Entity Central Index Key Document and entity information. Document And Entity Information [Abstract] Document Type Document Type Amendment Flag Amendment Flag Document Period End Date Document Period End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Trading Symbol Trading Symbol Entity Registrant Name Entity Registrant Name Entity Central Index Key Current Fiscal Year End Date Current Fiscal Year End Date Entity Well-known Seasoned Issuer Entity Well Known Seasoned Issuer Entity Current Reporting Status Entity Current Reporting Status Entity Voluntary Filers Entity Voluntary Filers Entity Filer Category Entity Filer Category Entity Small Business Entity Small Business Entity Emerging Growth Company Entity Emerging Growth Company Entity Shell Company Entity Shell Company Entity Common Stock, Shares Outstanding Entity Common Stock Shares Outstanding Entity Public Float Entity Public Float Purchase obligation current. Accrued interest noncurrent. Purchase obligation noncurrent. Milestone rights liabilities noncurrent. Statement Of Financial Position [Abstract] ASSETS Assets [Abstract] Current assets: Assets Current [Abstract] Cash and cash equivalents Cash And Cash Equivalents At Carrying Value Restricted cash Restricted Cash Current Accounts receivable, net Accounts Receivable Net Current Inventory Inventory Net Deferred costs from commercial product sales Other Deferred Costs Net Prepaid expenses and other current assets Prepaid Expense And Other Assets Current Total current assets Assets Current Property and equipment, net Property Plant And Equipment Net Other assets Other Assets Noncurrent Total assets Assets LIABILITIES AND STOCKHOLDERS' DEFICIT Liabilities And Stockholders Equity [Abstract] Current liabilities: Liabilities Current [Abstract] Accounts payable Accounts Payable Current Accrued expenses and other current liabilities Accrued Liabilities Current Facility financing obligation Other Long Term Debt Current Deferred revenue, net Deferred Revenue Current Deferred payments from collaborations - current Contract With Customer Liability Current Recognized loss on purchase commitments - current Purchase Obligation Current Total current liabilities Liabilities Current Note payable to related party Notes Payable Related Parties Noncurrent Accrued interest - note payable to related party Accrued Interest Noncurrent Senior convertible notes Convertible Long Term Notes Payable Recognized loss on purchase commitments - long term Purchase Obligation Noncurrent Deferred payments from collaborations - long term Contract With Customer Liability Noncurrent Milestone rights liability Milestone Rights Liabilities Noncurrent Total liabilities Liabilities Commitments and contingencies (Note 14) Commitments And Contingencies Stockholders' deficit: Stockholders Equity [Abstract] Undesignated preferred stock, $0.01 par value - 10,000,000 shares authorized; no shares issued or outstanding at December 31, 2018 and 2017 Preferred Stock Value Common stock, $0.01 par value - 280,000,000 shares authorized, 187,029,967 and 119,053,414 shares issued and outstanding at December 31, 2018 and 2017, respectively Common Stock Value Additional paid-in capital Additional Paid In Capital Common Stock Accumulated other comprehensive loss Accumulated Other Comprehensive Income Loss Net Of Tax Accumulated deficit Retained Earnings Accumulated Deficit Total stockholders' deficit Stockholders Equity Total liabilities and stockholders' deficit Liabilities And Stockholders Equity Undesignated preferred stock, par value Preferred Stock Par Or Stated Value Per Share Undesignated preferred stock, shares authorized Preferred Stock Shares Authorized Undesignated preferred stock, shares issued Preferred Stock Shares Issued Undesignated preferred stock, shares outstanding Preferred Stock Shares Outstanding Common stock, par value Common Stock Par Or Stated Value Per Share Common stock, shares authorized Common Stock Shares Authorized Common stock, shares issued Common Stock Shares Issued Common stock, shares outstanding Common Stock Shares Outstanding Gain (loss) on purchase commitments. Change in fair value of warrant liability. Income Statement [Abstract] Statement [Table] Statement [Table] Product and Service Product Or Service [Axis] Product and Service Products And Services [Domain] Commercial product sales Product [Member] Collaborations and services License And Service [Member] Revenue - other Product And Service Other [Member] Statement [Line Items] Statement [Line Items] Revenues: Revenues [Abstract] Total revenues Revenue From Contract With Customer Excluding Assessed Tax Expenses: Costs And Expenses [Abstract] Cost of goods sold Cost Of Goods And Services Sold Cost of revenue Cost Of Revenue Research and development Research And Development Expense Excluding Acquired In Process Cost Selling, general and administrative Selling General And Administrative Expense Property and equipment impairment Impairment Of Long Lived Assets Held For Use (Gain) loss on foreign currency translation Foreign Currency Transaction Gain Loss Realized Gain on purchase commitments Gain Loss On Purchase Commitments Total expenses Costs And Expenses (Loss) income from operations Operating Income Loss Other (expense) income: Nonoperating Income Expense [Abstract] Change in fair value of warrant liability Change In Fair