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<!-- Creation Date      : 2018-08-01T23:11:42.6238886+00:00 -->
<!-- Version            : 2.12.6766.32775 -->
<!-- Package ID         : 1cd272fb2956480c8b8ff9bd123577a1 -->
<!-- Copyright (c) 2018 Donnelley Financial, LLC. All Rights Reserved. -->
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  <element id="mnkd_ForeignCurrencyHedgingTransactionRenewablePeriod" name="ForeignCurrencyHedgingTransactionRenewablePeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="mnkd_NumberOfVehicleLeases" name="NumberOfVehicleLeases" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="mnkd_LeaseCommencementPeriod" name="LeaseCommencementPeriod" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="mnkd_OperatingLeasesAnnualIncreaseInRentExpense" name="OperatingLeasesAnnualIncreaseInRentExpense" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="mnkd_MaximumReimbursableAmountForTenantImprovements" name="MaximumReimbursableAmountForTenantImprovements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="mnkd_TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateProvisionalIncomeTaxExpenseBenefit" name="TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateProvisionalIncomeTaxExpenseBenefit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="mnkd_TaxCutsAndJobsActOf2017DecreaseInValuationAllowance" name="TaxCutsAndJobsActOf2017DecreaseInValuationAllowance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="mnkd_TaxCutsAndJobsActOf2017ChangeInTaxRateIncomeTaxExpenseBenefit" name="TaxCutsAndJobsActOf2017ChangeInTaxRateIncomeTaxExpenseBenefit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="mnkd_TaxCutsAndJobsActOf2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalIncomeTaxExpense" name="TaxCutsAndJobsActOf2017IncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalIncomeTaxExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
</schema>
