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>December 31,
2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Carrying<br />
value</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Estimated<br />
fair value</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Carrying<br />
value</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Estimated<br />
fair value</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">2013 notes</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">113.9</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">61.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">114.4</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">81.9</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">2015 notes</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">96.8</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">60.8</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">97.6</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">63.2</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
</table>
</div>
3.96
16000000
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Components of
the net deferred tax asset as of December 31, 2011 and 2012
are approximately as follows (in thousands):</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="80%"></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="6" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>December 31,</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Deferred tax
assets:</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Net operating loss
carryforwards</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">557,427</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">609,471</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Research and development
credits</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">59,848</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">65,315</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Capitalized
research</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">32,440</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">31,490</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Accrued expenses</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">2,827</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">2,922</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Non-qualified stock option
expense</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">27,964</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">30,928</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Depreciation</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">8,906</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">10,025</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Total net deferred tax
assets</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">689,412</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">750,151</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Valuation
allowance</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(689,412</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(750,151</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Net deferred tax
assets</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
</div>
77000
101522000
-0.94
3216
<div>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: Times New Roman" size="2"><b>9. Fair Value of
Financial Instruments</b></font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The carrying
amounts of financial instruments, which include cash equivalents
and accounts payable, approximate their fair values due to their
relatively short maturities. The fair value of the note payable to
related party cannot be reasonably estimated as the Company would
not be able to obtain a similar credit arrangement in the current
economic environment.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Cash
equivalents consist of highly liquid investments with original or
remaining maturities of 90 days or less at the time of purchase
that are readily convertible into cash. As of December 31,
2011 and 2012, the Company held $2.7 million and $61.8 million,
respectively of cash and cash equivalents, consisting of money
market funds of $0.6 million and $60.8 million, respectively, and
the remaining funds in non-interest bearing checking accounts. The
fair value of these money market funds was determined by using
quoted prices for identical investments in an active market (Level
1 in the fair value hierarchy).</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The following
is a summary of the carrying values and estimated fair values of
the Company’s senior convertible notes due in 2013 and 2015
(in millions).</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="66%"></td>
<td valign="bottom" width="5%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="5%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="5%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="5%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="6" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>December 31,
2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="6" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>December 31,
2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Carrying<br />
value</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Estimated<br />
fair value</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Carrying<br />
value</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Estimated<br />
fair value</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">2013 notes</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">113.9</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">61.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">114.4</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">81.9</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">2015 notes</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">96.8</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">60.8</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">97.6</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">63.2</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
</table>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The estimated
fair value of the senior convertible notes due 2013 was calculated
based on quoted prices in an active market (Level 1 in the fair
value hierarchy). The estimated fair value of the senior
convertible notes due 2015 was calculated based on model derived
valuations whose inputs were observable, such as the
Company’s stock price, and non-observable, such as the
Company’s long-term historical volatility (Level 3 in the
fair value hierarchy). As there is no current observable market for
the senior convertible notes due 2015, the Company determined the
estimated fair value using a convertible bond valuation model
within a lattice framework. The convertible bond valuation model
combined expected cash outflows with market-based assumptions
regarding risk-adjusted yields, stock price volatility and recent
price quotes and trading information regarding Company issued debt
instruments and shares of common stock into which the notes are
convertible.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Derivative
financial instruments are recognized as other assets or other
current liabilities in the financial statements and measured at
fair value. The fair value of foreign exchange hedging contracts
equals the carrying value at each balance sheet date. The fair
value of these contracts are determined using methodologies based
on market observable inputs (Level 2 in the fair value hierarchy),
including foreign currency spot rates. The Company used derivative
financial instruments to manage its exposure to foreign currency
exchange risks related to quarterly purchases on insulin. The
Company does not use derivative financial instruments for trading
or speculative purposes, nor does it use leveraged financial
instruments. Credit risk related to derivative financial
instruments was considered minimal and was managed by requiring
high credit standards for counterparties and through periodic
settlements of positions.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The
Company’s derivative financial instruments are not designated
as hedging instruments, and gains or losses resulting from changes
in the fair value are reported in other income (expense), in the
consolidated statements of operations. The Company entered into
foreign exchange hedging contracts with notional amounts totaling
$25.5 million and zero at December 31, 2010 and 2011,
respectively. The Company recorded an unrealized loss on the
foreign exchange hedging contracts of $0.2 million at
December 31, 2010. The Company recorded a realized loss of
$1.6 million and a realized gain of $1.3 million for the years
ended December 31, 2010 and 2011, respectively, on the
execution of quarterly foreign exchange hedging contracts. The
Company terminated these contracts during the quarter ended
March 31, 2011.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The estimated
fair values in connection with the February 2012 The Mann Group
Common Stock Purchase Agreement (“The February 2012 Forward
Purchase Contract”) and the October 2012 The Mann Group
Common Stock and Warrant Purchase Agreement (“The October
2012 Forward Purchase Contract”) was based on forward
purchase contract valuations (Level 3 in the fair value hierarchy).
See Note 10 <b><i>—</i></b> Common and preferred stock for
further discussion.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The following
roll-forward provides a summary of the changes in fair value of the
Company’s Level 3 forward purchase contracts during the year
ended December 31, 2012 (in thousands) :</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="61%"></td>
<td valign="bottom" width="11%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="11%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="11%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>The February 2012<br />
Forward Purchase<br />
Contract</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>The October 2012<br />
Forward Purchase<br />
Contract</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Total</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Beginning
Balance</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Issuance</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">1,080</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">28,237</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">29,317</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Adjustments to fair value
included in other income (expense)</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">12,011</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(13,248</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(1,237</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Transfers to additional
paid-in-capital</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(13,091</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(14,989</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(28,080</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Ending Balance</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
</div>
485065
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Concentration of Credit Risk</i> — Financial
instruments that potentially subject the Company to concentration
of credit risk consist of cash and cash equivalents. Cash and cash
equivalents consist primarily of interest-bearing accounts and are
regularly monitored by management and held in high credit quality
institutions.</font></p>
</div>
<div>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: Times New Roman" size="2"><b>6. Related-party
arrangements</b></font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">In October
2007, the Company entered into a $350.0 million loan arrangement
with its principal stockholder. In February 2009, the promissory
note underlying the loan arrangement was revised as a result of the
principal stockholder being licensed as a finance lender under the
California Finance Lenders Law. Accordingly, the lender was revised
to The Mann Group. Until January 1, 2013, interest on
outstanding principal amounts accrued at a fixed rate equal to the
one-year London Interbank Offered Rate (LIBOR) rate as reported by
the <i>Wall Street Journal</i> on the date of such advance plus
3% per annum. The borrowing rate was 4.5% at December 31,
2012. The promissory note underlying the loan arrangement was
amended at various dates during 2012. The most recent amendment
occurred in October 2012 to extend the maturity date to
January 1, 2014, extend the date through which the Company can
borrow under the promissory note to September 30, 2013, and
adjust the annual interest rate on all outstanding principal to the
one-year LIBOR rate on December 31, 2012 plus 5%, effective
beginning on January 1, 2013.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">As of
December 31, 2012, the total principal amount outstanding
under the credit facility was $119.6 million, and the amount
available for future borrowings was $125.4 million. Interest is due
and payable quarterly in arrears on the first day of each
calendar quarter for the preceding quarter, or at such other time
as the Company and The Mann Group mutually agree. All or any
portion of accrued and unpaid interest that becomes due and payable
may be paid-in-kind and capitalized at any time upon mutual
agreement of both parties. The Mann Group can require the Company
to prepay up to $200.0 million in advances that have been
outstanding for at least 12 months. If The Mann Group exercises
this right, the Company will have 90 days after The Mann Group
provides written notice (or the number of days to maturity of the
note if less than 90 days) to prepay such advances (see
discussion regarding letter agreement below).</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">In August 2010,
the Company entered into a letter agreement confirming a previous
commitment by The Mann Group to not require the Company to prepay
amounts outstanding under the amended and restated promissory note
if the prepayment would require the Company to use its working
capital resources. In the event of a default, all unpaid principal
and interest either becomes immediately due and payable or may be
accelerated at The Mann Group’s option, and the interest rate
will increase to the one-year LIBOR rate calculated on the date of
the initial advance or in effect on the date of default, whichever
is greater, plus 5% per annum. All borrowings under the loan
arrangement are unsecured. The loan arrangement contains no
financial covenants. There are no warrants associated with the loan
arrangement.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">On
August 10, 2010, the Company entered into a common stock
purchase agreement with The Mann Group. Under this common stock
purchase agreement, the Company was required to issue and sell, and
The Mann Group was obligated to purchase, the same number of shares
of the Company’s common stock that Seaside 88, LP
(“Seaside”) purchased on each closing date under its
agreement with the Company. The price of the shares that the
Company sold to The Mann Group under the agreement was equal to the
greater of $7.15 per share (the closing bid price of the
Company’s common stock on August 10, 2010) and the
closing bid price of the Company’s common stock on the
trading day immediately preceding the applicable closing date. The
aggregate purchase price for the shares of common stock the Company
issued and sold to The Mann Group was paid by cancelling an equal
amount of the outstanding principal under the $350.0 million
loan arrangement provided by The Mann Group. The August 2010
amendment and restatement of the Company’s promissory note
issued to The Mann Group in connection with the loan arrangement
also provided for the cancellation of indebtedness under the note
as described above and the elimination of the Company’s
ability to reborrow under the note the amount of any indebtedness
that was cancelled. The common stock purchase agreement with The
Mann Group terminated upon termination of the Seaside agreement in
the quarter ended September 30, 2011.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">In the fourth
quarter of 2010, the Company issued and sold a total of 2,100,000
shares of common stock to Seaside for net proceeds of $14.1 million
in accordance with the Company’s common stock purchase
agreement with Seaside. During the quarter ended March 31,
2011, the Company issued and sold a total of 1,400,000 shares of
common stock to Seaside for net proceeds of $9.7 million. No
additional shares of common stock were sold to Seaside under this
agreement subsequent to the quarter ended March 31, 2011. As
of December 31, 2011, the Company had issued and sold a total
of 3,500,000 shares of common stock to Seaside for net proceeds of
$23.8 million in accordance with the agreement. The agreement
with Seaside terminated during the quarter ended September 30,
2011. Concurrently, with the sales to Seaside, the Company issued
and sold a total of 2,100,000 and 1,400,000 shares of common stock
to The Mann Group, an entity controlled by the Company’s
principal stockholder, in 2010 and 2011, respectively, for a total
purchase price of $16.7 million and $11.1 million, respectively,
which was paid by the cancellation of outstanding principal under
the Company’s amended and restated promissory note with The
Mann Group.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">On
February 8, 2012, the Company sold $86.3 million worth of
units in an underwritten public offering, with each unit consisting
of one share of common stock and a warrant to purchase 0.6 of a
share of common stock. Concurrent with this public offering, The
Mann Group agreed to purchase $77.2 million worth of restricted
shares of common stock to be paid, at the discretion of the
Company, by cash or by cancellation of principal indebtedness under
the amended loan arrangement, subject to stockholder approval to
increase the number of authorized shares. In May 2012, the
Company’s stockholders approved an increase in the authorized
shares of common stock from 250,000,000 to 350,000,000. On
June 27, 2012, the Company completed the closing of the sale
of 31,250,000 share of its common stock through the cancellation of
outstanding indebtedness under the loan agreement (see Note 10
– Common and preferred stock).</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">In October
2012, the Company sold $92.0 million worth of units in an
underwritten public offering, with each unit to purchase one share
of common stock and a warrant to purchase at 0.75 of a share of
common stock. Concurrent with the underwritten public offering, the
Company entered into a Common Stock and Warrant Purchase Agreement
on October 18, 2012, in which the Company was required to
issue and sell and The Mann Group was obligated to purchase
40,000,000 restricted shares of the Company’s common stock at
a purchase price of $2.59 per share (the consolidated closing bid
price of the Company’s common stock on October 17,
2012), and 40,000,000 warrants to purchase up to an aggregate of
30,000,000 restricted shares of the Company’s common stock at
a purchase price of $0.125 for each share of the Company’s
common stock underlying the warrants, in exchange for cancellation
of outstanding principal under the $350 million amended and
restated promissory note with The Mann Group</font><font style="FONT-FAMILY: Times New Roman" size="2">.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The restricted
shares sold to The Mann Group may not be sold, pledged, assigned or
transferred unless (i) the shares have been registered with
the Securities and Exchange Commission (“SEC”) or
(ii) the restricted shares are exempt from SEC registration
requirements and the company has obtained an opinion from the
company’s counsel that the shares may be sold lawfully
without registration.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">As a result of
the special meeting of the Company’s stockholders held on
December 20, 2012 in which the Company’s stockholders
approved an amendment to its Amended and Restated Certificate of
Incorporation to increase the authorized shares of its common stock
from 350,000,000 shares to 550,000,000 shares, the Company
completed the closing of the Common Stock and Warrant Purchase
Agreement entered into with The Mann Group on October 18,
2012. The aggregate purchase price for the shares and warrants that
the Company issued to The Mann Group was approximately $107.4
million and was paid for by cancelling principal indebtedness owed
to The Mann Group under the amended and restated promissory note.
The cancelled principal amount became available for reborrowing.
Additionally, in accordance with the terms of the note, the Company
elected to capitalize the accrued and unpaid interest on the
cancelled principal amount that became due upon the closing (see
Note 10 – Common and preferred stock).</font></p>
<p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px; FONT-SIZE: 1px">
 </p>
<p style="MARGIN-TOP: 0px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The principal
amount outstanding under the loan arrangement as of
December 31, 2011 and 2012, respectively, subsequent to the
completion of the common stock purchase agreements was as follows
(in thousands):</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="89%"></td>
<td valign="bottom" width="5%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Principal amount
outstanding at December 31, 2011</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">277,203</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Borrowings</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">12,750</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Capitalization of accrued
and unpaid interest due and payable as of June 27,
2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">11,876</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Reduction of principal
indebtedness related to the issuance of common stock pursuant to
common stock purchase agreement completed on June 27,
2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(77,187</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Capitalization of accrued
and unpaid interest due and payable as of October 18,
2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">2,343</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Reduction of principal
indebtedness related to the issuance of common stock pursuant to
common stock purchase agreement completed on October 18,
2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(107,350</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Principal amount
outstanding at December 31, 2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">119,635</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
</table>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">As of
December 31, 2011, the Company had accrued and unpaid interest
of $5.9 million related to the amount outstanding and had $45.0
million of available borrowings under the loan agreement. As of
December 31, 2012, the Company had accrued and unpaid interest
of $2.2 million related to the amount outstanding and had $125.4
million of available borrowings. Interest expense on the
Company’s note payable to a related party for the years ended
December 31, 2010, 2011 and 2012 was $10.2 million, $10.9
million and $10.5 million, respectively.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">In connection
with certain meetings of the Company’s board of directors and
on other occasions when the Company’s business necessitated
air travel for the Company’s principal stockholder and other
Company employees, the Company utilized the principal
stockholder’s private aircraft, and the Company paid the
charter company that manages the aircraft on behalf of the
Company’s majority stockholder approximately $230,000,
$111,000 and $200,000, respectively, for the years ended
December 31, 2010, 2011 and 2012 on the basis of the
corresponding cost of commercial airfare.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The Company has
entered into indemnification agreements with each of its directors
and executive officers, in addition to the indemnification provided
for in its amended and restated certificate of incorporation and
amended and restated bylaws (see Note 13).</font></p>
</div>
14402000
0.000
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Contingencies</i> — Contingencies are recorded in
accordance with ASC 450 <i>Contingencies.</i> Accordingly, the
Company records a loss contingency for a liability when it is both
probable that a liability has been incurred and the amount of the
loss can be reasonably estimated.</font></p>
</div>
<div>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: Times New Roman" size="2"><b>14. Employee benefit
plans</b></font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The Company
administers a 401(k) Savings Retirement Plan (the “MannKind
Retirement Plan”) for its employees. For the years ended
December 31, 2010, 2011 and 2012, the Company contributed
$752,000, $777,000 and $571,000 respectively, to the MannKind
Retirement Plan.</font></p>
</div>
12750000
-119860000
10491000
-560000
7000
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Property and
equipment consist of the following (dollar amounts in
thousands):</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="71%"></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" rowspan="2" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Estimated</b></font><br />
<font style="FONT-FAMILY: Times New Roman" size="1"><b>Useful</b></font><br />
<font style="FONT-FAMILY: Times New Roman" size="1"><b>Life<br />
(Years)</b></font></td>
<td valign="bottom" rowspan="2"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="6" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>December 31,</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Land</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">5,273</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">5,273</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Buildings</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">39-40</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">54,948</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">54,948</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Building
improvements</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">5-40</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">114,247</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">114,245</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Machinery and
equipment</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">3-15</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">83,476</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">81,382</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Furniture, fixtures and
office equipment</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">5-10</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">5,249</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">5,239</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Computer equipment and
software</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">3</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">13,049</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">11,840</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Leasehold
improvements</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">53</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">17</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Construction in
progress</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">8,498</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">12,266</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top"></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">284,793</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">285,210</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Less accumulated
depreciation and amortization</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(91,764</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(101,249</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Property and equipment
— net</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">193,029</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">183,961</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
</div>
862000
4072000
1277572
2.86
3000000
637000
59159000
45473000
184537000
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>State
Research and Development Credit Exchange Receivable</i> — The
State of Connecticut provides certain companies with the
opportunity to exchange certain research and development income tax
credit carryforwards for cash in exchange for foregoing the
carryforward of the research and development credits. The program
provides for an exchange of research and development income tax
credits for cash equal to 65% of the value of corporation tax
credit available for exchange. Estimated amounts receivable under
the program are recorded as a reduction of research and development
expenses.</font></p>
</div>
4.25
1545000
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Total
stock-based compensation expense recognized in the accompanying
statements of operations is as follows (in thousands):</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="76%"></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="10" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Year Ended
December 31,</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2010</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Employee-related</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">13,478</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">11,202</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">13,224</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Consultant-related</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">102</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">2</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">68</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Total</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">13,580</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">11,204</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">13,292</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
</div>
9795600
<div>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 12px; TEXT-INDENT: 0px; LETTER-SPACING: normal; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><b><font style="FONT-FAMILY: 'Times New Roman'" size="2"><b>17. Subsequent
Event</b></font></b></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; LETTER-SPACING: normal; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">On March 18, 2013,
the Company entered into at-the-market issuance sales agreements
(the “ATM Agreements”) with two sales agents, under
which the Company may issue and sell shares of its common stock
having an aggregate offering price of up to $50.0 million under
each ATM Agreement (provided that in no event may the Company issue
and sell more than $50.0 million of shares of its common stock
under both ATM Agreements in the aggregate) from time to time
through either of the sales agents. Neither the Company nor either
of the sales agents has any obligation to sell shares of the
Company’s common stock under the ATM Agreements. Any sales of
common stock made under the ATM Agreements will be made in
“at the market” offerings as defined in Rule 415 of the
Securities Act of 1933, as amended.</font></font></p>
</div>
2.25
P2Y3M18D
1400000
<div>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="90%"></td>
<td valign="bottom" width="6%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Workforce<br />
Reduction</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Restructuring Balance,
February 10, 2011</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">6,659</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Cash payments</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(6,189</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Adjustment</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(403</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Restructuring Balance,
December 31, 2011</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">67</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Adjustment</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(67</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Restructuring Balance,
December 31, 2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
</div>
<div>
<p style="MARGIN-TOP: 0px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The following
table summarizes information about stock options
outstanding:</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="71%"></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Number</b></font><br />
<font style="FONT-FAMILY: Times New Roman" size="1"><b>of</b></font><br />
<font style="FONT-FAMILY: Times New Roman" size="1"><b>Shares</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Weighted</b></font><br />
<font style="FONT-FAMILY: Times New Roman" size="1"><b>Average</b></font><br />
<font style="FONT-FAMILY: Times New Roman" size="1"><b>Exercise</b></font><br />
<font style="FONT-FAMILY: Times New Roman" size="1"><b>Price</b></font><br />
<font style="FONT-FAMILY: Times New Roman" size="1"><b>per Share</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Aggregate</b></font><br />
<font style="FONT-FAMILY: Times New Roman" size="1"><b>Intrinsic</b></font><br />
<font style="FONT-FAMILY: Times New Roman" size="1"><b>Value ($000)</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Outstanding at January 1,
2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">10,082,351</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">5.67</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">168</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Granted</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">9,795,600</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">1.81</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Exercised</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(3,216</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">2.86</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Forfeit</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(715,131</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">3.96</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Expired</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(485,065</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">15.17</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Outstanding at
December 31, 2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">18,674,539</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">3.46</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">4,867</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Vested and expected to vest
at December 31, 2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">17,546,663</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">3.53</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">4,867</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Exercisable at
December 31, 2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">7,199,768</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">5.26</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">602</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
</table>
</div>
422260
9000
35000
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The Company
calculated the fair value of employee stock options granted during
the years ended December 31, 2010, 2011 and 2012 using the
following assumptions:</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="52%"></td>
<td valign="bottom" width="2%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="2%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="2%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="10" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Year Ended
December 31,</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2010</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Risk-free interest
rate</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">0.74% — 3.14%</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">0.10% — 2.43%</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">0.32% — 1.16%</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Expected lives</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">2.6 — 6.1 years</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">1.1 — 6.1
years</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">1.4 — 6.1
years</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Volatility</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">78% — 102%</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">76% — 83%</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">70% — 84%</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Dividends</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—    </font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—    </font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—    </font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
</table>
</div>
-169774000
-2000
179579000
-48000
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Income
Taxes</i> — Provisions for federal, foreign, state, and local
income taxes are calculated on pre-tax income based on current tax
law and include the cumulative effect of any changes in tax rates
from those used previously in determining deferred tax assets and
liabilities. Deferred income tax assets and liabilities are
recorded for the expected future tax consequences of temporary
differences between the financial statement carrying amounts and
the income tax basis of assets and liabilities. A valuation
allowance is recorded to reduce net deferred income tax assets to
amounts that are more likely than not to be realized (see Note
15).</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Income tax
positions are considered for uncertainty in accordance with ASC
740-10-25 <i>Income Taxes,</i> The Company believes that its income
tax filing positions and deductions will be sustained on audit and
does not anticipate any adjustments that will result in a material
change to its financial position. Therefore, no liabilities for
uncertain income tax positions have been recorded. If a tax
position does not meet the minimum statutory threshold to avoid
payment of penalties, the Company recognizes an expense for the
amount of the penalty in the period the tax position is claimed in
the tax return of the company. The Company recognizes interest
accrued related to unrecognized tax benefits in income tax expense,
if any. Penalties, if probable and reasonably estimable, are
recognized as a component of income tax expense.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Significant
management judgment is involved in determining the provision for
income taxes, deferred tax assets and liabilities and any valuation
allowance recorded against net deferred tax assets. Due to
uncertainties related to the realization of the Company’s
deferred tax assets as a result of its history of operating losses,
a valuation allowance has been established against the gross
deferred tax asset balance. The valuation allowance is based on
management’s estimates of taxable income by jurisdiction in
which the Company operates and the period over which deferred tax
assets will be recoverable. In the event that actual results differ
from these estimates or the Company adjusts these estimates in
future periods, a change in the valuation allowance may be needed,
which could materially impact the Company’s financial
position and results of operations.</font></p>
</div>
571000
11139000
<div>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Potentially dilutive
securities outstanding are summarized as follows:</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 0px; FONT: 6px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
</p>
<table style="TEXT-TRANSFORM: none; TEXT-INDENT: 0px; BORDER-COLLAPSE: collapse; FONT-FAMILY: 'Times New Roman'; LETTER-SPACING: normal; WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="66%"></td>
<td valign="bottom" width="2%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="2%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="2%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="10" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>December 31,</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>2010</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Exercise of common stock
options</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">7,760,833</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">10,082,351</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">18,674,539</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Conversion of senior
convertible notes into common stock</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">19,826,113</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">19,826,113</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">19,826,113</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Exercise of common stock
warrants</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">86,062,440</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Vesting of restricted
stock units</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">3,271,644</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">4,140,388</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">3,761,031</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top"></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">30,858,590</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">34,048,852</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">128,324,123</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
<font style="FONT-FAMILY: Times New Roman" size="2"><br class="Apple-interchange-newline" /></font></div>
<div>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: Times New Roman" size="2"><b>4. Property and
equipment</b></font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Property and
equipment consist of the following (dollar amounts in
thousands):</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="71%"></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" rowspan="2" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Estimated</b></font><br />
<font style="FONT-FAMILY: Times New Roman" size="1"><b>Useful</b></font><br />
<font style="FONT-FAMILY: Times New Roman" size="1"><b>Life<br />
(Years)</b></font></td>
<td valign="bottom" rowspan="2"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="6" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>December 31,</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Land</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">5,273</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">5,273</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Buildings</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">39-40</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">54,948</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">54,948</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Building
improvements</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">5-40</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">114,247</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">114,245</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Machinery and
equipment</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">3-15</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">83,476</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">81,382</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Furniture, fixtures and
office equipment</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">5-10</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">5,249</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">5,239</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Computer equipment and
software</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">3</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">13,049</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">11,840</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Leasehold
improvements</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">53</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">17</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Construction in
progress</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">8,498</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">12,266</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top"></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">284,793</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">285,210</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Less accumulated
depreciation and amortization</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(91,764</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(101,249</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Property and equipment
— net</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">193,029</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">183,961</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Leasehold
improvements are amortized over four years which is the shorter of
the term of the lease or the service lives of the improvements.
