Accounting Policies [Abstract] Accounting Policies [Abstract] Accounts Payable and Accrued Liabilities Disclosure [Text Block] Accrued expenses and other current liabilities Accounts Payable, Current Accounts payable Accounts Receivable, Net, Current Receivables from collaboration Accrued Expenses and Other Current Liabilities [Line Items] Accrued Expenses and Other Current Liabilities [Line Items] Accrued Expenses and Other Current Liabilities [Line Items] Accrued Expenses and Other Current Liabilities [Table] Accrued Expenses and Other Current Liabilities [Table] Accrued Expenses and Other Current Liabilities [Table] Accrued Liabilities, Current Accrued expenses and other current liabilities Accrued expenses and other current liabilities Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Less accumulated depreciation and amortization Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive loss Additional Paid in Capital, Common Stock Additional paid-in capital Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash provided by (used) in operating activities: Alfred Mann Foundation [Member] Alfred Mann Foundation [Member] Mann Foundation Allocated Share-based Compensation Expense Stock-based compensation Amended Agreement [Member] Amended Agreement [Member] Amended Agreement Amendment Flag Amendment Flag Amortization of Debt Discount (Premium) Accretion expense- debt discount Amortization of Debt Issuance Costs Accretion expense- debt issuance cost Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Potentially dilutive securities outstanding Antidilutive Securities [Axis] Antidilutive Securities [Axis] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Area Of Office Space Leased Area Of Office Space Leased Area of office space leased Arrangements and Non-arrangement Transactions [Domain] Arrangements and Non-arrangement Transactions [Domain] Assets Total assets Assets [Abstract] ASSETS Assets, Current Total current assets Assets, Current [Abstract] Current assets: Securities or Other Assets Sold under Agreements to Repurchase [Axis] Securities or Other Assets Sold under Agreements to Repurchase [Axis] Assets Sold under Agreements to Repurchase, Type [Domain] Assets Sold under Agreements to Repurchase, Type [Domain] Available borrowings under the loan agreement. Available Borrowings Under Loan Agreement Additional borrowings Available Loan Balance Cancelled Available Loan Balance Cancelled Aggregate principal amount cancelled Award Type [Axis] Award Type [Axis] Basis of Presentation. Basis Of Presentation [Policy Text Block] Basis of Presentation Building Improvements [Member] Building Improvements Building [Member] Buildings Business. Business [Policy Text Block] Business Cash and Cash Equivalents, at Carrying Value CASH AND CASH EQUIVALENTS, END OF PERIOD CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD Cash and cash equivalents Cash and cash equivalents Cash and Cash Equivalents, Period Increase (Decrease) NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS Class A Warrants [Member] Class A Warrants [Member] A Warrants Class B Warrants [Member] Class B Warrants [Member] B Warrants Class Of Warrant Issuance Date Class Of Warrant Issuance Date Warrant liability issuance date Class of Warrant or Right [Axis] Class of Warrant or Right [Axis] Class of Warrant or Right [Domain] Class of Warrant or Right [Domain] Class Of Warrant Or Right Exercised Class Of Warrant Or Right Exercised Class of warrants exercised Class of Warrant or Right, Exercise Price of Warrants or Rights Exercise price of warrants Class of Warrant or Right, Expiration Period Class of Warrant or Right, Expiration Period Class of warrants expiration period upon issuance Class of Warrant or Right [Line Items] Class of Warrant or Right [Line Items] Class of Warrant or Right, Number of Securities Called by Each Warrant or Right Warrants to purchase of common stock Class of Warrant or Right, Outstanding Warrants outstanding Class Of Warrant Or Rights Month Year From Which Warrants Or Rights Exercisable Class Of Warrant Or Rights Month Year From Which Warrants Or Rights Exercisable Warrants exercisable date Class of Warrant or Right [Table] Class of Warrant or Right [Table] Collaboration Agreements, Expiration Date Collaboration Agreements, Expiration Date Collaboration agreements expiration date Collaboration and License Agreement Collaboration and License Agreement [Member] License and Collaboration Agreement with Sanofi Collaborative Arrangement Disclosure [Text Block] Collaboration arrangement Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Commitments