Entity Central Index Key
Cover [Abstract]
Document Type
Document Type
Amendment Flag
Amendment Flag
Document Period End Date
Document Period End Date
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Trading Symbol
Trading Symbol
Entity Registrant Name
Entity Registrant Name
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Well-known Seasoned Issuer
Entity Well Known Seasoned Issuer
Entity Current Reporting Status
Entity Current Reporting Status
Entity Voluntary Filers
Entity Voluntary Filers
Entity Filer Category
Entity Filer Category
Entity Small Business
Entity Small Business
Entity Emerging Growth Company
Entity Emerging Growth Company
Entity Shell Company
Entity Shell Company
Entity File Number
Entity File Number
Entity Tax Identification Number
Entity Tax Identification Number
Entity Address, Address Line One
Entity Address Address Line1
Entity Address, Address Line Two
Entity Address Address Line2
Entity Address, City or Town
Entity Address City Or Town
Entity Address, State or Province
Entity Address State Or Province
Entity Address, Postal Zip Code
Entity Address Postal Zip Code
City Area Code
City Area Code
Local Phone Number
Local Phone Number
Entity Common Stock, Shares Outstanding
Entity Common Stock Shares Outstanding
Entity Public Float
Entity Public Float
Document Annual Report
Document Annual Report
Document Transition Report
Document Transition Report
Entity Incorporation, State or Country Code
Entity Incorporation State Country Code
Title of 12(b) Security
Security12b Title
Security Exchange Name
Security Exchange Name
Entity Interactive Data Current
Entity Interactive Data Current
Purchase obligation current.
Promissory notes noncurrent.
Accrued interest noncurrent.
Credit facility noncurrent.
Purchase obligation noncurrent.
Milestone rights liabilities noncurrent.
Statement Of Financial Position [Abstract]
ASSETS
Assets [Abstract]
Current assets:
Assets Current [Abstract]
Cash and cash equivalents
Cash And Cash Equivalents At Carrying Value
Restricted cash
Restricted Cash Current
Short-term investments
Short Term Investments
Accounts receivable, net
Accounts Receivable Net Current
Inventory
Inventory Net
Prepaid expenses and other current assets
Prepaid Expense And Other Assets Current
Total current assets
Assets Current
Property and equipment, net
Property Plant And Equipment Net
Other assets
Other Assets Noncurrent
Total assets
Assets
LIABILITIES AND STOCKHOLDERS' DEFICIT
Liabilities And Stockholders Equity [Abstract]
Current liabilities:
Liabilities Current [Abstract]
Accounts payable
Accounts Payable Current
Accrued expenses and other current liabilities
Accrued Liabilities Current
Facility financing obligation
Other Long Term Debt Current
Short-term note payable
Notes Payable Current
Deferred revenue — current
Contract With Customer Liability Current
Recognized loss on purchase commitments — current
Purchase Obligation Current
Total current liabilities
Liabilities Current
Promissory notes
Promissory Notes Noncurrent
Accrued interest — promissory notes
Accrued Interest Noncurrent
Long-term Midcap credit facility
Credit Facility Noncurrent
Senior convertible notes
Convertible Long Term Notes Payable
Recognized loss on purchase commitments — long term
Purchase Obligation Noncurrent
Operating lease liability
Operating Lease Liability Noncurrent
Deferred revenue — long term
Contract With Customer Liability Noncurrent
Milestone rights liability
Milestone Rights Liabilities Noncurrent
Total liabilities
Liabilities
Commitments and contingencies (Note 13)
Commitments And Contingencies
Stockholders' deficit:
Stockholders Equity [Abstract]
Undesignated preferred stock, $0.01 par value — 10,000,000 shares authorized; no shares issued or outstanding at December 31, 2019 and 2018
Preferred Stock Value
Common stock, $0.01 par value — 280,000,000 shares authorized, 211,787,573 and 187,029,967 shares issued and outstanding at December 31, 2019 and 2018, respectively
Common Stock Value
Additional paid-in capital
Additional Paid In Capital Common Stock
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income Loss Net Of Tax
Accumulated deficit
Retained Earnings Accumulated Deficit
Total stockholders' deficit
Stockholders Equity
Total liabilities and stockholders' deficit
Liabilities And Stockholders Equity
Undesignated preferred stock, par value
Preferred Stock Par Or Stated Value Per Share
Undesignated preferred stock, shares authorized
Preferred Stock Shares Authorized
Undesignated preferred stock, shares issued
Preferred Stock Shares Issued
Undesignated preferred stock, shares outstanding
Preferred Stock Shares Outstanding
Common stock, par value
Common Stock Par Or Stated Value Per Share
Common stock, shares authorized
Common Stock Shares Authorized
Common stock, shares issued
Common Stock Shares Issued
Common stock, shares outstanding
Common Stock Shares Outstanding
Interest expenses incurred on promissory notes.
Income Statement [Abstract]
Statement [Table]
Statement [Table]
Product and Service
Product Or Service [Axis]
Product and Service
Products And Services [Domain]
Commercial product sales
Product [Member]
Collaborations and services
License And Service [Member]
Statement [Line Items]
Statement [Line Items]
Revenues:
Revenues [Abstract]
Total revenues
Revenue From Contract With Customer Excluding Assessed Tax
Expenses:
Costs And Expenses [Abstract]
Cost of goods sold
Cost Of Goods And Services Sold
Cost of revenue
Cost Of Revenue
Research and development
Research And Development Expense Excluding Acquired In Process Cost
Selling, general and administrative
Selling General And Administrative Expense
Gain on foreign currency translation
Foreign Currency Transaction Gain Loss Realized
Total expenses
Costs And Expenses
Loss from operations
Operating Income Loss
Other (expense) income:
Nonoperating Income Expense [Abstract]
Interest income
Investment Income Interest
Interest expense on notes
Interest Expense Debt
Interest expense on promissory notes
Interest Expense Incurred On Promissory Notes
Gain (loss) on extinguishment of debt
Gains Losses On Extinguishment Of Debt
Other expense
Other Nonoperating Income Expense
Total other expense
Nonoperating Income Expense
Loss before income tax expense
Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest
Provision for income taxes
Income Tax Expense Benefit
Net loss
Net Income Loss
Net loss per share — basic and diluted
Earnings Per Share Basic And Diluted
Shares used to compute net loss per share — basic and diluted
Weighted Average Number Of Share Outstanding Basic And Diluted
Statement Of Income And Comprehensive Income [Abstract]
Net loss
Other comprehensive loss:
Other Comprehensive Income Loss Net Of Tax Period Increase Decrease [Abstract]
Cumulative translation loss
Other Comprehensive Income Foreign Currency Transaction And Translation Gain Loss Arising During Period Net Of Tax
Comprehensive loss
Comprehensive Income Net Of Tax
Common stock issued in direct placement shares.
Common stock issued in direct placement value.
Adjustments to additional paid in capital direct placement issuance costs.
Adjustments to additional paid in capital shares issued public offering issuance cost.
Stock issued during period shares market price stock purchase plan.
Stock issued during period value market price stock purchase plan.
Adjustments to additional paid in capital amortization of shelf fees.
Adjustments to additional paid in capital issuance of warrants pursuant to credit facility.
Stock issued during period shares exercise of warrants.
Stock issued during period value exercise of warrants.
Adjustments to additional paid in capital warrant modification.
Adjustments to additional paid in capital repurchased warrant.
Statement Of Stockholders Equity [Abstract]
Additional Paid-in Capital
Statement Equity Components [Axis]
Equity Component
Equity Component [Domain]
Common Stock
Common Stock [Member]
Additional Paid-in Capital
Additional Paid In Capital [Member]
Accumulated Other Comprehensive Income (Loss)
Accumulated Other Comprehensive Income [Member]
Accumulated Deficit
Retained Earnings [Member]
Debt Instrument
Debt Instrument [Axis]
Debt Instrument, Name
Debt Instrument Name [Domain]
Note payable to related party.
Note Payable to Related Party
Note Payable To Related Party [Member]
Senior convertible notes.
Senior Convertible Notes
Senior Convertible Notes [Member]
Facility financing obligation.
Facility Financing Obligation
Facility Financing Obligation [Member]
Promissory notes.
