Accounting Policies [Abstract] Accounting Policies [Abstract] Accounts Payable and Accrued Liabilities Disclosure [Text Block] Accrued expenses and other current liabilities Accounts Payable, Current Accounts payable Accounts Receivable, Net, Current Receivables from collaboration Accrued Expenses and Other Current Liabilities [Line Items] Accrued Expenses and Other Current Liabilities [Line Items] Accrued Expenses and Other Current Liabilities [Line Items] Accrued Expenses and Other Current Liabilities [Table] Accrued Expenses and Other Current Liabilities [Table] Accrued Expenses and Other Current Liabilities [Table] Accrued Liabilities, Current Accrued expenses and other current liabilities Accrued expenses and other current liabilities Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Less accumulated depreciation and amortization Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive loss Achievement of Product Sales Milestone [Member] Achievement of Product Sales Milestone [Member] Product Sales Milestones Additional Paid in Capital, Common Stock Additional paid-in capital Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash (used in) provided by operating activities: Aggregate Offering Price Under Each Agreement Aggregate Offering Price Under Each Agreement Offering price of common stock under agreement Agreement. Agreements [Axis] Agreements [Axis] Agreements. Agreements [Domain] Agreements [Domain] Agreement Type [Axis] Agreement Type [Axis] Agreement Type [Axis] Agreement Type [Domain] Agreement Type [Domain] Agreement Type [Domain] Allocated Share-based Compensation Expense Stock-based compensation Amended Agreement [Member] Amended Agreement [Member] Amended Agreement Amendment Flag Amendment Flag Amortization of Debt Discount (Premium) Accretion expense - debt discount Premium of issuance of 2018 debt Amortization of Financing Costs Accretion expense- debt issuance cost Amortization of Financing Costs and Discounts Accretion expense Amortization period of lease hold improvements. Amortization Period Of Lease Hold Improvements Amortization period of lease hold improvements Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Antidilutive securities Arrangements and Non-arrangement Transactions [Domain] Arrangements and Non-arrangement Transactions [Domain] Assets Total assets Assets [Abstract] ASSETS Assets, Current Total current assets Assets, Current [Abstract] Current assets: At Market Sales Agreement [Member] At Market Sales Agreement [Member] ATM Agreements Available borrowings under the loan agreement. Available Borrowings Under Loan Agreement Additional borrowings Available Loan Balance Cancelled Available Loan Balance Cancelled Aggregate principal amount cancelled Award Type [Axis] Award Type [Axis] Basis of Presentation. Basis Of Presentation Policy [Text Block] Basis of Presentation Building Improvements [Member] Building Improvements Building [Member] Buildings Business. Business Policy [Text Block] Business Cash and Cash Equivalents, at Carrying Value CASH AND CASH EQUIVALENTS, END OF PERIOD CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD Cash and cash equivalents Cash and cash equivalents Cash and Cash Equivalents, Period Increase (Decrease) NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS Class of Stock [Line Items] Class of Stock [Line Items] Collaboration and License Agreement [Member] Collaboration and License Agreement [Member] License and Collaboration Agreement with Sanofi Collaborative Arrangement Disclosure [Text Block] Collaboration arrangement Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Commitments and Contingencies Commitments and contingencies Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Text Block] Commitments and contingencies Commitments and Contingencies [Line Items] Commitments and Contingencies [Line Items] Commitments and Contingencies [Line Items] Commitments and Contingencies [Table] Commitments and Contingencies [Table] Commitments and Contingencies [Table] Common and preferred stock. Common And Preferred Stock [Text Block] Common and preferred stock Common stock loaned under share lending agreement, shares. Common Stock Loaned Under Share Lending Agreement Shares Common stock loaned under share lending agreement, shares Common Stock, Par or Stated Value Per Share Common stock, par value Common Stock, Shares Authorized Common stock, shares authorized Common Stock, Shares, Issued Common stock, shares issued Common Stock, Shares, Outstanding Common stock, shares outstanding Common Stock, Value, Issued Common stock, $0.01 par value - 550,000,000 shares authorized at September 30, 2015 and December 31, 2014; 418,263,814 and 406,059,089 shares issued and outstanding at September 30, 2015 and December 31, 2014, respectively Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive loss Computer equipment and software. Computer Equipment And Software [Member] Computer Equipment and Software Construction in Progress Expenditures Incurred but Not yet Paid Non-cash construction in progress and property and equipment Construction in Progress [Member] Construction in Progress Construction Payable, Current Construction in progress Contingent Liability Contingent Liability Contingent