<?xml version="1.0" encoding="us-ascii"?>
<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2023-02-23T09:24:21.9960684+00:00 -->
<!-- Version            : 5.0.1.753 -->
<!-- Package ID         : c0466dbaf1b246c7b52d8570aa9c0ca8 -->
<!-- Copyright (c) 2023 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="mnkd_SeniorConvertibleNotesInterestMember" name="SeniorConvertibleNotesInterestMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ConvertibleNotePrincipalMember" name="ConvertibleNotePrincipalMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ConvertibleNoteInterestMember" name="ConvertibleNoteInterestMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AtTheMarketOfferingMember" name="AtTheMarketOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TheMannGroupLLCMember" name="TheMannGroupLLCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_InterestOnMilestonePayment" name="InterestOnMilestonePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_InterestExpenseOnPromissoryNotes" name="InterestExpenseOnPromissoryNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_IncreaseDecreaseInRecognizedLossOnPurchaseCommitments" name="IncreaseDecreaseInRecognizedLossOnPurchaseCommitments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_IncreaseDecreaseInOperatingLeaseLiabilities" name="IncreaseDecreaseInOperatingLeaseLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_IncreaseDecreaseInAccruedInterestOnPromissoryNotes" name="IncreaseDecreaseInAccruedInterestOnPromissoryNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PurchaseOfAvailableForSaleSecurities" name="PurchaseOfAvailableForSaleSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_MilestonePayments" name="MilestonePayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_ProceedsFromNetIssuanceOfCommonStockAssociatedWithStockOptionsAndRestrictedStockUnits" name="ProceedsFromNetIssuanceOfCommonStockAssociatedWithStockOptionsAndRestrictedStockUnits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_ProceedsFromMarketPriceStockPurchasePlanAndFromEmployeeStockPurchasePlan" name="ProceedsFromMarketPriceStockPurchasePlanAndFromEmployeeStockPurchasePlan" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_PaymentOnFinancingLiability" name="PaymentOnFinancingLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_ProceedsFromSaleLeasebackTransaction" name="ProceedsFromSaleLeasebackTransaction" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DepositForSaleLeasebackTransaction" name="DepositForSaleLeasebackTransaction" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PaymentOfCreditFacilityPrepaymentPenalty" name="PaymentOfCreditFacilityPrepaymentPenalty" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_AtTheMarketIssuanceMember" name="AtTheMarketIssuanceMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ReclassificationOfInvestmentsFromLongTermToCurrent" name="ReclassificationOfInvestmentsFromLongTermToCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_ReclassificationOfConvertibleNotesAndInterestReceivable" name="ReclassificationOfConvertibleNotesAndInterestReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_PremiumOnConvertibleNote" name="PremiumOnConvertibleNote" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PaymentsOnDebtAndInterestThroughCommonStockIssuance" name="PaymentsOnDebtAndInterestThroughCommonStockIssuance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_AdditionOfRightOfUseAssets" name="AdditionOfRightOfUseAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_RightOfUseAssetsModification" name="RightOfUseAssetsModification" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_CommonStockIssuanceToSettleEmployeeStockPurchasePlanLiability" name="CommonStockIssuanceToSettleEmployeeStockPurchasePlanLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_ContingentMilestoneLiability" name="ContingentMilestoneLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_CommonStockIssuedForAcquisitionOfInProcessResearchAndDevelopment" name="CommonStockIssuedForAcquisitionOfInProcessResearchAndDevelopment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_IssuanceOfWarrantsAssociatedWithCreditFacility" name="IssuanceOfWarrantsAssociatedWithCreditFacility" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_ReceivableFromCommonStockOffering" name="ReceivableFromCommonStockOffering" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_BusinessPolicyTextBlock" name="BusinessPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_BasisOfPresentationPolicyTextBlock" name="BasisOfPresentationPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_RevenueFromContractWithCustomerFromCommercialProductSalesPolicyTextBlock" name="RevenueFromContractWithCustomerFromCommercialProductSalesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_RevenueFromContractWithCustomerFromCollaborationsAndServicesPolicyTextBlock" name="RevenueFromContractWithCustomerFromCollaborationsAndServicesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_CostOfRevenuesPolicyTextBlock" name="CostOfRevenuesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PreLaunchInventoryPolicyTextBlock" name="PreLaunchInventoryPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