Promissory notes
Promissory Notes [Member]
Sale of Stock
Subsidiary Sale Of Stock [Axis]
Sale of Stock
Sale Of Stock Name Of Transaction [Domain]
Public Offering
I P O [Member]
At-the-market offering.
At-the-market Offering
At The Market Offering [Member]
At-the-market placement.
At-The-Market-Placement
At The Market Placement [Member]
Adjustments for New Accounting Pronouncements
Adjustments For New Accounting Pronouncements [Axis]
Type of Adoption
Type Of Adoption [Member]
Topic 606
Accounting Standards Update201409 [Member]
Related Party
Related Party Transactions By Related Party [Axis]
Related Party
Related Party [Domain]
Mann group.
Mann Group
Mann Group [Member]
Beginning Balance
Beginning Balance (in shares)
Shares Outstanding
Exercise of stock options
Stock Issued During Period Value Stock Options Exercised
Exercise of stock options (in shares)
Stock Issued During Period Shares Stock Options Exercised
Issuance of common stock from the release of restricted stock units
Stock Issued During Period Value Restricted Stock Award Net Of Forfeitures
Issuance of common stock from the release of restricted stock units (in shares)
Stock Issued During Period Shares Restricted Stock Award Net Of Forfeitures
Issuance of common stock under Employee Stock Purchase Plan
Stock Issued During Period Value Employee Stock Purchase Plan
Issuance of common stock under Employee Stock Purchase Plan (in shares)
Stock Issued During Period Shares Employee Stock Purchase Plans
Stock-based compensation expense
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
Issuance of common stock pursuant to conversion notes
Stock Issued During Period Value Conversion Of Convertible Securities
Issuance of common stock pursuant to conversion notes (in shares)
Stock Issued During Period Shares Conversion Of Convertible Securities
Issuance of common stock — direct placement
Common Stock Issued In Direct Placement Value
Issuance of common stock — direct placement
Common Stock Issued In Direct Placement Shares
Issuance costs associated with direct placement
Adjustments To Additional Paid In Capital Direct Placement Issuance Costs
Issuance of common stock
Stock Issued During Period Value New Issues
Issuance of common stock (in shares)
Stock Issued During Period Shares New Issues
Issuance cost associated with public offering
Adjustments To Additional Paid In Capital Shares Issued Public Offering Issuance Cost
Issuance costs associated with at-the-market placement
Adjustments To Additional Paid In Capital Stock Issued Issuance Costs
Issuance of common stock under Market Price Stock Purchase Plan
Stock Issued During Period Value Market Price Stock Purchase Plan
Issuance of common stock under Market Price Stock Purchase Plan (in shares)
Stock Issued During Period Shares Market Price Stock Purchase Plan
Amortization of shelf fees
Adjustments To Additional Paid In Capital Amortization Of Shelf Fees
Cumulative translation (loss) gain
Adjustment to adopt ASU 2014-09 (Topic 606)
New Accounting Pronouncement Or Change In Accounting Principle Effect Of Adoption Quantification
Issuance of warrants pursuant to MidCap Credit Facility
Adjustments To Additional Paid In Capital Issuance Of Warrants Pursuant To Credit Facility
Issuance of common stock from the exercise of warrants
Stock Issued During Period Value Exercise Of Warrants
Issuance of common stock from the exercise of warrants (in Share)
Stock Issued During Period Shares Exercise Of Warrants
Warrant modification
Adjustments To Additional Paid In Capital Warrant Modification
Repurchase of warrants
Adjustments To Additional Paid In Capital Repurchased Warrant
Ending Balance
Ending Balance (in shares)
Payment-in-kind interest on promissory notes.
Interest expenses on promissory notes.
Operating lease right of use asset amortization.
Gain loss on warrant transactions.
Increase decrease in recognized loss on purchase commitments.
Increase decrease in operating lease liabilities.
Increase decrease in accrued interest on promissory notes.
Milestone payments.
Repayment of issuance of credit facility.
Repayments of issuance promissory notes.
Addition of right-of-use assets
Payment of facility obligation through common stock issuance.
Payment of interest on senior convertible notes through common stock issuance
Common stock issuance to settle employee stock purchase plan liability
Issuance of warrants associated with Credit Facility.
Statement Of Cash Flows [Abstract]
Public offering.
Public Offering
Public Offering [Member]
At-the-market issuance.
At The Market Issuance
At The Market Issuance [Member]
CASH FLOWS FROM OPERATING ACTIVITIES:
Net Cash Provided By Used In Operating Activities [Abstract]
Net loss
Profit Loss
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract]
Payment-in-kind interest on promissory notes
Payment In Kind Interest On Promissory Notes
Interest expense on promissory notes
Interest Expense On Promissory Notes
Stock-based compensation expense
Share Based Compensation
Gain on foreign currency translation
(Gain) loss on extinguishment of debt
Amortization of right-of-use assets
Operating Lease Right Of Use Asset Amortization
Depreciation, amortization and accretion
Depreciation And Amortization
Loss on warrant transactions
Gain Loss On Warrant Transactions
Gain on sale, abandonment/disposal or impairment of property and equipment
Gain Loss On Disposition Of Assets
Write-off of inventory
Production Related Impairments Or Charges
Other, net
Other Noncash Income Expense
Changes in operating assets and liabilities:
Increase Decrease In Operating Capital [Abstract]
Accounts receivable, net
Increase Decrease In Accounts Receivable
Inventory
Increase Decrease In Inventories
Prepaid expenses and other current assets
Increase Decrease In Prepaid Deferred Expense And Other Assets
Other assets
Increase Decrease In Other Operating Assets
Accounts payable
Increase Decrease In Accounts Payable
Accrued expenses and other current liabilities
Increase Decrease In Accrued Liabilities And Other Operating Liabilities
Deferred revenue
Increase Decrease In Contract With Customer Liability
Recognized loss on purchase commitments
Increase Decrease In Recognized Loss On Purchase Commitments
Operating lease liabilities
Increase Decrease In Operating Lease Liabilities
Accrued interest on Mann Group promissory notes
Increase Decrease In Accrued Interest On Promissory Notes
Net cash used in operating activities
Net Cash Provided By Used In Operating Activities
CASH FLOWS FROM INVESTING ACTIVITIES:
Net Cash Provided By Used In Investing Activities [Abstract]
Purchase of treasury bills
Payments To Acquire Short Term Investments
Proceeds from sale of treasury bills
Proceeds From Sale Of Short Term Investments
Purchase of property and equipment
Payments To Acquire Property Plant And Equipment
Proceeds from sale of property and equipment
Proceeds From Sale Of Property Plant And Equipment
Purchase of limited liability company ownership interest
Payments To Acquire Limited Partnership Interests
Net cash used in investing activities
Net Cash Provided By Used In Investing Activities
CASH FLOWS FROM FINANCING ACTIVITIES:
Net Cash Provided By Used In Financing Activities [Abstract]
Proceeds from promissory notes
Proceeds From Notes Payable
Proceeds from MidCap Credit Facility
Proceeds From Lines Of Credit
Proceeds from senior convertible notes
Proceeds From Convertible Debt
Principal payments on Mann Group promissory notes
Repayments Of Notes Payable
Principal payments on senior convertible notes
Repayments Of Convertible Debt
Principal payments on facility financing obligation
Repayments Of Lines Of Credit
Issuance of common stock from the exercise of warrants
Proceeds From Warrant Exercises
Proceeds from public offering
Proceeds From Issuance Initial Public Offering
Milestone payment
Milestone Payments
Issuance cost associated with MidCap Credit Facility
Repayment Of Issuance Of Credit Facility
Issuance cost associated with Mann Group promissory notes
Repayments Of Issuance Promissory Notes
Issuance costs
Payments Of Stock Issuance Costs
Repurchase of warrants
Payments For Repurchase Of Warrants
Exercise of stock options
Proceeds From Stock Options Exercised
Proceeds from direct placement
Proceeds From Issuance Of Private Placement
Proceeds from market price stock purchase plan
Proceeds From Stock Plans
Issuance cost associated with direct placement
Payment Of Financing And Stock Issuance Costs
Other
Proceeds From Payments For Other Financing Activities
Net cash provided by financing activities
Net Cash Provided By Used In Financing Activities
NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS AND RESTRICTED CASH
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, BEGINNING OF PERIOD
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, END OF PERIOD
