Entity Central Index Key Document and entity information. Document And Entity Information [Abstract] Document Type Document Type Amendment Flag Amendment Flag Document Period End Date Document Period End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Trading Symbol Trading Symbol Entity Registrant Name Entity Registrant Name Entity Central Index Key Current Fiscal Year End Date Current Fiscal Year End Date Entity Filer Category Entity Filer Category Entity Common Stock, Shares Outstanding Entity Common Stock Shares Outstanding Deferred collaborative credit current. Purchase obligation current. Accrued interest noncurrent. Purchase obligation noncurrent. Deferred collaborative credit noncurrent. Milestone rights liability and other liabilities, noncurrent. Statement Of Financial Position [Abstract] ASSETS Assets [Abstract] Current assets: Assets Current [Abstract] Cash and cash equivalents Cash And Cash Equivalents At Carrying Value Accounts receivable, net Accounts Receivable Net Current Receivable from Sanofi Accounts And Other Receivables Net Current Inventory Inventory Net Asset held for sale Assets Held For Sale Not Part Of Disposal Group Current Deferred costs from commercial product sales Other Deferred Costs Net Prepaid expenses and other current assets Prepaid Expense And Other Assets Current Total current assets Assets Current Property and equipment - net Property Plant And Equipment Net Other assets Other Assets Noncurrent Total assets Assets LIABILITIES AND STOCKHOLDERS' DEFICIT Liabilities And Stockholders Equity [Abstract] Current liabilities: Liabilities Current [Abstract] Accounts payable Accounts Payable Current Accrued expenses and other current liabilities Accrued Liabilities Current Facility financing obligation Other Long Term Debt Current Deferred revenue - net Deferred Revenue Current Deferred payments from collaboration - current Deferred Collaborative Credit Current Recognized loss on purchase commitments - current Purchase Obligation Current Total current liabilities Liabilities Current Note payable to principal stockholder Notes Payable Related Parties Noncurrent Accrued interest - note payable to principal stockholder Accrued Interest Noncurrent Senior convertible notes Convertible Long Term Notes Payable Recognized loss on purchase commitments - long term Purchase Obligation Noncurrent Deferred payments from collaboration - long term Deferred Collaborative Credit Noncurrent Warrant liability Derivative Liabilities Noncurrent Milestone rights liability and other liabilities Milestone Rights Liability And Other Liabilities Noncurrent Total liabilities Liabilities Commitments and contingencies (Note 11) Commitments And Contingencies Stockholders' deficit: Stockholders Equity [Abstract] Undesignated preferred stock, $0.01 par value - 10,000,000 shares authorized; no shares issued or outstanding at September 30, 2017 and December 31, 2016 Preferred Stock Value Common stock, $0.01 par value - 140,000,000 shares authorized, 104,707,116 and 95,680,831 shares issued and outstanding at September 30, 2017 and December 31, 2016, respectively Common Stock Value Additional paid-in capital Additional Paid In Capital Common Stock Accumulated other comprehensive loss Accumulated Other Comprehensive Income Loss Net Of Tax Accumulated deficit Retained Earnings Accumulated Deficit Total stockholders' deficit Stockholders Equity Total liabilities and stockholders' deficit Liabilities And Stockholders Equity Undesignated preferred stock, par value Preferred Stock Par Or Stated Value Per Share Undesignated preferred stock, shares authorized Preferred Stock Shares Authorized Undesignated preferred stock, shares issued Preferred Stock Shares Issued Undesignated preferred stock, shares outstanding Preferred Stock Shares Outstanding Common stock, par value Common Stock Par Or Stated Value Per Share Common stock, shares authorized Common Stock Shares Authorized Common stock, shares issued Common Stock Shares Issued Common stock, shares outstanding Common Stock Shares Outstanding Net revenue from collaboration. Product costs from collaboration. Gain (loss) on purchase commitments. Change in fair value of warrant liability. Income Statement [Abstract] Revenues: Revenues [Abstract] Net revenue - commercial product sales Sales Revenue Goods Net Net revenue - collaboration Net Revenue From Collaboration Revenue - other Other Sales Revenue Net Total revenues Sales Revenue Net Expenses: Costs And Expenses [Abstract] Cost of goods sold Cost Of Goods Sold Product costs - collaboration Product Costs From Collaboration Research and development Research And Development Expense Excluding Acquired In Process Cost Selling, general and administrative Selling General And Administrative Expense Property and equipment impairment Impairment Of Long Lived Assets Held For Use Loss on foreign currency translation Foreign Currency Transaction Gain Loss Realized Gain on purchase commitment Gain Loss On Purchase Commitments Total expenses Costs And Expenses (Loss) income