and Contingencies Commitments and contingencies Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Text Block] Commitments and contingencies Commitments and Contingencies [Line Items] Commitments and Contingencies [Line Items] Commitments and Contingencies [Line Items] Commitments and Contingencies [Table] Commitments and Contingencies [Table] Commitments and Contingencies [Table] Common stock loaned under share lending agreement, shares. Common Stock Loaned Under Share Lending Agreement Shares Return of loaned common stock (in shares) Common Stock [Member] Common Stock Common Stock, Par or Stated Value Per Share Common stock, par value Common Stock, Shares Authorized Common stock, shares authorized Common Stock, Shares, Issued Common stock, shares issued Common Stock, Shares, Outstanding Common stock, shares outstanding Common Stock, Value, Issued Common stock, $0.01 par value - 700,000,000 and 550,000,000 shares authorized at June 30, 2016 and December 31, 2015, respectively; 477,741,850 and 428,670,943 shares issued and outstanding at June 30, 2016 and December 31, 2015, respectively Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive loss Computer equipment and software. Computer Equipment And Software [Member] Computer Equipment and Software Construction in Progress Expenditures Incurred but Not yet Paid Non-cash construction in progress and property and equipment Construction in Progress [Member] Construction in Progress Construction Payable, Current Construction in progress Contingent Liability Contingent Liability Contingent liability for milestone payments Conversion of Stock, Shares Converted Number of shares to be converted Convertible Debt Securities [Member] Convertible Debt Securities Convertible Notes Payable, Noncurrent Senior convertible notes Costs and Expenses Total operating expenses Credit Facility [Axis] Credit Facility [Axis] Credit Facility [Domain] Credit Facility [Domain] Current Fiscal Year End Date Current Fiscal Year End Date Debt Disclosure [Abstract] Debt Disclosure [Abstract] Debt Disclosure [Text Block] Facility Agreement Debt Instrument [Axis] Debt Instrument [Axis] Debt Instrument, Basis Spread on Variable Rate Interest rate (LIBOR) Long-term Debt, Gross Carrying value Net carrying amount Debt Instrument, Convertible, Conversion Price Conversion price of shares Debt Instrument, Convertible, Conversion Ratio No of convertible shares Debt Instrument, Convertible, Threshold Consecutive Trading Days Consecutive trading days Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger Percentage of conversion price equaling stock price Debt Instrument, Convertible, Threshold Trading Days Number of trading days Debt Instrument, Date of First Required Payment Principal repayment schedule, start date Debt Instrument Date Of Last Required Payment Debt Instrument Date Of Last Required Payment Principal repayment schedule, end date Debt Instrument, Description of Variable Rate Basis Description of variable rate interest Debt Instrument, Face Amount Debt facility principal amount Principal amount Debt Instrument, Fair Value Disclosure Estimated fair value Debt Instrument, Interest Rate, Stated Percentage Senior notes, effective interest rate Debt Instrument [Line Items] Debt Instrument [Line Items] Debt Instrument, Maturity Date Maturity date Debt Instrument, Name [Domain] Debt Instrument, Name [Domain] Debt Instrument, Redemption, Description Debt Instrument, redemption description Debt Instrument, Redemption, Period [Axis] Debt Instrument, Redemption, Period [Axis] Debt Instrument, Redemption, Period [Domain] Debt Instrument, Redemption, Period [Domain] Debt Instrument, Redemption, Period Two [Member] If certain fundamental changes occur Debt Instrument, Redemption Price, Percentage Percentage of repurchase price Schedule of Long-term Debt Instruments [Table] Schedule of Long-term Debt Instruments [Table] Debt Instrument, Unamortized Premium Unamortized premium Deerfield Management Company L.P. Deerfield Management Company Lp [Member] Deerfield Deferred Costs, Noncurrent Deferred cost Deferred Costs, Current Deferred costs from collaboration Debt Issuance Costs, Gross Debt Issuance Cost Deferred Revenue Deferred revenue from collaboration product shipments Deferred Revenue, Current Deferred payments from collaboration Depreciation, Depletion and Amortization, Nonproduction Depreciation and accretion Depreciation, Depletion and Amortization Depreciation and amortization expense Derivative Liability, Current Warrant liability Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Accounting