Depreciation and amortization expense related to property and
equipment for the years ended December 31, 2010, 2011 and
2012, and the cumulative period from February 14, 1991 (date
of inception) to December 31, 2012 was $16.5 million, $14.6
million, $13.0 million and $121.8 million, respectively.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">No asset
impairment was recognized during the years ended December 31,
2010, 2011 and 2012.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">In December
2009, the Company recognized a loss on disposal of approximately
$12.8 million in research and development expense related to the
abandonment of first-generation inhaler specific assets which would
no longer be used as the Company pursued the commercialization of
the next-generation device.</font></p>
</div>
715131
-117000
300000
146995000
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Comprehensive Income (Loss)</i> — Other comprehensive
income (loss) (OCI) is recorded in accordance with ASC 220-10-45
<i>Comprehensive Income,</i> which requires that all components of
comprehensive income (loss) be reported in the financial statements
in the period in which they are recognized. OCI includes certain
changes in stockholders’ equity that are excluded from net
income. Specifically, the Company includes in OCI unrealized gains
and losses on its available-for-sale securities and cumulative
translation gains and losses.</font></p>
</div>
4.49
<div>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: Times New Roman" size="2"><b>15. Income
taxes</b></font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Deferred income
taxes reflect the tax effects of temporary differences between the
carrying amounts of assets and liabilities for financial reporting
and income tax purposes. A valuation allowance is established when
uncertainty exists as to whether all or a portion of the net
deferred tax assets will be realized. Components of the net
deferred tax asset as of December 31, 2011 and 2012 are
approximately as follows (in thousands):</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="80%"></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="6" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>December 31,</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Deferred tax
assets:</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Net operating loss
carryforwards</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">557,427</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">609,471</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Research and development
credits</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">59,848</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">65,315</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Capitalized
research</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">32,440</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">31,490</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Accrued expenses</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">2,827</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">2,922</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Non-qualified stock option
expense</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">27,964</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">30,928</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Depreciation</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">8,906</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">10,025</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Total net deferred tax
assets</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">689,412</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">750,151</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: Times New Roman" size="2">Valuation
allowance</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(689,412</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(750,151</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Net deferred tax
assets</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The
Company’s net deferred tax assets as of December 31,
2011, consist of $718.2 million of gross deferred tax assets and
$28.8 million of gross deferred tax liabilities. The
Company’s net deferred tax assets as of December 31,
2012, consist of $784.6 million of gross deferred tax assets and
$34.4 million of gross deferred tax liabilities.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 4%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The
Company’s effective income tax rate differs from the
statutory federal income tax rate as follows for the years ended
December 31, 2010, 2011 and 2012:</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="82%"></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="10" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>December 31,</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2010</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Federal tax benefit
rate</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">35.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">35.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">35.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">State tax benefit, net of
federal benefit</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Permanent items</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Intercompany transfer of
intellectual property</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(5.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(5.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(4.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Valuation
allowance</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(30.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(30.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(31.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Effective income tax
rate</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">0.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">0.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">0.0</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">As required by
ASC 740 <i>Income Taxes</i> (“ASC 740”), management of
the Company has evaluated the positive and negative evidence
bearing upon the realizability of its deferred tax assets.
Management has concluded, in accordance with the applicable
accounting standards, that it is more likely than not that the
Company may not realize the benefit of its deferred tax assets due
to net losses since inception. Accordingly, the net deferred tax
assets have been fully reserved. Management reevaluates the
positive and negative evidence on an annual basis. During the years
ended December 31, 2010, 2011 and 2012, the change in the
valuation allowance was $56.5 million, $57.2 million and $60.7
million, respectively, for income taxes.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">At
December 31, 2012, the Company had federal and state net
operating loss carryforwards of approximately $1.6 billion and $1.1
billion available, respectively, to reduce future taxable income
and which will expire at various dates beginning in 2013 and 2014,
respectively. As a result of the Company’s initial public
offering, an ownership change within the meaning of Internal
Revenue Code Section 382 occurred in August 2004. As a result,
federal net operating loss and credit carry forwards of
approximately $216.0 million are subject to an annual use
limitation of approximately $13.0 million. The annual limitation is
cumulative and therefore, if not fully utilized in a year can be
utilized in future years in addition to the Section 382
limitation for those years. The federal net operating losses
generated subsequent to the Company’s initial public offering
in August 2004 are currently not subject to any such limitation as
there have been no ownership changes since August 2004 within the
meaning of Internal Revenue Code Section 382. At
December 31, 2012, the Company had research and development
credits of $77.4 million that expire at various dates through
2033.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The Company has
evaluated the impact of ASC 740 on its financial statements, which
was effective beginning January 1, 2007. The evaluation of a
tax position in accordance with this guidance is a two-step
process. The first step is recognition: the enterprise determines
whether it is more-likely-than-not that a tax position will be
sustained upon examination, including resolution of any related
appeals or litigation processes, based on the technical merits of
the position. In evaluating whether a tax position has met the
more-likely-than-not recognition threshold, the enterprise should
presume that the position will be examined by the appropriate
taxing authority that would have full knowledge of all relevant
information. The second step is measurement: a tax position that
meets the more-likely-than-not recognition threshold is measured to
determine the amount of benefit to recognize in the financial
statements. The tax position is measured at the largest amount of
benefit that is greater than 50 percent likely of being realized
upon ultimate settlement. Tax positions that previously failed to
meet the more-likely-than-not recognition threshold should be
recognized in the first subsequent financial reporting period in
which that threshold is met. Previously recognized tax positions
that no longer meet the more-likely-than-not recognition threshold
should be derecognized in the first subsequent financial reporting
period in which that threshold is no longer met. The Company
believes that its income tax filing positions and deductions will
be sustained on audit and does not anticipate any adjustments that
will result in a material change to its financial position.
Therefore, no liabilities for uncertain income tax positions have
been recorded. Tax years since 1993 remain subject to examination
by the major tax jurisdictions in which the Company is subject to
tax.</font></p>
</div>
675000
0.350
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Principles
of Consolidation</i> – The consolidated financial statements
include the accounts of the Company and its wholly-owned
subsidiaries. Intercompany balances and transactions have been
eliminated.</font></p>
</div>
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Exit or
Disposal Activities</i> — The obligations related to exit or
disposal activities, including reductions in force, are accounted
for in accordance with ASC 420-10-30 <i>Exit or Disposal Cost
Obligations,</i> (“ASC 420-10-30”)<i>.</i> In
accordance with ASC 420-10-30, a liability for costs associated
with an exit or disposal activity is recognized when the liability
is incurred and establishes that fair value is the objective for
initial measurements of the liability.</font></p>
</div>
<div>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: Times New Roman" size="2"><b>16. Selected quarterly
financial data (unaudited)</b></font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The following
unaudited selected quarterly financial data has been prepared on
the same basis as the audited information and includes all
adjustments necessary to present fairly the information set forth
in the Company’s consolidated financial statements and notes
herein. As a development stage enterprise, the Company has
experienced fluctuations in its quarterly results related to the
development of its lead product candidate, AFREZZA, and in its
expansion of the product candidate portfolio. The Company expects
these fluctuations to continue in the future. Due to these and
other factors, the quarterly operating results are not indicative
of the Company’s future performance.</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="60%"></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>March 31</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>June 30</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>September 30</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>December 31</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom" colspan="14" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>(In thousands, except
per share data)</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2"><b>2011</b></font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Net loss</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(41,525</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(44,480</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(38,402</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(36,397</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Net loss applicable to
common stockholders</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(41,525</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(44,480</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(38,402</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(36,397</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Net loss per share
applicable to common stockholders — basic and
diluted</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(0.34</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(0.37</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(0.31</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(0.30</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Weighted average common
shares used to compute basic and diluted net loss per share
applicable to common stockholders</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">121,057</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">121,708</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">122,130</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">122,357</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
<p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px; FONT-SIZE: 1px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="60%"></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>March 31</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>June 30</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>September 30</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>December 31</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom" colspan="14" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>(In thousands, except
per share data)</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2"><b>2012</b></font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Net loss</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(38,173</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(36,578</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(42,834</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(51,781</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Net loss applicable to
common stockholders</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(38,173</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(36,578</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(42,834</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(51,781</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Net loss per share
applicable to common stockholders — basic and
diluted</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(0.27</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(0.23</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(0.22</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(0.23</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Weighted average common
shares used to compute basic and diluted net loss per share
applicable to common stockholders</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">143,154</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">159,859</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">190,534</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">229,234</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
</div>
60700000
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Accrued
expenses and other current liabilities are comprised of the
following (in thousands):</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="84%"></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="6" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>December 31,</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Salary and related
expenses</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">8,997</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">10,074</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Research and clinical trial
costs</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">2,383</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">5,995</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Accrued interest</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">8,262</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">4,533</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Construction in
progress</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">3,878</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Other</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">1,094</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">1,297</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Accrued expenses and other
current liabilities</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">20,736</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">25,777</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
</div>
15075000
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Research and
Development Expenses</i> — Research and development expenses
consist primarily of costs associated with the clinical trials of
the Company’s product candidates, manufacturing supplies and
other development materials, including raw material purchases of
insulin, compensation and other expenses for research and
development personnel, costs for consultants and related contract
research, facility costs, and depreciation. Research and
development costs, which are net of any tax credit exchange
recognized for the Connecticut state research and development
credit exchange program, are expensed as incurred consistent with
ASC 730-10 <i>Research and Development.</i></font></p>
</div>
-0.310
13292000
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The following
unaudited selected quarterly financial data has been prepared on
the same basis as the audited information and includes all
adjustments necessary to present fairly the information set forth
in the Company’s consolidated financial statements and notes
herein. As a development stage enterprise, the Company has
experienced fluctuations in its quarterly results related to the
development of its lead product candidate, AFREZZA, and in its
expansion of the product candidate portfolio. The Company expects
these fluctuations to continue in the future. Due to these and
other factors, the quarterly operating results are not indicative
of the Company’s future performance.</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="60%"></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>March 31</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>June 30</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>September 30</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>December 31</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom" colspan="14" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>(In thousands, except
per share data)</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2"><b>2011</b></font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Net loss</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(41,525</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(44,480</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(38,402</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(36,397</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Net loss applicable to
common stockholders</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(41,525</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(44,480</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(38,402</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(36,397</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Net loss per share
applicable to common stockholders — basic and
diluted</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(0.34</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(0.37</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(0.31</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(0.30</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Weighted average common
shares used to compute basic and diluted net loss per share
applicable to common stockholders</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">121,057</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">121,708</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">122,130</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">122,357</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
<p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px; FONT-SIZE: 1px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="60%"></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>March 31</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>June 30</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>September 30</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>December 31</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom" colspan="14" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>(In thousands, except
per share data)</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2"><b>2012</b></font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Net loss</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(38,173</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(36,578</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(42,834</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(51,781</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Net loss applicable to
common stockholders</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(38,173</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(36,578</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(42,834</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(51,781</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Net loss per share
applicable to common stockholders — basic and
diluted</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(0.27</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(0.23</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(0.22</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(0.23</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Weighted average common
shares used to compute basic and diluted net loss per share
applicable to common stockholders</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">143,154</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">159,859</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">190,534</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">229,234</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
</div>
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Senior
convertible notes consist of the following (in
thousands):</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="82%"></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="6" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>December 31,</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2"><b>2013
notes</b></font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Principal amount</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">115,000</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">115,000</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Unaccreted debt issuance
expense</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(1,140</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(557</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Net carrying
amount</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">113,860</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">114,443</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2"><b>2015
notes</b></font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Principal amount</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">100,000</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">100,000</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Unaccreted debt issuance
expense</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(3,218</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(2,417</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Net carrying
amount</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">96,782</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">97,583</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Senior convertible
notes</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">210,642</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">212,026</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
</div>
P4Y
9755000
<div>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 12px; TEXT-INDENT: 0px; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><b><font style="FONT-FAMILY: 'Times New Roman'" size="2"><b>13. Commitments and
contingencies</b></font></b></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2"><i>Operating
Leases </i>—
The Company leases certain facilities and equipment under various
operating leases, which expire at various dates through 2013. As of
December 31, 2012, future minimum rental payments required
under operating leases consist of $21,000 for the year ending
December 31, 2013.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Rent expense under all
operating leases for the years ended December 31, 2010, 2011
and 2012 was approximately $1.2 million, $766,000 and $675,000,
respectively.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2"><i>Capital
Leases </i>—
The Company’s capital leases were not material for the years
ended December 31, 2010, 2011 and 2012.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2"><i>Supply Agreement
— </i>In
November 2007, the Company entered into a long-term supply
agreement (the “Supply Agreement”) with N.V. Organon
(“Organon”), now a subsidiary of Merck & Co.,
Inc., pursuant to which Organon manufactured and supplied specified
quantities of recombinant human insulin to the Company. In June
2011, the Company entered into a letter agreement (the
“Letter Agreement”) with Organon to settle a dispute
that arose between the Company and Organon in connection with the
termination by the Company of the Supply Agreement. Under the terms
of the Letter Agreement, the Company paid Organon an aggregate of
$16.0 million in two installments, each of which was paid
after the Company received certain quantities of recombinant human
insulin manufactured and supplied by Organon. The Letter Agreement
is in full and final settlement of, and the Company and Organon
agreed to release each other from, any and all actions and claims
that the Company and Organon had or may have against each other in
connection with the dispute regarding the Supply Agreement and
related matters. The Company has concluded that the Letter
Agreement represents a multiple element arrangement consisting of
two elements representing the purchase of insulin and a contract
cancellation fee. The Company has allocated the $16.0 million
settlement in the following manner: first to the fair value of the
insulin received, which was recorded as expense of $8.4 million and
the remaining $7.6 million to the contract cancellation fee. These
charges were recorded to “Research and development”
operating expenses in the consolidated statements of
operations.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2"><i>Guarantees and
Indemnifications </i>— In the ordinary
course of its business, the Company makes certain indemnities,
commitments and guarantees under which it may be required to make
payments in relation to certain transactions. The Company, as
permitted under Delaware law and in accordance with its Bylaws,
indemnifies its officers and directors for certain events or
occurrences, subject to certain limits, while the officer or
director is or was serving at the Company’s request in such
capacity. The term of the indemnification period is for the
officer’s or director’s lifetime. The maximum amount of
potential future indemnification is unlimited; however, the Company
has a director and officer insurance policy that may enable it to
recover a portion of any future amounts paid. The Company believes
the fair value of these indemnification agreements is minimal. The
Company has not recorded any liability for these indemnities in the
accompanying consolidated balance sheets. However, the Company
accrues for losses for any known contingent liability, including
those that may arise from indemnification provisions, when future
payment is probable. No such losses have been recorded to
date.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 0px; FONT: 1px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2"><i>Litigation </i>— The Company is
subject to legal proceedings and claims which arise in the ordinary
course of its business. As of the date hereof, the Company believes
that the final disposition of such matters will not have a material
adverse effect on the financial position, results of operations or
cash flows of the Company. The Company maintains liability
insurance coverage to protect the Company’s assets from
losses arising out of or involving activities associated with
ongoing and normal business operations. In accordance with ASC
450 <i>Contingencies</i>, the
Company records a provision for a liability when it is both
probable that a liability has been incurred and the amount of the
loss can be reasonably estimated. The Company’s policy is to
accrue for legal expenses in connection with legal proceeding and
claims as they are incurred.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2"><b>The Securities
Action</b>. Beginning January 31, 2011, several complaints
were filed in the U.S. District Court for the Central District of
California against us and four of our officers – Alfred E.