SUPPLEMENTAL CASH FLOWS DISCLOSURES:
Supplemental Cash Flow Information [Abstract]
Interest paid in cash, net of amounts capitalized
Interest Paid Net
Income taxes paid in cash
Income Taxes Paid
NON-CASH INVESTING AND FINANCING ACTIVITIES:
Noncash Investing And Financing Items [Abstract]
Payment on promissory notes through issuance of common stock
Notes Issued1
Addition of right-of-use assets upon adoption of new lease guidance
Addition Of Right Of Use Assets
Payment of facility obligation through common stock issuance
Payment Of Facility Obligation Through Common Stock Issuance
Payment of senior convertible notes through common stock issuance
Stock Issued1
Payment of interest on senior convertible notes through common stock issuance
Payment Of Interest On Senior Convertible Notes Through Common Stock Issuance
Common stock issuance to settle employee stock purchase plan liability
Common Stock Issuance To Settle Employee Stock Purchase Plan Liability
Issuance of warrants associated with MidCap Credit Facility
Issuance Of Warrants Associated With Credit Facility
Documents Incorporated by Reference
Documents Incorporated By Reference [Text Block]
Accounting Policies [Abstract]
Description of Business
Organization Consolidation And Presentation Of Financial Statements Disclosure And Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Inventory Disclosure [Abstract]
Inventories
Inventory Disclosure [Text Block]
Property Plant And Equipment [Abstract]
Property and Equipment
Property Plant And Equipment Disclosure [Text Block]
Payables And Accruals [Abstract]
Accrued Expenses and Other Current Liabilities
Accounts Payable And Accrued Liabilities Disclosure [Text Block]
Related Party Transactions [Abstract]
Loan Arrangement with Former Related Party
Related Party Transactions Disclosure [Text Block]
Debt Disclosure [Abstract]
Borrowings
Debt Disclosure [Text Block]
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Collaboration and Licensing Arrangements
Collaborative Arrangement Disclosure [Text Block]
Fair Value Disclosures [Abstract]
Fair Value of Financial Instruments
Fair Value Disclosures [Text Block]
Equity [Abstract]
Common and Preferred Stock
Stockholders Equity Note Disclosure [Text Block]
Earnings Per Share [Abstract]
Earnings Per Common Share ("EPS")
Earnings Per Share [Text Block]
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Stock Award Plans
Disclosure Of Compensation Related Costs Share Based Payments [Text Block]
Commitments And Contingencies Disclosure [Abstract]
Commitments and Contingencies
Commitments And Contingencies Disclosure [Text Block]
Compensation And Retirement Disclosure [Abstract]
Employee Benefit Plans
Pension And Other Postretirement Benefits Disclosure [Text Block]
Income Tax Disclosure [Abstract]
Income Taxes
Income Tax Disclosure [Text Block]
Quarterly Financial Information Disclosure [Abstract]
Selected quarterly financial data (unaudited)
Quarterly Financial Information [Text Block]
Business.
Business
Business Policy [Text Block]
Basis of Presentation.
Basis of Presentation
Basis Of Presentation Policy [Text Block]
Principles of Consolidation
Consolidation Policy [Text Block]
Segment Information
Segment Reporting Policy Policy [Text Block]
Revenue Recognition
Revenue Recognition Policy [Text Block]
Revenue from contract with customer from commercial product sales.
Revenue Recognition - Net Revenue - Commercial Product Sales
Revenue From Contract With Customer From Commercial Product Sales Policy [Text Block]
Revenue from contract with customer from collaborations and services.
Revenue Recognition- Net Revenue - Collaborations and Services
Revenue From Contract With Customer From Collaborations And Services Policy [Text Block]
Milestone Payments
Debt Policy [Text Block]
Cost of Goods Sold
Cost Of Sales Policy [Text Block]
Cash and Cash Equivalents and Restricted Cash
Cash And Cash Equivalents Restricted Cash And Cash Equivalents Policy
Short-term Investments
Investment Policy [Text Block]
Concentration of Credit Risk
Concentration Risk Credit Risk
Accounts Receivable and Allowance for Doubtful Accounts
Receivables Trade And Other Accounts Receivable Allowance For Doubtful Accounts Policy
Pre-launch inventory.
Pre Launch Inventory
Pre Launch Inventory Policy [Text Block]
Inventories
Inventory Policy [Text Block]
Impairment of Long-Lived Assets
Impairment Or Disposal Of Long Lived Assets Policy [Text Block]
Loss on purchase commitments.
Recognized Loss on Purchase Commitments
Loss On Purchase Commitments Policy Policy [Text Block]
Milestone rights liability.
Milestone Rights Liability
Milestone Rights Liability Policy [Text Block]
Fair Value of Financial Instruments
Fair Value Of Financial Instruments Policy
Income Taxes
Income Tax Policy [Text Block]
Contingencies
Commitments And Contingencies Policy [Text Block]
Stock-Based Compensation
Compensation Related Costs Policy [Text Block]
Clinical Trial Expense
Clinical Trial Expenses
Clinical Trial Expense Policy [Text Block]
Net Income or (Loss) Per Share of Common Stock
Earnings Per Share Policy [Text Block]
Recently Adopted Accounting Standards
New Accounting Pronouncements Policy Policy [Text Block]
Recently issued accounting standards.
Recently Issued Accounting Standards
Recently Issued Accounting Standards Policy [Text Block]
Contract with customer liability.
Schedule of Deferred Revenue Related to Revenue Recognized for Collaborations and Services
Contract With Customer Liability Table [Text Block]
Schedule of Reconciliation of Cash, Cash Equivalents, and Restricted Cash
Schedule Of Restricted Cash And Cash Equivalents [Text Block]
Schedule of Accounts Receivable, Net
Schedule Of Accounts Notes Loans And Financing Receivable [Text Block]
Components of Inventory
Schedule Of Inventory Current Table [Text Block]
Property and Equipment, Net
Property Plant And Equipment [Text Block]
Accrued Expenses and Other Current Liabilities
Schedule Of Accrued Liabilities Table [Text Block]
Summary of Carrying Amount of Borrowings
Schedule Of Debt Table [Text Block]
Schedule of Line of Credit Facility Debt and Key Terms
Schedule Of Line Of Credit Facilities [Text Block]
Schedule of Maturities of Our Borrowings
Schedule Of Maturities Of Long Term Debt Table [Text Block]
Schedule of amortization of debt issuance cost and debt discount.
Schedule of Amortization of Premium and Accretion of Debt Issuance Costs
Schedule Of Amortization Of Debt Issuance Cost And Debt Discount Table [Text Block]
Schedule of Revenue from Collaboration and Services
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions Table [Text Block]
Fair Value Measurement of Debt Instruments Based on Discounted Cash Flow Model and Sensitive to Change in Yield
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques Table [Text Block]
Fair Value of Financial Instruments
Schedule Of Fair Value Assets And Liabilities Measured On Recurring Basis Table [Text Block]
Components of Basic and Diluted EPS Computations
Schedule Of Earnings Per Share Basic And Diluted Table [Text Block]
Potential Dilutive Securities Outstanding that are Considered Antidilutive
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block]
Stock Based Award Plans
Disclosure Of Share Based Compensation Arrangements By Share Based Payment Award [Text Block]
Stock Based Compensation Expense Recognized in Accompanying Consolidated Statements of Operations by Category
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Text Block]
Assumptions Used to Calculate Fair Value of Employee Stock Options
Schedule Of Share Based Payment Award Employee Stock Purchase Plan Valuation Assumptions Table [Text Block]
Summary of Stock Options Outstanding
Schedule Of Share Based Compensation Stock Options Activity Table [Text Block]
Summary of Restricted Stock Unit Activity
Schedule Of Sharebased Compensation Restricted Stock And Restricted Stock Units Activity Table [Text Block]
Annual Purchase Requirements under Amended Contract
Long Term Purchase Commitment [Text Block]
Schedule of Future Minimum Office And Vehicle Lease Payments
Lessee Operating Lease Liability Maturity Table [Text Block]
Loss from Continuing Operations Before Provision for Income Tax
Schedule Of Income Before Income Tax Domestic And Foreign Table [Text Block]
Provision for Income Taxes
Schedule Of Components Of Income Tax Expense Benefit Table [Text Block]
Components of Net Deferred Tax Assets
Schedule Of Deferred Tax Assets And Liabilities Table [Text Block]
Effective Income Tax Rate
Schedule Of Effective Income Tax Rate Reconciliation Table [Text Block]
Selected Quarterly Financial Data
Schedule Of Quarterly Financial Information Table [Text Block]
Organization, consolidation and presentation of financial statements disclosure.