from operations Operating Income Loss Other income (expense): Nonoperating Income Expense [Abstract] Change in fair value of warrant liability Change In Fair Value Of Warrant Liability Interest income Investment Income Interest Interest expense on notes Interest Expense Debt Interest expense on note payable to principal stockholder Related Party Transaction Expenses From Transactions With Related Party Loss on extinguishment of debt Gains Losses On Extinguishment Of Debt Other (expense) income Other Nonoperating Income Expense Total other (expense) income Nonoperating Income Expense (Loss) income before benefit for income taxes Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest Income tax benefit Income Tax Expense Benefit Net (loss) income Net Income Loss Net (loss) income per share - basic Earnings Per Share Basic Net (loss) income per share - diluted Earnings Per Share Diluted Shares used to compute basic net (loss) income per share Weighted Average Number Of Shares Outstanding Basic Shares used to compute diluted net (loss) income per share Weighted Average Number Of Diluted Shares Outstanding Statement Of Income And Comprehensive Income [Abstract] Net (loss) income Other comprehensive income (loss): Other Comprehensive Income Loss Net Of Tax Period Increase Decrease [Abstract] Cumulative translation gain (loss) Other Comprehensive Income Foreign Currency Transaction And Translation Gain Loss Arising During Period Net Of Tax Comprehensive (loss) income Comprehensive Income Net Of Tax Interest on note payable to principal stockholder. Warrant issuance costs. Increase (decrease) in other deferred charges. Increase (decrease) in deferred collaborative revenue. Increase (decrease) in purchase commitment loss. The cash inflow from the additional capital contribution to the entity including any warrants issued. Proceeds are net of cash outflows for issuance costs related to the transaction. Statement Of Cash Flows [Abstract] CASH FLOWS FROM OPERATING ACTIVITIES: Net Cash Provided By Used In Operating Activities Continuing Operations [Abstract] Adjustments to reconcile net (loss) income to net cash used in operating activities: Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract] Depreciation, amortization and accretion Depreciation And Amortization Stock-based compensation expense Share Based Compensation Loss on extinguishment of debt Gain on disposal of property and equipment Gain Loss On Disposition Of Assets Interest incurred through borrowings under Sanofi Loan Facility Paid In Kind Interest Interest on note payable to principal stockholder Interest On Note Payable To Principal Stockholder Warrant issuance cost Warrant Issuance Costs Change in fair value of warrant liability Other, net Other Noncash Income Expense Changes in operating assets and liabilities: Increase Decrease In Operating Capital [Abstract] Accounts receivable, net Increase Decrease In Accounts Receivable Receivable from Sanofi Increase Decrease In Accounts And Notes Receivable Inventory Increase Decrease In Inventories Deferred costs from collaboration Increase Decrease In Deferred Charges Deferred costs from commercial product sales Increase Decrease In Other Deferred Charges Prepaid expenses and other current assets Increase Decrease In Prepaid Deferred Expense And Other Assets Other assets Increase Decrease In Other Operating Assets Accounts payable Increase Decrease In Accounts Payable Accrued expenses and other current liabilities Increase Decrease In Accrued Liabilities And Other Operating Liabilities Deferred sales from collaboration Increase Decrease In Deferred Collaborative Revenue Deferred payments from collaboration Increase Decrease In Customer Advances And Deposits Deferred revenue, net Increase Decrease In Deferred Revenue Recognized loss on purchase commitments Increase Decrease In Purchase Commitment Loss Net cash used in operating activities Net Cash Provided By Used In Operating Activities Continuing Operations CASH FLOWS FROM INVESTING ACTIVITIES: Net Cash Provided By Used In Investing Activities Continuing Operations [Abstract] Purchase of property and equipment Payments To Acquire Property Plant And Equipment Net proceeds from sale of asset held for sale Proceeds From Sale Of Productive Assets Proceeds from sale of property and equipment Proceeds From Sale Of Property Plant And Equipment Net cash provided by (used in) investing activities Net Cash Provided By Used In Investing Activities Continuing Operations CASH FLOWS FROM FINANCING ACTIVITIES: Net Cash Provided By Used In Financing Activities Continuing Operations [Abstract] Proceeds from issuance of common stock Proceeds From Issuance Of Common Stock And Warrants Net Proceeds from direct placement Proceeds From Issuance Of Private Placement Issuance cost associated with direct placement Payment Of Financing And Stock Issuance Costs Principal payments on facility financing obligation Repayments Of Lines Of Credit Borrowings on note payable to principal stockholder Proceeds From Related Party