Mann, Hakan S. Edstrom, Dr. Peter C. Richardson (a former
officer) and Matthew J. Pfeffer – on behalf of certain
purchasers of our common stock. The complaints include claims
asserted under Sections 10(b) and 20(a) of the Exchange Act and
were brought as purported shareholder class actions. In general,
the complaints alleged that the defendants violated federal
securities laws by making materially false and misleading
statements regarding our business and prospects for AFREZZA,
thereby artificially inflating the price of the Company’s
common stock. The U.S. District Court for the Central District of
California consolidated the pending actions for all purposes. The
consolidated action is referred to as the Securities
Action.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">On July 23, 2012,
the Company, while continuing to deny all allegations of wrongdoing
or liability whatsoever arising out of the Securities Action, and
without in any way admitting fault or liability, entered into a
stipulation of settlement to resolve the Securities Action. The
current and former officers and directors named as individual
defendants in the consolidated lawsuits also entered into the
stipulation of settlement.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">In exchange for a release
of all claims by the class members, among others, and a dismissal
of the consolidated lawsuits, the Company agreed (i) to cause
the Company’s insurers to pay class members and their
attorneys a total of $16.0 million; and (ii) to issue to class
members and their attorneys 2,777,778 shares of the Company’s
common stock. The Company also agreed that if the consolidated
closing bid price for the Company’s common stock is below
$1.00 per share on the date the U.S. District Court enters an order
of final judgment, then the Company will issue into the Escrow
Account an additional 1,000,000 shares of its common stock. On
September 12, 2012, the U.S. District Court preliminarily
approved the settlement.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">On December 21,
2012, the U.S. District Court issued the Order and Final Judgment,
providing final approval of the settlement for the securities
action. The Order and Final Judgment consisted of requiring the
Company to cause its insurers to pay $16.0 million and to issue the
2,777,778 shares of its common stock in accordance with the
stipulation of settlement. The Order and Final Judgment did not
include the requirement of the Company to issue the additional
1,000,000 shares of its common stock. In late September and in
early October, following the preliminary approval of the
settlement, the Company’s insurers remitted payment of the
$16.0 million into the Escrow Account. On December 31, 2012,
following final approval of the settlement, the Company initiated
the transfer of the 2,777,778 shares of its common stock into the
Escrow Account. The stock transfer settled on January 2, 2013.
The shares were issued pursuant to an exemption from registration
provided by Section 3(a)(10) of the Securities Act of 1933, as
amended. As of December 31, 2012, the Securities Action was
concluded.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2"><b>The Derivative
Actions</b>. Beginning in February 2011, several shareholder
derivative complaints were filed in the Superior Court of
California for the County of Los Angeles and in the U.S. District
Court for the Central District of California against all of the
Company’s directors and certain of its officers. The
complaints in the shareholder derivative actions allege breaches of
fiduciary duties by the defendants and other violations of law. In
general, the complaints allege that the defendants caused or
allowed for the dissemination of materially false and misleading
statements regarding its business and prospects for AFREZZA,
thereby artificially inflating the price of its common stock. The
Superior Court of California for the County of Los Angeles
consolidated the actions pending before it. The consolidated state
derivative actions are referred to as the State Derivative Action.
The U.S. District Court for the Central District of California has
also consolidated the derivative actions pending before it. The
consolidated federal derivative actions are referred to as the
Federal Derivative Action. The State Derivative Action and the
Federal Derivative Action are collectively referred to as the
Derivative Actions.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">On August 3, 2012,
the Company, while continuing to deny all allegations of wrongdoing
or liability whatsoever arising out of the Derivative Actions and
without in any way admitting fault or liability, entered into a
stipulation of settlement to resolve the Derivative Action. Subject
to preliminary and final approval of the settlement by the U.S.
District Court and notice to shareholders, and in an exchange for a
release of all claims by the plaintiffs, among others, and a
dismissal of the Derivative Actions, the Company agreed (i) to
adopt certain corporate governance measures, (ii) to cause the
Company’s insurers to pay the plaintiffs’ attorneys a
total of $800,000, and (iii) to issue plaintiffs’
attorneys 225,000 shares of the Company’s common stock. On
September 12, 2012, the U.S. District Court preliminarily
approved the settlement.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">On November 19,
2012, the U.S. District Court issued the Order and Final Judgment,
providing final approval of the settlement for the derivative
action. The Order and Final Judgment consisted of requiring the
Company to cause its insurers to pay $800,000 and to issue the
225,000 shares of its common stock in accordance with the
stipulation of settlement. In late September and in early October,
following the preliminary approval of the settlement, the
Company’s insurers remitted payment of the $800,000 into an
account established by the plaintiffs’ attorneys. In December
2012, following final approval of the settlement, the Company
transferred the 225,000 shares of its common stock into an
investment brokerage account established by the plaintiffs’
attorneys. The shares were issued pursuant to an exemption from
registration provided by Section 3(a)(10) of the Securities
Act of 1933, as amended. As of December 31, 2012, the
Derivative Actions were concluded.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">As a result of settlement
discussions with the plaintiffs taking place in the latter part of
the quarter ended June 30, 2012 and entering into the
stipulation of settlement for the Securities Action on
July 23, 2012 and for the Derivative Action on August 3,
2012, the Company determined that the liabilities pertaining to
both the securities and derivative lawsuits were probable as of
June 30, 2012. The Company’s financial statements as of
and for the three months ended June 30, 2012 reflect the
following accruals:</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 0px; FONT: 6px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"></p>
<table style="TEXT-TRANSFORM: none; TEXT-INDENT: 0px; BORDER-COLLAPSE: collapse; FONT-FAMILY: 'Times New Roman'; LETTER-SPACING: normal; WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" border="0" cellspacing="0" cellpadding="0" width="100%">
<tr>
<td width="4%"><font size="1"> </font></td>
<td valign="top" width="4%" align="left"><font style="FONT-FAMILY: 'Times New Roman'" size="2">(i)</font></td>
<td valign="top" align="left"><font style="FONT-FAMILY: 'Times New Roman'" size="2"><i>Cash
consideration</i>. The Company recorded a current liability of
$16.8 million under “Accrued expense and other current
liabilities” and a corresponding current asset under
“Prepaid expenses and other current asset” to reflect a
receivable from the Company’s insurers. The Company has
determined that the collectability of the receivable from the
insurers is probable. The cash obligation resulted in no charge to
the Company’s Condensed Consolidated Statements of Operations
for the period.</font></td>
</tr>
</table>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 0px; FONT: 6px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"></p>
<table style="TEXT-TRANSFORM: none; TEXT-INDENT: 0px; BORDER-COLLAPSE: collapse; FONT-FAMILY: 'Times New Roman'; LETTER-SPACING: normal; WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" border="0" cellspacing="0" cellpadding="0" width="100%">
<tr>
<td width="4%"><font size="1"> </font></td>
<td valign="top" width="4%" align="left"><font style="FONT-FAMILY: 'Times New Roman'" size="2">(ii)</font></td>
<td valign="top" align="left"><font style="FONT-FAMILY: 'Times New Roman'" size="2"><i>Stock
consideration</i>. The Company recorded a charge to “General
and administrative” expenses and an estimated current
liability under “Accrued expense and other current
liabilities” of $7.7 million representing the estimated fair
value of the 3,002,778 common shares to be issued in the aggregate
subject to court approval.</font></td>
</tr>
</table>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 0px; FONT: 6px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"></p>
<table style="TEXT-TRANSFORM: none; TEXT-INDENT: 0px; BORDER-COLLAPSE: collapse; FONT-FAMILY: 'Times New Roman'; LETTER-SPACING: normal; WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" border="0" cellspacing="0" cellpadding="0" width="100%">
<tr>
<td width="4%"><font size="1"> </font></td>
<td valign="top" width="4%" align="left"><font style="FONT-FAMILY: 'Times New Roman'" size="2">(iii)</font></td>
<td valign="top" align="left"><font style="FONT-FAMILY: 'Times New Roman'" size="2"><i>Additional stock
consideration</i>. The Company concluded that the contingent
obligation to issue an additional 1,000,000 shares of its common
stock, as defined in the stipulation of settlement agreement for
the Securities Action, met the definition of a derivative
instrument in accordance with ASC 815 <i>Derivatives and
Hedging</i>. The Company estimated the fair value of the derivative
instrument using the Monte Carlo simulation model to forecast the
contingent obligation applying probabilities that the stock price
will be lower than $1.00 based on the following assumptions:
expected volatility of 60%, risk free interest rate of 0.16% and
final judgment dates ranging from four to six months. As a result,
the Company estimated the fair value of this contingent obligation
to be immaterial.</font></td>
</tr>
</table>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 0px; FONT: 1px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">As of September 30,
2012, the Company estimated the aggregate fair value of the stock
consideration at $8.6 million and recognized an increase in
the contingent liability of $901,000 during the quarter ended
September 30, 2012. During the quarter ended
September 30, 2012, the Company remeasured the additional
stock consideration using the Monte Carlo simulation model to
forecast the contingent obligation applying probabilities that the
stock price will be lower than $1.00 based on the following
assumptions: expected volatility of 54%, risk free interest rate of
0.1% and final judgment date on or before December 31, 2012.
As a result, the Company estimated the fair value of this
contingent obligation related to the additional stock consideration
to be immaterial.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 12px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">The Company considered
the following in its financial statements as of and for the year
ended December 31, 2012:</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 0px; FONT: 6px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"></p>
<table style="TEXT-TRANSFORM: none; TEXT-INDENT: 0px; BORDER-COLLAPSE: collapse; FONT-FAMILY: 'Times New Roman'; LETTER-SPACING: normal; WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" border="0" cellspacing="0" cellpadding="0" width="100%">
<tr>
<td width="4%"><font size="1"> </font></td>
<td valign="top" width="4%" align="left"><font style="FONT-FAMILY: 'Times New Roman'" size="2">(i)</font></td>
<td valign="top" align="left"><font style="FONT-FAMILY: 'Times New Roman'" size="2"><i>Cash
consideration</i>. Upon satisfying the conditions of cash payment
during the fourth quarter of 2012 and receiving final approvals of
settlement, the Company relieved from its balance sheet the
$16.8 million of current liability and current receivable from
insurers as of December 31, 2012.</font></td>
</tr>
</table>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 0px; FONT: 6px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"></p>
<table style="TEXT-TRANSFORM: none; TEXT-INDENT: 0px; BORDER-COLLAPSE: collapse; FONT-FAMILY: 'Times New Roman'; LETTER-SPACING: normal; WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" border="0" cellspacing="0" cellpadding="0" width="100%">
<tr>
<td width="4%"><font size="1"> </font></td>
<td valign="top" width="4%" align="left"><font style="FONT-FAMILY: 'Times New Roman'" size="2">(ii)</font></td>
<td valign="top" align="left"><font style="FONT-FAMILY: 'Times New Roman'" size="2"><i>Stock
consideration</i>. As of December 31, 2012, the Company
satisfied the conditions of issuing 225,000 shares of its common
stock on the Derivative Action. With respect to the Securities
Action, the issuance of 2,777,778 shares was initiated prior to
year end and subsequently settled after year end. The Company
concluded that the requirement to deliver these shares of common
stock met the definition of a financial instrument representing a
contingent forward contract in accordance with ASC 815 <i>Derivatives and
Hedging </i>and
that the forward contract met the criteria for equity
classification, and further remeasurement through settlement was
not required. The forward contract to issue shares settled on
January 2, 2013, upon consummation of the delivery of these
shares. The final fair values of the stock consideration are
summarized in the following table:</font></td>
</tr>
</table>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 0px; FONT: 6px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"></p>
<table style="TEXT-TRANSFORM: none; TEXT-INDENT: 0px; BORDER-COLLAPSE: collapse; FONT-FAMILY: 'Times New Roman'; LETTER-SPACING: normal; WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" border="0" cellspacing="0" cellpadding="0" width="84%" align="center">
<tr>
<td width="52%"></td>
<td valign="bottom" width="8%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="8%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="8%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Number</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>of</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Shares</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Closing Price<br />
Per Share on<br />
Final<br />
Approval</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Date</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Final Fair Value  of<br />
Stock</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Consideration</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Derivative
Action</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">225,000</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">1.94</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">436,500</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Securities
Action</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">2,777,778</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">2.18</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">6,055,556</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 3em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Total</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">3,002,778</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">6,492,056</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 0px; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); MARGIN-LEFT: 131px; WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">In recognizing the fair
value of the total stock consideration to equity on the date of
final approval of the respective settlements, the Company released
the previously recorded litigation accrual of $8.6 million,
recognized the fair value of the total stock consideration of $6.5
million to equity, and recorded an adjustment to decrease legal
expense by $2.1 million in the fourth quarter of
2012.</font></font></p>
</div>
<div>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: Times New Roman" size="2"><b>5. Accrued expenses and
other current liabilities</b></font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Accrued
expenses and other current liabilities are comprised of the
following (in thousands):</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="84%"></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="6" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>December 31,</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Salary and related
expenses</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">8,997</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">10,074</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Research and clinical trial
costs</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">2,383</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">5,995</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Accrued interest</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">8,262</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">4,533</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Construction in
progress</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">3,878</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Other</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">1,094</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">1,297</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Accrued expenses and other
current liabilities</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">20,736</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">25,777</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
</div>
-906000
128324123
-169366000
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Impairment
of Long-Lived Assets</i> — The Company evaluates long-lived
assets for impairment whenever events or changes in circumstances
indicate that the carrying value of an asset may not be recoverable
in accordance with ASC 360-10-35 <i>Property Plant and
Equipment.</i> Assets are considered to be impaired if the carrying
value may not be recoverable based upon management’s
assessment of the following events or changes in
circumstances:</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%">
<tr>
<td width="2%"><font size="1"> </font></td>
<td valign="top" width="1%" align="left"><font style="FONT-FAMILY: Times New Roman" size="2">•</font></td>
<td valign="top" width="1%"><font size="1"> </font></td>
<td valign="top" align="left">
<p align="left"><font style="FONT-FAMILY: Times New Roman" size="2">significant changes in the Company’s strategic business
objectives and utilization of the assets;</font></p>
</td>
</tr>
</table>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%">
<tr>
<td width="2%"><font size="1"> </font></td>
<td valign="top" width="1%" align="left"><font style="FONT-FAMILY: Times New Roman" size="2">•</font></td>
<td valign="top" width="1%"><font size="1"> </font></td>
<td valign="top" align="left">
<p align="left"><font style="FONT-FAMILY: Times New Roman" size="2">a determination that the carrying value of such assets can not
be recovered through undiscounted cash flows;</font></p>
</td>
</tr>
</table>
<p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px; FONT-SIZE: 1px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%">
<tr>
<td width="2%"><font size="1"> </font></td>
<td valign="top" width="1%" align="left"><font style="FONT-FAMILY: Times New Roman" size="2">•</font></td>
<td valign="top" width="1%"><font size="1"> </font></td>
<td valign="top" align="left">
<p align="left"><font style="FONT-FAMILY: Times New Roman" size="2">loss of legal ownership or title to the assets;</font></p>
</td>
</tr>
</table>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%">
<tr>
<td width="2%"><font size="1"> </font></td>
<td valign="top" width="1%" align="left"><font style="FONT-FAMILY: Times New Roman" size="2">•</font></td>
<td valign="top" width="1%"><font size="1"> </font></td>
<td valign="top" align="left">
<p align="left"><font style="FONT-FAMILY: Times New Roman" size="2">a significant adverse change in legal factors or in the
business climate that could affect the value of a long-lived asset
(asset group), including an adverse action or assessment by a
regulator; or</font></p>
</td>
</tr>
</table>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%">
<tr>
<td width="2%"><font size="1"> </font></td>
<td valign="top" width="1%" align="left"><font style="FONT-FAMILY: Times New Roman" size="2">•</font></td>
<td valign="top" width="1%"><font size="1"> </font></td>
<td valign="top" align="left">
<p align="left"><font style="FONT-FAMILY: Times New Roman" size="2">the impact of significant negative industry or economic
trends.</font></p>
</td>
</tr>
</table>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">If the Company
believes an asset to be impaired, the impairment recognized is the
amount by which the carrying value of the assets exceeds the fair
value of the assets. Any write-downs would be treated as permanent
reductions in the carrying amount of the asset and an operating
loss would be recognized. No asset impairment was recognized during
the years ended December 31, 2010, 2011 and 2012,
respectively.</font></p>
</div>
<div>
<table style="TEXT-TRANSFORM: none; TEXT-INDENT: 0px; BORDER-COLLAPSE: collapse; FONT-FAMILY: 'Times New Roman'; LETTER-SPACING: normal; WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" border="0" cellspacing="0" cellpadding="0" width="100%">
<tr>
<td valign="top" align="left"><font style="FONT-FAMILY: 'Times New Roman'" size="2">The final fair values of
the stock consideration are summarized in the following
table:</font></td>
</tr>
</table>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 0px; FONT: 6px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
 </p>
<table style="TEXT-TRANSFORM: none; TEXT-INDENT: 0px; BORDER-COLLAPSE: collapse; FONT-FAMILY: 'Times New Roman'; LETTER-SPACING: normal; WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" border="0" cellspacing="0" cellpadding="0" width="84%" align="center">
<tr>
<td width="52%"></td>
<td valign="bottom" width="8%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="8%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="8%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Number</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>of</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Shares</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Closing Price<br />
Per Share on<br />
Final<br />
Approval</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Date</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Final Fair Value  of<br />
Stock</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Consideration</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Derivative
Action</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">225,000</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">1.94</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">436,500</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Securities
Action</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">2,777,778</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">2.18</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">6,055,556</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 3em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Total</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">3,002,778</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">6,492,056</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
<br class="Apple-interchange-newline" /></div>
-408000
<div>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: Times New Roman" size="2"><b>2. Summary of
significant accounting policies</b></font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Financial
Statement Estimates</i> — The preparation of financial
statements in conformity with accounting principles generally
accepted in the United States of America (“GAAP”)
requires management to make estimates and assumptions that affect
the amounts reported in the financial statements and accompanying
notes. Actual results could differ from those estimates. The more
significant estimates reflected in these accompanying financial
statements involve assessing long-lived assets for impairment,
accrued expenses, including clinical trial expenses, valuation of
forward purchase contracts, valuation of stock-based compensation
and the determination of the provision for income taxes and
corresponding deferred tax assets and liabilities and any valuation
allowance recorded against net deferred tax assets.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Cash and
Cash Equivalents</i> — The Company considers all highly
liquid investments with original or remaining maturities of 90 days
or less at the time of purchase, that are readily convertible into
cash to be cash equivalents.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Concentration of Credit Risk</i> — Financial
instruments that potentially subject the Company to concentration
of credit risk consist of cash and cash equivalents. Cash and cash
equivalents consist primarily of interest-bearing accounts and are
regularly monitored by management and held in high credit quality
institutions.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>State
Research and Development Credit Exchange Receivable</i> — The
State of Connecticut provides certain companies with the
opportunity to exchange certain research and development income tax
credit carryforwards for cash in exchange for foregoing the
carryforward of the research and development credits. The program
provides for an exchange of research and development income tax
credits for cash equal to 65% of the value of corporation tax
credit available for exchange. Estimated amounts receivable under
the program are recorded as a reduction of research and development
expenses.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Fair Value
of Financial Instruments</i> — The Company utilizes fair
value measurement guidance prescribed by GAAP to value its
financial instruments. The guidance includes a definition of fair
value, prescribes methods for measuring fair value, establishes a
fair value hierarchy based on the inputs used to measure fair value
and expands disclosures about the use of fair value measurements.
The valuation techniques utilized are based upon observable and
unobservable inputs. Observable inputs reflect market data obtained
from independent sources, while unobservable inputs reflect
internal market assumptions. These two types of inputs create the
following fair value hierarchy:</font></p>
<p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px; MARGIN-LEFT: 4%">
<font style="FONT-FAMILY: Times New Roman" size="2">Level 1 – Quoted prices for identical
instruments in active markets.</font></p>
<p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px; MARGIN-LEFT: 4%">
<font style="FONT-FAMILY: Times New Roman" size="2">Level 2 – Quoted prices for similar instruments
in active markets; quoted prices for identical or similar
instruments in markets that are not active; and model-derived
valuations whose inputs are observable or whose significant value
drivers are observable.</font></p>
<p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px; MARGIN-LEFT: 4%">
<font style="FONT-FAMILY: Times New Roman" size="2">Level 3 – Significant inputs to the valuation
model are unobservable.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Goodwill and
Identifiable Intangibles</i> — As a result of the merger with
AlleCure and CTL on December 12, 2001, as described in Note 1,
goodwill of $151.4 million was recorded at the entity level in
2001. Upon adoption of ASC 350-10 <i>Intangibles- Goodwill and
Other,</i> the Company adopted a policy of testing goodwill and
intangible assets with indefinite lives for impairment at least
annually, as of December 31, with any related impairment
losses being recognized in earnings when identified. In December
2002 the Company concluded that the major AlleCure product
development program should be terminated and that the clinical
trials of the CTL product should be halted and returned to the
research stage. As a result of this determination, the Company
closed the CTL facility and reduced headcount for AlleCure and CTL
by approximately 50%. In connection with the annual test for
impairment of goodwill as of December 31, 2002, the Company
determined that on the basis of the internal study, the goodwill
recorded for the AlleCure and CTL units was potentially impaired.