Organization, Consolidation and Presentation of Financial Statements Disclosure [Table]
Organization Consolidation And Presentation Of Financial Statements Disclosure [Table]
Organization Consolidation And Presentation Of Financial Statements Disclosure [Table]
Credit Facility
Credit Facility [Axis]
Credit Facility
Credit Facility [Domain]
MidCap Credit Facility.
MidCap Credit Facility
Mid Cap Credit Facility [Member]
Tranche 2
Tranche 2
Tranche Two [Member]
Tranche 3.
Tranche 3
Tranche Three [Member]
Legal Entity
Legal Entity [Axis]
Entity
Entity [Domain]
Deerfield Management Company L.P.
Deerfield
Deerfield Management Company Lp [Member]
The mann group llc.
The Mann Group LLC
The Mann Group L L C [Member]
Related Party Transaction
Related Party Transaction [Axis]
Related Party Transaction
Related Party Transaction [Domain]
New loan arrangement.
New Loan Arrangement
New Loan Arrangement [Member]
Convertible promissory note.
Convertible Promissory Note
Convertible Promissory Note [Member]
Non-convertible promissory note.
Non-Convertible Promissory Note
Non Convertible Promissory Note [Member]
Senior subordinated exchange convertible notes due two thousand twenty one.
2021 Notes
Senior Subordinated Exchange Convertible Notes Due Two Thousand Twenty One [Member]
June two thousand twenty promissory note.
June 2020 Note
June Two Thousand Twenty Promissory Note [Member]
December two thousand twenty promissory note.
December 2020 Note
December Two Thousand Twenty Promissory Note [Member]
Senior subordinated exchange convertible notes due november two thousand twenty four.
2024 Convertible Notes
Senior Subordinated Exchange Convertible Notes Due November Two Thousand Twenty Four [Member]
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Principal amount
Debt Instrument Face Amount
Debt instrument covenant minimum target net revenue.
Principal amount, credit facility
Line Of Credit Facility Maximum Borrowing Capacity
Amount outstanding
Lines Of Credit Current
Amount available under credit facility
Line Of Credit Facility Remaining Borrowing Capacity
Debt instrument, minimum target net revenue
Debt Instrument Covenant Minimum Target Net Revenue
Debt instrument minimum cash covenant.
Minimum cash covenant
Debt Instrument Minimum Cash Covenant
Repayments of aggregate principal amount
Repayments Of Senior Debt
Repayments of debt
Repayments Of Related Party Debt
Remaining debt amount
Notes Payable Related Parties Noncurrent
Conversion price of shares
Debt Instrument Convertible Conversion Price1
Debt instrument maturity month and year.
Reducing senior subordinated interest rate, percentage
Debt Instrument Interest Rate Increase Decrease
Maturity period, month and year
Debt Instrument Maturity Month And Year
Senior notes, effective interest rate
Debt Instrument Interest Rate Stated Percentage
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date
Revenue Remaining Performance Obligation Expected Timing Of Satisfaction Start Date [Axis]
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Remaining performance obligation, Expected timing of satisfaction, period
Revenue Remaining Performance Obligation Expected Timing Of Satisfaction Period1
Sales return period.
Statistical Measurement
Range [Axis]
Statistical Measurement
Range [Member]
Minimum
Minimum [Member]
Maximum
Maximum [Member]
AFREZZA product sales
Income Statement Location
Income Statement Location [Axis]
Income Statement Location
Income Statement Location [Domain]
Cost of Goods Sold
Cost Of Sales [Member]
Insulin.
Insulin
Insulin [Member]
Milestone Rights Liability
Milestone Rights Liability
Milestone Rights Liability [Member]
(“ASC”) Topic 842 – Leases
Accounting Standards Update201602 [Member]
Sales return right following product expiration in months
Sales Return Period
Contract with customer liability upfront and milestone payments.
Contract with customer liability pass through payments.
Revenue From Contract With Customer [Abstract]
Beginning balance
Contract With Customer Liability
Upfront and milestone payments
Contract With Customer Liability Upfront And Milestone Payments
Pass through payments
Contract With Customer Liability Pass Through Payments
Revenue — collaborations and services
Contract With Customer Liability Revenue Recognized
Ending balance
Long-term purchase commitment amendment fee.
Purchase commitments, amendment fees
Long Term Purchase Commitment Amendment Fee
Total cash, cash equivalents, and restricted cash
Wholesaler distribution fees and prompt pay discounts.
Reserve for returns.
Receivables [Abstract]
Accounts Receivable, gross
Accounts Receivable Gross Current
Wholesaler distribution fees and prompt pay discounts
Wholesaler Distribution Fees And Prompt Pay Discounts
Reserve for returns
Reserve For Returns
Accounts receivable, net
Number of wholesale distributors.
Percentage of sales from major customers.
Number of wholesale distributors
Number Of Wholesale Distributors
Percentage of sales from major wholesale distributors
Percentage Of Sales From Major Customers
Asset impairments
Impairment Of Long Lived Assets To Be Disposed Of
Loss on purchase commitments
Purchase Obligation
Contingent Liability
Contingent liability remaining payable amount.
Contingent liability for milestone payments
Contingent Liability
Contingent liability remain payable
Contingent Liability Remaining Payable Amount
Milestone rights liabilities current and noncurrent.
Remaining milestone rights liability
Milestone Rights Liabilities Current And Noncurrent
Liabilities for uncertain income tax positions
Liability For Uncertain Tax Positions Noncurrent
New accounting pronouncement or change in accounting principle, cumulative effect of change on net assets liabilities.
Increase in total assets and total liabilities
New Accounting Pronouncement Or Change In Accounting Principle Cumulative Effect Of Change On Net Assets Liabilities
Raw materials
Inventory Raw Materials Net Of Reserves
Work-in-process
Inventory Work In Process Net Of Reserves
Finished goods
Inventory Finished Goods Net Of Reserves
Total inventory
Percentage of material received.
Inventory Current [Table]
Inventory Current [Table]
Inventory
Public Utilities Inventory [Axis]
Inventory
Public Utilities Inventory Type [Domain]
pre-launch inventory.
Pre-launch Inventory
Pre Launch Inventory [Member]
Inventory [Line Items]
Inventory [Line Items]
Raw materials inventory
Inventory Raw Materials
Percentage of material received
Percentage Of Material Received
Write-down of inventory
Schedule Of Property Plant And Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Property, Plant and Equipment, Type
Property Plant And Equipment By Type [Axis]
Property, Plant and Equipment, Type
Property Plant And Equipment Type [Domain]
Land
Land [Member]
Buildings
Building [Member]
Building Improvements
Building Improvements [Member]
Machinery and Equipment
Machinery And Equipment [Member]
Furniture, fixtures and office equipment.
Furniture, fixtures and office equipment
Furniture Fixtures And Office Equipment [Member]
Computer equipment and software.
Computer Equipment and Software
Computer Equipment And Software [Member]
Construction in Progress
Construction In Progress [Member]
Property Plant And Equipment [Line Items]
Property Plant And Equipment [Line Items]
Property and equipment - gross
Property Plant And Equipment Gross
Less accumulated depreciation
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
Total property and equipment, net
Estimated Useful Life (Years)
Property Plant And Equipment Useful Life
Furniture and fixtures, manufacturing equipment and labratory equipment.
Furniture and Fixtures, Manufacturing Equipment and Laboratory Equipment
Furniture And Fixtures Manufacturing Equipment And Labratory Equipment [Member]
Manufacturing equipment and computer hardware.