Debt Payment of employment taxes related to vested restricted stock units Payments Related To Tax Withholding For Share Based Compensation Net cash provided by financing activities Net Cash Provided By Used In Financing Activities Continuing Operations NET DECREASE IN CASH AND CASH EQUIVALENTS Cash And Cash Equivalents Period Increase Decrease CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD CASH AND CASH EQUIVALENTS, END OF PERIOD SUPPLEMENTAL CASH FLOWS DISCLOSURES: Supplemental Cash Flow Information [Abstract] Interest paid in cash, net of amounts capitalized Interest Paid Net NON-CASH INVESTING AND FINANCING ACTIVITIES: Noncash Investing And Financing Items [Abstract] Repayment of facility financing obligation through issuance of common stock Stock Issued1 Capitalization of interest on note payable to principal stockholder Interest Paid Capitalized Reclassification of warrant liability to additional paid-in capital Liabilities Assumed1 Reclassification of deferred payments from collaboration to Sanofi Loan Facility and loss share obligation Loans Assumed1 Accounting Policies [Abstract] Description of Business and Significant Accounting Policies Organization Consolidation And Presentation Of Financial Statements Disclosure And Significant Accounting Policies [Text Block] Inventory Disclosure [Abstract] Inventory Inventory Disclosure [Text Block] Property Plant And Equipment [Abstract] Property and Equipment Property Plant And Equipment Disclosure [Text Block] Payables And Accruals [Abstract] Accrued Expenses and Other Current Liabilities Accounts Payable And Accrued Liabilities Disclosure [Text Block] Related Party Transactions [Abstract] Related-Party Arrangements Related Party Transactions Disclosure [Text Block] Debt Disclosure [Abstract] Borrowings Debt Disclosure [Text Block] Organization Consolidation And Presentation Of Financial Statements [Abstract] Collaboration Arrangements Collaborative Arrangement Disclosure [Text Block] Goodwill And Intangible Assets Disclosure [Abstract] Sale of Intellectual Property Intangible Assets Disclosure [Text Block] Fair Value Disclosures [Abstract] Fair Value of Financial Instruments Fair Value Disclosures [Text Block] Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] Stock-Based Compensation Expense Disclosure Of Compensation Related Costs Share Based Payments [Text Block] Commitments And Contingencies Disclosure [Abstract] Commitments and Contingencies Commitments And Contingencies Disclosure [Text Block] Income Tax Disclosure [Abstract] Income Taxes Income Tax Disclosure [Text Block] Restructuring And Related Activities [Abstract] Restructuring Charges Restructuring And Related Activities Disclosure [Text Block] Earnings Per Share [Abstract] Net Income (Loss) Per Common Share Earnings Per Share [Text Block] Subsequent Events [Abstract] Subsequent Events Subsequent Events [Text Block] Business. Business Business Policy [Text Block] Reclassifications Prior Period Reclassification Adjustment Description Accounting changes and error corrections. Correction of an Immaterial Error Accounting Changes And Error Corrections Policy [Text Block] Revenue Recognition Revenue Recognition Policy [Text Block] Revenue Recognition - Net Revenue - Commercial Product Sales Revenue Recognition Sales Of Goods Gross to net adjustments. Gross-to-net Adjustments Gross To Net Adjustments Policy [Text Block] Wholesaler distribution fees. Wholesaler Distribution Fees Wholesaler Distribution Fees Policy [Text Block] Prompt Pay Discounts Revenue Recognition Discounts Patient discount and co pay assistance programs. Patient Discount and Co-Pay Assistance Programs Patient Discount And Co Pay Assistance Programs Policy [Text Block] Deferred costs Revenue Recognition Deferred Revenue Revenue Recognition- Net Revenue - Collaborations Revenue Recognition Multiple Element Arrangements Revenue recognition, bulk sales. Revenue Recognition - Revenue - Other Revenue Recognition Bulk Sales Policy [Text Block] Cost of Goods Sold Cost Of Sales Policy [Text Block] Accounts Receivable and Allowances Receivables Trade And Other Accounts Receivable Allowance For Doubtful Accounts Policy Inventories Inventory Policy [Text Block] Leases Lessee Leases Policy [Text Block] Loss on purchase commitments. Recognized Loss on Purchase Commitments Loss On Purchase Commitments Policy Policy [Text Block] Fair Value of Financial Instruments Fair Value Of Financial Instruments Policy Stock-Based Compensation Compensation Related Costs Policy [Text Block] Warrants. Warrants Warrants Policy [Text Block] Net Income or Loss Per Share of Common Stock Earnings Per Share Policy [Text Block] Recently issued accounting standards. Recently Issued Accounting Standards Recently Issued Accounting Standards Policy [Text Block] Summary of Correction of Error for Prior Period Presented and to Conform to Current Year Presentation Schedule Of Error Corrections And Prior Period Adjustments [Text Block] Components of Inventory Schedule Of Inventory Current Table [Text Block]