The Company performed the second step of the annual impairment test
as of December 31, 2002 for each of the potentially impaired
reporting units and estimated the fair value of the AlleCure and
CTL programs using the expected present value of future cash flows
which were expected to be negligible. Accordingly, the goodwill
balance of $151.4 million was determined to be fully impaired and
an impairment loss was recorded in 2002. Subsequent to
December 31, 2002, the Company had no goodwill or intangibles
with indefinite lives included on its balance sheets.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Property and
Equipment</i> — Property and equipment are recorded at cost
and depreciated using the straight-line method over the estimated
useful lives of the related assets. Leasehold improvements are
amortized over the term of the lease or the service lives of the
improvements, whichever is shorter. Assets under construction are
not depreciated until placed into service.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Impairment
of Long-Lived Assets</i> — The Company evaluates long-lived
assets for impairment whenever events or changes in circumstances
indicate that the carrying value of an asset may not be recoverable
in accordance with ASC 360-10-35 <i>Property Plant and
Equipment.</i> Assets are considered to be impaired if the carrying
value may not be recoverable based upon management’s
assessment of the following events or changes in
circumstances:</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%">
<tr>
<td width="2%"><font size="1"> </font></td>
<td valign="top" width="1%" align="left"><font style="FONT-FAMILY: Times New Roman" size="2">•</font></td>
<td valign="top" width="1%"><font size="1"> </font></td>
<td valign="top" align="left">
<p align="left"><font style="FONT-FAMILY: Times New Roman" size="2">significant changes in the Company’s strategic business
objectives and utilization of the assets;</font></p>
</td>
</tr>
</table>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%">
<tr>
<td width="2%"><font size="1"> </font></td>
<td valign="top" width="1%" align="left"><font style="FONT-FAMILY: Times New Roman" size="2">•</font></td>
<td valign="top" width="1%"><font size="1"> </font></td>
<td valign="top" align="left">
<p align="left"><font style="FONT-FAMILY: Times New Roman" size="2">a determination that the carrying value of such assets can not
be recovered through undiscounted cash flows;</font></p>
</td>
</tr>
</table>
<p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px; FONT-SIZE: 1px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%">
<tr>
<td width="2%"><font size="1"> </font></td>
<td valign="top" width="1%" align="left"><font style="FONT-FAMILY: Times New Roman" size="2">•</font></td>
<td valign="top" width="1%"><font size="1"> </font></td>
<td valign="top" align="left">
<p align="left"><font style="FONT-FAMILY: Times New Roman" size="2">loss of legal ownership or title to the assets;</font></p>
</td>
</tr>
</table>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%">
<tr>
<td width="2%"><font size="1"> </font></td>
<td valign="top" width="1%" align="left"><font style="FONT-FAMILY: Times New Roman" size="2">•</font></td>
<td valign="top" width="1%"><font size="1"> </font></td>
<td valign="top" align="left">
<p align="left"><font style="FONT-FAMILY: Times New Roman" size="2">a significant adverse change in legal factors or in the
business climate that could affect the value of a long-lived asset
(asset group), including an adverse action or assessment by a
regulator; or</font></p>
</td>
</tr>
</table>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%">
<tr>
<td width="2%"><font size="1"> </font></td>
<td valign="top" width="1%" align="left"><font style="FONT-FAMILY: Times New Roman" size="2">•</font></td>
<td valign="top" width="1%"><font size="1"> </font></td>
<td valign="top" align="left">
<p align="left"><font style="FONT-FAMILY: Times New Roman" size="2">the impact of significant negative industry or economic
trends.</font></p>
</td>
</tr>
</table>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">If the Company
believes an asset to be impaired, the impairment recognized is the
amount by which the carrying value of the assets exceeds the fair
value of the assets. Any write-downs would be treated as permanent
reductions in the carrying amount of the asset and an operating
loss would be recognized. No asset impairment was recognized during
the years ended December 31, 2010, 2011 and 2012,
respectively.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Accounts
Payable and Accrued Expenses</i> — All liabilities, including
accounts payable and accrued expenses, are recorded consistent with
the definition of liabilities and accrual
accounting<i>.</i></font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Income
Taxes</i> — Provisions for federal, foreign, state, and local
income taxes are calculated on pre-tax income based on current tax
law and include the cumulative effect of any changes in tax rates
from those used previously in determining deferred tax assets and
liabilities. Deferred income tax assets and liabilities are
recorded for the expected future tax consequences of temporary
differences between the financial statement carrying amounts and
the income tax basis of assets and liabilities. A valuation
allowance is recorded to reduce net deferred income tax assets to
amounts that are more likely than not to be realized (see Note
15).</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Income tax
positions are considered for uncertainty in accordance with ASC
740-10-25 <i>Income Taxes,</i> The Company believes that its income
tax filing positions and deductions will be sustained on audit and
does not anticipate any adjustments that will result in a material
change to its financial position. Therefore, no liabilities for
uncertain income tax positions have been recorded. If a tax
position does not meet the minimum statutory threshold to avoid
payment of penalties, the Company recognizes an expense for the
amount of the penalty in the period the tax position is claimed in
the tax return of the company. The Company recognizes interest
accrued related to unrecognized tax benefits in income tax expense,
if any. Penalties, if probable and reasonably estimable, are
recognized as a component of income tax expense.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Significant
management judgment is involved in determining the provision for
income taxes, deferred tax assets and liabilities and any valuation
allowance recorded against net deferred tax assets. Due to
uncertainties related to the realization of the Company’s
deferred tax assets as a result of its history of operating losses,
a valuation allowance has been established against the gross
deferred tax asset balance. The valuation allowance is based on
management’s estimates of taxable income by jurisdiction in
which the Company operates and the period over which deferred tax
assets will be recoverable. In the event that actual results differ
from these estimates or the Company adjusts these estimates in
future periods, a change in the valuation allowance may be needed,
which could materially impact the Company’s financial
position and results of operations.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Contingencies</i> — Contingencies are recorded in
accordance with ASC 450 <i>Contingencies.</i> Accordingly, the
Company records a loss contingency for a liability when it is both
probable that a liability has been incurred and the amount of the
loss can be reasonably estimated.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Stock-Based
Compensation</i> — As of December 31, 2012, the Company
had three active stock-based compensation plans, which are
described more fully in Note 12. The Company accounts for all
share-based payments to employees, including grants of stock awards
and the compensatory elements of the employee stock purchase plan
in accordance with ASC 718 <i>Compensation- Stock Compensation</i>
(“ASC 718”)<i>.</i> ASC 718 requires all share-based
payments to employees, including grants of stock options,
restricted stock units, performance-based awards and the
compensatory elements of employee stock purchase plans, to be
recognized in the income statement based upon the fair value of the
awards at the grant date. The Company uses the Black-Scholes option
valuation model to estimate the grant date fair value of employee
stock options and the compensatory elements of employee stock
purchase plans. Restricted stock units are valued based on the
market price on the grant date. The Company evaluates stock awards
with performance conditions as to the probability that the
performance conditions will be met and estimates the date at which
the performance conditions will be met in order to properly
recognize stock-based compensation expense over the requisite
service period.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 4%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Warrants</i>
— The Company has issued warrants to purchase shares of its
common stock. Warrants have been accounted for within equity in
accordance with the provisions of ASC 815-40 Derivatives and
Hedging, Contracts in an Entity’s Own Stock, previously EITF
Issue No. 00-19: Accounting for Derivative Financial Instruments
Indexed to, and Potentially Settled in, a Company’s Own
Stock<i>.</i></font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Forward
Contracts</i> — The Company has entered into agreements with
The Mann Group whereby the Company agreed to sell and The Mann
Group agreed to purchase common stock and/or warrants. These
agreements have been accounted for as forward contracts, having met
the definition of derivative instruments in accordance with the
provisions of ASC 815 <i>Derivatives and Hedging</i>. The Company
determines the fair value of the forward contract upon its
issuance, records fair value adjustments of the forward contract to
Other income (expense) during the reporting period and through the
settlement of the forward contract, and reclassifies the forward
contract to equity upon settlement of the forward
contract.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Comprehensive Income (Loss)</i> — Other comprehensive
income (loss) (OCI) is recorded in accordance with ASC 220-10-45
<i>Comprehensive Income,</i> which requires that all components of
comprehensive income (loss) be reported in the financial statements
in the period in which they are recognized. OCI includes certain
changes in stockholders’ equity that are excluded from net
income. Specifically, the Company includes in OCI unrealized gains
and losses on its available-for-sale securities and cumulative
translation gains and losses.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Research and
Development Expenses</i> — Research and development expenses
consist primarily of costs associated with the clinical trials of
the Company’s product candidates, manufacturing supplies and
other development materials, including raw material purchases of
insulin, compensation and other expenses for research and
development personnel, costs for consultants and related contract
research, facility costs, and depreciation. Research and
development costs, which are net of any tax credit exchange
recognized for the Connecticut state research and development
credit exchange program, are expensed as incurred consistent with
ASC 730-10 <i>Research and Development.</i></font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Clinical
Trial Expenses</i> — Clinical trial expenses, which are
reflected in research and development expenses in the accompanying
statements of operations, result from obligations under contracts
with vendors, consultants, and clinical site agreements in
connection with conducting clinical trials. The financial terms of
these contracts are subject to negotiations which vary from
contract to contract and may result in payment flows that do not
match the periods over which materials or services are provided to
the Company under such contracts. The appropriate level of trial
expenses are reflected in the Company’s financial statements
by matching period expenses with period services and efforts
expended. These expenses are recorded according to the progress of
the trial as measured by patient progression and the timing of
various aspects of the trial. Clinical trial accrual estimates are
determined through discussions with internal clinical personnel and
outside service providers as to the progress or state of completion
of trials, or the services completed. Service provider status is
then compared to the contractually obligated fee to be paid for
such services. During the course of a clinical trial, the Company
may adjust the rate of clinical expense recognized if actual
results differ from management’s estimates. The date on which
certain services commence, the level of services performed on or
before a given date and the cost of the services are often
judgmental.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Interest
Expense</i> — Interest costs are expensed as incurred, except
to the extent such interest is related to construction in progress,
in which case interest is capitalized. Interest expense, net of
interest capitalized, for the years ended December 31, 2010,
2011 and 2012 was $17.4 million, $21.8 million and $21.6 million,
respectively. Interest costs capitalized was not significant for
the year ended December 31, 2010 and were $0.4 million and
$0.3 million for the years ended December 31, 2011 and 2012,
respectively.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Net Loss Per
Share of Common Stock</i> — Basic net loss per share excludes
dilution for potentially dilutive securities and is computed by
dividing loss applicable to common stockholders by the weighted
average number of common shares outstanding during the period.
Diluted net loss per share reflects the potential dilution that
could occur if securities or other contracts to issue common stock
were exercised or converted into common stock. Potentially dilutive
securities are excluded from the computation of diluted net loss
per share for all of the periods presented in the accompanying
statements of operations because the reported net loss in each of
these periods results in their inclusion being
antidilutive.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Exit or
Disposal Activities</i> — The obligations related to exit or
disposal activities, including reductions in force, are accounted
for in accordance with ASC 420-10-30 <i>Exit or Disposal Cost
Obligations,</i> (“ASC 420-10-30”)<i>.</i> In
accordance with ASC 420-10-30, a liability for costs associated
with an exit or disposal activity is recognized when the liability
is incurred and establishes that fair value is the objective for
initial measurements of the liability.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Recently
Issued Accounting Standards —</i> In June 2011, the FASB
issued Accounting Standards Update (“ASU”)
No. 2011-05, <i>Comprehensive Income (Topic 220):
“Presentation of Comprehensive Income.”</i> This update
improves the comparability, consistency and transparency of
financial reporting and increases the prominence of items reported
in other comprehensive income. This update is effective for interim
and annual periods beginning after December 15, 2011. In
December 2011, the FASB issued ASU No. 2011-12,
<i>Comprehensive Income (Topic 220): Deferral of the Effective Date
for Amendments to the Presentation of</i> <i>Reclassifications of
Items Out of Accumulated Other Comprehensive Income in ASU
No. 2011-05.</i> This update deferred only those changes in
ASU No. 2011-05 that related to the presentation of
reclassification adjustments. In February 2013, the FASB issued ASU
2013-02, <i>Comprehensive Income (Topic 220) – Reporting of
Amounts Reclassified Out of Accumulated Other Comprehensive
Income.</i> These amendments do not change the current requirements
for reporting net income or other comprehensive income in the
financial statements. These amendments provide for additional
disclosure requirements for amounts reclassified out of accumulated
other comprehensive income. These amendments are effective
prospectively for interim and annual periods beginning after
December 15, 2012. Early adoption is permitted. Effective
January 1, 2012, the Company adopted the new requirements as
set forth in ASU No. 2011-05 in the disclosure of
comprehensive income on the Company’s consolidated financial
statements. The Company is evaluating the impact, if any, of the
adoption of ASU No. 2013-02 will have on the Company’s
consolidated financial statements.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">In May 2011,
the FASB issued Accounting Standards Update No. 2011-04 for
Fair Value Measurement (Topic 820): “Amendments to Achieve
Common Fair Value Measurement and Disclosure Requirements in U.S.
GAAP and IFRSs”. This update addresses how to measure fair
value and requires new disclosures about fair value measurements.
The amendments in this update are effective for interim and annual
periods beginning after December 15, 2011. Effective the
quarter ended March 31, 2012, the Company adopted the
requirements as set forth in this guidance.</font></p>
</div>
-169366000
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Financial
Statement Estimates</i> — The preparation of financial
statements in conformity with accounting principles generally
accepted in the United States of America (“GAAP”)
requires management to make estimates and assumptions that affect
the amounts reported in the financial statements and accompanying
notes. Actual results could differ from those estimates. The more
significant estimates reflected in these accompanying financial
statements involve assessing long-lived assets for impairment,
accrued expenses, including clinical trial expenses, valuation of
forward purchase contracts, valuation of stock-based compensation
and the determination of the provision for income taxes and
corresponding deferred tax assets and liabilities and any valuation
allowance recorded against net deferred tax assets.</font></p>
</div>
<div>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: Times New Roman" size="2"><b>1. Description of
business and basis of presentation</b></font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Business</i>
— MannKind Corporation and subsidiaries (the
“Company”) is a biopharmaceutical company focused on
the discovery, development and commercialization of therapeutic
products for diseases such as diabetes. The Company’s lead
product candidate, AFREZZA, (insulin human [rDNA origin])
inhalation powder, is an ultra rapid-acting insulin therapy that is
in late-stage clinical investigation for the treatment of adults
with type 1 or type 2 diabetes for the control of
hyperglycemia.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">AFREZZA
consists of the Company’s proprietary Technosphere particles
onto which insulin molecules are loaded. These loaded particles are
then aerosolized and inhaled deep into the lung using the
Company’s AFREZZA inhaler.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Basis of
Presentation</i> — The Company is considered to be in the
development stage as its primary activities and since incorporation
has been establishing its facilities, recruiting personnel,
conducting research and development, business development, business
and financial planning, and raising capital. It is costly to
develop therapeutic products and conduct clinical trials for the
Company’s products. Since its inception through
December 31, 2012, the Company has reported accumulated net
losses of $2.1 billion, which include a goodwill impairment charge
of $151.4 million (see Note 2), and cumulative negative cash flow
from operations of $1.6 billion. At December 31, 2012,
the Company’s capital resources consisted of cash and cash
equivalents of $61.8 million.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">In October
2007, the Company entered into a $350.0 million loan arrangement
with its principal stockholder, The Mann Group, LLC (“The
Mann Group”). In December 2012, the Company amended and
restated the promissory note underlying the loan arrangement to,
among other things, extend the maturity date of the promissory note
to January 1, 2014, extend the date through which the Company
can borrow under the promissory note to September 30, 2013,
and adjust the annual interest rate on all outstanding principal to
the one-year London Interbank Offered Rate (LIBOR) on
December 31, 2012 plus 5%, effective January 1, 2013 (see
Note 6 — Related-party arrangements).</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">In October
2012, concurrently with an underwritten public offering (see Note
10 — Common and preferred stock), The Mann Group agreed to
purchase $107.4 million worth of restricted shares of common stock
and restricted warrants in exchange for cancellation of principal
under the $350.0 million amended and restated promissory note, the
closing of which was completed in December 31, 2012. Following
the cancellation of the principal amount and the capitalization of
the accrued and unpaid interest, the total principal amount
outstanding under the amended and restated promissory note was
$119.6 million, and the Company had $125.4 million available for
borrowing under the amended and restated promissory note (see Note
6 — Related-party arrangements). On December 15, 2013,
$115.0 million aggregate principal will be due under the 3.75%
Senior Convertible Notes for unconverted securities on that date
(see Note 7 — Senior convertible notes).</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Based upon the
Company’s current expectations, management believes the
Company’s existing capital resources, including the available
borrowings under our loan arrangement with The Mann Group, as
amended, will enable it to continue planned operations through at
least the third quarter of 2013. However, the Company cannot
provide assurances that its plans will not change or that changed
circumstances will not result in the depletion of its capital
resources more rapidly than it currently anticipates. The Company
will need to raise additional capital, whether through the sale of
equity or debt securities, a strategic business collaboration with
a pharmaceutical company, the establishment of other funding
facilities, licensing arrangements, asset sales or other means, in
order to continue the development and commercialization of AFREZZA
and other product candidates and to support its other ongoing
activities. However, the Company cannot provide assurances that
such additional capital will be available whether through the sale
of equity or debt securities, a strategic business collaboration
with a pharmaceutical company, the establishment of other funding
facilities, licensing arrangements, asset sales or other means.
This raises substantial doubt about the Company’s ability to
continue as a going concern. The financial statements do not
include any adjustments that might result from the outcome of these
uncertainties.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">On
December 12, 2001, the stockholders of AlleCure Corp.
(“AlleCure”) and CTL ImmunoTherapies Corp.
(“CTL”) voted to exchange their shares for shares of
Pharmaceutical Discovery Corporation (“PDC”).
Upon</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: Times New Roman" size="2">approval of the merger, PDC
then changed its name to MannKind Corporation. PDC was incorporated
in the State of Delaware on February 14, 1991. The
stockholders of PDC did not vote on the merger. At the date of the
merger, Mr. Alfred Mann owned 76% of PDC, 59% of AlleCure and
69% of CTL. Accordingly, only the minority interest of AlleCure and
CTL was stepped up to fair value using the purchase method of
accounting. As a result of this purchase accounting, in-process
research and development of $19.7 million and goodwill of $151.4
million were recorded at the entity level. The historical basis of
PDC and the historical basis relating to the ownership interests of
Mr. Mann in AlleCure and CTL have been reflected in the
financial statements. For periods prior to December 12, 2001,
the results of operations have been presented on a combined basis.
All references in the accompanying financial statements and notes
to the financial statements to number of shares, sales price and
per share amounts of the Company’s capital stock have been
retroactively restated to reflect the share exchange ratios for
each of the entities that participated in the merger.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">For periods
subsequent to December 12, 2001, the accompanying financial
statements have been presented on a consolidated basis and include
the wholly-owned subsidiaries, AlleCure and CTL. On
December 31, 2002, AlleCure and CTL merged with and into
MannKind and ceased to be separate entities.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Principles
of Consolidation</i> – The consolidated financial statements
include the accounts of the Company and its wholly-owned
subsidiaries. Intercompany balances and transactions have been
eliminated.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Segment
Information</i> — In accordance with Accounting Standards
Codification (“ASC”) 280-10-50 <i>Segment
Reporting</i>, operating segments are identified as components of
an enterprise about which separate discrete financial information
is available for evaluation by the chief operating decision-maker
in making decisions regarding resource allocation and assessing
performance. To date, the Company has viewed its operations and
manages its business as one segment operating primarily in the
United States of America.</font></p>
</div>
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Net Loss Per
Share of Common Stock</i> — Basic net loss per share excludes
dilution for potentially dilutive securities and is computed by
dividing loss applicable to common stockholders by the weighted
average number of common shares outstanding during the period.