for stock-based compensation Document And Entity Information [Abstract] Document And Entity Information [Abstract] Document And Entity Information [Abstract] Document Fiscal Period Focus Document Fiscal Period Focus Document Fiscal Year Focus Document Fiscal Year Focus Document Information [Line Items] Document Information [Line Items] Document Information [Table] Document Information [Table] Document Period End Date Document Period End Date Document Type Document Type Earnings Per Share [Abstract] Earnings Per Share [Abstract] Earnings Per Share, Basic and Diluted Net loss per share - basic and diluted Earnings Per Share [Text Block] Net loss per common share Employee-related Liabilities, Current Salary and related expenses Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized Unrecognized compensation cost, share-based compensation arrangements Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition Weighted average vesting period for unrecognized compensation cost Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Share-based Awards Other than Options Unrecognized compensation cost related to non-option Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options Unrecognized compensation cost related to options Employee Stock Option [Member] Stock Options Entity Central Index Key Entity Central Index Key Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Entity [Domain] Entity [Domain] Entity Filer Category Entity Filer Category Entity Registrant Name Entity Registrant Name Equity [Abstract] Equity [Abstract] Equity Component [Domain] Equity Component [Domain] Executive Officer [Member] Executive Officer Facility Financing Obligation [Member] Facility Financing Obligation [Member] Facility financing obligation Fair Value Adjustment of Warrants Warrant fair value adjustment Asset Class [Domain] Asset Class [Domain] Fair Value Assumptions, Expected Volatility Rate Fair value assumption, stock price volatility Fair Value Assumptions, Risk Free Interest Rate Fair value assumption, risk-free rate Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] Asset Class [Axis] Asset Class [Axis] Fair Value, by Balance Sheet Grouping [Table] Fair Value, by Balance Sheet Grouping [Table] Fair Value, Hierarchy [Axis] Fair Value, Hierarchy [Axis] Fair Value Disclosures [Abstract] Fair Value Disclosures [Abstract] Fair Value Disclosures [Text Block] Fair Value of Financial Instruments Fair Value Inputs, Discount Rate Market discount rate Fair Value, Inputs, Level 3 [Member] Fair Value, Inputs, Level 3 Fair Value Hierarchy [Domain] Fair Value Hierarchy [Domain] Fair Value of Financial Instruments [Line Items] Fair Value of Financial Instruments [Line Items] Fair Value of Financial Instruments [Line Items] Fair Value of Financial Instruments, Policy [Policy Text Block] Fair Value of Financial Instruments Fair Value of Financial Instruments [Table] Fair Value of Financial Instruments [Table] Fair Value of Financial Instruments [Table] Financial Liabilities Fair Value Disclosure Financial liabilities fair value Financial Liabilities Fair Value Disclosure [Abstract] Financial liabilities: Foreign Currency Transaction Loss, before Tax Foreign currency transaction loss Loss on foreign currency exchange Furniture, fixtures and office equipment. Furniture Fixtures And Office Equipment [Member] Furniture, fixtures and office equipment Gain (Loss) on Disposition of Property Plant Equipment, Excluding Oil and Gas Property and Timber Property Loss on disposal of property and equipment Impairment Charge on Reclassified Assets Impairment charges allocated to individual asset groups Income Approach Valuation Technique [Member] Income Approach Valuation Technique Income Statement [Abstract] Income Statement [Abstract] Income Tax Disclosure [Abstract] Income Tax Disclosure [Abstract] Income Tax Disclosure [Text Block] Income taxes Increase (Decrease) in Accounts and Other Receivables Receivables from Collaboration Increase (Decrease) in Accounts Payable Accounts payable Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities Accrued expenses and other current liabilities Increase (Decrease) in Customer Advances and Deposits Deferred payment from collaboration Increase (Decrease) in Deferred Charges Deferred costs from collaboration Increase (Decrease) in Deferred Revenue Deferred sales from collaboration Increase (Decrease) in Inventories Inventory Increase (Decrease) in Operating Capital [Abstract] Changes in assets and liabilities: Increase (Decrease) in Other Operating Assets Other assets Increase (Decrease) in Other