Value Of Warrant Liability Interest income Investment Income Interest Interest expense on notes Interest Expense Debt Interest expense on note payable to related party Related Party Transaction Expenses From Transactions With Related Party (Loss) gain on extinguishment of debt Gains Losses On Extinguishment Of Debt Other income (expense) Other Nonoperating Income Expense Total other (expense) income Nonoperating Income Expense (Loss) income before income tax expense Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest Provision for income taxes Income Tax Expense Benefit Net (loss) income Net Income Loss Net (loss) income per share - basic Earnings Per Share Basic Net (loss) income per share - diluted Earnings Per Share Diluted Shares used to compute basic net (loss) income per share Weighted Average Number Of Shares Outstanding Basic Shares used to compute diluted net (loss) income per share Weighted Average Number Of Diluted Shares Outstanding Statement Of Income And Comprehensive Income [Abstract] Net (loss) income Other comprehensive income (loss): Other Comprehensive Income Loss Net Of Tax Period Increase Decrease [Abstract] Cumulative translation gain (loss) Other Comprehensive Income Foreign Currency Transaction And Translation Gain Loss Arising During Period Net Of Tax Comprehensive (loss) income Comprehensive Income Net Of Tax Adjustments to additional paid in capital restricted stock units taxes paid in cash. Common Stock and Warrants Issued in Direct Placement Shares Common Stock and Warrants Issued in Direct Placement Value Adjustments to additional paid in capital direct placement issuance costs. Adjustments to additional paid in capital proceeds allocated to warrant liabilities. Common stock issued in direct placement shares. Common stock issued in direct placement value. Adjustments to additional paid in capital reclassification of warrants from liability to equity shares. Adjustments To Additional Paid In Capital Reclassification Of Warrants From Liability To Equity Adjustments to additional paid in capital amortization of shelf fees. Adjustments to additional paid in capital shares issued public offering issuance cost. Stock issued during period shares market price stock purchase plan. Stock issued during period value market price stock purchase plan. Statement Of Stockholders Equity [Abstract] Additional Paid-in Capital Statement Equity Components [Axis] Equity Component Equity Component [Domain] Common Stock Common Stock [Member] Additional Paid-in Capital Additional Paid In Capital [Member] Accumulated Other Comprehensive Income (Loss) Accumulated Other Comprehensive Income [Member] Accumulated Deficit Retained Earnings [Member] Debt Instrument Debt Instrument [Axis] Debt Instrument, Name Debt Instrument Name [Domain] Note payable to related party. Note Payable to Related Party Note Payable To Related Party [Member] Facility financing obligation. Facility Financing Obligation Facility Financing Obligation [Member] Senior convertible notes. Senior Convertible Notes Senior Convertible Notes [Member] Sale of Stock Subsidiary Sale Of Stock [Axis] Sale of Stock Sale Of Stock Name Of Transaction [Domain] At-the-market placement. At-the-market Placement At The Market Pacement [Member] Public Offering I P O [Member] Adjustments for New Accounting Pronouncements Adjustments For New Accounting Pronouncements [Axis] Type of Adoption Type Of Adoption [Member] Topic 606 Accounting Standards Update201409 [Member] Beginning Balance Beginning Balance (in shares) Shares Outstanding Exercise of stock options Stock Issued During Period Value Stock Options Exercised Exercise of stock options (in shares) Stock Issued During Period Shares Stock Options Exercised Issuance of common shares from the release of restricted stock units Stock Issued During Period Value Restricted Stock Award Net Of Forfeitures Issuance of common shares from the release of restricted stock units (in shares) Stock Issued During Period Shares Restricted Stock Award Net Of Forfeitures Issuance of common shares under Employee Stock Purchase Plan Stock Issued During Period Value Employee Stock Purchase Plan Issuance of common shares under Employee Stock Purchase Plan (in shares) Stock Issued During Period Shares Employee Stock Purchase Plans Stock-based compensation expense Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value Restricted stock units taxes paid in cash Adjustments To Additional Paid In Capital Restricted Stock Units Taxes Paid In Cash Issuance of shares pursuant to conversion notes Stock Issued During Period Value Conversion Of Convertible Securities Issuance of shares pursuant to conversion notes (in shares) Stock Issued During Period Shares Conversion Of Convertible Securities Issuance of direct placement — common stock and warrants Common Stock And Warrants Issued In Direct Placement Value Issuance of direct placement - common stock and warrants (in shares) Common Stock And Warrants Issued In Direct Placement Shares Issuance of direct placement — common stock Common Stock Issued In Direct Placement Value Issuance of direct placement — common stock (in shares) Common Stock Issued In Direct Placement Shares Issuance costs associated with direct placement Adjustments To Additional Paid In Capital Direct Placement Issuance Costs Issuance cost associated with public offering