Diluted net loss per share reflects the potential dilution that
could occur if securities or other contracts to issue common stock
were exercised or converted into common stock. Potentially dilutive
securities are excluded from the computation of diluted net loss
per share for all of the periods presented in the accompanying
statements of operations because the reported net loss in each of
these periods results in their inclusion being
antidilutive.</font></p>
</div>
<div>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">The following table
summarizes information about the Company’s stock-based award
plans as of December 31, 2012:</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 0px; FONT: 6px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
</p>
<table style="TEXT-TRANSFORM: none; TEXT-INDENT: 0px; BORDER-COLLAPSE: collapse; FONT-FAMILY: 'Times New Roman'; LETTER-SPACING: normal; WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="66%"></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Outstanding</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Options</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Outstanding</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Restricted</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Stock
Units</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Shares Available</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>for</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Future
Issuance</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">2004 Equity Incentive
Plan</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">17,983,708</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">3,761,031</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">6,521,347</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">2004 Non-Employee
Directors’ Stock Option Plan</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">690,831</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">109,169</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Total</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">18,674,539</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">3,761,031</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">6,630,516</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
<font style="FONT-FAMILY: Times New Roman" size="2"><br class="Apple-interchange-newline" /></font></div>
<div>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 12px; TEXT-INDENT: 0px; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><b><font style="FONT-FAMILY: 'Times New Roman'" size="2"><b>12. Stock award
plans</b></font></b></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">As of December 31,
2012, the Company has three active stock-based compensation
plans— the 2004 Equity Incentive Plan (the
“Plan”), the 2004 Non-Employee Directors’ Stock
Option Plan (the “NED Plan”), and the 2004 Employee
Stock Purchase Plan (the “ESPP”). The Plan provides for
the granting of stock awards including stock options and restricted
stock units, to employees, directors and consultants. The NED Plan
provides for the automatic, non-discretionary grant of options to
the Company’s non-employee directors. The following table
summarizes information about the Company’s stock-based award
plans as of December 31, 2012:</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 0px; FONT: 6px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"></p>
<table style="TEXT-TRANSFORM: none; TEXT-INDENT: 0px; BORDER-COLLAPSE: collapse; FONT-FAMILY: 'Times New Roman'; LETTER-SPACING: normal; WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="66%"></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Outstanding</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Options</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Outstanding</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Restricted</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Stock
Units</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Shares Available</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>for</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Future
Issuance</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">2004 Equity Incentive
Plan</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">17,983,708</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">3,761,031</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">6,521,347</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">2004 Non-Employee
Directors’ Stock Option Plan</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">690,831</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">109,169</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Total</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">18,674,539</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">3,761,031</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">6,630,516</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">The Company’s board
of directors determines eligibility, vesting schedules and exercise
prices for stock awards granted under the Plan. The NED Plan
provides for automatic, non-discretionary grant of options to the
Company’s non-employee directors. Options and other stock
awards under the Plan and the NED Plan expire not more than ten
years from the date of the grant and are exercisable upon vesting.
Stock options generally vest over four years. Current stock option
grants vest and become exercisable at the rate of 25% after one
year and ratably on a monthly basis over a period of 36 months
thereafter. Restricted stock units generally vest at a rate of
25% per year over four years with consideration satisfied by
service to the Company. Performance-based awards vest upon
achieving pre-determined performance milestones which are expected
to occur over periods ranging from 13 months to 96 months from the
date of grant. All but one of the milestones is considered probable
as of December 31, 2012. The Plan provides for full
acceleration of vesting if an employee is terminated within
thirteen months of a change in control, as defined in the
Plan.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">On May 17, 2012, the
Compensation Committee also approved a management proposal designed
to encourage employee retention. The proposal involved the
grant of stock options and restricted stock units to employees,
including executive officers of the Company. 3,942,500 options
were granted with vesting terms subject to MannKind
Corporation’s achievement of specified regulatory and
business development milestones related to AFREZZA. 3,892,500
options were granted with time-based vesting terms of 25% every 6
months beginning November 1, 2012, to be fully vested on
May 1, 2014. The performance-based options and time-based
stock options had a grant date fair value of $0.60 and $1.12,
respectively and stock compensation expense associated with these
grants will be approximately $6.7 million over the award
period.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">On March 3, 2011,
the Compensation Committee approved a management proposal designed
to encourage employee retention. The proposal involved the issuance
of restricted stock units and stock options to the majority of
employees and executive officers of the Company. A total of
1,177,300 restricted stock units and 1,467,500 stock options were
granted under the Plan. These units vest 50% annually for two years
and will be fully vested on March 3, 2013. Stock compensation
expense associated with these grants will be recorded on a straight
line basis from March 3, 2011 through March 3, 2013 and
will be approximately $8.2 million over the award
period.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">On May 21,
2009, June 2, 2011, and May 17, 2012 the
Company’s stockholders approved amendments to the Plan to
increase the number of shares of common stock available for
issuance under the plan by 5,000,000, 6,000,000, and 10,000,000
shares, respectively.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">On July 9, 2008, the
Company announced an Offer to Exchange Outstanding Options to
Purchase Common Stock (the “Offer”) under which the
Company offered eligible employees the opportunity to exchange
out-of-the money stock options covering up to an aggregate of
5,417,840 shares on a grant by grant basis for a reduced number of
restricted stock units. The Offer expired on August 6, 2008.
Pursuant to the Offer, the Company accepted for exchange options to
purchase an aggregate of 4,493,509 shares of the Company’s
common stock and issued restricted stock units covering an
aggregate of 2,246,781 shares of the Company’s common stock.
For the restricted stock units issued pursuant to the offer, both
the remaining estimated unamortized stock compensation expense
related to the exchanged options of approximately $13.9 million and
the estimated incremental stock compensation expense resulting from
the exchange of approximately $3.7 million was amortized over the
vesting period ending on August 1, 2010.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">In March 2004, the
Company’s board of directors approved the ESPP, which became
effective upon the closing of the Company’s initial public
offering. Initially, the aggregate number of shares that could be
sold under the plan was 2,000,000 shares of common stock. On
January 1 of each year, for a period of ten years beginning
January 1, 2005, the share reserve automatically increases by
the lesser of: 700,000 shares, 1% of the total number of shares of
common stock outstanding on that date, or an amount as may be
determined by the board of directors. However, under no event can
the annual increase cause the total number of shares reserved under
the ESPP to exceed 10% of the total number of shares of capital
stock outstanding on December 31 of the prior year. On
January 1, 2010, 2011 and 2012 the ESPP share reserve was
increased by 700,000, 700,000 and 700,000 shares, respectively. As
of December 31, 2012, 2,674,003 shares were available for
issuance under the ESPP. For the years ended December 31,
2010, 2011 and 2012 the Company sold 287,597, 282,816 and 422,260
shares, respectively, of its common stock to employees
participating in the ESPP. The ESPP purchase for the period ending
December 31, 2012 was initiated prior to year end but did not
settle until January 3, 2013. As a result, the shares sold are
reflected in the ESPP share reserves but is excluded from common
stock outstanding as of December 31, 2012.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 0px; FONT: 1px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">In accordance with ASC
718, share-based payment transactions are recognized as
compensation cost based on the fair value of the instrument on the
date of grant. The Company accounts for non-employee stock-based
compensation expense based on the estimated fair value of the
options, which is determined using the Black-Scholes option
valuation model and amortizes such expense on a straight-line basis
over the service period for time-based awards and over the expected
dates of achievement for performance-based awards. These awards are
subject to re-measurement until service is complete. As of
December 31, 2012, there were options to purchase 243,033
shares of common stock outstanding to
consultants.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">During the years ended
December 31, 2010, 2011 and 2012 the Company recorded
stock-based compensation expense related to its stock award plans
and the ESPP of $13.6 million, $11.2 million, and $13.3 million,
respectively.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Total stock-based
compensation expense recognized in the accompanying statements of
operations is as follows (in thousands):</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 0px; FONT: 6px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"></p>
<table style="TEXT-TRANSFORM: none; TEXT-INDENT: 0px; BORDER-COLLAPSE: collapse; FONT-FAMILY: 'Times New Roman'; LETTER-SPACING: normal; WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="76%"></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="10" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Year Ended
December 31,</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>2010</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Employee-related</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">13,478</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">11,202</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">13,224</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Consultant-related</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">102</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">2</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">68</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Total</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">13,580</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">11,204</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">13,292</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Total stock-based
compensation expense recognized in the accompanying statements of
operations is included in the following categories (in
thousands):</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 0px; FONT: 6px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"></p>
<table style="TEXT-TRANSFORM: none; TEXT-INDENT: 0px; BORDER-COLLAPSE: collapse; FONT-FAMILY: 'Times New Roman'; LETTER-SPACING: normal; WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="76%"></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="10" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Year Ended
December 31,</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>2010</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Research and
development</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">7,926</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">5,366</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">6,167</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">General and
administrative</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">5,654</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">5,838</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">7,125</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Total</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">13,580</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">11,204</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">13,292</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">The Company uses the
Black-Scholes option valuation model to estimate the grant date
fair value of employee stock options. The expected term of an
option granted is based on combining historical exercise data with
expected weighted time outstanding. Expected weighted time
outstanding is calculated by assuming the settlement of outstanding
awards is at the midpoint between the remaining weighted average
vesting date and the expiration date.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">The Company estimates
volatility using the historical volatility of its stock. The
Company has selected risk-free interest rates based on U.S.
Treasury securities with an equivalent expected term in effect on
the date the options were granted. Additionally, the Company uses
historical data and management judgment to estimate stock option
exercise behavior and employee turnover rates to estimate the
number of stock option awards that will eventually vest. The
Company calculated the fair value of employee stock options granted
during the years ended December 31, 2010, 2011 and 2012 using
the following assumptions:</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 0px; FONT: 6px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"></p>
<table style="TEXT-TRANSFORM: none; TEXT-INDENT: 0px; BORDER-COLLAPSE: collapse; FONT-FAMILY: 'Times New Roman'; LETTER-SPACING: normal; WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="52%"></td>
<td valign="bottom" width="2%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="2%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="2%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="10" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Year Ended
December 31,</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>2010</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Risk-free interest
rate</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">0.74% — 3.14%</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">0.10% — 2.43%</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">0.32% — 1.16%</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Expected lives</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">2.6 — 6.1 years</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">1.1 — 6.1
years</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">1.4 — 6.1
years</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Volatility</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">78% — 102%</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">76% — 83%</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">70% — 84%</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Dividends</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">—    </font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">—    </font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">—    </font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
</table>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 0px; FONT: 1px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">The following table
summarizes information about stock options
outstanding:</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 0px; FONT: 6px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"></p>
<table style="TEXT-TRANSFORM: none; TEXT-INDENT: 0px; BORDER-COLLAPSE: collapse; FONT-FAMILY: 'Times New Roman'; LETTER-SPACING: normal; WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="71%"></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Number</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>of</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Shares</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Weighted</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Average</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Exercise</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Price</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>per Share</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Aggregate</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Intrinsic</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Value ($000)</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Outstanding at January 1,
2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">10,082,351</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">5.67</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">168</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Granted</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">9,795,600</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">1.81</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Exercised</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">(3,216</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">2.86</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Forfeit</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">(715,131</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">3.96</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Expired</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">(485,065</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">15.17</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Outstanding at
December 31, 2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">18,674,539</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">3.46</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">4,867</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Vested and expected to
vest at December 31, 2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">17,546,663</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">3.53</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">4,867</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Exercisable at
December 31, 2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">7,199,768</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">5.26</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">602</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
</table>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">The weighted average
grant date fair value of the stock options granted during the years
ended December 31, 2010, 2011 and 2012 was $4.06, $2.04, and
$0.99 per option, respectively. The total intrinsic value of
options exercised during the years ended December 31, 2010,
2011 and 2012 was $1.6 million, $443,000, and $1,000, respectively.
Intrinsic value is measured using the fair market value at the date
of exercise (for options exercised) or at December 31 (for
outstanding options), less the applicable exercise
price.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Cash received from the
exercise of options during the years ended December 31, 2010,
2011 and 2012 was approximately $924,000, $625,000, and $9,200,
respectively. The weighted-average remaining contractual terms for
options outstanding, vested and expected to vest, and exercisable
at December 31, 2012 was 8.1 years, 8.0 years and 6.5 years,
respectively.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">A summary of restricted
stock unit activity for the year ended December 31, 2012 is
presented below:</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 0px; FONT: 6px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"></p>
<table style="TEXT-TRANSFORM: none; TEXT-INDENT: 0px; BORDER-COLLAPSE: collapse; FONT-FAMILY: 'Times New Roman'; LETTER-SPACING: normal; WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="80%"></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Number</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>of</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Shares</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Weighted</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Average</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Grant Date</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Fair
Value</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>per
Share</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Outstanding at January 1,
2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">4,137,688</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">4.47</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Granted</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">1,371,455</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">2.25</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Vested</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">(1,277,572</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">4.25</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Forfeited</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">(470,540</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">4.49</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Outstanding at December
31, 2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">3,761,031</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">3.73</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
</table>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">The total restricted
stock units expected to vest as of December 31, 2012 was
3,254,819 with a weighted average grant date fair value of $3.74.
The total intrinsic value of restricted stock units expected to
vest as of December 31, 2012 was $7.5 million. Intrinsic value
of restricted stock units expected to vest is measured using the
closing share price at December 31, 2012.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Total intrinsic value of
restricted stock units vested during the years ended
December 31, 2010, 2011 and 2012 was $10.5 million, $1.7
million, and $2.9 million, respectively. Intrinsic value of
restricted stock units vested is measured using the closing share
price on the day prior to the vest date. The total fair value of
restricted stock units vested during the years ended
December 31, 2010, 2011 and 2012 was $11.4 million, $1.6
million, and $3.0 million, respectively.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 0px; FONT: 1px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">As of December 31,
2012, there was $12.2 million and $7.8 million of unrecognized
compensation expense related to options and restricted stock units,
respectively, which is expected to be recognized over the weighted
average vesting period of 2.3 years. The Company evaluates stock
awards with performance conditions as to the probability that the
performance conditions will be met and estimates the date at which
the performance conditions will be met in order to properly
recognize stock-based compensation expense over the requisite
service period. As of December 31, 2012, there was $107,000
and $3.7 million of unrecognized expenses related to
performance-based options and restricted stock units, respectively,
for milestones not considered probable of
achievement.</font></font></p>
</div>
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Fair Value
of Financial Instruments</i> — The Company utilizes fair
value measurement guidance prescribed by GAAP to value its
financial instruments. The guidance includes a definition of fair
value, prescribes methods for measuring fair value, establishes a
fair value hierarchy based on the inputs used to measure fair value
and expands disclosures about the use of fair value measurements.
The valuation techniques utilized are based upon observable and
unobservable inputs. Observable inputs reflect market data obtained
from independent sources, while unobservable inputs reflect
internal market assumptions. These two types of inputs create the
following fair value hierarchy:</font></p>
<p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px; MARGIN-LEFT: 4%">
<font style="FONT-FAMILY: Times New Roman" size="2">Level 1 – Quoted prices for identical
instruments in active markets.</font></p>
<p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px; MARGIN-LEFT: 4%">
<font style="FONT-FAMILY: Times New Roman" size="2">Level 2 – Quoted prices for similar instruments
in active markets; quoted prices for identical or similar
instruments in markets that are not active; and model-derived
valuations whose inputs are observable or whose significant value
drivers are observable.</font></p>
<p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px; MARGIN-LEFT: 4%">
<font style="FONT-FAMILY: Times New Roman" size="2">Level 3 – Significant inputs to the valuation
model are unobservable.</font></p>
</div>
-1237000
470540
<div>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">A summary of restricted
stock unit activity for the year ended December 31, 2012 is
presented below:</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 0px; FONT: 6px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; LETTER-SPACING: normal; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
</p>
<table style="TEXT-TRANSFORM: none; TEXT-INDENT: 0px; BORDER-COLLAPSE: collapse; FONT-FAMILY: 'Times New Roman'; LETTER-SPACING: normal; WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="80%"></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="4%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Number</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>of</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Shares</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: rgb(0,0,0) 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Weighted</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Average</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Grant Date</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>Fair
Value</b></font><br />
<font style="FONT-FAMILY: 'Times New Roman'" size="1"><b>per
Share</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Outstanding at January 1,
2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">4,137,688</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">4.47</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Granted</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">1,371,455</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">2.25</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Vested</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">(1,277,572</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">4.25</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 2em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Forfeited</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">(470,540</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">4.49</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Outstanding at December
31, 2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">3,761,031</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: 'Times New Roman'" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: 'Times New Roman'" size="2">3.73</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: 'Times New Roman'" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: rgb(0,0,0) 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
</table>
<font style="FONT-FAMILY: Times New Roman" size="2"><br class="Apple-interchange-newline" /></font></div>
<div>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: Times New Roman" size="2"><b>7. Senior convertible
notes</b></font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Senior
convertible notes consist of the following (in
thousands):</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="82%"></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="6" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>December 31,</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2"><b>2013
notes</b></font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Principal amount</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">115,000</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">115,000</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Unaccreted debt issuance
expense</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(1,140</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(557</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Net carrying
amount</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">113,860</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">114,443</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2"><b>2015
notes</b></font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
<td valign="bottom"></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Principal amount</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">100,000</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">100,000</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Unaccreted debt issuance
expense</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(3,218</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(2,417</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Net carrying
amount</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">96,782</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">97,583</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Senior convertible
notes</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">210,642</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">212,026</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
<font size="1"> </font></p>
<p style="MARGIN-TOP: 0px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">On
August 18, 2010, the Company completed a Rule 144A offering of
$100.0 million aggregate principal amount of 5.75% Senior
Convertible Notes due 2015 (the “2015 notes”). The 2015
notes are governed by the terms of an indenture dated as of
August 24, 2010 (the “2015 Note Indenture”). The
2015 notes bear interest at the rate of 5.75% per year on the
principal amount, payable in cash semi-annually in arrears on
February 15 and August 15 of each year, beginning
February 15, 2011. The Company had accrued interest of $2.2
million as of December 31, 2011 and 2012 related to the 2015
notes. The 2015 notes are general, unsecured, senior obligations of
the Company and effectively rank junior in right of payment to all
of the Company’s secured debt, to the extent of the value of
the assets securing such debt, and to the debt and all other
liabilities of the Company’s subsidiaries. The maturity date
of the 2015 notes is August 15, 2015 and payment is due in
full on that date for unconverted securities. Holders of the 2015
notes may convert, at any time prior to the close of business on
the business day immediately preceding the stated maturity date,
any outstanding principal into shares of the Company’s common
stock at an initial conversion rate of 147.0859 shares per $1,000
principal amount, which is equal to a conversion price of
approximately $6.80 per share, subject to adjustment. Except in
certain circumstances, if the Company undergoes a fundamental
change: (1) the Company will pay a make-whole premium on the
2015 notes converted in connection with a fundamental change by
increasing the conversion rate on such Notes, which amount, if any,
will be based on the Company’s common stock price and the
effective date of the fundamental change, and (2) each holder
of 2015 notes will have the option to require the Company to
repurchase all or any portion of such holder’s Notes at a
repurchase price of 100% of the principal amount of the Notes to be
repurchased plus accrued and unpaid interest, if any. The Company
may elect to redeem some or all of the 2015 notes if the closing
stock price has equaled 150% of the conversion price for at least
20 of the 30 consecutive trading days ending on the trading day
before the Company’s redemption notice. The redemption price
will equal 100% of the principal amount of the 2015 notes to be
redeemed, plus accrued and unpaid interest, if any, to, but
excluding, the redemption date, plus a make-whole payment equal to
the sum of the present values of the remaining scheduled interest
payments through and including August 15, 2015 (other than
interest accrued up to, but excluding, the redemption date). The
Company will be obligated to make the make-whole payment on all the
2015 notes called for redemption and converted during the period
from the date the Company mailed the notice of redemption to and
including the redemption date. The Company may elect to make the
make-whole payment in cash or shares of its common stock, subject
to certain limitations. Under the terms of the 2015 Note Indenture,
the conversion option can be net-share settled and the maximum
number of shares that could be required to be delivered under the
contract, including the make-whole shares, is fixed and less than
the number of authorized and unissued shares less the maximum
number of shares that could be required to be delivered during the
contract period under existing commitments. Applying the
Company’s sequencing policy, the Company performed an
analysis at the time of the offering of the 2015 notes and each
reporting date since and concluded that the number of available
authorized shares at the time of the offering and each subsequent
reporting date was sufficient to deliver the number of shares that
could be required to be delivered during the contract period under
existing commitments.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The Company
incurred approximately $4.2 million in issuance costs which are
recorded as an offset to the 2015 notes in the accompanying
condensed consolidated balance sheets. These costs are being
charged to interest expense using the effective interest method
over the term of the 2015 notes.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">On
December 12, 2006, the Company completed an offering of $115.0
million aggregate principal amount of 3.75% Senior Convertible
Notes due 2013 (the “2013 notes”), including $15.0
million aggregate principal amount of the 2013 notes sold pursuant
to the underwriters’ over-allotment option that was exercised
in full. The 2013 notes are governed by the terms of an indenture
dated as of November 1, 2006 and a First Supplemental
Indenture, dated as of December 12, 2006 (the “2013 Note
Indenture”). The 2013 notes bear interest at the rate of
3.75% per year on the principal amount, payable in cash
semi-annually in arrears on June 15 and December 15 of
each year, beginning June 15, 2007. The Company had accrued
interest of $192,000 as of December 31, 2011 and 2012. The
2013 notes are general, unsecured, senior obligations of the
Company and effectively rank junior in right of payment to all of
the Company’s secured debt, to the extent of the value of the
assets securing such debt, and to the debt and all other
liabilities of the Company. The maturity date of the 2013 notes is
December 15, 2013 and payment is due in full on that date for
unconverted securities. Holders may convert, at any time prior to
the close of business on the business day immediately preceding the
stated maturity date, any outstanding 2013 notes into shares of the
Company’s common stock at an initial conversion rate of
44.5002 shares per $1,000 principal amount of 2013 notes, which is
equal to a conversion price of approximately $22.47 per share,
subject to adjustment. Except in certain circumstances, if the
Company undergoes a fundamental change: (1) the Company will
pay a make-whole premium on the 2013 notes converted in connection
with a fundamental change by increasing the conversion rate on such
2013 notes, which amount, if any, will be based on the
Company’s common stock price and the effective date of the
fundamental change, and (2) each holder of the 2013 notes will
have the option to require the Company to repurchase all or any
portion of such holder’s 2013 notes at a repurchase price of
100% of the principal amount of the 2013 notes to be repurchased
plus accrued and unpaid interest, if any. Under the terms of the
2013 Note Indenture, the conversion option can be net-share settled
and the maximum number of shares that could be required to be
delivered under the contract, including the make-whole shares, is
fixed and less than the number of authorized and unissued shares
less the maximum number of shares that could be required to be
delivered during the contract period under existing commitments.