Operating Liabilities Other liabilities Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other current assets Increase Decrease in Purchase Commitment Loss Current Increase Decrease in Purchase Commitment Loss Current Purchase commitment loss - current Increase Decrease in Purchase Commitment Loss Noncurrent Increase Decrease in Purchase Commitment Loss Noncurrent Non-current purchase commitment loss Insulin [Member] Insulin [Member] Insulin Put Interest Expense, Debt Interest expense on notes Interest on Note Payable to Principal Stockholder Interest on Note Payable to Principal Stockholder Interest on note payable to principal stockholder Interest Paid, Net Interest paid in cash, net of amounts capitalized Interest Payable, Current Accrued interest Interest Payable Accrued interest payable Inventory, Current [Table] Inventory, Current [Table] Inventory Disclosure [Abstract] Inventory Disclosure [Abstract] Inventory Disclosure [Text Block] Inventories Inventory, Finished Goods, Net of Reserves Finished goods Inventory [Line Items] Inventory [Line Items] Inventory, Net Inventory Total Inventory Inventory, Raw Materials, Net of Reserves Raw materials Inventory, Work in Process, Net of Reserves Work-in-process Investment Income, Interest Interest income Issue Of Warrants To Purchase Shares Of Common Stock Issue Of Warrants To Purchase Shares Of Common Stock Number of warrants available for purchase common shares Land [Member] Land Operating Leases, Rent Expense Lease payments Lease and Rental Expense [Line Items] Lease and Rental Expense [Line Items] Lease and Rental Expense [Line Items] Lease and Rental Expense [Table] Lease and Rental Expense [Table] Lease and Rental Expense [Table] Lease Expiration Month Year Lease Expiration Month Year Lease expiration period Leases [Abstract] Leases [Abstract] Legal Entity [Axis] Legal Entity [Axis] Letter agreement. Letter Of Agreement [Member] Letter Agreement Liabilities Total liabilities Liabilities and Equity Total Liabilities and Equity [Abstract] LIABILITIES AND STOCKHOLDERS' DEFICIT Liabilities, Current Total current liabilities Liabilities, Current [Abstract] Current liabilities: Financial and Nonfinancial Liabilities, Fair Value Disclosure Fair value of warrants liability Fair value of Milestone Rights Long-term Line of Credit Principal amount outstanding under credit facility Line of Credit Facility, Maximum Borrowing Capacity Maximum secured loan facility Line of Credit Facility, Remaining Borrowing Capacity Amount available for future borrowings Line Of Credit Facility Restricted Borrowing Capacity Line Of Credit Facility Restricted Borrowing Capacity Available amount of credit facility under covenant restrictions Loan agreement with related party. Loan Agreement With Related Party Loan agreement with related party Loan arrangement. Loan Arrangement [Member] Loan Arrangement Loans Assumed Reclassification of deferred payments from collaboration to Sanofi Loan Facility and loss share obligation London Interbank Offered Rate (LIBOR) [Member] LIBOR Long-term Debt, Percentage Bearing Fixed Interest, Percentage Rate Fixed borrowing rate Long-term Debt [Text Block] Senior convertible notes Long-term Debt, Type [Axis] Long-term Debt, Type [Axis] Long-term Debt, Type [Domain] Long-term Debt, Type [Domain] Loans Payable, Noncurrent Secured loan facility, amount owed Long-term Purchase Commitment, Amount Purchase commitment amount under Insulin Supply Agreement Long Term Purchase Commitment Amount Purchased Long Term Purchase Commitment Amount Purchased Purchase obligation, purchased amount Long Term Purchase Commitment Cancellation Fees Long Term Purchase Commitment Cancellation Fees Purchase commitment cancellation fees Long Term Purchase Commitment, Expiration Date Long Term Purchase Commitment, Expiration Date Supply Agreement expiration period Long-term purchase commitment, renewal time period. Long-term Purchase Commitment, Renewal Time Period Supply Agreement renewal period Loss Contingency, Accrual, Noncurrent Sanofi loan facility and profit/loss share obligation Losses On Purchase Commitments Losses On Purchase Commitments Loss on purchase commitments Loss on Purchase Commitments, Policy [Policy Text Block] Loss on Purchase Commitments, Policy [Policy Text Block] Loss on purchase commitments Loss Sharing Agreement, Amount Loss Sharing Agreement, Amount Company's total portion of loss sharing Machinery and Equipment [Member] Machinery and Equipment Manufacturing Costs Product manufacturing Market Approach Valuation Technique [Member] Market Approach Valuation