Manufacturing Equipment and Computer Hardware
Manufacturing Equipment And Computer Hardware [Member]
Depreciation Expense
Depreciation
Amount of divestiture of long-lived
Property Plant And Equipment Disposals
Customer Discounts And Allowances
Sales And Marketing Related Expenses Accrued
Current portion of milestone right liability.
Accrued expenses and other current liabilities.
Accrued Expenses And Other Current Liabilities [Abstract]
Salary and related expenses
Employee Related Liabilities Current
Discounts and allowances for commercial product sales
Customer Discounts And Allowances
Deferred lease liability
Direct Financing Lease Deferred Selling Profit
Professional fees
Accrued Professional Fees Current
Accrued interest
Interest Payable Current
Sales and marketing services
Sales And Marketing Related Expenses Accrued
Other
Other Accrued Liabilities Current
Current portion of milestone rights liability
Current Portion Of Milestone Right Liability
Accrued expenses and other current liabilities
Percentage of beneficial interest owned.
Trustee substantial portion disposed term.
Percentage of common stock shares outstanding.
Additional common stock shares reserved for issuance.
Percentage of beneficially own in excess.
Written notice period from related party.
Schedule Of Related Party Transactions By Related Party [Table]
Schedule Of Related Party Transactions By Related Party [Table]
Title of Individual
Title Of Individual [Axis]
Title of Individual
Title Of Individual With Relationship To Entity [Domain]
Mr.Mann
Chief Executive Officer [Member]
Loan arrangement.
Loan Arrangement
Loan Arrangement [Member]
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Percentage of beneficial interest owned
Percentage Of Beneficial Interest Owned
Trustee substantial portion disposed term
Trustee Substantial Portion Disposed Term
Percentage of common stock shares outstanding
Percentage Of Common Stock Shares Outstanding
Additional common stock shares reserved for issuance
Additional Common Stock Shares Reserved For Issuance
Percentage of beneficially own in excess
Percentage Of Beneficially Own In Excess
Written notice period
Written Notice Period From Related Party
Accrued interest due to related party
Debt Instrument [Table]
Debt Instrument [Table]
Deerfield credit facility.
Deerfield Credit Facility
Deerfield Credit Facility [Member]
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Mann Group promissory notes
Credit Facility
Line Of Credit
Senior notes
Senior Notes
Total debt — net carrying amount
Long Term Debt
Accrued paid in kind interest.
Five point seven five percent two thousand twenty four convertible notes.
5.75% 2024 Convertible Notes
Five Point Seven Five Percent Two Thousand Twenty Four Convertible Notes [Member]
Credit facility due july two thousand nineteen.
9.75% Credit Facility Due July 2019
Credit Facility Due July Two Thousand Nineteen [Member]
Credit facility due august two thousand nineteen.
9.75% Credit Facility Due August 2019
Credit Facility Due August Two Thousand Nineteen [Member]
Credit facility due may two thousand nineteen.
8.75% Credit Facility Due May 2019
Credit Facility Due May Two Thousand Nineteen [Member]
Variable Rate
Variable Rate [Axis]
Variable Rate
Variable Rate [Domain]
LIBOR
London Interbank Offered Rate L I B O R [Member]
Amount Due
Accrued interest paid-in-kind
Accrued Paid In Kind Interest
Debt instrument floor rate.
Annual interest rate
Annual interest rate
Debt Instrument Basis Spread On Variable Rate1
Interest rate floor
Debt Instrument Floor Rate
Maturity date
Debt Instrument Maturity Date
Conversion price
2020
Long Term Debt Maturities Repayments Of Principal Remainder Of Fiscal Year
2021
Long Term Debt Maturities Repayments Of Principal In Year Two
2022
Long Term Debt Maturities Repayments Of Principal In Year Three
2023
Long Term Debt Maturities Repayments Of Principal In Year Four
2024
Long Term Debt Maturities Repayments Of Principal In Year Five
Thereafter
Long Term Debt Maturities Repayments Of Principal After Year Five
Total principal payments
Debt Instrument Carrying Amount
Unamortized discount
Debt Instrument Unamortized Discount
Debt issuance costs
Deferred Finance Costs Net
Debt instrument additional borrowing capacity.
Two thousand nineteen notes.
2019 notes
Two Thousand Nineteen Notes [Member]
Eight point seven five senior convertible notes due two thousand nineteen.
Tranche B notes
Eight Point Seven Five Senior Convertible Notes Due Two Thousand Nineteen [Member]
Deerfield facility financing obligation.
Facility Financing Obligation
Deerfield Facility Financing Obligation [Member]
Conversion of notes to common shares, value
Debt Conversion Converted Instrument Amount1
Debt instrument additional borrowing capacity
Debt Instrument Additional Borrowing Capacity
Debt instrument, remaining borrowing capacity
Debt Instrument Unused Borrowing Capacity Amount
Repayments of aggregate principal amount
Two thousand nineteen notes tranche one.
2019 Notes Tranche 1
Two Thousand Nineteen Notes Tranche One [Member]
Exchange in aggregate principal amount
Unamortized debt issuance costs and debt discount
Debt Instrument Unamortized Discount Premium And Debt Issuance Costs Net
Payment for milestone rights liabilities.
Milestone rights liabilities current.
Milestone interest expense.
Payment for milestone liability
Payment For Milestone Rights Liabilities
Milestone rights liability, current
Milestone Rights Liabilities Current
Milestone interest expense
Milestone Interest Expense
Tranche one.
Tranche 1
Tranche One [Member]
Tranche one and tranche two.
Tranche 1 and Tranche 2
Tranche One And Tranche Two [Member]
Debt Instrument, Redemption, Period
Debt Instrument Redemption Period [Axis]
Debt Instrument, Redemption, Period
Debt Instrument Redemption Period [Domain]
Between First Anniversary and Prior to Second Anniversary of Closing Date
Debt Instrument Redemption Period Two [Member]
Prior to First Anniversary of Closing Date
Debt Instrument Redemption Period One [Member]
After Second Anniversary and Prior to Third Anniversary of Closing Date
Debt Instrument Redemption Period Three [Member]
Tranche two and three.
Tranche 2 and 3 [Member]
Tranche Two And Three [Member]
Principal amount
Advance of borrowing
Proceeds From Secured Lines Of Credit
Unamortized debt issuance costs
Unamortized debt discount
Debt instrument exit fee percentage.
Debt Instrument Exit Fee Percentage
Debt Instrument Exit Fee Percentage
Debt instrument payment number of equal monthly installments.
Early termination fees percentage.
Interest rate (LIBOR)
Debt payable number of equal monthly installments
Debt Instrument Payment Number Of Equal Monthly Installments
Debt instrument payment term description
Debt Instrument Frequency Of Periodic Payment
Early termination fees, percentage
Early Termination Fees Percentage
Credit facility, origination fee
Debt Instrument Fee Amount
Interest on loans increased, percentage
Term loan advance percentage of amount drawdown.
Term loan advance percentage of amount drawdown
Term Loan Advance Percentage Of Amount Drawdown
Warrants to purchase of common stock
Class Of Warrant Or Right Number Of Securities Called By Each Warrant Or Right
Exercise price of warrants
Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1
Senior notes due two thousand twenty one.
2021 Notes
Senior Notes Due Two Thousand Twenty One [Member]
Two thousand twenty four convertible notes.
2024 Convertible Notes
Two Thousand Twenty Four Convertible Notes [Member]
Collaborative Arrangement and Arrangement Other than Collaborative
Type Of Arrangement [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Arrangements And Nonarrangement Transactions [Member]
Privately-negotiated exchange agreement.
Privately Negotiated Exchange Agreement
Privately Negotiated Exchange Agreement [Member]
Bruce & Co Inc.
Bruce & Co.,Inc.
Bruce And Co Inc [Member]
Senior notes outstanding
Issuance of common stock to note holders
Debt Conversion Converted Instrument Shares Issued1
Exchange price per share
Shares Issued Price Per Share
Debt instrument, maturity date, description
Debt Instrument Maturity Date Description
Principal amount per share.