_LossOnPurchaseCommitmentsPolicyPolicyTextBlock" name="LossOnPurchaseCommitmentsPolicyPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_MilestoneRightsLiabilityPolicyTextBlock" name="MilestoneRightsLiabilityPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ClinicalTrialExpensePolicyTextBlock" name="ClinicalTrialExpensePolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_RecentlyIssuedAccountingStandardsPolicyTextBlock" name="RecentlyIssuedAccountingStandardsPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_VGoMember" name="VGoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ScheduleOfFairValueOfAssetsAndFinancingLiabilityOnTotalInvestmentsTableTextBlock" name="ScheduleOfFairValueOfAssetsAndFinancingLiabilityOnTotalInvestmentsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ScheduleOfActivitiesAndEndingReserveBalanceTableTextBlock" name="ScheduleOfActivitiesAndEndingReserveBalanceTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DiscountsAndAllowancesForCommercialProductSalesTableTextBlock" name="DiscountsAndAllowancesForCommercialProductSalesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ScheduleOfAmortizationOfDebtIssuanceCostAndDebtDiscountTableTextBlock" name="ScheduleOfAmortizationOfDebtIssuanceCostAndDebtDiscountTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_UnitedTherapeuticsCorporationMember" name="UnitedTherapeuticsCorporationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ContractWithCustomerLiabilityTableTextBlock" name="ContractWithCustomerLiabilityTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ScheduleOfRevisedAnticipatedCashFlowsFromTransactionsAllocatedPerformanceObligationsTableTextBlock" name="ScheduleOfRevisedAnticipatedCashFlowsFromTransactionsAllocatedPerformanceObligationsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ScheduleOfEffectOfModificationOnTransactionPriceTableTextBlock" name="ScheduleOfEffectOfModificationOnTransactionPriceTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ScheduleOfLeaseTermAndDiscountRateTableTextBlock" name="ScheduleOfLeaseTermAndDiscountRateTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentMinimumCashCovenant" name="DebtInstrumentMinimumCashCovenant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems" name="OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable" name="OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_MidCapCreditFacilityMember" name="MidCapCreditFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TrancheTwoMember" name="TrancheTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_SalesReturnPeriod" name="SalesReturnPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_SummaryOfSignificantAccountingPoliciesLineItems" name="SummaryOfSignificantAccountingPoliciesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_SummaryOfSignificantAccountingPoliciesTable" name="SummaryOfSignificantAccountingPoliciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ConvertiblePromissoryNoteMember" name="ConvertiblePromissoryNoteMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ThironaBioIncMember" name="ThironaBioIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CommitmentAssetMember" name="CommitmentAssetMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_InsulinMember" name="InsulinMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_MilestoneRightsLiabilityMember" name="MilestoneRightsLiabilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DeerfieldManagementCompanyLpMember" name="DeerfieldManagementCompanyLpMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ProductSalesMember" name="ProductSalesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CommitmentAsset" name="CommitmentAsset" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_LossOnPurchaseCommitmentsNumberOfContractsRecognized" name="LossOnPurchaseCommitmentsNumberOfContractsRecognized" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ContingentLiabilityRemainingPayableAmount" name="ContingentLiabilityRemainingPayableAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_ContingentLiability" name="ContingentLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_QrumPharmaIncorporatedMember" name="QrumPharmaIncorporatedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_GlobalAdjustedNetSalesOfProductsExceedsFiftyMillionMember" name="GlobalAdjustedNetSalesOfProductsExceedsFiftyMillionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AdjustedNetSalesAreGreaterThanOrEqualToTwoHundredMillionMember" name="AdjustedNetSalesAreGreaterThanOrEqualToTwoHundredMillionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AssetAcquisitionMilestonePaymentPayable" name="AssetAcquisitionMilestonePaymentPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_AnnualRevenueMilestonesRangesForMilestonePayments" name="AnnualRevenueMilestonesRangesForMilestonePayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_GoodwillAmortizationPeriod" name="GoodwillAmortizationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseRightOfUseAssets" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseRightOfUseAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAndNoncurrentLiabilities" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAndNoncurrentLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseLiability" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_BusinessAcquisitionRepaymentOfDebt" name="BusinessAcquisitionRepaymentOfDebt" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_BusinessCombinationAccumulatedCost" name="BusinessCombinationAccumulatedCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PercentageOfRoyaltyPaymentOnNetSales" name="PercentageOfRoyaltyPaymentOnNetSales" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mnkd_GlobalAdjustedNetSalesOfProductsReferenceAmountForRoyaltyPercentage" name="GlobalAdjustedNetSalesOfProductsReferenceAmountForRoyaltyPercentage" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_DueInOneYearOrLessMember" name="DueInOneYearOrLessMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_FairValueOfFinancialInstrumentsLineItems" name="FairValueOfFinancialInstrumentsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_FairValueOfFinancialInstrumentsTable" name="FairValueOfFinancialInstrumentsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AmortizedCostMember" name="AmortizedCostMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_GrossUnrealizedHoldingLossesMember" name="GrossUnrealizedHoldingLossesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_EstimatedFairValueMember" name="EstimatedFairValueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AccruedInterestReceivable" name="AccruedInterestReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_AmountReceivableOnMaturedInvestment" name="AmountReceivableOnMaturedInvestment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_NumberOfWholesaleDistributors" name="NumberOfWholesaleDistributors" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PercentageOfAccountsReceivableFromMajorCustomers" name="PercentageOfAccountsReceivableFromMajorCustomers" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PercentageOfSalesFromMajorCustomers" name="PercentageOfSalesFromMajorCustomers" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PercentageOfCollaborationsAndServicesNetAccountsReceivables" name="PercentageOfCollaborationsAndServicesNetAccountsReceivables" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PercentageOfRevenueFromMajorCustomersCollaborationsAndServices" name="PercentageOfRevenueFromMajorCustomersCollaborationsAndServices" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PromptPayDiscountReserveAllowanceForWholesaleDistributionFeesAndAccountsReceivablesReturnReserve" name="PromptPayDiscountReserveAllowanceForWholesaleDistributionFeesAndAccountsReceivablesReturnReserve" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PromptPayDiscountReserveAllowanceForWholesaleDistributionFeesAndAccountsReceivablesReturnReserveProvisions" name="PromptPayDiscountReserveAllowanceForWholesaleDistributionFeesAndAccountsReceivablesReturnReserveProvisions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PromptPayDiscountReserveAllowanceForWholesaleDistributionFeesAndAccountsReceivablesReturnReserveDeductions" name="PromptPayDiscountReserveAllowanceForWholesaleDistributionFeesAndAccountsReceivablesReturnReserveDeductions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_ReserveBalanceAbstract" name="ReserveBalanceAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_PreLaunchInventoryMember" name="PreLaunchInventoryMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AgreementWithRetailPharmacyMember" name="AgreementWithRetailPharmacyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_FurnitureFixturesAndOfficeEquipmentMember" name="FurnitureFixturesAndOfficeEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ComputerEquipmentAndSoftwareMember" name="ComputerEquipmentAndSoftwareMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_UTEquipmentMember" name="UTEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ManufacturingEquipmentsAndComputerHardwareMember" name="ManufacturingEquipmentsAndComputerHardwareMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ManufacturingEquipmentComputerHardwareAndSoftwareComputerEquipmentLabEquipmentAndBuildingImprovementsMember" name="ManufacturingEquipmentComputerHardwareAndSoftwareComputerEquipmentLabEquipmentAndBuildingImprovementsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CasperLLCMember" name="CasperLLCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_SaleLeasebackTransactionLeaseAgreementPeriods" name="SaleLeasebackTransactionLeaseAgreementPeriods" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_CustomerDiscountsAndAllowances" name="CustomerDiscountsAndAllowances" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_ReturnsReserveForAcquiredProduct" name="ReturnsReserveForAcquiredProduct" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_CurrentPortionOfMilestoneRightLiability" name="CurrentPortionOfMilestoneRightLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_RetailInventoryPurchase" name="RetailInventoryPurchase" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_DiscountsAndAllowancesForCommercialProductSales" name="DiscountsAndAllowancesForCommercialProductSales" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_DiscountsAndAllowancesForCommercialProductSalesProvisions" name="DiscountsAndAllowancesForCommercialProductSalesProvisions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_DiscountsAndAllowancesForCommercialProductSalesDeductions" name="DiscountsAndAllowancesForCommercialProductSalesDeductions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DiscountsAndAllowancesForCommercialProductSalesBalancesFromAcquisition" name="DiscountsAndAllowancesForCommercialProductSalesBalancesFromAcquisition" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_DiscountsAndAllowancesForCommercialProductSalesAbstract" name="DiscountsAndAllowancesForCommercialProductSalesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DebtPremiumRecognizedInAdditionalPaidInCapital" name="DebtPremiumRecognizedInAdditionalPaidInCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PromissoryNotesMember" name="PromissoryNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DebtInstrumentMaturityMonthAndYear" name="DebtInstrumentMaturityMonthAndYear" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_AccruedPaidInKindInterest" name="AccruedPaidInKindInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_DebtInstrumentFloorRate" name="DebtInstrumentFloorRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentCapInterestRate" name="DebtInstrumentCapInterestRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_NonConvertiblePromissoryNoteMember" name="NonConvertiblePromissoryNoteMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_PriorToMidcapCreditFacilityAmendmentMember" name="PriorToMidcapCreditFacilityAmendmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_PriorToFirstAmendmentMember" name="PriorToFirstAmendmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NumberOfTradingDays" name="NumberOfTradingDays" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ConsecutiveTradingDays" name="ConsecutiveTradingDays" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentConvertibleConversionPricePercentage" name="DebtInstrumentConvertibleConversionPricePercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PrincipalAmountPerShare" name="PrincipalAmountPerShare" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_MeasurementPeriodPercentage" name="MeasurementPeriodPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentInitialConversionPriceOfPremiumPercentage" name="DebtInstrumentInitialConversionPriceOfPremiumPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentOutstandingPrincipalAmountRedeemed" name="DebtInstrumentOutstandingPrincipalAmountRedeemed" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PrepaymentOfSecuredLinesOfCredit" name="PrepaymentOfSecuredLinesOfCredit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_TrancheOneMember" name="TrancheOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TrancheThreeMember" name="TrancheThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DebtInstrumentAdvanceAvailableDate" name="DebtInstrumentAdvanceAvailableDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentExtendedInterestOnlyDate" name="DebtInstrumentExtendedInterestOnlyDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_MaximumValueOfAdditionalInvestmentLimit" name="MaximumValueOfAdditionalInvestmentLimit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DebtInstrumentMinimumUnrestrictedCashAndShortTermInvestments" name="DebtInstrumentMinimumUnrestrictedCashAndShortTermInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_DebtInstrumentUnamortizedPrepaymentPenalty" name="DebtInstrumentUnamortizedPrepaymentPenalty" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_EarlyTerminationFeesPercentage" name="EarlyTerminationFeesPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentPaymentNumberOfEqualMonthlyInstallments" name="DebtInstrumentPaymentNumberOfEqualMonthlyInstallments" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_LineOfCreditFacilityPrincipalPaymentStartDate" name="LineOfCreditFacilityPrincipalPaymentStartDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_TermLoanAdvancePercentageOfAmountDrawdown" name="TermLoanAdvancePercentageOfAmountDrawdown" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PrivatelyNegotiatedExchangeAgreementMember" name="PrivatelyNegotiatedExchangeAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_LoanArrangementMember" name="LoanArrangementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NonConvertibleNoteMember" name="NonConvertibleNoteMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NewLoanArrangementMember" name="NewLoanArrangementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AccruedInterestMember" name="AccruedInterestMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DebtInstrumentFairValueInExcessOfFaceAmount" name="DebtInstrumentFairValueInExcessOfFaceAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_CommonStockIssuedToPayInterest" name="CommonStockIssuedToPayInterest" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PaycheckProtectionProgramCARESActMember" name="PaycheckProtectionProgramCARESActMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AmortizationOfDebtDiscount" name="AmortizationOfDebtDiscount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