Technique Maximum [Member] Maximum Milestone payments include payments to our partners related to alliance and collaboration agreements. Milestone payments for intangible assets Milestone payment Milestone Rights Liability Milestone Rights Liability [Member] Milestone Rights Liability Minimum [Member] Minimum Money Market Funds, at Carrying Value Cash equivalents, money market funds Mortgage Loan [Member] Mortgage Loan [Member] Mortgage Loan Net Cash Provided by (Used in) Financing Activities, Continuing Operations Net cash provided by financing activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] CASH FLOWS FROM FINANCING ACTIVITIES: Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net cash used in investing activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] CASH FLOWS FROM INVESTING ACTIVITIES: Net Cash Provided by (Used in) Operating Activities, Continuing Operations Net cash used in operating activities Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] CASH FLOWS FROM OPERATING ACTIVITIES: Net Income (Loss) Attributable to Parent Net loss Net loss Net Income Loss Per Common Share [Line Items] Net Income Loss Per Common Share [Line Items] Net Income Loss Per Common Share [Line Items] Net Income Loss Per Common Share [Table] Net Income Loss Per Common Share [Table] Net Income Loss Per Common Share [Table] Notes Payable, Related Parties, Noncurrent Note payable to principal stockholder Number of months advances outstanding. Number Of Months Advances Outstanding Number of months advances outstanding Operating Expenses [Abstract] Operating expenses: Operating Income (Loss) Loss from operations Operating loss Sharing [Member] Operating loss Sharing [Member] Operating loss Sharing Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] Organization, Consolidation and Presentation of Financial Statements Disclosure [Table] Organization, Consolidation and Presentation of Financial Statements Disclosure [Table] Organization, Consolidation and Presentation of Financial Statements Disclosure [Table] Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] Description of business and basis of presentation Other Accrued Liabilities, Current Other Other Assets, Noncurrent Other assets Other Commitment Other commitments with other suppliers Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Gain (Loss) Arising During Period, Net of Tax Other comprehensive (loss) income - cumulative translation (loss) gain Other Comprehensive Income (Loss), Net of Tax Other comprehensive (loss) gain Other Comprehensive Income (Loss), Net of Tax [Abstract] Other comprehensive loss: Other Deferred Credits, Current Deferred sales from collaboration Other Liabilities, Noncurrent Other liabilities Other Long-term Debt, Current Facility financing obligation Short term liability Other Long-term Debt, Noncurrent Long term liability Other Noncash Income (Expense) Other, net Other Nonoperating Income (Expense) Other (expense) income Own-share Lending Arrangement, Shares, Issued Shares loaned under the share lending arrangement Paid-in-Kind Interest Interest incurred through borrowings under Sanofi Loan Facility Paid-in-kind interest Payables and Accruals [Abstract] Payables and Accruals [Abstract] Payment of Financing and Stock Issuance Costs Issuance costs associated with the direct placement Payments Related to Tax Withholding for Share-based Compensation Payment of employment taxes related to vested restricted stock units Payments to Acquire Property, Plant, and Equipment Purchase of property and equipment Potential Milestone Payments To Be Received Potential Milestone Payments To Be Received Milestone receivable Preferred Stock, Par or Stated Value Per Share Undesignated preferred stock, par value Preferred Stock, Shares Authorized Undesignated preferred stock, shares authorized Preferred Stock, Shares Issued Undesignated preferred stock, shares issued Preferred Stock, Shares Outstanding Undesignated preferred stock, shares outstanding Preferred Stock, Value, Issued Undesignated preferred stock, $0.01 par value - 10,000,000 shares authorized; no shares issued or outstanding at June 30, 2016 and December 31, 2015 Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Principal amount per share. Principal Amount Per Share Principal amount per share Principal Owner [Member] Principal stockholder Proceeds from Collection of Long-term Loans to Related Parties Secured loan facility, amount earned Proceeds from Issuance of Common Stock Proceeds from issuance of common stock pursuant to ATM issuance The cash inflow from the additional capital