No of convertible shares
Debt Instrument Convertible Conversion Ratio1
Principal amount per share
Principal Amount Per Share
Debt default, description
Default Longterm Debt Description Of Violation Or Event Of Default
Percentage of repurchase price
Debt Instrument Redemption Price Percentage
Debt instrument convertible threshold consecutive trading day.
Debt Instrument, redemption description
Debt Instrument Redemption Description
Percentage of conversion price equaling stock price
Debt Instrument Convertible Threshold Percentage Of Stock Price Trigger
Number of trading days
Debt Instrument Convertible Threshold Trading Days
Consecutive trading days
Debt Instrument Convertible Threshold Consecutive Trading Day
Unamortized premium
Debt Instrument Unamortized Premium
Accrued Paid-in-Kind Interest
Debt instrument, date of first required interest payment
Debt Instrument Date Of First Required Payment1
Amortization of debt premium.
Amortization of debt discount.
Amortization of debt premium
Amortization Of Debt Premium
Amortization of debt discount
Amortization Of Debt Discount
Accretion expense — debt issuance cost
Amortization Of Financing Costs And Discounts
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
License agreement.
License Agreement
License Agreement [Member]
Research agreement.
Research Agreement
Research Agreement [Member]
Collaboration and license agreement.
Collaboration and License Agreement
Collaboration And License Agreement [Member]
Distribution agreement.
Distribution Agreement
Distribution Agreement [Member]
United Therapeutics Corporation.
United Therapeutics Corporation
United Therapeutics Corporation [Member]
Counterparty Name
Counterparty Name [Axis]
Counterparty Name
Repurchase Agreement Counterparty Name [Domain]
Receptor Life Science Inc.
Receptor
Receptor Life Science Inc [Member]
Cipla Ltd.
Cipla Ltd
Cipla Ltd [Member]
Biomm S.A.
Biomm S.A.
Biomm S A [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Total revenue from collaborations and services
Upfront payment received.
Milestone payment received.
Potential milestone payments to be received.
Additional option exercise and development milestone payments to be received.
Engineering consulting services.
Engineering Consulting Services
Engineering Consulting Services [Member]
Product prototype.
Product Prototype
Product Prototype [Member]
Supply and distribution agreement.
Supply and Distribution Agreement
Supply And Distribution Agreement [Member]
Biomm
License and Distribution Agreement
License And Distribution Agreement [Member]
Income Tax Authority
Income Tax Authority [Axis]
Income Tax Authority
Income Tax Authority [Domain]
Foreign Country
Foreign Country [Member]
Income Tax Authority, Name
Income Tax Authority Name [Axis]
Income Tax Authority, Name
Income Tax Authority Name [Domain]
India Tax Authority
Ministry Of Finance India [Member]
Upfront payment received
Upfront Payment Received
Milestone Payment Received
Milestone Payment Received
Potential milestone payments to be receive
Potential Milestone Payments To Be Received
Additional option exercise and development milestone payments to be receive
Additional Option Exercise And Development Milestone Payments To Be Received
Total transaction price
Revenue Remaining Performance Obligation
Deferred revenue
Deferred revenue - current
Deferred revenue - long term
Deferred revenue recognition period
Revenue performance obligation, method used
Revenue Performance Obligation Satisfied Over Time Method Used Description
Deferred revenue - nonrefundable license fee
Revenue — collaborations and services
Date of agreement initiation for marketing and distribution.
Marketing and distribution agreement date
Date Of Agreement Initiation For Marketing And Distribution
Income Taxes Paid
Fair value of financial instruments.
Fair Value of Financial Instruments [Table]
Fair Value Of Financial Instruments [Table]
Fair Value Of Financial Instruments [Table]
Cash and Cash Equivalents
Cash And Cash Equivalents [Axis]
Cash and Cash Equivalents
Restricted Cash And Cash Equivalents Cash And Cash Equivalents [Member]
Money Market Funds
Money Market Funds [Member]
U.S. Treasury bills or notes.
U S Treasury Securities [Member]
Fair Value Of Financial Instruments [Line Items]
Fair Value Of Financial Instruments [Line Items]
Fair value of debt instruments to related party description.
Fair value of note payable to related party, description
Fair Value Of Debt Instruments To Related Party Description
Change in fair value of note payable value due to change in interest rate percentage.
Note payable, percentage of interest rate change.
Change in fair value of note payable percentage due to change in interest rate percentage.
Mann Group Promissory Notes.
Mann Group Promissory Notes
Mann Group Promissory Notes [Member]
Senior Notes
Senior Notes [Member]
Measurement Input Type
Measurement Input Type [Axis]
Measurement Input Type
Measurement Input Type [Domain]
Note payable yield changes one.
Note Payable Yield Changes 1
Note Payable Yield Changes One [Member]
Note payable yield changes two.
Note Payable Yield Changes 2
Note Payable Yield Changes Two [Member]
Note payable yield changes three.
Note Payable Yield Changes 3
Note Payable Yield Changes Three [Member]
Note payable yield changes four.
Note Payable Yield Changes 4
Note Payable Yield Changes Four [Member]
Note payable, percentage of yield
Debt Instrument Measurement Input
Note payable, percentage of interest rate increases (decreases)
Note Payable Percentage Of Interest Rate Change
Note payable to related party, fair value
Notes Payable Fair Value Disclosure
Change in fair value of note payable value due to change in interest rate percentage
Change In Fair Value Of Note Payable Value Due To Change In Interest Rate Percentage
Increase (decrease) in fair value of note payable percentage due to increases (decreases) in interest rate percentage
Change In Fair Value Of Note Payable Percentage Due To Change In Interest Rate Percentage
Fair Value By Balance Sheet Grouping [Table]
Fair Value By Balance Sheet Grouping [Table]
Measurement Basis
Fair Value By Measurement Basis [Axis]
Fair Value Disclosure Item Amounts [Default]
Portion At Fair Value Fair Value Disclosure [Member]
Fair Value Measurement
Fair Value Disclosure Item Amounts [Domain]
Carrying Value
Carrying Reported Amount Fair Value Disclosure [Member]
Estimate of Fair Value Measurement
Estimate Of Fair Value Fair Value Disclosure [Member]
Fair Value Hierarchy and NAV
Fair Value By Fair Value Hierarchy Level [Axis]
Fair Value Hierarchy and NAV
Fair Value Measurements Fair Value Hierarchy [Domain]
Fair Value, Inputs, Level 3
Fair Value Inputs Level3 [Member]
Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items]
Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items]
Financial liabilities:
Financial Liabilities Fair Value Disclosure [Abstract]
Financial liabilities fair value
Financial Liabilities Fair Value Disclosure
Embedded derivatives
Embedded Derivative Fair Value Of Embedded Derivative Liability
Schedule Of Stock By Class [Table]
Schedule Of Stock By Class [Table]
Contolled equity offering sales agreement.
Contolled Equity Offering Sales Agreement
Contolled Equity Offering Sales Agreement [Member]
At market issuance sales agreement.
At Market Issuance Sales Agreement
At Market Issuance Sales Agreement [Member]
Purchasers.
Purchase Agreements
Purchasers [Member]
Cantor fitzgerald.
Cantor Fitzgerald
Cantor Fitzgerald [Member]
Warrants
Warrant [Member]
Underwriting agreement.
Underwriting Agreement with Leerink Partners LLC
Underwriting Agreement [Member]
Class of Stock [Line Items]
Class Of Stock [Line Items]
Amount of net proceeds from issuance of securities
Proceeds From Issuance Of Common Stock
Stock purchase agreements date
Sale Of Stock Transaction Date
Number of shares sold during the period
Class of warrants or rights expiration date.
Closing of offering date.
Warrants to purchase common stock
Class Of Warrant Or Right Outstanding
Exercise price of warrants
Warrants expiration, date
Class Of Warrants Or Rights Expiration Date
Closing of Offering Date
Closing Of Offering Date
Class of warrant or right modified.
Class of warrant or right exercised.
Class of warrant or right expired unexercised.
Remaining Warrants Available for Purchase.