liability for milestone payments Convertible Debt [Line Items] Convertible Debt [Line Items] Convertible Debt [Line Items] Convertible Debt [Member] Convertible Debt Convertible Debt Securities [Member] Convertible Debt Securities Convertible Debt [Table] Convertible Debt [Table] Convertible Debt [Table] Convertible Notes Payable, Noncurrent Senior convertible notes-long term Convertible Notes Payable, Current Senior convertible notes-current Credit Facility [Axis] Credit Facility [Axis] Credit Facility [Domain] Credit Facility [Domain] Current Fiscal Year End Date Current Fiscal Year End Date Debt Conversion, Converted Instrument, Amount Principal amount of debt converted Debt Conversion, Converted Instrument, Shares Issued Number of shares issued up on conversion of debt Debt Conversion, Original Debt, Amount Aggregate principal amount for conversion Issuance of common stock pursuant to conversion of facility financing obligation Debt Disclosure [Abstract] Debt Disclosure [Abstract] Debt Disclosure [Text Block] Facility Agreement Debt Instrument, Basis Spread on Variable Rate Interest rate (LIBOR) Long-term Debt, Gross Carrying value Net carrying amount Debt Instrument, Convertible, Conversion Price Conversion price of shares Debt Instrument, Convertible, Conversion Ratio No of convertible shares Debt Instrument, Convertible, Threshold Consecutive Trading Days Consecutive trading days Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger Percentage of conversion price equaling stock price Debt Instrument, Convertible, Threshold Trading Days Number of trading days Debt Instrument, Date of First Required Payment Principal repayment schedule, start date Debt Instrument Date Of Last Required Payment Debt Instrument Date Of Last Required Payment Principal repayment schedule, end date Debt Instrument, Description of Variable Rate Basis Description of variable rate interest Debt Instrument, Face Amount Debt facility principal amount Principal amount Debt Instrument, Fair Value Disclosure Estimated fair value Debt Instrument, Interest Rate, Stated Percentage Senior notes, effective interest rate Debt Instrument [Line Items] Debt Instrument [Line Items] Debt Instrument, Maturity Date Maturity date Debt Instrument, Redemption, Description Debt Instrument, redemption description Debt Instrument, Redemption Price, Percentage Percentage of repurchase price Schedule of Long-term Debt Instruments [Table] Schedule of Long-term Debt Instruments [Table] Debt Instrument, Unamortized Premium Unamortized premium Debt Issuance Cost Debt Issuance Cost Deerfield Management Company Lp [Member] Deerfield Management Company Lp [Member] Deerfield Deferred Costs, Noncurrent Deferred cost Deferred product costs from collaboration Deferred Revenue Deferred revenue from collaboration product shipments Deferred Revenue, Current Deferred payments from collaboration Depreciation, Depletion and Amortization, Nonproduction Depreciation and accretion Depreciation and amortization expense. Depreciation And Amortization Expense [Table Text Block] Depreciation and Amortization Expense Related to Property and Equipment Depreciation and Other Amortization Expenses [Line Items] Depreciation and Other Amortization Expenses [Line Items] Depreciation and Other Amortization Expenses [Line Items] Depreciation and Other Amortization Expenses [Table] Depreciation and Other Amortization Expenses [Table] Depreciation and Other Amortization Expenses [Table] Depreciation, Depletion and Amortization Depreciation and amortization expense Development Milestone Events [Member] Development Milestone Events [Member] Development Milestone Event Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Accounting for stock-based compensation Document And Entity Information [Abstract] Document And Entity Information [Abstract] Document And Entity Information [Abstract] Document Fiscal Period Focus Document Fiscal Period Focus Document Fiscal Year Focus Document Fiscal Year Focus Document Information [Line Items] Document Information [Line Items] Document Information [Table] Document Information [Table] Document Period End Date Document Period End Date Document Type Document Type Earnings Per Share [Abstract] Earnings Per Share [Abstract] Earnings Per Share, Basic and Diluted Net loss per share - basic and diluted Earnings Per Share [Text Block] Net loss per common share Employee-related Liabilities, Current Salary and related expenses Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized Unrecognized compensation cost related to non vested stock options Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition Weighted average vesting period for unrecognized compensation cost Employee Stock Option [Member] Stock Options Entity Central Index Key Entity Central Index Key Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Entity [Domain] Entity [Domain] Entity Filer Category Entity Filer Category Entity Registrant Name Entity Registrant Name Equity [Abstract] Equity [Abstract] Extinguishment of Debt, Gain (Loss), Net of Tax Loss on extinguishment of debt Facility Agreement [Member] Facility Agreement [Member] Facility Agreement Facility Financing Obligation [Member] Facility Financing Obligation [Member] Facility