contribution to the entity including any warrants issued. Proceeds are net of cash outflows for issuance costs related to the transaction. Proceeds From Issuance Of Common Stock And Warrants Net Proceeds from issuance of common stock Proceeds from offering of common stocks and warrants, net Proceeds from Issuance of Private Placement Proceeds from direct placement Proceeds from (Payments for) Other Financing Activities Other Proceeds From Put Options Exercised Proceeds From Put Options Exercised Proceeds from the exercise of the Insulin Put Option Proceeds from Related Party Debt Secured loan facility, amount borrowed Proceeds from Sale of Property, Plant, and Equipment Proceeds from sale of property and equipment Product [Member] AFREZZA product sales Products and Services [Axis] Products and Services [Axis] Products and Services [Domain] Products and Services [Domain] Profit Loss Sharing Agreement Allocation Percentage Profit Loss Sharing Agreement Allocation Percentage Profits and losses sharing percentage Profit Sharing Agreement Amount Profit Sharing Agreement Amount Company's total portion of profit sharing Property, Plant and Equipment [Abstract] Property, Plant and Equipment [Abstract] Property, Plant and Equipment, Type [Axis] Property, Plant and Equipment, Type [Axis] Property, Plant and Equipment Disclosure [Text Block] Property and equipment Property, Plant and Equipment, Gross Property and equipment - gross Property, Plant and Equipment [Line Items] Property, Plant and Equipment [Line Items] Property, Plant and Equipment, Net Property and equipment - net Property and equipment - net Property, Plant and Equipment [Table Text Block] Property and Equipment, Net and Depreciation and Amortization Expense Related to Property and Equipment Property, Plant and Equipment, Type [Domain] Property, Plant and Equipment, Type [Domain] Property, Plant and Equipment, Useful Life Estimated Useful Life (Years) Purchase Obligation Purchase obligation Purchase Obligation Current Purchase Obligation Current Purchase commitment loss - current Purchase Obligation, Due in Fourth Year Purchase obligation, due in 2019 Purchase Obligation, Due in Remainder of Fiscal Year Purchase Obligation, Due in Remainder of Fiscal Year Purchase obligation, due in 2016 Purchase Obligation, Due in Second Year Purchase obligation, due in 2017 Purchase Obligation, Due in Third Year Purchase obligation, due in 2018 Purchase Obligation Noncurrent Purchase Obligation Noncurrent Non-current purchase commitment loss Range [Axis] Range [Axis] Range [Domain] Range [Domain] Recently issued accounting standards. Recently Issued Accounting Standards [Policy Text Block] Recently Issued Accounting Standards Reclassification of Deferred Costs from Loss on Purchase Commitment to Deferred Costs from Collaboration Reclassification of Deferred Costs from Loss on Purchase Commitment to Deferred Costs from Collaboration Reclassification of deferred costs from loss on purchase commitment to deferred costs from collaboration Registered Offering [Member] Registered Offering [Member] Registered Offering Related party debt. Related Party Debt [Member] Related Party Debt Related Party [Domain] Related Party [Domain] Related Party Transaction [Axis] Related Party Transaction [Axis] Related Party Transaction Debt Instrument Prepayment Related Party Transaction Debt Instrument Prepayment Amount prepaid for cancellation of indebtedness Related Party Transaction [Domain] Related Party Transaction [Domain] Related Party Transaction, Expenses from Transactions with Related Party Interest expense on note payable to principal stockholder Related Party Transaction [Line Items] Related Party Transaction [Line Items] Related party transaction prepayment period. Related Party Transaction Prepayment Period Related party transaction prepayment period Related Party Transactions [Abstract] Related Party Transactions [Abstract] Related Party [Axis] Related Party [Axis] Related Party Transactions Disclosure [Text Block] Related-party arrangements Research and Development Expense (Excluding Acquired in Process Cost) Research and development Restricted Stock [Member] Restricted Stock Restricted Stock Units (RSUs) [Member] Restricted Stock Units (RSUs) Retained Earnings (Accumulated Deficit) Accumulated deficit Revenue Recognition, Deferred Revenue [Policy Text Block] Deferred product costs from collaboration Sale Of Common Stock In Underwritten Public Offering Sale Of Common Stock In Underwritten Public Offering Number of shares sold in underwritten public offering Revenue, Net Revenue Sanofi