Repurchase of common stock , shares
Stock Repurchased During Period Shares
Repurchase of common stock , value
Stock Repurchased During Period Value
Additional paid-in capital
Additional Paid In Capital
Other expense
Warrants modified
Class Of Warrant Or Right Modified
Warrants exercised
Class Of Warrant Or Right Exercised
Warrants expired unexercised
Class Of Warrant Or Right Expired Unexercised
Remaining warrants available for purchase
Remaining Warrants Available For Purchase
EPS — basic and diluted:
Earnings Per Share Basic And Diluted [Abstract]
Net loss (numerator)
Weighted average common shares (denominator)
Net loss per share
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Antidilutive Securities
Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis]
Antidilutive Securities, Name
Antidilutive Securities Name [Domain]
Exercise of Common Stock Options
Employee Stock Option [Member]
Conversion of convertible notes payable to former related party into common stock.
Conversion of Convertible Notes Payable to Former Related Party into Common Stock
Conversion Of Convertible Notes Payable To Former Related Party Into Common Stock [Member]
Exercise of warrants associated with public offering.
Exercise of Warrants Associated with Public Offering
Exercise Of Warrants Associated With Public Offering [Member]
Exercise of warrants associated with midcap credit facility.
Exercise of Warrants Associated with Midcap Credit Facility
Exercise Of Warrants Associated With Midcap Credit Facility [Member]
Conversion of convertible notes into common stock.
Conversion of Convertible Notes into Common Stock
Conversion Of Convertible Notes Into Common Stock [Member]
Vesting of Restricted Stock Units
Restricted Stock [Member]
Employee stock purchase plan.
Employee Stock Purchase Plan
Employee Stock Purchase Plan [Member]
Exercise of Common Stock Warrants
Exercise of warrants associated with direct placement.
Exercise of Warrants Associated with Direct Placement
Exercise Of Warrants Associated With Direct Placement [Member]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Anti-dilutive securities excluded from computation of earnings per share
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Plan Name
Plan Name [Axis]
Plan Name
Plan Name [Domain]
Equity incentive plan twenty eighteen.
2018 Equity Incentive Plan
Equity Incentive Plan Twenty Eighteen [Member]
Award Type
Award Type [Axis]
Award Type
Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain]
Stock Options
Restricted Stock
Vesting
Vesting [Axis]
Vesting
Vesting [Domain]
Tranche One
Share Based Compensation Award Tranche One [Member]
Performance-based Stock Options
Performance Shares [Member]
Employee stock options and performance based options.
Options and Performance-based Options
Employee Stock Options And Performance Based Options [Member]
Restricted Stock Units
Restricted Stock Units R S U [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Equity incentive plan, shares
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Authorized
Vesting period
Sharebased Compensation Arrangement By Sharebased Payment Award Expiration Period
Vesting period
Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1
Vesting rights percentage
Sharebased Compensation Arrangement By Sharebased Payment Award Award Vesting Rights Percentage
Two Thousand Four Equity Incentive Plan [Member]
2004 Equity Incentive Plan
Two Thousand Four Equity Incentive Plan [Member]
Equity incentive plan twenty thirteen.
2013 Equity Incentive Plan
Equity Incentive Plan Twenty Thirteen [Member]
Two Thousand Four Non Employee Directors Stock Option Plan [Member]
2004 Non Employee Directors Stock Option Plan
Two Thousand Four Non Employee Directors Stock Option Plan [Member]
Outstanding Options
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
Outstanding Restricted Stock Units
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Number
Shares Available for Future Issuance
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant
Stock-based compensation
Allocated Share Based Compensation Expense
Research and development
Research And Development Expense [Member]
Selling, General and Administrative Expenses
Selling General And Administrative Expenses [Member]
Cost of revenue collaborations and services.
Cost of Revenue — Collaborations and Services
Cost Of Revenue Collaborations And Services [Member]
Share based compensation
Transfers From (To) Parent [Abstract]
Transfers From To Parent [Abstract]
Minimum
Maximum
Risk free interest rate, minimum
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Minimum
Risk free interest rate, maximum
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Maximum
Expected lives
Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1
Volatility, minimum
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Minimum
Volatility, maximum
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Maximum
Dividends
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate
Number of Shares
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Roll Forward
Outstanding at January 1, 2019
Granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
Exercised
Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period
Expired
Share Based Compensation Arrangement By Share Based Payment Award Options Expirations In Period
Outstanding at December 31, 2019
Exercisable at December 31, 2019
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number
Weighted Average Exercise Price per Share
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Rollforward
Outstanding at January 1, 2019
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
Granted
Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
Exercised
Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price
Forfeited
Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price
Expired
Share Based Compensation Arrangements By Share Based Payment Award Options Expirations In Period Weighted Average Exercise Price
Outstanding at December 31, 2019
Exercisable at December 31, 2019
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price
Weighted Average Remaining Contractual Term (Years)
Share Based Compensation Arrangement By Share Based Payment Award Options Additional Disclosures [Abstract]
Outstanding
Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2
Exercisable at December 31, 2019
Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested And Expected To Vest Exercisable Weighted Average Remaining Contractual Term1
Share-based Compensation Arrangement by Share-based Payment Award, Options, Aggregate Intrinsic Value [Abstract]
Aggregate Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Options Aggregate Intrinsic Value [Abstract]
Outstanding at January 1, 2019
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value
Outstanding at December 31, 2019
Exercisable at December 31, 2019
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Intrinsic Value1
Weighted average grant date fair value of the stock options granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
Cash received from the exercise of options
Compensation cost
Sharebased Compensation Arrangement By Sharebased Payment Award Compensation Cost1
Unrecognized compensation expense related to options
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Stock Options
Number of Shares
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Roll Forward
Outstanding at January 1, 2019
Granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period
Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period
Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeited In Period
Outstanding at December 31, 2019
Weighted Average Grant Date Fair Value per Share
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value Roll Forward
Outstanding at January 1, 2019
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value
Granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Grant Date Fair Value
Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Weighted Average Grant Date Fair Value
Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeitures Weighted Average Grant Date Fair Value
Outstanding at December 31, 2019
Share based compensation arrangement by share based payment award equity instruments other than options in period grant date fair value outstanding.
Total fair value of restricted stock units vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Total Fair Value
Total grant date fair value of restricted stock units outstanding
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options In Period Grant Date Fair Value Outstanding
Unrecognized compensation expense related to non-option
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Share Based Awards Other Than Options
Weighted average vesting period for unrecognized compensation expense
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1
Commitments and Contingencies [Line Items]
Commitments and Contingencies [Table]
Commitments And Contingencies [Table]
Commitments And Contingencies [Table]
Vehicle Leases
Vehicles [Member]
Lease agreement with enterprise.
Lease Agreement with Enterprise
Lease Agreement With Enterprise [Member]
Office.
Office Lease
Office [Member]
Russell Ranch Road II LLC.
Russell Ranch Road II LLC
Russell Ranch Road I I L L C [Member]
Commitments And Contingencies [Line Items]
Commitments And Contingencies [Line Items]
Purchase obligation extended term.
Purchase obligation extended term
Purchase Obligation Extended Term
Purchase Obligation Due In Sixth Year
Purchase Obligation Due In Seventh Year
Purchase Obligation Fiscal Year Maturity [Abstract]
2020
Purchase Obligation Due In Next Twelve Months
2021
Purchase Obligation Due In Second Year
2022
Purchase Obligation Due In Third Year
2023
Purchase Obligation Due In Fourth Year
2024
Purchase Obligation Due In Fifth Year
2025
Purchase Obligation Due In Sixth Year
2026
Purchase Obligation Due In Seventh Year
Payment of long term purchase commitment amendment fee.
Payment of long term purchase commitment, amendment fees
Payment Of Long Term Purchase Commitment Amendment Fee
Long Term Purchase Commitment, Expiration Date
Long-term purchase commitment, renewal time period.
Foreign currency hedging transaction period.
Supply Agreement expiration period
Long Term Purchase Commitment Expiration Date
Supply Agreement renewal period
Longterm Purchase Commitment Renewal Time Period
Foreign currency hedging transactions period
Foreign Currency Hedging Transaction Period
Class of warrant or right exercisable.
Warrants exercisable
Class Of Warrant Or Right Exercisable
Number of vehicle leases.
Number of vehicle leases removed.
Operating lease reduction in right of use asset.
Reduction in operating lease liability.
Other non current assets.
Operating lease other liabilities current.
Number of vehicle leases
Number Of Vehicle Leases
Operating lease rent expenses
Operating Lease Expense
Number of vehicle leases removed
Number Of Vehicle Leases Removed
Gain or loss recorded for leases removed
Gain Loss On Termination Of Lease
Lease expiration period
Lessee Operating Lease Lease Not Yet Commenced Term Of Contract1
Reduction in operating lease right-of-use assets
Operating Lease Reduction In Right Of Use Asset
Reduction in operating lease liabilities
Reduction In Operating Lease Liability
Operating lease right-of-use assets
Operating Lease Right Of Use Asset
Operating lease liabilities
Operating Lease Liability
Operating lease, current assets
Operating Lease Other Non Current Assets
Operating lease, other current liabilities
Operating Lease Other Liabilities Current
Operating leases annual increase in rent expense.
Percentage of annual increase in lease payment
Operating Leases Annual Increase In Rent Expense
Lease expiration date
Lease Expiration Date1
Lease renewal option
Lessee Operating Lease Renewal Term
Reimbursement amount received for tenant improvements.
Reimbursement amount received for tenant improvements
Reimbursement Amount Received For Tenant Improvements
Operating lease costs
Operating Lease Cost
Operating lease, cash paid
Operating Lease Payments
Variable lease costs
Variable Lease Cost
Operating lease, weighted average discount rate
Operating Lease Weighted Average Discount Rate Percent
Operating lease, weighted-average remaining lease term
Operating Lease Weighted Average Remaining Lease Term1
Operating lease rent expenses
Operating Leases Rent Expense Net
Operating Lease Liabilities Payments Due [Abstract]
Office and vehicle.
office and vehicle
Office And Vehicle [Member]
2019
Lessee Operating Lease Liability Payments Remainder Of Fiscal Year
2020
Lessee Operating Lease Liability Payments Due Year Two
2021
Lessee Operating Lease Liability Payments Due Year Three
2022
Lessee Operating Lease Liability Payments Due Year Four
2023
Lessee Operating Lease Liability Payments Due Year Five
Total
Lessee Operating Lease Liability Payments Due
2019
Operating Leases Future Minimum Payments Due Current
2020
Operating Leases Future Minimum Payments Due In Two Years
2021
Operating Leases Future Minimum Payments Due In Three Years
2022
Operating Leases Future Minimum Payments Due In Four Years
2023
Operating Leases Future Minimum Payments Due In Five Years
Total
Operating Leases Future Minimum Payments Due
Employer contribution savings retirement plan
Defined Benefit Plan Contributions By Employer
United States
Income Loss From Continuing Operations Before Income Taxes Domestic
Foreign
Income Loss From Continuing Operations Before Income Taxes Foreign
Income Taxes [Line Items]
Income Taxes [Table]
Income Taxes [Table]
Income Taxes [Table]
New Jersey
New Jersey Division Of Taxation [Member]
Connecticut tax authority.
Connecticut
Connecticut Tax Authority [Member]
State
State And Local Jurisdiction [Member]
Federal
Internal Revenue Service I R S [Member]
Income Taxes [Line Items]
Income Taxes [Line Items]
Provision for income taxes
Current
Current Income Tax Expense Benefit Continuing Operations [Abstract]
U.S. federal
Current Federal Tax Expense Benefit
U.S. state
Current State And Local Tax Expense Benefit
Non-U.S.
Current Foreign Tax Expense Benefit
Total current
Current Income Tax Expense Benefit
Deferred
Deferred Income Tax Expense Benefit Continuing Operations [Abstract]
U.S. federal
Deferred Federal Income Tax Expense Benefit
U.S. state
Deferred State And Local Income Tax Expense Benefit
Non-U.S.
Deferred Foreign Income Tax Expense Benefit
Total deferred
Deferred Income Tax Expense Benefit
Valuation allowance
Valuation Allowance Deferred Tax Asset Change In Amount
Total
Deferred Tax Assets Capitalized Research Expenses
Deferred Tax Assets Milestone Rights
Deferred Tax Assets, Tax Deferred Expense (Accrual Adjustment)
Deferred Tax Assets Loss on Purchase Commitment
Deferred Tax Assets Capitalized Costs
Deferred tax assets lease liabilities.
Deferred tax assets interest expense limitation.
Deferred tax assets product revenue and other.
Deferred tax liabilities right of use asset.
Deferred tax assets:
Components Of Deferred Tax Assets [Abstract]
Net operating loss carryforwards
Deferred Tax Assets Operating Loss Carryforwards
Research and development credits
Deferred Tax Assets Tax Credit Carryforwards Research
Capitalized research
Deferred Tax Assets Capitalized Research Expenses
Milestone Rights
Deferred Tax Assets Milestone Rights
Accrued expenses
Deferred Tax Assets Tax Deferred Expense Accrual Adjustment
Loss on purchase commitment
Deferred Tax Assets Loss On Purchase Commitment
Non-qualified stock option expense
Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost
Capitalized patent costs
Deferred Tax Assets Capitalized Costs
Other
Deferred Tax Assets Tax Deferred Expense Other
Lease liability
Deferred Tax Assets Lease Liabilities
Interest expense limitation
Deferred Tax Assets Interest Expense Limitation
Depreciation
Deferred Tax Assets Other
Deferred Product Revenue & Costs
Deferred Tax Assets Product Revenue And Costs
Total net deferred tax assets
Deferred Tax Assets Gross
Valuation allowance
Deferred Tax Assets Valuation Allowance
Net deferred tax assets
Deferred Tax Assets Net
Deferred tax liabilities:
Components Of Deferred Tax Liabilities [Abstract]
Right of use asset
Deferred Tax Liabilities Right Of Use Asset
Other prepaids
Deferred Tax Liabilities Prepaid Expenses
Total deferred tax liabilities
Deferred Income Tax Liabilities
Net deferred tax assets
Deferred Tax Assets Liabilities Net
Effective Income Tax Rate Reconciliation Permanent Items
Effective income tax rate reconciliation effect of tax law changes.
Effective income tax rate reconciliation expirations of attribute.
Effective income tax rate reconciliation foreign withholding tax.
Federal tax benefit rate
Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
Permanent items
Effective Income Tax Rate Reconciliation Permanent Items
Tax law changes
Effective Income Tax Rate Reconciliation Effect Of Tax Law Changes
Stock based compensation
Effective Income Tax Rate Reconciliation Nondeductible Expense Share Based Compensation Cost
Tax attribute expirations
Effective Income Tax Rate Reconciliation Expirations Of Attribute
Foreign withholding tax
Effective Income Tax Rate Reconciliation Foreign Withholding Tax
Valuation allowance
Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
Effective income tax rate
Effective Income Tax Rate Continuing Operations
Valuation allowance of deferred tax asset
Change in the valuation allowance
Federal operating loss carryforwards
Deferred Tax Assets Operating Loss Carryforwards Domestic
State operating loss carryforwards
Deferred Tax Assets Operating Loss Carryforwards State And Local
Federal operation loss carryforwards, not subject to expiration
Deferred Tax Assets Operating Loss Carryforwards Not Subject To Expiration
Operating Loss Carryforwards Subject To Limitation
Net Operating Loss Carryforward Annual Limitation
Operating loss carryforwards, limitations on use
Operating Loss Carryforwards Limitations On Use
Net operating loss carryforwards
Operating Loss Carryforwards Subject To Limitation
Net operating loss and credit carryforwards, annual use limitation
Net Operating Loss Carryforward Annual Limitation
Research and Development Credits, Begin to Expire
Deferred tax assets tax credit carryforwards research not expire.
Research and development credits begin to expire
Research And Development Credits Begin To Expire
Research and development credits not expire
Deferred Tax Assets Tax Credit Carryforwards Research Not Expire
Undistributed earnings from its foreign subsidiaries
Undistributed Earnings Of Foreign Subsidiaries
Adjustment of deferred tax liability due to adoption of new leases guidance
Adjustment of deferred tax asset due to adoption of new leases guidance
Net revenues
Weighted average common shares used to compute net loss per share — basic and diluted