Adjustments To Additional Paid In Capital Shares Issued Public Offering Issuance Cost Proceeds allocated to warrant liabilities Adjustments To Additional Paid In Capital Proceeds Allocated To Warrant Liabilities Issuance of stock Stock Issued During Period Value New Issues Issuance of at-the-market placement (in shares) Stock Issued During Period Shares New Issues Issuance costs associated with at-the-market placement Adjustments To Additional Paid In Capital Stock Issued Issuance Costs Reclassification of warrant liability to equity Adjustments To Additional Paid In Capital Reclassification Of Warrants From Liability To Equity Reclassification of warrant liability to equity (in shares) Adjustments To Additional Paid In Capital Reclassification Of Warrants From Liability To Equity Shares Issuance of shares under Market Price Stock Purchase Plan Stock Issued During Period Value Market Price Stock Purchase Plan Issuance of shares under Market Price Stock Purchase Plan (in shares) Stock Issued During Period Shares Market Price Stock Purchase Plan Amortization of shelf fees Adjustments To Additional Paid In Capital Amortization Of Shelf Fees Cumulative translation (loss) gain Adjustment to adopt ASU 2014-09 (Topic 606) New Accounting Pronouncement Or Change In Accounting Principle Effect Of Adoption Quantification Ending Balance Ending Balance (in shares) Interest on note payable to related party. Warrant issuance costs. Increase (decrease) in other deferred charges. Increase (decrease) in deferred collaboration payments. Increase (decrease) in deferred collaborative revenue. Increase decrease in purchase commitment (gain) loss. Payments of note payable to related party through common stock issuance. Reclassification of property plant and equipment to assets held for sale noncash. Statement Of Cash Flows [Abstract] Public offering. Public Offering Public Offering [Member] At-the-market issuance. At-the-market Issuance At The Market Issuance [Member] CASH FLOWS FROM OPERATING ACTIVITIES: Net Cash Provided By Used In Operating Activities [Abstract] Net (loss) income Profit Loss Adjustments to reconcile net (loss) income to net cash used in operating activities: Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract] Depreciation, amortization and accretion Depreciation And Amortization Stock-based compensation expense Share Based Compensation Change in fair value of warrant liability Fair Value Adjustment Of Warrants (Gain) Loss on foreign currency translation (Gain) Loss on extinguishment of debt Interest incurred through borrowings under Sanofi Loan Facility Paid In Kind Interest Interest on note payable to related party Interest On Note Payable To Related Party Series A warrant issuance cost Warrant Issuance Costs Other, net Other Noncash Income Expense (Gain) loss on sale, abandonment/disposal or impairment of property and equipment Gain Loss On Disposition Of Assets Gain on purchase commitments Write-off of inventory Production Related Impairments Or Charges Changes in operating assets and liabilities: Increase Decrease In Operating Capital [Abstract] Accounts receivable, net Increase Decrease In Accounts Receivable Receivable from Sanofi Increase Decrease In Accounts And Notes Receivable Inventory Increase Decrease In Inventories Deferred costs from commercial product sales Increase Decrease In Other Deferred Charges Deferred costs from collaboration Increase Decrease In Deferred Charges Prepaid expenses and other current assets Increase Decrease In Prepaid Deferred Expense And Other Assets Other assets Increase Decrease In Other Operating Assets Accounts payable Increase Decrease In Accounts Payable Accrued expenses and other current liabilities Increase Decrease In Accrued Liabilities And Other Operating Liabilities Deferred revenue Increase Decrease In Contract With Customer Liability Deferred payments from collaboration Increase Decrease In Deferred Collaboration Payments Deferred sales from collaboration Increase Decrease In Deferred Collaborative Revenue Loss on purchase commitments Increase Decrease In Purchase Commitment Gain Loss Net cash used in operating activities Net Cash Provided By Used In Operating Activities CASH FLOWS FROM INVESTING ACTIVITIES: Net Cash Provided By Used In Investing Activities [Abstract] Purchase of property and equipment Payments To Acquire Property Plant And Equipment Net proceeds from sale of asset held for sale Proceeds From Sale Of Productive Assets Proceeds from sale of property and equipment Proceeds From Sale Of Property Plant And Equipment Net cash provided by (used in) investing activities Net Cash Provided By Used In Investing Activities CASH FLOWS FROM FINANCING ACTIVITIES: Net Cash Provided By Used In Financing Activities [Abstract] Proceeds from direct placement of common stock Proceeds From Issuance Of Private Placement Issuance cost associated with direct placement Payment Of Financing And Stock Issuance Costs Proceeds from issuance of common stock Proceeds From Issuance Of Common Stock Issuance costs Payments Of Stock Issuance Costs Principal payments on facility financing obligation Repayments Of Lines Of Credit Payment of employment taxes related to vested restricted stock units Payments Related To Tax Withholding For Share Based Compensation Borrowings on note payable to related party Proceeds From Related Party Debt