financing obligation Asset Class [Domain] Asset Class [Domain] Asset Class [Axis] Asset Class [Axis] Fair Value, Hierarchy [Axis] Fair Value, Hierarchy [Axis] Fair Value Disclosures [Abstract] Fair Value Disclosures [Abstract] Fair Value Disclosures [Text Block] Fair Value of Financial Instruments Fair Value Inputs, Discount Rate Market discount rate Fair Value, Inputs, Level 3 [Member] Fair Value, Inputs, Level 3 Fair Value Hierarchy [Domain] Fair Value Hierarchy [Domain] Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Transfers, Net Transfers of assets between fair value measurement Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Transfers, Net Transfers of liabilities between fair value measurement Fair Value of Financial Instruments [Line Items] Fair Value of Financial Instruments [Line Items] Fair Value of Financial Instruments [Line Items] Fair Value of Financial Instruments, Policy [Policy Text Block] Fair Value of Financial Instruments Fair Value of Financial Instruments [Table] Fair Value of Financial Instruments [Table] Fair Value of Financial Instruments [Table] Filing and Completion of Regulatory Approvals [Member] Filing and Completion of Regulatory Approvals [Member] Regulatory Approvals Furniture, fixtures and office equipment. Furniture Fixtures And Office Equipment [Member] Furniture, fixtures and office equipment Gain (Loss) on Disposition of Property Plant Equipment, Excluding Oil and Gas Property and Timber Property Loss on disposal of property and equipment Gain (Loss) on Disposition of Intangible Assets Income from sale of intellectual property Gains (Losses) on Extinguishment of Debt Loss on extinguishment of debt General and Administrative Expense General and administrative General and Administrative Expense [Member] General and administrative Income Approach Valuation Technique [Member] Income Approach Valuation Technique Income (Loss) from Continuing Operations before Income Taxes, Extraordinary Items, Noncontrolling Interest Loss before benefit for income taxes Income Statement [Abstract] Income Statement [Abstract] Income Statement Location [Axis] Income Statement Location [Axis] Income Statement Location [Domain] Income Statement Location [Domain] Income Tax Disclosure [Abstract] Income Tax Disclosure [Abstract] Income Tax Disclosure [Text Block] Income taxes Income Tax Expense (Benefit) Income tax benefit Increase (Decrease) in Accounts and Other Receivables Receivables from Collaboration Increase (Decrease) in Accounts Payable Accounts payable Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities Accrued expenses and other current liabilities Increase (Decrease) in Customer Advances and Deposits Deferred up-front payment from collaboration agreement Increase (Decrease) in Deferred Charges Deferred product costs from collaboration Increase (Decrease) in Deferred Revenue Deferred product sales from collaboration Increase (Decrease) in Inventories Inventory Increase (Decrease) in Operating Capital [Abstract] Changes in assets and liabilities: Increase (Decrease) in Other Operating Assets Other assets Increase (Decrease) in Other Operating Liabilities Other liabilities Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other current assets Interest Expense, Debt Interest expense on notes Interest expense on notes Interest Expense Related To Milestone Payment Interest Expense Related To Milestone Payment Interest expense related to milestone payment Interest Paid Interest paid in cash, net of amounts capitalized Interest Payable, Current Accrued interest Interest Payable Interest payable Inventory, Current [Table] Inventory, Current [Table] Inventory Disclosure [Abstract] Inventory Disclosure [Abstract] Inventory Disclosure [Text Block] Inventories Inventory, Finished Goods, Net of Reserves Finished goods Inventory [Line Items] Inventory [Line Items] Inventory, Net Inventory Total inventories Inventory, Raw Materials, Net of Reserves Raw materials Inventory, Work in Process, Net of Reserves Work-in-process Investment Income, Interest Interest income Land [Member] Land Leasehold Improvements [Member] Leasehold Improvements Legal Entity [Axis] Legal Entity [Axis] Letter agreement. Letter Agreement [Member] Letter Agreement Liabilities Total liabilities Liabilities and Equity Total Liabilities and Equity [Abstract] LIABILITIES AND STOCKHOLDERS' DEFICIT Liabilities, Current Total current liabilities Liabilities, Current [Abstract] Current liabilities: Financial and Nonfinancial Liabilities, Fair Value Disclosure Fair value of Milestone Rights Long-term Line of Credit Principal amount outstanding under credit facility Line of Credit Facility, Maximum Borrowing Capacity Maximum secured loan facility Line of Credit Facility, Remaining Borrowing Capacity Amount available for future borrowings Line Of Credit Facility Restricted Borrowing Capacity Line Of Credit Facility Restricted Borrowing Capacity Available amount of credit facility under covenant restrictions Loan agreement with related party. Loan Agreement With Related Party Loan agreement with related party Loan arrangement. Loan Arrangement [Member] Loan Arrangement Loans Assumed Reclassification of deferred payments from collaboration to Sanofi loan