_MilestoneRightsLiabilitiesCurrentAndNoncurrent" name="MilestoneRightsLiabilitiesCurrentAndNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PaymentForMilestoneRightsLiabilities" name="PaymentForMilestoneRightsLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_MilestoneRightsLiabilityCurrent" name="MilestoneRightsLiabilityCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_BaringsGlobalMilestoneRightsMember" name="BaringsGlobalMilestoneRightsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_LicenseAgreementMember" name="LicenseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CommercialSupplyAgreementMember" name="CommercialSupplyAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CoPromotionAgreementMember" name="CoPromotionAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CollaborationAndLicenseAgreementMember" name="CollaborationAndLicenseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_LicenseAndDistributionAgreementMember" name="LicenseAndDistributionAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_OtherAgreementMember" name="OtherAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ResearchAgreementMember" name="ResearchAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_VerticePharmaLLCMember" name="VerticePharmaLLCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ReceptorLifeScienceIncMember" name="ReceptorLifeScienceIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CiplaLtdMember" name="CiplaLtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ContractWithCustomerLiabilityAdditions" name="ContractWithCustomerLiabilityAdditions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_ContractWithCustomerLiabilityCollaborationsAndServicesRevenue" name="ContractWithCustomerLiabilityCollaborationsAndServicesRevenue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_RoyaltiesArrangementMember" name="RoyaltiesArrangementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AdditionalOptionExerciseAndDevelopmentMilestonePaymentsToBeReceived" name="AdditionalOptionExerciseAndDevelopmentMilestonePaymentsToBeReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_UpfrontPaymentReceived" name="UpfrontPaymentReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_MilestonePaymentReceived" name="MilestonePaymentReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_ClinicalSuppliesMember" name="ClinicalSuppliesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TyvasoDPIMember" name="TyvasoDPIMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ManufacturingServicesMember" name="ManufacturingServicesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NextGenResearchAndDevelopmentServicesMember" name="NextGenResearchAndDevelopmentServicesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TransactionPriceForTheContractualObligationsMember" name="TransactionPriceForTheContractualObligationsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TransactionPriceForThePerformanceObligationsMember" name="TransactionPriceForThePerformanceObligationsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CommercializationAndContinuousImprovementActivitiesMember" name="CommercializationAndContinuousImprovementActivitiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AmendmentToCoPromotionAgreementMember" name="AmendmentToCoPromotionAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_SupplyAndDistributionAgreementMember" name="SupplyAndDistributionAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_BiommSAMember" name="BiommSAMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ResearchAndDevelopmentServicesAndLicenseMember" name="ResearchAndDevelopmentServicesAndLicenseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_PreCommercialServicesMember" name="PreCommercialServicesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_FacilityExpansionServicesMember" name="FacilityExpansionServicesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_RevenueRemainingPerformanceObligationAnticipatedCashFlow" name="RevenueRemainingPerformanceObligationAnticipatedCashFlow" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_AgreementAmendmentDescription" name="AgreementAmendmentDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_AllocatedTransactionPrice" name="AllocatedTransactionPrice" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_PercentageOfModificationOfPreviouslyFixedConsideration" name="PercentageOfModificationOfPreviouslyFixedConsideration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DateOfAgreementInitiationForMarketingAndDistribution" name="DateOfAgreementInitiationForMarketingAndDistribution" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_MannGroupConvertibleNoteMember" name="MannGroupConvertibleNoteMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ContingentMilestoneLiabilityMember" name="ContingentMilestoneLiabilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_NotePayablePercentageOfInterestRateChange" name="NotePayablePercentageOfInterestRateChange" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtInstrumentMeasurementInputAfterChange" name="DebtInstrumentMeasurementInputAfterChange" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mnkd_SubstantialPremiumBasedOnFairValuePostModificationRecognizedAsAdditionalPaidInCapital" name="SubstantialPremiumBasedOnFairValuePostModificationRecognizedAsAdditionalPaidInCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_ContolledEquityOfferingSalesAgreementMember" name="ContolledEquityOfferingSalesAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_AtMarketIssuanceSalesAgreementMember" name="AtMarketIssuanceSalesAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CantorFitzgeraldMember" name="CantorFitzgeraldMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_JuneTwoThousandTwentyNoteMember" name="JuneTwoThousandTwentyNoteMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DecemberTwoThousandTwentyNoteMember" name="DecemberTwoThousandTwentyNoteMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_UnderwritingAgreementMember" name="UnderwritingAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_RemainingWarrantsAvailableForPurchase" name="RemainingWarrantsAvailableForPurchase" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtConversionConvertedInstrumentSharesIssuedForAccruedInterestOfNotes" name="DebtConversionConvertedInstrumentSharesIssuedForAccruedInterestOfNotes" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DebtConversionConvertedInstrumentAccruedInterestOfNotesValue" name="DebtConversionConvertedInstrumentAccruedInterestOfNotesValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_MarketPriceStockPurchasePlan" name="MarketPriceStockPurchasePlan" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_EarningPerShareBasicAndDilutedAbstract" name="EarningPerShareBasicAndDilutedAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_SeniorConvertibleNotesMember" name="SeniorConvertibleNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CommonStockOptionsAndPerformanceBasedStockOptionAwardsMember" name="CommonStockOptionsAndPerformanceBasedStockOptionAwardsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_WarrantsAssociatedWithMidcapCreditFacilityMember" name="WarrantsAssociatedWithMidcapCreditFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_EmployeeStockPurchasePlanMember" name="EmployeeStockPurchasePlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_RestrictedStockUnitsAndMarketRestrictedStockUnitsMember" name="RestrictedStockUnitsAndMarketRestrictedStockUnitsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantIncreasedByShares" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantIncreasedByShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mnkd_EquityIncentivePlanTwentyEighteenMember" name="EquityIncentivePlanTwentyEighteenMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_EquityIncentivePlanTwentyThirteenMember" name="EquityIncentivePlanTwentyThirteenMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_GroupOneMember" name="GroupOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_GroupTwoMember" name="GroupTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_GroupThreeMember" name="GroupThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_GroupFourMember" name="GroupFourMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_GroupFiveMember" name="GroupFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_RestrictedStockUnitsAndOptionsMember" name="RestrictedStockUnitsAndOptionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_EmployeeStockOptionsAndPerformanceBasedOptionsMember" name="EmployeeStockOptionsAndPerformanceBasedOptionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_EmployeeMember" name="EmployeeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ExerciseOrStrikePriceOfFairMarketValueOfUnderlyingCommonStockOnDateOfGrantReacquiredOrWithheld" name="ExerciseOrStrikePriceOfFairMarketValueOfUnderlyingCommonStockOnDateOfGrantReacquiredOrWithheld" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ShareBasedCompensationArrangementByShareBasedPaymentAwardVestingDate" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardVestingDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_PercentileRankOfShareholderReturnOfStock" name="PercentileRankOfShareholderReturnOfStock" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_ShareBasedCompensationArrangementByShareBasedPaymentAwardTargetPercentage" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardTargetPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_TwoThousandFourEquityIncentivePlanMember" name="TwoThousandFourEquityIncentivePlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CostOfRevenueCollaborationsAndServicesMember" name="CostOfRevenueCollaborationsAndServicesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TransfersFromToParentAbstract" name="TransfersFromToParentAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsInPeriodGrantDateFairValueOutstanding" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsInPeriodGrantDateFairValueOutstanding" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DiscountOnPurchasePricePercentageOfFairMarketValue" name="DiscountOnPurchasePricePercentageOfFairMarketValue" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_MilestoneRightLiability" name="MilestoneRightLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_CommitmentsAndContingenciesLineItems" name="CommitmentsAndContingenciesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CommitmentsAndContingenciesTable" name="CommitmentsAndContingenciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_MasterLeaseAgreementWithEnterpriseMember" name="MasterLeaseAgreementWithEnterpriseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_OfficeMember" name="OfficeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_RussellRanchRoadIILLCMember" name="RussellRanchRoadIILLCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_MarlboroughLeaseMember" name="MarlboroughLeaseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_LeaseRepurchaseDescription" name="LeaseRepurchaseDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_FinanceLeaseLiabilityDiscountedPaymentsDue" name="FinanceLeaseLiabilityDiscountedPaymentsDue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_PaymentOfLongTermPurchaseCommitmentAmendmentFee" name="PaymentOfLongTermPurchaseCommitmentAmendmentFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_LongTermPurchaseCommitmentExpirationDate" name="LongTermPurchaseCommitmentExpirationDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_LongtermPurchaseCommitmentRenewalTimePeriod" name="LongtermPurchaseCommitmentRenewalTimePeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_NumberOfVehicleLeasesRetired" name="NumberOfVehicleLeasesRetired" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_NumberOfVehicleLeasesReplaced" name="NumberOfVehicleLeasesReplaced" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_NumberOfVehicleLeases" name="NumberOfVehicleLeases" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_OperatingLeasesAnnualIncreaseInRentExpense" name="OperatingLeasesAnnualIncreaseInRentExpense" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_LeaseExpirationMonthAndYear" name="LeaseExpirationMonthAndYear" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_OfficeAndVehicleMember" name="OfficeAndVehicleMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_OneYearServiceMember" name="OneYearServiceMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_TwoYearServiceMember" name="TwoYearServiceMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_DeferredTaxAssetsCapitalizedResearchExpenses" name="DeferredTaxAssetsCapitalizedResearchExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DeferredTaxAssetsMilestoneRights" name="DeferredTaxAssetsMilestoneRights" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DeferredTaxAssetsTaxDeferredExpenseAccrualAdjustment" name="DeferredTaxAssetsTaxDeferredExpenseAccrualAdjustment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DeferredTaxAssetsLossOnPurchaseCommitment" name="DeferredTaxAssetsLossOnPurchaseCommitment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DeferredTaxAssetsCapitalizedCosts" name="DeferredTaxAssetsCapitalizedCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DeferredTaxAssetsLeaseLiabilities" name="DeferredTaxAssetsLeaseLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DeferredTaxAssetsInterestExpenseLimitation" name="DeferredTaxAssetsInterestExpenseLimitation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DeferredTaxAssetsProductRevenueAndCosts" name="DeferredTaxAssetsProductRevenueAndCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_DeferredTaxLiabilitiesRightOfUseAsset" name="DeferredTaxLiabilitiesRightOfUseAsset" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mnkd_EffectiveIncomeTaxRateReconciliationPermanentItems" name="EffectiveIncomeTaxRateReconciliationPermanentItems" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_EffectiveIncomeTaxRateReconciliationExpirationsOfAttribute" name="EffectiveIncomeTaxRateReconciliationExpirationsOfAttribute" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_EffectiveIncomeTaxRateReconciliationForeignWithholdingTax" name="EffectiveIncomeTaxRateReconciliationForeignWithholdingTax" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_IncomeTaxesLineItems" name="IncomeTaxesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_IncomeTaxesTable" name="IncomeTaxesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_ConnecticutTaxAuthorityMember" name="ConnecticutTaxAuthorityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_CaliforniaDivisionOfTaxationMember" name="CaliforniaDivisionOfTaxationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mnkd_OperatingLossCarryforwardsSubjectToLimitation" name="OperatingLossCarryforwardsSubjectToLimitation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_NetOperatingLossCarryforwardAnnualLimitation" name="NetOperatingLossCarryforwardAnnualLimitation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DeferredTaxAssetsTaxCreditCarryforwardsResearchNotExpire" name="DeferredTaxAssetsTaxCreditCarryforwardsResearchNotExpire" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mnkd_ResearchAndDevelopmentCreditsBeginToExpire" name="ResearchAndDevelopmentCreditsBeginToExpire" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mnkd_DeferredTaxAssetsTaxCreditCarryforwardsResearchExpire" name="DeferredTaxAssetsTaxCreditCarryforwardsResearchExpire" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
</xsd:schema>