Applying the Company’s sequencing policy, the Company
performed an analysis at the time of the offering of the 2013 notes
and each reporting date since and concluded that the number of
available authorized shares at the time of the offering and each
subsequent reporting date was sufficient to deliver the number of
shares that could be required to be delivered during the contract
period under existing commitments.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The Company
incurred approximately $3.7 million in debt issuance costs which
are recorded as an offset to the debt in the accompanying balance
sheet. These costs are being charged to interest expense using the
effective interest method over the term of the 2013
notes.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Accretion of
debt issuance expense in connection with the Notes offerings during
the years ended December 31, 2011 and 2012 were $1.3 million
and $1.4 million, respectively.</font></p>
</div>
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Interest
Expense</i> — Interest costs are expensed as incurred, except
to the extent such interest is related to construction in progress,
in which case interest is capitalized. Interest expense, net of
interest capitalized, for the years ended December 31, 2010,
2011 and 2012 was $17.4 million, $21.8 million and $21.6 million,
respectively. Interest costs capitalized was not significant for
the year ended December 31, 2010 and were $0.4 million and
$0.3 million for the years ended December 31, 2011 and 2012,
respectively.</font></p>
</div>
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Goodwill and
Identifiable Intangibles</i> — As a result of the merger with
AlleCure and CTL on December 12, 2001, as described in Note 1,
goodwill of $151.4 million was recorded at the entity level in
2001. Upon adoption of ASC 350-10 <i>Intangibles- Goodwill and
Other,</i> the Company adopted a policy of testing goodwill and
intangible assets with indefinite lives for impairment at least
annually, as of December 31, with any related impairment
losses being recognized in earnings when identified. In December
2002 the Company concluded that the major AlleCure product
development program should be terminated and that the clinical
trials of the CTL product should be halted and returned to the
research stage. As a result of this determination, the Company
closed the CTL facility and reduced headcount for AlleCure and CTL
by approximately 50%. In connection with the annual test for
impairment of goodwill as of December 31, 2002, the Company
determined that on the basis of the internal study, the goodwill
recorded for the AlleCure and CTL units was potentially impaired.
The Company performed the second step of the annual impairment test
as of December 31, 2002 for each of the potentially impaired
reporting units and estimated the fair value of the AlleCure and
CTL programs using the expected present value of future cash flows
which were expected to be negligible. Accordingly, the goodwill
balance of $151.4 million was determined to be fully impaired and
an impairment loss was recorded in 2002. Subsequent to
December 31, 2002, the Company had no goodwill or intangibles
with indefinite lives included on its balance sheets.</font></p>
</div>
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The following
roll-forward provides a summary of the changes in fair value of the
Company’s Level 3 forward purchase contracts during the year
ended December 31, 2012 (in thousands) :</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="61%"></td>
<td valign="bottom" width="11%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="11%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="11%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>The February 2012<br />
Forward Purchase<br />
Contract</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>The October 2012<br />
Forward Purchase<br />
Contract</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Total</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Beginning
Balance</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Issuance</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">1,080</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">28,237</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">29,317</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Adjustments to fair value
included in other income (expense)</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">12,011</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(13,248</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(1,237</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Transfers to additional
paid-in-capital</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(13,091</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(14,989</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(28,080</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Ending Balance</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">—</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom"> </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
</div>
21600000
0.99
-48000
167735000
166864000
16000000
128324123
-1237000
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Basis of
Presentation</i> — The Company is considered to be in the
development stage as its primary activities and since incorporation
has been establishing its facilities, recruiting personnel,
conducting research and development, business development, business
and financial planning, and raising capital. It is costly to
develop therapeutic products and conduct clinical trials for the
Company’s products. Since its inception through
December 31, 2012, the Company has reported accumulated net
losses of $2.1 billion, which include a goodwill impairment charge
of $151.4 million (see Note 2), and cumulative negative cash flow
from operations of $1.6 billion. At December 31, 2012,
the Company’s capital resources consisted of cash and cash
equivalents of $61.8 million.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">In October
2007, the Company entered into a $350.0 million loan arrangement
with its principal stockholder, The Mann Group, LLC (“The
Mann Group”). In December 2012, the Company amended and
restated the promissory note underlying the loan arrangement to,
among other things, extend the maturity date of the promissory note
to January 1, 2014, extend the date through which the Company
can borrow under the promissory note to September 30, 2013,
and adjust the annual interest rate on all outstanding principal to
the one-year London Interbank Offered Rate (LIBOR) on
December 31, 2012 plus 5%, effective January 1, 2013 (see
Note 6 — Related-party arrangements).</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">In October
2012, concurrently with an underwritten public offering (see Note
10 — Common and preferred stock), The Mann Group agreed to
purchase $107.4 million worth of restricted shares of common stock
and restricted warrants in exchange for cancellation of principal
under the $350.0 million amended and restated promissory note, the
closing of which was completed in December 31, 2012. Following
the cancellation of the principal amount and the capitalization of
the accrued and unpaid interest, the total principal amount
outstanding under the amended and restated promissory note was
$119.6 million, and the Company had $125.4 million available for
borrowing under the amended and restated promissory note (see Note
6 — Related-party arrangements). On December 15, 2013,
$115.0 million aggregate principal will be due under the 3.75%
Senior Convertible Notes for unconverted securities on that date
(see Note 7 — Senior convertible notes).</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Based upon the
Company’s current expectations, management believes the
Company’s existing capital resources, including the available
borrowings under our loan arrangement with The Mann Group, as
amended, will enable it to continue planned operations through at
least the third quarter of 2013. However, the Company cannot
provide assurances that its plans will not change or that changed
circumstances will not result in the depletion of its capital
resources more rapidly than it currently anticipates. The Company
will need to raise additional capital, whether through the sale of
equity or debt securities, a strategic business collaboration with
a pharmaceutical company, the establishment of other funding
facilities, licensing arrangements, asset sales or other means, in
order to continue the development and commercialization of AFREZZA
and other product candidates and to support its other ongoing
activities. However, the Company cannot provide assurances that
such additional capital will be available whether through the sale
of equity or debt securities, a strategic business collaboration
with a pharmaceutical company, the establishment of other funding
facilities, licensing arrangements, asset sales or other means.
This raises substantial doubt about the Company’s ability to
continue as a going concern. The financial statements do not
include any adjustments that might result from the outcome of these
uncertainties.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">On
December 12, 2001, the stockholders of AlleCure Corp.
(“AlleCure”) and CTL ImmunoTherapies Corp.
(“CTL”) voted to exchange their shares for shares of
Pharmaceutical Discovery Corporation (“PDC”).
Upon</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: Times New Roman" size="2">approval of the merger, PDC
then changed its name to MannKind Corporation. PDC was incorporated
in the State of Delaware on February 14, 1991. The
stockholders of PDC did not vote on the merger. At the date of the
merger, Mr. Alfred Mann owned 76% of PDC, 59% of AlleCure and
69% of CTL. Accordingly, only the minority interest of AlleCure and
CTL was stepped up to fair value using the purchase method of
accounting. As a result of this purchase accounting, in-process
research and development of $19.7 million and goodwill of $151.4
million were recorded at the entity level. The historical basis of
PDC and the historical basis relating to the ownership interests of
Mr. Mann in AlleCure and CTL have been reflected in the
financial statements. For periods prior to December 12, 2001,
the results of operations have been presented on a combined basis.
All references in the accompanying financial statements and notes
to the financial statements to number of shares, sales price and
per share amounts of the Company’s capital stock have been
retroactively restated to reflect the share exchange ratios for
each of the entities that participated in the merger.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">For periods
subsequent to December 12, 2001, the accompanying financial
statements have been presented on a consolidated basis and include
the wholly-owned subsidiaries, AlleCure and CTL. On
December 31, 2002, AlleCure and CTL merged with and into
MannKind and ceased to be separate entities.</font></p>
</div>
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Business</i>
— MannKind Corporation and subsidiaries (the
“Company”) is a biopharmaceutical company focused on
the discovery, development and commercialization of therapeutic
products for diseases such as diabetes. The Company’s lead
product candidate, AFREZZA, (insulin human [rDNA origin])
inhalation powder, is an ultra rapid-acting insulin therapy that is
in late-stage clinical investigation for the treatment of adults
with type 1 or type 2 diabetes for the control of
hyperglycemia.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">AFREZZA
consists of the Company’s proprietary Technosphere particles
onto which insulin molecules are loaded. These loaded particles are
then aerosolized and inhaled deep into the lung using the
Company’s AFREZZA inhaler.</font></p>
</div>
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Accounts
Payable and Accrued Expenses</i> — All liabilities, including
accounts payable and accrued expenses, are recorded consistent with
the definition of liabilities and accrual
accounting<i>.</i></font></p>
</div>
<div>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 12px; TEXT-INDENT: 0px; LETTER-SPACING: normal; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><b><font style="FONT-FAMILY: 'Times New Roman'" size="2"><b>10. Common and
preferred stock</b></font></b></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; LETTER-SPACING: normal; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2"><i>Private
Placements </i>— On August 5,
2005, the Company closed a $175.0 million private placement of
common stock and the concurrent issuance of warrants for the
purchase of additional shares of common stock to accredited
investors including the Company’s principal stockholder who
purchased $87.3 million of the private placement. The Company sold
17,132,000 shares of common stock in the private placement,
together with warrants to purchase up to 3,426,000 shares of common
stock at an exercise price of $12.228 per share which became
exercisable on February 1, 2006 and expired on August 5,
2010. In connection with this private placement, the Company paid
$4.5 million in commissions to the placement agents and incurred
$300,000 in other offering expenses which resulted in net proceeds
of approximately $170.2 million.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; LETTER-SPACING: normal; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2"><i>Public Equity
Offerings </i>— On August 5,
2009, the Company sold 8,360,000 shares of its common stock,
including 960,000 shares sold pursuant to the full exercise of an
over-allotment option granted to the underwriters of the offering,
at a public offering price of $7.35 per share. The Company’s
principal stockholder purchased 1,000,000 of these shares from the
underwriters at a price per share of $8.11. The sale of common
stock resulted in aggregate net proceeds to the Company of
approximately $59.7 million after deducting offering
expenses.</font></font></p>
<p style="PADDING-BOTTOM: 0px; TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; LETTER-SPACING: normal; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Included in the common
stock outstanding as of December 31, 2010, 2011 and 2012 are
9,000,000 shares of common stock loaned to Bank of America under a
share lending agreement in connection with the offering of the
$100.0 million aggregate principal amount of 2015 notes (see Note
7). Bank of America is obligated to return the borrowed shares (or,
in certain circumstances, the cash value thereof) to the Company on
or about the 45</font><font style="FONT-FAMILY: 'Times New Roman'" size="1"><sup style="POSITION: relative; BOTTOM: 0.8ex; VERTICAL-ALIGN: baseline">th</sup></font><font style="FONT-FAMILY: 'Times New Roman'" size="2"> business
day following the date as of which the entire principal amount of
the notes ceases to be outstanding, subject to extension or
acceleration in certain circumstances or early termination at Bank
of America’s option. The Company did not receive any proceeds
from the sale of the borrowed shares by Bank of America, but the
Company did receive a nominal lending fee of $0.01 per share from
Bank of America for the use of borrowed shares.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 0px; LETTER-SPACING: normal; FONT: 1px 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"> </font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 0px; TEXT-INDENT: 2%; LETTER-SPACING: normal; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">On August 10, 2010,
the Company entered into an agreement with Seaside for the sale of
up to 18,200,000 shares of common stock in increments of 700,000
shares on a bi-weekly basis with the first closing date scheduled
for September 22, 2010 provided that certain conditions are
met, including for a particular closing to take place, the ten-day
volume weighted average trading price for the Company’s
common stock immediately prior to such closing must be at least
$6.50 per share. If the ten-day volume weighted average trading
price for a particular closing was below $6.50 per share, then that
closing did not occur and the aggregate number of shares to be
purchased was reduced by 700,000 shares. The purchase price per
share at each closing was equal to 92% of that 10-day volume
weighted average price. During the years ended December 31,
2010 and 2011, the Company issued and sold a total of 2,100,000 and
1,400,000 shares of common stock, respectively, to Seaside for net
proceeds of $14.1 million and $9.7 million, respectively, in
accordance with the agreement. The agreement with Seaside
terminated during the quarter ended September 30, 2011. During
the agreement, the Company issued and sold a total of 3,500,000
shares of common stock to Seaside for net proceeds of $23.8
million. In conjunction with the Seaside agreement, on
August 10, 2010, the Company entered into a common stock
purchase agreement with The Mann Group. Under this common stock
purchase agreement, the Company was required to issue and sell, and
The Mann Group was obligated to purchase at a price equal to the
greater of $7.15 per share (the closing bid price of the
Company’s common stock on August 10, 2010) and the
closing bid price of common stock on the trading day immediately
preceding the applicable closing date, the same number of shares of
the Company’s common stock that Seaside purchased on each
closing date under its agreement with the Company (see Note 6).
Concurrently with the Seaside closing, the Company issued and sold
2,100,000 and 1,400,000 shares to The Mann Group as of
December 31, 2010 and 2011, respectively, for a total purchase
price of $16.7 million and $11.1 million, respectively, which was
paid by the cancellation of outstanding principal under the
Company’s loan agreement with The Mann Group. The agreement
with The Mann Group terminated during the quarter ended
September 30, 2011. During the agreement, the Company issued
and sold a total of 3,500,000 shares of common stock to The Mann
Group that had resulted in total reduction in the note payable to
related party of $27.8 million.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; LETTER-SPACING: normal; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">On February 8, 2012,
the Company sold 35,937,500 units in an underwritten public
offering, including 4,687,500 units sold pursuant to the full
exercise of an over-allotment option granted to the underwriters,
with each unit consisting of one share of common stock and a
warrant to purchase 0.6 of a share of common stock. All of the
securities were offered by the Company at a combined price to the
public of $2.40 per unit and the underwriters purchased the units
at a price of $2.256 per unit. Net proceeds from this offering were
approximately $80.6 million, excluding any warrant exercises. The
21,562,500 shares of common stock underlying the warrants are
exercisable at $2.40 per share and expire four years from the date
of the issuance. The shares of common stock and warrants are
immediately separable and were issued separately. Concurrent with
the February 2012 underwritten public offering, the Company entered
into a common stock purchase agreement with The Mann Group,
pursuant to which the Company agreed to sell and The Mann Group
agreed to purchase 31,250,000 shares of the Company’s
restricted common stock at a price of $2.47 per share, the closing
of which was subject to the expiration or termination of the
waiting period under the Hart-Scott-Rodino Antitrust Improvements
Act of 1976, as amended (“HSR Clearance”), and the
Company’s receipt of stockholder approval to increase the
authorized number of shares of our common stock. In June 2012,
following HSR Clearance and the Company’s receipt of such
stockholder approval, The Mann Group purchased $77.2 million worth
of restricted shares of common stock which were paid through the
cancellation of principal indebtedness under the revolving amended
loan arrangement with The Mann Group (see Note 6 —
Related-party arrangements).</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; LETTER-SPACING: normal; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">The Company concluded
that The Mann Group common stock purchase agreement represented a
contingent forward purchase contract that met the definition of a
derivative instrument in accordance with ASC 815 <i>Derivatives and Hedging
(“ASC 815”). </i>Of the 31,250,000 shares
issuable pursuant to the common stock purchase agreement, the
portion of the derivative instrument representing 14.7 million
shares were recorded as equity (“Equity Portion”) as
they met the criteria for equity classification under ASC
815-40 <i>Derivatives
and</i> <i>Hedging,
Contracts in an Entity’s Own Stock. </i>The remaining
16.5 million shares (“Non-Equity Portion”)
required classification outside of equity as the Company did not
have sufficient available shares at the time of issuance. The
Company revalued the Non-Equity Portion of the forward purchase
contract at each reporting date and recorded a fair value
adjustment within “Other income (expense)”. At the
time of issuance, the fair value of the forward purchase contract
was $2.0 million. The Equity Portion of $0.9 million
was classified as equity, and the Non-Equity Portion of $1.1
million was initially recorded to “Prepaid expenses and
other current assets.”</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; LETTER-SPACING: normal; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">On May 17, 2012, the
Company’s stockholders approved an increase in its authorized
shares of common stock from 250,000,000 to 350,000,000.