Aventis Sanofi Aventis [Member] Sanofi-Aventis Deutschland GmbH Schedule of Accrued Liabilities [Table Text Block] Accrued Expenses and Other Current Liabilities Schedule of Amortization of Debt Issuance Cost and Debt Discount [Table Text Block] Schedule of Amortization of Debt Issuance Cost and Debt Discount [Table Text Block] Accretion of Debt Issuance Cost and Debt Discount Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Potential Dilutive Securities Outstanding Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] Schedule of Long-term Debt Instruments [Table Text Block] Summary of Senior Convertible Notes Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Fair Value of Financial Instruments Schedule of Inventory, Current [Table Text Block] Components of Inventories Schedule of Other Operating Cost and Expense, by Component [Table Text Block] Schedule of Lease Payments to the Mann Foundation Property, Plant and Equipment [Table] Property, Plant and Equipment [Table] Schedule of Related Party Transactions, by Related Party [Table] Schedule of Related Party Transactions, by Related Party [Table] Schedule of Share-based Compensation, Activity [Table Text Block] Stock-Based Compensation Expense Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Selling, General and Administrative Expense Selling, general and administrative Senior Convertible Notes Due Two Thousand Eighteen Senior Convertible Notes Due Two Thousand Eighteen [Member] 5.75% Senior convertible notes due August 15, 2018 Senior Convertible Notes [Member] Senior Convertible Notes [Member] Senior Convertible Notes Share-based Compensation Stock-based compensation expense Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period Share based payment award , vesting period Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross Aggregate number of shares granted to awards, share-based compensation arrangements Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Share-based Compensation Arrangement by Share-based Payment Award, Options,grant date fair value Equity Award [Domain] Equity Award [Domain] Share Price Share price on date of conversion Equity Components [Axis] Equity Components [Axis] Statement [Line Items] Statement [Line Items] Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Statement of Comprehensive Income [Abstract] Statement of Comprehensive Income [Abstract] Statement [Table] Statement [Table] Stock Granted, Value, Share-based Compensation, Gross Fair value of stock granted, share-based compensation arrangements Stockholders' Equity Attributable to Parent Total stockholders' deficit Stockholders' Equity Attributable to Parent [Abstract] Stockholders' deficit: Stockholders' Equity Note Disclosure [Text Block] Warrants Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Number of restricted stock units issued Stock Issued During Period, Shares, Share-based Compensation, Net of Forfeitures Number of stock options issued Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures Fair value of Restricted stock options granted , value Stock Issued During Period, Value, Share-based Compensation, Net of Forfeitures Fair value of the stock options granted , value Sublease Agreement [Member] Sublease Agreement [Member] Sublease Agreement Supplemental Cash Flow Information [Abstract] SUPPLEMENTAL CASH FLOWS DISCLOSURES: Supply Commitment Arrangement [Domain] Supply Commitment Arrangement [Domain] Supply Commitment [Axis] Supply Commitment [Axis] Title of Individual [Axis] Title of Individual [Axis] Relationship to Entity [Domain] Relationship to Entity [Domain] Trading Symbol Trading Symbol Tranche B Tranche B [Member] Less portion of commitment asset Two Thousand Nineteen Notes Two Thousand Nineteen Notes [Member] Senior convertible notes due December 31, 2019 Type of Arrangement and Non-arrangement Transactions [Axis] Type of Arrangement and Non-arrangement Transactions [Axis] Unamortized Debt Issuance Expense Unaccreted debt issuance costs Uncategorized [Abstract] Uncategorized [Abstract] Uncategorized [Abstract] Valuation Technique [Axis] Valuation Technique [Axis] Valuation Technique [Domain] Valuation Technique [Domain] Variable Rate [Axis] Variable Rate [Axis] Variable Rate [Domain] Variable Rate [Domain] Warrant Issuance Costs Warrant Issuance Costs Warrant issuance cost Warrant liability. Warrant Liability [Member] Warrant Liability Warrant [Member] Warrant Warrants Policy Warrants Policy [Text Block] Warrant Weighted Average Number of Shares Outstanding, Basic and Diluted Shares used to compute basic and diluted net loss per share