Accordingly, the shares of common stock needed to consummate The
Mann Group common stock purchase agreement dated February 2,
2012 became available. As of May 17, 2012, the fair value
of the Non-Equity Portion was $13.1 million. As of result of
receiving stockholder approval of the increase in authorized
shares, the Non-Equity Portion met the criteria for equity
classification. Consequently, the Company reclassified the $13.1
million from “Prepaid expenses and other current
assets” to “Additional paid-in
capital.”</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; LETTER-SPACING: normal; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">The fair value of the
forward purchase contract is highly sensitive to the discount
applied for lack of marketability and the stock price, and changes
in this discount and/or the stock price caused the value of the
forward purchase contract to change significantly. As of and for
the year ended December 31, 2012, the Company recognized the
change in fair value of $12.0 million in “Other income
(expense).” The Company revalued the Non-Equity Portion using
a forward contract valuation formula, in which the forward contract
was estimated to be equal to the valuation date stock price of
$2.40 at issuance and $1.69 at May 17, 2012 minus the strike
price discounted to the valuation date using a risk-free rate of
0.08% at issuance and 0.18% at May 17, 2012. As the
shares which would be received upon settlement were unregistered,
the Company applied a discount for lack of marketability of 2.57%
at issuance and 0.42% at May 17, 2012 based on quantitative
put models, adjusted to take into account qualitative factors,
including the fact that the Company’s stock was publicly
traded and the fact that there was no contractual restriction on
the unregistered shares being registered.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; LETTER-SPACING: normal; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">In October 2012, pursuant
to a previously filed Shelf Registration, which was declared
effective by the SEC on September 24, 2012, the Company sold
in an underwritten public offering 40,000,000 shares of its common
stock, together with warrants to purchase up to 30,000,000 shares
of the Company’s common stock. In addition, the Company sold
pursuant to the full exercise of an over-allotment option granted
to the underwriters, an additional 6,000,000 shares of common stock
, together with warrants to purchase up to an aggregate of
4,500,000 shares of common stock. All of the securities were sold
together with a warrant for a combined purchase price of $2.00 per
unit. The shares of common stock and warrants are immediately
separable and were issued separately. Net proceeds from this
offering were approximately $86.3 million (after deducting
discounts and commissions to the underwriters and offering
expenses), excluding any future proceeds from the exercise of the
warrants. Each warrant entitles the holder to purchase 0.75 of a
share of common stock. The warrants are exercisable at $2.60 per
share and will expire in October 2013. The Company performed an
analysis of the warrants to determine their appropriate
classification and concluded that the warrants should be classified
within equity.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; LETTER-SPACING: normal; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">Concurrent with the
underwritten public offering, the Company entered into a Common
Stock and Warrant Purchase agreement, in which the Company was
required to issue and sell and The Mann Group was obligated to
purchase 40,000,000 restricted shares of the Company’s common
stock and 40,000,000 warrants to purchase up to an aggregate of
30,000,000 restricted shares of the Company’s common stock in
a separate private placement. The restricted shares were sold to
The Mann Group at $2.59 per share (the consolidated closing bid
price of the Company’s common stock on October 17,
2012), and the warrants were sold to The Mann Group at a purchase
price of $0.125 for each share of the Company’s common stock
underlying the warrants, in exchange for cancellation of
outstanding principal under the $350 million amended and restated
promissory note with The Mann Group. The restricted shares and
warrants were sold to The Mann Group for an aggregate purchase
price of $107.4 million. Following receipt of stockholder approval,
in December 2012, to increase the Company’s authorized shares
of common stock from 350,000,000 to 550,000,000, the Common Stock
and Warrant Purchase agreement was consummated, and the shares of
common stock and warrants were issued to The Mann
Group.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; LETTER-SPACING: normal; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">On the date the Common
Stock and Warrant Purchase agreement was entered into with The Mann
Group, the Company did not have a sufficient number of authorized,
unissued and available common shares to satisfy their commitments
under this agreement. The Company characterized the Common Stock
and Warrant Purchase agreement as a forward contract, in accordance
with ASC 815-40, to deliver a single unit comprising 40,000,000
shares of restricted common stock and 40,000,000 warrants to
purchase 30,000,000 shares of restricted common stock that should
be classified as assets or liabilities accounted for at fair
value.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; LETTER-SPACING: normal; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">At the time of issuance,
the Company determined the fair value of the forward contract to be
$28.2 million and recorded a current asset. On December 20,
2012, the date at which a sufficient number of authorized and
unissued common shares became available following approval by the
stockholders to increase its authorized shares of common stock, the
Company re-valued the forward contract and recorded a fair value
adjustment to “Other income (expense)” of $13.2 million
expense. Therefore, having met the criteria for equity
classification, the Company reclassified the remaining balance of
the forward contract of $15.0 million to additional paid in
capital. In addition, the Company performed an analysis of the
warrants to determine their appropriate classification once the
forward contract settled and concluded that the warrants should be
classified within equity.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; LETTER-SPACING: normal; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">The fair value of the
forward purchase contract is highly sensitive to the discount
applied for lack of marketability and the stock price, and changes
in this discount and/or the stock price caused the value of the
Forward Contract to change significantly. The value of the
derivative instrument was calculated using a forward contract
valuation formula in which the forward contract is estimated to be
equal to the valuation date stock price minus the strike price
discounted to the valuation date using a risk-free rate of 0.11% at
issuance on October 18, 2012 and 0.00% at closing on
December 20, 2012. As the shares which would be received
upon settlement are currently unregistered, the Company applied a
discount for lack of marketability of 2.3% at October 18, 2012
and 1.5% at December 20, 2012 to reflect this lack of
marketability based on quantitative put models, adjusted to take
into account qualitative factors, including the fact that the
Company’s stock is publicly traded and the fact that there is
no contractual restriction on the unregistered shares being
registered.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; LETTER-SPACING: normal; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">The Company then
determined that upon the settlement of the forward contracts, the
common stock and warrants represent freestanding financial
instruments and should be initially recorded at their relative fair
values based on the total consideration received. The total
consideration received equaled the $107.4 million principal amount
of indebtedness cancelled less the recorded value of the forward
contracts on December 20, 2012, the date immediately before
settlement.</font></font></p>
<p style="TEXT-TRANSFORM: none; MARGIN-TOP: 6px; TEXT-INDENT: 2%; LETTER-SPACING: normal; FONT: medium 'Times New Roman'; WHITE-SPACE: normal; MARGIN-BOTTOM: 0px; COLOR: rgb(0,0,0); WORD-SPACING: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><font style="FONT-FAMILY: 'Times New Roman'" size="2">The Company is authorized
to issue 550,000,000 shares of common stock, par value $0.01 per
share, and 10,000,000 shares of undesignated preferred stock, par
value $0.01 per share, issuable in one or more series designated by
the Company’s board of directors. No other class of capital
stock is authorized. As of December 31, 2011 and 2012,
131,522,945 and 286,035,082 shares of common stock, respectively,
were issued and outstanding and no shares of preferred stock were
outstanding.</font></font></p>
</div>
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Recently
Issued Accounting Standards —</i> In June 2011, the FASB
issued Accounting Standards Update (“ASU”)
No. 2011-05, <i>Comprehensive Income (Topic 220):
“Presentation of Comprehensive Income.”</i> This update
improves the comparability, consistency and transparency of
financial reporting and increases the prominence of items reported
in other comprehensive income. This update is effective for interim
and annual periods beginning after December 15, 2011. In
December 2011, the FASB issued ASU No. 2011-12,
<i>Comprehensive Income (Topic 220): Deferral of the Effective Date
for Amendments to the Presentation of</i> <i>Reclassifications of
Items Out of Accumulated Other Comprehensive Income in ASU
No. 2011-05.</i> This update deferred only those changes in
ASU No. 2011-05 that related to the presentation of
reclassification adjustments. In February 2013, the FASB issued ASU
2013-02, <i>Comprehensive Income (Topic 220) – Reporting of
Amounts Reclassified Out of Accumulated Other Comprehensive
Income.</i> These amendments do not change the current requirements
for reporting net income or other comprehensive income in the
financial statements. These amendments provide for additional
disclosure requirements for amounts reclassified out of accumulated
other comprehensive income. These amendments are effective
prospectively for interim and annual periods beginning after
December 15, 2012. Early adoption is permitted. Effective
January 1, 2012, the Company adopted the new requirements as
set forth in ASU No. 2011-05 in the disclosure of
comprehensive income on the Company’s consolidated financial
statements. The Company is evaluating the impact, if any, of the
adoption of ASU No. 2013-02 will have on the Company’s
consolidated financial statements.</font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">In May 2011,
the FASB issued Accounting Standards Update No. 2011-04 for
Fair Value Measurement (Topic 820): “Amendments to Achieve
Common Fair Value Measurement and Disclosure Requirements in U.S.
GAAP and IFRSs”. This update addresses how to measure fair
value and requires new disclosures about fair value measurements.
The amendments in this update are effective for interim and annual
periods beginning after December 15, 2011. Effective the
quarter ended March 31, 2012, the Company adopted the
requirements as set forth in this guidance.</font></p>
</div>
80600000
7500000
90 days or less at the time of purchase
2033
0.25
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Forward
Contracts</i> — The Company has entered into agreements with
The Mann Group whereby the Company agreed to sell and The Mann
Group agreed to purchase common stock and/or warrants. These
agreements have been accounted for as forward contracts, having met
the definition of derivative instruments in accordance with the
provisions of ASC 815 <i>Derivatives and Hedging</i>. The Company
determines the fair value of the forward contract upon its
issuance, records fair value adjustments of the forward contract to
Other income (expense) during the reporting period and through the
settlement of the forward contract, and reclassifies the forward
contract to equity upon settlement of the forward
contract.</font></p>
</div>
2900000
438000
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 4%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Warrants</i>
— The Company has issued warrants to purchase shares of its
common stock. Warrants have been accounted for within equity in
accordance with the provisions of ASC 815-40 Derivatives and
Hedging, Contracts in an Entity’s Own Stock, previously EITF
Issue No. 00-19: Accounting for Derivative Financial Instruments
Indexed to, and Potentially Settled in, a Company’s Own
Stock<i>.</i></font></p>
</div>
P4Y
180855000
184537000
29317000
3002778
-682000
906000
0.65
28080000
P90D
<div>
<p style="MARGIN-TOP: 0px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The principal
amount outstanding under the loan arrangement as of
December 31, 2011 and 2012, respectively, subsequent to the
completion of the common stock purchase agreements was as follows
(in thousands):</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="89%"></td>
<td valign="bottom" width="5%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Principal amount
outstanding at December 31, 2011</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">277,203</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Borrowings</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">12,750</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Capitalization of accrued
and unpaid interest due and payable as of June 27,
2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">11,876</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Reduction of principal
indebtedness related to the issuance of common stock pursuant to
common stock purchase agreement completed on June 27,
2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(77,187</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Capitalization of accrued
and unpaid interest due and payable as of October 18,
2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">2,343</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Reduction of principal
indebtedness related to the issuance of common stock pursuant to
common stock purchase agreement completed on October 18,
2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">(107,350</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">) </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Principal amount
outstanding at December 31, 2012</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">119,635</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
</table>
</div>
-290000
<div>
<p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: Times New Roman" size="2"><b>3. State research and
development credit exchange receivable</b></font></p>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">The State of
Connecticut provides certain companies with the opportunity to
exchange certain research and development income tax credit
carryforwards for cash in exchange for forgoing the carryforward of
the research and development income tax credits. The program
provides for an exchange of research and development income tax
credits for cash equal to 65% of the value of corporation tax
credit available for exchange. Estimated amounts receivable under
the program are recorded as a reduction of research and development
expenses. During the years ended December 31, 2010, 2011 and
2012, research and development expenses were offset by $385,000,
$609,000 and $289,000, respectively, in connection with the
program.</font></p>
</div>
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2"><i>Clinical
Trial Expenses</i> — Clinical trial expenses, which are
reflected in research and development expenses in the accompanying
statements of operations, result from obligations under contracts
with vendors, consultants, and clinical site agreements in
connection with conducting clinical trials. The financial terms of
these contracts are subject to negotiations which vary from
contract to contract and may result in payment flows that do not
match the periods over which materials or services are provided to
the Company under such contracts. The appropriate level of trial
expenses are reflected in the Company’s financial statements
by matching period expenses with period services and efforts
expended. These expenses are recorded according to the progress of
the trial as measured by patient progression and the timing of
various aspects of the trial. Clinical trial accrual estimates are
determined through discussions with internal clinical personnel and
outside service providers as to the progress or state of completion
of trials, or the services completed. Service provider status is
then compared to the contractually obligated fee to be paid for
such services. During the course of a clinical trial, the Company
may adjust the rate of clinical expense recognized if actual
results differ from management’s estimates. The date on which
certain services commence, the level of services performed on or
before a given date and the cost of the services are often
judgmental.</font></p>
</div>
200000
6056000
438000
6056000
800000
<div>
<p style="MARGIN-TOP: 6px; TEXT-INDENT: 2%; MARGIN-BOTTOM: 0px">
<font style="FONT-FAMILY: Times New Roman" size="2">Total
stock-based compensation expense recognized in the accompanying
statements of operations is included in the following categories
(in thousands):</font></p>
<p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; FONT-SIZE: 6px">
 </p>
<table style="BORDER-COLLAPSE: collapse" border="0" cellspacing="0" cellpadding="0" width="100%" align="center">
<tr>
<td width="76%"></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
<td valign="bottom" width="3%"></td>
<td></td>
<td></td>
<td></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="10" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Year Ended
December 31,</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2010</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2011</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2012</b></font></td>
<td valign="bottom"><font size="1"> </font></td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Research and
development</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">7,926</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">5,366</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">6,167</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr>
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">General and
administrative</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">5,654</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">5,838</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">7,125</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 1px solid"> </p>
</td>
<td> </td>
</tr>
<tr bgcolor="#CCEEFF">
<td valign="top">
<p style="TEXT-INDENT: -1em; MARGIN-LEFT: 1em"><font style="FONT-FAMILY: Times New Roman" size="2">Total</font></p>
</td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">13,580</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">11,204</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
<td valign="bottom"><font size="1">  </font></td>
<td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2">$</font></td>
<td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">13,292</font></td>
<td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td>
</tr>
<tr style="FONT-SIZE: 1px">
<td valign="bottom"></td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
<td valign="bottom">  </td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td valign="bottom">
<p style="BORDER-TOP: #000000 3px double"> </p>
</td>
<td> </td>
</tr>
</table>
</div>
7125000
6167000
2013-12-15
13091
1080
12011
14989
28237
-13248
13224000
68000
0.0032
P1Y4M24D
0.70
P13M
2013
P12M
P4M
P5Y
P39Y
P3Y
P5Y
0.0116
P6Y1M6D
0.84
P10Y
P96M
2014
0.045
200000000
P6M
P40Y
P40Y
P15Y
P10Y
1.94
225000
2.18
1000000
1.00
2777778
2777778
3002778
1.00
P4Y
71250000
3000
2000
713000
211000
9000
886000
819000
81938000
2000
225000
13292000
860000
183824000
9000
-915000
166045000
-1237000
436000
6056000
-2000
-48000
-169366000
28080
29317
-1237
-67000
P3Y
8400000
7600000
15000000
86062440
3761031
19826113
18674539
77187000
107350000
10000000
900000
-911000
10000
998000
890000
-911000
23800000
3500000
11100000
3500000
-2000
-2061265000
-1099000
14219000
4418000
3900000
-2267000
952000
-2104918000
1742000
4220000
121800000
137918000
796393000
454000
1467573000
22260000
19726000
3331000
1028000
2758000
126777000
387750000
-1596261000
38825000
-327678000
36996000
26000
4072000
15000000
327746000
61840000
70000000
425704000
1667000
230000
2570000
3166000
-2105294000
-6000
1985779000
-48000
39933000
796779000
-990000
2064431000
35049000
5248000
59152000
-2104912000
3460000
207050000
-382000
151428000
-2128124000
48000
-1237000
1397756000
191000
212334000
50000000
29317000
50000000
2949000
4296000
-24253000
13027000
171154000
1921000
623000
28080000
-763000
3018000
438000
6056000
-0.34
-41525000
-41525000
121057000
9700000
1400000
-0.37
-44480000
-44480000
121708000
-0.27
-38173000
-38173000
143154000
-0.23
-36578000
-36578000
159859000
-0.31
-38402000
-38402000
122130000
-0.22
-42834000
-42834000
190534000
14100000
2100000
-0.30
-36397000
-36397000
122357000
-0.23
-51781000
-51781000
229234000
0000899460
2012-10-01
2012-12-31
0000899460
2011-10-01
2011-12-31
0000899460
mnkd:SeasideEightEightLimitedPartnershipMember
2010-10-01
2010-12-31
0000899460
2012-07-01
2012-09-30
0000899460
2011-07-01
2011-09-30
0000899460
2012-04-01
2012-06-30
0000899460
2012-01-01
2012-03-31
0000899460
2011-04-01
2011-06-30
0000899460
mnkd:SeasideEightEightLimitedPartnershipMember
2011-01-01
2011-03-31
0000899460
2011-01-01
2011-03-31
0000899460
1991-02-14
2012-12-31
0000899460
mnkd:MannGroupMember
2010-01-01
2011-12-31
0000899460
mnkd:SeasideEightEightLimitedPartnershipMember
2010-01-01
2011-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
1991-02-14
1992-02-29
0000899460
us-gaap:AdditionalPaidInCapitalMember
1991-02-14
1992-02-29
0000899460
us-gaap:CommonStockMember
1991-02-14
1992-02-29
0000899460
1991-02-14
1992-02-29
0000899460
2012-02-09
2012-03-17
0000899460
mnkd:DateTwoMember
2012-01-01
2012-12-31
0000899460
mnkd:DateOneMember
2012-01-01
2012-12-31
0000899460
us-gaap:StockOptionsMember
2012-01-01
2012-12-31
0000899460
us-gaap:ConvertibleDebtSecuritiesMember
2012-01-01
2012-12-31
0000899460
us-gaap:RestrictedStockMember
2012-01-01
2012-12-31
0000899460
us-gaap:WarrantMember
2012-01-01
2012-12-31
0000899460
us-gaap:SeriesBPreferredStockMember
2012-01-01
2012-12-31
0000899460
mnkd:TerminationCostsMember
2012-01-01
2012-12-31
0000899460
mnkd:ExpensesMember
2012-01-01
2012-12-31
0000899460
mnkd:ComputerEquipmentAndSoftwareMember
2012-01-01
2012-12-31
0000899460
mnkd:WorkforceReductionMember
2012-01-01
2012-12-31
0000899460
us-gaap:FairValueInputsLevel3Member
2012-01-01
2012-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2012-01-01
2012-12-31
0000899460
us-gaap:OtherComprehensiveIncomeMember
2012-01-01
2012-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2012-01-01
2012-12-31
0000899460
us-gaap:CommonStockMember
2012-01-01
2012-12-31
0000899460
mnkd:WarrantLiabilityMember
2012-01-01
2012-12-31
0000899460
mnkd:SecuritiesAndDerivativeLawsuitsMember
2012-01-01
2012-12-31
0000899460
mnkd:SecuritiesActionMember
2012-01-01
2012-12-31
0000899460
mnkd:DerivativeActionsMember
2012-01-01
2012-12-31
0000899460
mnkd:FurnitureFixturesAndOfficeEquipmentMemberus-gaap:MaximumMember
2012-01-01
2012-12-31
0000899460
us-gaap:MachineryAndEquipmentMemberus-gaap:MaximumMember
2012-01-01
2012-12-31
0000899460
us-gaap:BuildingMemberus-gaap:MaximumMember
2012-01-01
2012-12-31
0000899460
us-gaap:BuildingImprovementsMemberus-gaap:MaximumMember
2012-01-01
2012-12-31
0000899460
mnkd:SecuritiesAndDerivativeLawsuitsMemberus-gaap:MaximumMember
2012-01-01
2012-12-31
0000899460
us-gaap:MaximumMember
2012-01-01
2012-12-31
0000899460
mnkd:FurnitureFixturesAndOfficeEquipmentMemberus-gaap:MinimumMember
2012-01-01
2012-12-31
0000899460
us-gaap:MachineryAndEquipmentMemberus-gaap:MinimumMember
2012-01-01
2012-12-31
0000899460
us-gaap:BuildingMemberus-gaap:MinimumMember
2012-01-01
2012-12-31
0000899460
us-gaap:BuildingImprovementsMemberus-gaap:MinimumMember
2012-01-01
2012-12-31
0000899460
mnkd:SecuritiesAndDerivativeLawsuitsMemberus-gaap:MinimumMember
2012-01-01
2012-12-31
0000899460
us-gaap:MinimumMember
2012-01-01
2012-12-31
0000899460
mnkd:ConsultantMember
2012-01-01
2012-12-31
0000899460
mnkd:EmployeeMember
2012-01-01
2012-12-31
0000899460
mnkd:OctoberTwentyTwelveForwardContractMemberus-gaap:FairValueInputsLevel3Member
2012-01-01
2012-12-31
0000899460
mnkd:FebruaryTwentyTwelveForwardContractMemberus-gaap:FairValueInputsLevel3Member
2012-01-01
2012-12-31
0000899460
mnkd:SeniorConvertibleNotesDueTwoThousandThirteenMember
2012-01-01
2012-12-31
0000899460
mnkd:ResearchAndDevelopmentMember
2012-01-01
2012-12-31
0000899460
mnkd:GeneralAndAdministrativeMember
2012-01-01
2012-12-31
0000899460
2012-01-01
2012-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2008-01-01
2008-12-31
0000899460
us-gaap:OtherComprehensiveIncomeMember
2008-01-01
2008-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2008-01-01
2008-12-31
0000899460
us-gaap:CommonStockMember
2008-01-01
2008-12-31
0000899460
2008-01-01
2008-12-31
0000899460
mnkd:SeriesCConvertiblePreferredStockSubscriptionsReceivableMember
2004-01-01
2004-12-31
0000899460
mnkd:SeriesCConvertiblePreferredStockIssuableMember
2004-01-01
2004-12-31
0000899460
mnkd:NotesReceivableFromStockholdersMember
2004-01-01
2004-12-31
0000899460
mnkd:NotesReceivableFromOfficersMember
2004-01-01
2004-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2004-01-01
2004-12-31
0000899460
mnkd:SeriesBConvertiblePreferredStockMember
2004-01-01
2004-12-31
0000899460
mnkd:SeriesCConvertiblePreferredStockMember
2004-01-01
2004-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2004-01-01
2004-12-31
0000899460
us-gaap:CommonStockMember
2004-01-01
2004-12-31
0000899460
2004-01-01
2004-12-31
0000899460
mnkd:NotesReceivableFromStockholdersMember
2000-01-01
2000-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2000-01-01
2000-12-31
0000899460
mnkd:SeriesBConvertiblePreferredStockMember
2000-01-01
2000-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2000-01-01
2000-12-31
0000899460
us-gaap:CommonStockMember
2000-01-01
2000-12-31
0000899460
2000-01-01
2000-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
1996-01-01
1996-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
1996-01-01
1996-12-31
0000899460
us-gaap:CommonStockMember
1996-01-01
1996-12-31
0000899460
1996-01-01
1996-12-31
0000899460
us-gaap:StockOptionsMember
2011-01-01
2011-12-31
0000899460
us-gaap:ConvertibleDebtSecuritiesMember
2011-01-01
2011-12-31
0000899460
us-gaap:RestrictedStockMember
2011-01-01
2011-12-31
0000899460
us-gaap:SeriesCPreferredStockMember
2011-01-01
2011-12-31
0000899460
mnkd:ResearchAndDevelopmentMember
2011-01-01
2011-12-31
0000899460
mnkd:GeneralAndAdministrativeMember
2011-01-01
2011-12-31
0000899460
mnkd:MannGroupMember
2011-01-01
2011-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2011-01-01
2011-12-31
0000899460
us-gaap:OtherComprehensiveIncomeMember
2011-01-01
2011-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2011-01-01
2011-12-31
0000899460
us-gaap:CommonStockMember
2011-01-01
2011-12-31
0000899460
us-gaap:MaximumMember
2011-01-01
2011-12-31
0000899460
us-gaap:MinimumMember
2011-01-01
2011-12-31
0000899460
mnkd:ConsultantMember
2011-01-01
2011-12-31
0000899460
mnkd:EmployeeMember
2011-01-01
2011-12-31
0000899460
mnkd:ResearchAndDevelopmentMember
2011-01-01
2011-12-31
0000899460
mnkd:GeneralAndAdministrativeMember
2011-01-01
2011-12-31
0000899460
2011-01-01
2011-12-31
0000899460
mnkd:MannGroupMember
2010-04-01
2011-03-31
0000899460
mnkd:SeasideEightEightLimitedPartnershipMember
2010-04-01
2011-03-31
0000899460
us-gaap:StockOptionsMember
2010-01-01
2010-12-31
0000899460
us-gaap:ConvertibleDebtSecuritiesMember
2010-01-01
2010-12-31
0000899460
us-gaap:RestrictedStockMember
2010-01-01
2010-12-31
0000899460
mnkd:MannGroupMember
2010-01-01
2010-12-31
0000899460
mnkd:SeasideEightEightLimitedPartnershipMember
2010-01-01
2010-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2010-01-01
2010-12-31
0000899460
us-gaap:OtherComprehensiveIncomeMember
2010-01-01
2010-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2010-01-01
2010-12-31
0000899460
us-gaap:CommonStockMember
2010-01-01
2010-12-31
0000899460
us-gaap:MaximumMember
2010-01-01
2010-12-31
0000899460
us-gaap:MinimumMember
2010-01-01
2010-12-31
0000899460
mnkd:ConsultantMember
2010-01-01
2010-12-31
0000899460
mnkd:EmployeeMember
2010-01-01
2010-12-31
0000899460
mnkd:ResearchAndDevelopmentMember
2010-01-01
2010-12-31
0000899460
mnkd:GeneralAndAdministrativeMember
2010-01-01
2010-12-31
0000899460
2010-01-01
2010-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2009-01-01
2009-12-31
0000899460
us-gaap:OtherComprehensiveIncomeMember
2009-01-01
2009-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2009-01-01
2009-12-31
0000899460
us-gaap:CommonStockMember
2009-01-01
2009-12-31
0000899460
2009-01-01
2009-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2007-01-01
2007-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2007-01-01
2007-12-31
0000899460
us-gaap:CommonStockMember
2007-01-01
2007-12-31
0000899460
2007-01-01
2007-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2006-01-01
2006-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2006-01-01
2006-12-31
0000899460
us-gaap:CommonStockMember
2006-01-01
2006-12-31
0000899460
2006-01-01
2006-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2005-01-01
2005-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2005-01-01
2005-12-31
0000899460
us-gaap:CommonStockMember
2005-01-01
2005-12-31
0000899460
2005-01-01
2005-12-31
0000899460
mnkd:SeriesCConvertiblePreferredStockSubscriptionsReceivableMember
2003-01-01
2003-12-31
0000899460
mnkd:SeriesCConvertiblePreferredStockIssuableMember
2003-01-01
2003-12-31
0000899460
mnkd:NotesReceivableFromStockholdersMember
2003-01-01
2003-12-31
0000899460
mnkd:NotesReceivableFromOfficersMember
2003-01-01
2003-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2003-01-01
2003-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2003-01-01
2003-12-31
0000899460
us-gaap:CommonStockMember
2003-01-01
2003-12-31
0000899460
2003-01-01
2003-12-31
0000899460
mnkd:NotesReceivableFromStockholdersMember
2002-01-01
2002-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2002-01-01
2002-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2002-01-01
2002-12-31
0000899460
us-gaap:CommonStockMember
2002-01-01
2002-12-31
0000899460
2002-01-01
2002-12-31
0000899460
mnkd:NotesReceivableFromStockholdersMember
2001-01-01
2001-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2001-01-01
2001-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2001-01-01
2001-12-31
0000899460
us-gaap:CommonStockMember
2001-01-01
2001-12-31
0000899460
2001-01-01
2001-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
1999-01-01
1999-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
1999-01-01
1999-12-31
0000899460
us-gaap:CommonStockMember
1999-01-01
1999-12-31
0000899460
1999-01-01
1999-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
1998-01-01
1998-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
1998-01-01
1998-12-31
0000899460
us-gaap:CommonStockMember
1998-01-01
1998-12-31
0000899460
1998-01-01
1998-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
1997-01-01
1997-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
1997-01-01
1997-12-31
0000899460
us-gaap:CommonStockMember
1997-01-01
1997-12-31
0000899460
1997-01-01
1997-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
1995-01-01
1995-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
1995-01-01
1995-12-31
0000899460
us-gaap:CommonStockMember
1995-01-01
1995-12-31
0000899460
1995-01-01
1995-12-31
0000899460
mnkd:NotesReceivableFromStockholdersMember
1993-03-01
1994-02-28
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
1993-03-01
1994-02-28
0000899460
us-gaap:AdditionalPaidInCapitalMember
1993-03-01
1994-02-28
0000899460
us-gaap:CommonStockMember
1993-03-01
1994-02-28
0000899460
1993-03-01
1994-02-28
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
1992-03-01
1993-02-28
0000899460
us-gaap:AdditionalPaidInCapitalMember
1992-03-01
1993-02-28
0000899460
us-gaap:CommonStockMember
1992-03-01
1993-02-28
0000899460
1992-03-01
1993-02-28
0000899460
mnkd:WorkforceReductionMember
2011-02-11
2011-12-31
0000899460
us-gaap:MaximumMember
2012-12-01
2012-12-31
0000899460
2012-12-01
2012-12-31
0000899460
2009-12-01
2009-12-31
0000899460
2002-12-01
2002-12-31
0000899460
mnkd:LoanArrangementMember
2012-10-01
2012-10-31
0000899460
us-gaap:RestrictedStockMemberus-gaap:PrivatePlacementMember
2012-10-01
2012-10-31
0000899460
us-gaap:WarrantMemberus-gaap:PrivatePlacementMember
2012-10-01
2012-10-31
0000899460
mnkd:LoanArrangementMembermnkd:RelatedPartyDebtMember
2012-10-01
2012-10-31
0000899460
2012-10-01
2012-10-31
0000899460
2007-10-01
2007-10-31
0000899460
2004-08-01
2004-08-31
0000899460
2012-05-01
2012-05-31
0000899460
mnkd:StockOptionAndAwardPlansMember
2010-07-02
2010-08-01
0000899460
2011-05-03
2011-06-02
0000899460
us-gaap:MaximumMember
2004-03-01
2004-03-31
0000899460
mnkd:EmployeeStockPurchasePlansMember
2004-03-01
2004-03-31
0000899460
2004-03-01
2004-03-31
0000899460
2011-01-11
2011-02-10
0000899460
mnkd:SeniorConvertibleNotesDueTwoThousandFifteenMember
2010-07-19
2010-08-18
0000899460
mnkd:MannGroupMember
2010-07-11
2010-08-10
0000899460
mnkd:SeasideEightEightLimitedPartnershipMember
2010-07-11
2010-08-10
0000899460
mnkd:PublicOfferingMembermnkd:UnderwritersOverallotmentOptionMember
2009-07-06
2009-08-05
0000899460
mnkd:PublicOfferingMemberus-gaap:PrincipalOwnerMember
2009-07-06
2009-08-05
0000899460
mnkd:PublicOfferingMember
2009-07-06
2009-08-05
0000899460
us-gaap:PrincipalOwnerMemberus-gaap:PrivatePlacementMember
2005-07-06
2005-08-05
0000899460
us-gaap:PrivatePlacementMember
2005-07-06
2005-08-05
0000899460
mnkd:NotesReceivableFromStockholdersMember
1994-03-01
1994-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
1994-03-01
1994-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
1994-03-01
1994-12-31
0000899460
us-gaap:CommonStockMember
1994-03-01
1994-12-31
0000899460
1994-03-01
1994-12-31
0000899460
2012-11-21
2012-12-20
0000899460
mnkd:SeniorConvertibleNotesDueTwoThousandThirteenMember
2006-11-13
2006-12-12
0000899460
2001-11-13
2001-12-12
0000899460
2012-09-19
2012-10-18
0000899460
mnkd:LetterAgreementMember
2010-08-02
2010-08-31
0000899460
mnkd:StockOptionAndAwardPlansMember
2008-06-10
2008-07-09
0000899460
mnkd:TimeBasedAwardsMember
2012-04-18
2012-05-17
0000899460
mnkd:PerformanceBasedShareAwardsMember
2012-04-18
2012-05-17
0000899460
2012-04-18
2012-05-17
0000899460
2009-04-22
2009-05-21
0000899460
mnkd:RelatedPartyDebtMember
2009-02-01
2009-02-28
0000899460
2012-01-01
2012-09-30
0000899460
2011-02-11
2011-03-03
0000899460
mnkd:ConsultantMember
2012-12-31
0000899460
mnkd:MilestonesNotConsideredProbableOfAchievementMember
2012-12-31
0000899460
mnkd:PerformanceBasedStockOptionsMember
2012-12-31
0000899460
mnkd:RestrictedStockUnitMember
2012-12-31
0000899460
us-gaap:OptionMember
2012-12-31
0000899460
mnkd:DateTwoMember
2012-12-31
0000899460
mnkd:DateOneMember
2012-12-31
0000899460
mnkd:OtherIncomeExpenseMember
2012-12-31
0000899460
mnkd:ComputerEquipmentAndSoftwareMember
2012-12-31
0000899460
mnkd:FurnitureFixturesAndOfficeEquipmentMember
2012-12-31
0000899460
us-gaap:MachineryAndEquipmentMember
2012-12-31
0000899460
us-gaap:LandMember
2012-12-31
0000899460
us-gaap:BuildingMember
2012-12-31
0000899460
us-gaap:ConstructionInProgressMember
2012-12-31
0000899460
us-gaap:BuildingImprovementsMember
2012-12-31
0000899460
us-gaap:LeaseholdImprovementsMember
2012-12-31
0000899460
us-gaap:FairValueInputsLevel3Member
2012-12-31
0000899460
mnkd:MannGroupMember
2012-12-31
0000899460
mnkd:AdjustmentsMember
2012-12-31
0000899460
us-gaap:EquityMember
2012-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2012-12-31
0000899460
us-gaap:OtherComprehensiveIncomeMember
2012-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2012-12-31
0000899460
us-gaap:CommonStockMember
2012-12-31
0000899460
mnkd:ForwardPurchaseContractsMembermnkd:MannGroupMember
2012-12-31
0000899460
mnkd:SecuritiesAndDerivativeLawsuitsMember
2012-12-31
0000899460
mnkd:SecuritiesActionMember
2012-12-31
0000899460
mnkd:DerivativeActionsMember
2012-12-31
0000899460
mnkd:OctoberTwentyTwelveForwardContractMemberus-gaap:FairValueInputsLevel3Member
2012-12-31
0000899460
mnkd:FebruaryTwentyTwelveForwardContractMemberus-gaap:FairValueInputsLevel3Member
2012-12-31
0000899460
mnkd:ForwardPurchaseContractsMembermnkd:OtherThanEquityMembermnkd:MannGroupMember
2012-12-31
0000899460
mnkd:ForwardPurchaseContractsMembermnkd:EquityComponentMembermnkd:MannGroupMember
2012-12-31
0000899460
mnkd:SeniorConvertibleNotesDueTwoThousandFifteenMember
2012-12-31
0000899460
mnkd:SeniorConvertibleNotesDueTwoThousandThirteenMember
2012-12-31
0000899460
us-gaap:MoneyMarketFundsMember
2012-12-31
0000899460
mnkd:TwoThousandFourNonEmployeeDirectorsStockOptionPlanMember
2012-12-31
0000899460
mnkd:TwoThousandFourEquityIncentivePlanMember
2012-12-31
0000899460
mnkd:EmployeeStockPurchasePlansMember
2012-12-31
0000899460
mnkd:CurrentAssetMember
2012-12-31
0000899460
2012-12-31
0000899460
mnkd:ComputerEquipmentAndSoftwareMember
2011-12-31
0000899460
mnkd:FurnitureFixturesAndOfficeEquipmentMember
2011-12-31
0000899460
us-gaap:MachineryAndEquipmentMember
2011-12-31
0000899460
us-gaap:LandMember
2011-12-31
0000899460
us-gaap:BuildingMember
2011-12-31
0000899460
us-gaap:ConstructionInProgressMember
2011-12-31
0000899460
us-gaap:BuildingImprovementsMember
2011-12-31
0000899460
us-gaap:LeaseholdImprovementsMember
2011-12-31
0000899460
mnkd:WorkforceReductionMember
2011-12-31
0000899460
us-gaap:FairValueInputsLevel3Member
2011-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2011-12-31
0000899460
us-gaap:OtherComprehensiveIncomeMember
2011-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2011-12-31
0000899460
us-gaap:CommonStockMember
2011-12-31
0000899460
mnkd:OctoberTwentyTwelveForwardContractMemberus-gaap:FairValueInputsLevel3Member
2011-12-31
0000899460
mnkd:FebruaryTwentyTwelveForwardContractMemberus-gaap:FairValueInputsLevel3Member
2011-12-31
0000899460
mnkd:SeniorConvertibleNotesDueTwoThousandFifteenMember
2011-12-31
0000899460
mnkd:SeniorConvertibleNotesDueTwoThousandThirteenMember
2011-12-31
0000899460
us-gaap:MoneyMarketFundsMember
2011-12-31
0000899460
2011-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2010-12-31
0000899460
us-gaap:OtherComprehensiveIncomeMember
2010-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2010-12-31
0000899460
us-gaap:CommonStockMember
2010-12-31
0000899460
mnkd:SeniorConvertibleNotesDueTwoThousandThirteenMember
2010-12-31
0000899460
2010-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2009-12-31
0000899460
us-gaap:OtherComprehensiveIncomeMember
2009-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2009-12-31
0000899460
us-gaap:CommonStockMember
2009-12-31
0000899460
2009-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2008-12-31
0000899460
us-gaap:OtherComprehensiveIncomeMember
2008-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2008-12-31
0000899460
us-gaap:CommonStockMember
2008-12-31
0000899460
2008-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2007-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2007-12-31
0000899460
us-gaap:CommonStockMember
2007-12-31
0000899460
2007-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2006-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2006-12-31
0000899460
us-gaap:CommonStockMember
2006-12-31
0000899460
2006-12-31
0000899460
mnkd:UnderwritersOverallotmentOptionMembermnkd:SeniorConvertibleNotesDueTwoThousandThirteenMember
2006-12-12
0000899460
mnkd:SeniorConvertibleNotesDueTwoThousandThirteenMember
2006-12-12
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2005-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2005-12-31
0000899460
us-gaap:CommonStockMember
2005-12-31
0000899460
2005-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2004-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2004-12-31
0000899460
us-gaap:CommonStockMember
2004-12-31
0000899460
2004-12-31
0000899460
mnkd:SeriesCConvertiblePreferredStockSubscriptionsReceivableMember
2003-12-31
0000899460
mnkd:SeriesCConvertiblePreferredStockIssuableMember
2003-12-31
0000899460
mnkd:NotesReceivableFromStockholdersMember
2003-12-31
0000899460
mnkd:NotesReceivableFromOfficersMember
2003-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2003-12-31
0000899460
mnkd:SeriesBConvertiblePreferredStockMember
2003-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2003-12-31
0000899460
us-gaap:CommonStockMember
2003-12-31
0000899460
2003-12-31
0000899460
mnkd:NotesReceivableFromStockholdersMember
2002-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2002-12-31
0000899460
mnkd:SeriesBConvertiblePreferredStockMember
2002-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2002-12-31
0000899460
us-gaap:CommonStockMember
2002-12-31
0000899460
2002-12-31
0000899460
mnkd:NotesReceivableFromStockholdersMember
2001-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2001-12-31
0000899460
mnkd:SeriesBConvertiblePreferredStockMember
2001-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2001-12-31
0000899460
us-gaap:CommonStockMember
2001-12-31
0000899460
2001-12-31
0000899460
mnkd:PharmaceuticalDiscoveryCorporationMember
2001-12-12
0000899460
mnkd:CtlImmunoTherapiesCorpMember
2001-12-12
0000899460
mnkd:AllecureCorpMember
2001-12-12
0000899460
2001-12-12
0000899460
mnkd:NotesReceivableFromStockholdersMember
2000-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
2000-12-31
0000899460
mnkd:SeriesBConvertiblePreferredStockMember
2000-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
2000-12-31
0000899460
us-gaap:CommonStockMember
2000-12-31
0000899460
2000-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
1999-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
1999-12-31
0000899460
us-gaap:CommonStockMember
1999-12-31
0000899460
1999-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
1998-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
1998-12-31
0000899460
us-gaap:CommonStockMember
1998-12-31
0000899460
1998-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
1997-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
1997-12-31
0000899460
us-gaap:CommonStockMember
1997-12-31
0000899460
1997-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
1996-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
1996-12-31
0000899460
us-gaap:CommonStockMember
1996-12-31
0000899460
1996-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
1995-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
1995-12-31
0000899460
us-gaap:CommonStockMember
1995-12-31
0000899460
1995-12-31
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
1994-12-31
0000899460
us-gaap:AdditionalPaidInCapitalMember
1994-12-31
0000899460
us-gaap:CommonStockMember
1994-12-31
0000899460
1994-12-31
0000899460
mnkd:NotesReceivableFromStockholdersMember
1994-02-28
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
1994-02-28
0000899460
us-gaap:AdditionalPaidInCapitalMember
1994-02-28
0000899460
us-gaap:CommonStockMember
1994-02-28
0000899460
1994-02-28
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
1993-02-28
0000899460
us-gaap:AdditionalPaidInCapitalMember
1993-02-28
0000899460
us-gaap:CommonStockMember
1993-02-28
0000899460
1993-02-28
0000899460
mnkd:DeficitAccumulatedDuringDevelopmentStageMember
1992-02-29
0000899460
us-gaap:AdditionalPaidInCapitalMember
1992-02-29
0000899460
us-gaap:CommonStockMember
1992-02-29
0000899460
1992-02-29
0000899460
us-gaap:WarrantMember
2012-10-31
0000899460
mnkd:LoanArrangementMembermnkd:RelatedPartyDebtMember
2012-10-31
0000899460
us-gaap:WarrantMembermnkd:MannGroupMember
2012-10-31
0000899460
mnkd:MannGroupMember
2012-10-31
0000899460
mnkd:AfterAmendmentMember
2012-10-31
0000899460
mnkd:MannGroupMember
2012-10-31
0000899460
2012-10-31
0000899460
2012-09-30
0000899460
mnkd:LetterAgreementMember
2010-08-31
0000899460
2004-08-31
0000899460
2012-06-29
0000899460
2012-06-27
0000899460
2012-05-31
0000899460
mnkd:StockOptionAndAwardPlansMember
2008-07-09
0000899460
mnkd:AtMarketSalesAgreementMemberus-gaap:SubsequentEventMember
2013-03-18
0000899460
2013-03-13
0000899460
mnkd:EmployeeStockPurchasePlansMember
2004-03-31
0000899460
mnkd:DerivativeActionsMember
2012-08-03
0000899460
mnkd:TimeBasedAwardsMember
2012-05-17
0000899460
mnkd:ForwardPurchaseContractsMembermnkd:MannGroupMember
2012-05-17
0000899460
mnkd:ForwardPurchaseContractsMembermnkd:OtherThanEquityMembermnkd:MannGroupMember
2012-05-17
0000899460
mnkd:OtherThanEquityMember
2012-05-17
0000899460
2012-05-17
0000899460
mnkd:PublicMember
2012-02-08
0000899460
mnkd:UnderwritersMember
2012-02-08
0000899460
mnkd:RelatedPartyMember
2012-02-08
0000899460
mnkd:WarrantLiabilityMember
2012-02-08
0000899460
2012-02-08
0000899460
mnkd:WorkforceReductionMember
2011-02-10
0000899460
mnkd:SeniorConvertibleNotesDueTwoThousandFifteenMember
2010-08-18
0000899460
mnkd:SeasideEightEightLimitedPartnershipMember
2010-08-10
0000899460
us-gaap:MinimumMembermnkd:SeasideEightEightLimitedPartnershipMember
2010-08-10
0000899460
mnkd:RelatedPartyDebtMember
2009-02-28
0000899460
us-gaap:PrivatePlacementMember
2005-08-05
iso4217:USD
mnkd:Right
shares
pure
iso4217:USD
shares
iso4217:USD
mnkd:Employee