facility London Interbank Offered Rate (LIBOR) [Member] LIBOR Long-term Debt Principal amount of outstanding debt Long-term Debt, Percentage Bearing Fixed Interest, Percentage Rate Fixed borrowing rate Long-term Debt [Text Block] Senior convertible notes Long-term Debt, Type [Axis] Long-term Debt, Type [Axis] Long-term Debt, Type [Domain] Long-term Debt, Type [Domain] Loans Payable, Noncurrent Secured loan facility, amount owed Long-term Purchase Commitment, Amount Purchase commitment amount under Insulin Supply Agreement Loss Contingency, Accrual, Noncurrent Sanofi loan facility and loss share obligation Loss Sharing Agreement, Amount Loss Sharing Agreement, Amount Loss sharing amount reclassified to loan facility and loss share obligation Machinery and Equipment [Member] Machinery and Equipment Manufacturing Costs Product manufacturing Manufacturing Milestone Events [Member] Manufacturing Milestone Events [Member] Manufacturing Milestone Events Maximum [Member] Maximum Milestone Events [Axis] Milestone Events [Axis] Milestone Events [Axis] Milestone Events [Domain] Milestone Events [Domain] Milestone Events [Domain] Milestone payments include payments to our partners related to alliance and collaboration agreements. Milestone payments for intangible assets Milestone payment Milestone Rights Liability [Member] Milestone Rights Liability [Member] Milestone Rights Liability Minimum [Member] Minimum Money Market Funds, at Carrying Value Cash equivalents, money market funds Net Cash Provided by (Used in) Financing Activities, Continuing Operations Net cash (used in) provided by financing activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] CASH FLOWS FROM FINANCING ACTIVITIES: Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net cash used in investing activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] CASH FLOWS FROM INVESTING ACTIVITIES: Net Cash Provided by (Used in) Operating Activities, Continuing Operations Net cash (used in) provided by operating activities Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] CASH FLOWS FROM OPERATING ACTIVITIES: Net Income (Loss) Attributable to Parent Net loss Net loss Net Income Loss Per Common Share [Line Items] Net Income Loss Per Common Share [Line Items] Net Income Loss Per Common Share [Line Items] Net Income Loss Per Common Share [Table] Net Income Loss Per Common Share [Table] Net Income Loss Per Common Share [Table] Nominal lending fee. Nominal Lending Fee Nominal lending fee Non Cash Financing Activities Loan Commitment Asset. Non Cash Financing Activities Loan Commitment Asset Tranche B Commitment Asset Notes Payable, Related Parties, Noncurrent Note payable to principal stockholder Number of Milestones Achieved Number of Milestones Achieved Number of milestones achieved Number of months advances outstanding. Number Of Months Advances Outstanding Number of months advances outstanding Operating Expenses Total operating expenses Operating Expenses [Abstract] Operating expenses: Operating Income (Loss) Loss from operations Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] Organization, Consolidation and Presentation of Financial Statements Disclosure [Table] Organization, Consolidation and Presentation of Financial Statements Disclosure [Table] Organization, Consolidation and Presentation of Financial Statements Disclosure [Table] Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] Description of business and basis of presentation Other Accrued Liabilities, Current Other Other Assets, Noncurrent Other assets Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Gain (Loss) Arising During Period, Net of Tax Other comprehensive (loss) income - cumulative translation (loss) gain Other Deferred Credits, Current Deferred product sales from collaboration Other Liabilities, Noncurrent Other liabilities Other Long-term Debt, Current Facility financing obligation Short term liability Other Long-term Debt, Noncurrent Long term liability Other Noncash Income (Expense) Other, net Other Nonoperating Income (Expense) Other income Own-share Lending Arrangement, Shares, Issued Shares loaned under the share lending arrangement Own-share Lending Arrangement, Shares, Outstanding Companies common stock share outstanding Paid-in-Kind Interest Interest paid through borrowings under Sanofi Loan Facility Paid-in-kind interest Payables and Accruals [Abstract] Payables and Accruals [Abstract] Payment For Contingent Liabilities Payment For Contingent Liabilities Required payment pursuant to the terms of the Milestone Agreement Payments of Debt Issuance Costs Payment of debt issuance costs on 2018 notes Payments of Stock Issuance Costs Issuance costs of ATM Payments Related to Tax Withholding for Share-based Compensation Payment of employment taxes related to vested restricted stock units Payments to Acquire Property, Plant, and Equipment Purchase of property and equipment Percentage of Net Proceed From Sale of Notes Percentage of Net Proceed From Sale of Notes Prepayment of loan percentage of net cash proceeds sale Potential Milestone Payments Potential Milestone Payments Potential milestone payment Potential Milestone Payments To Be Received Potential Milestone Payments To Be Received Milestone receivable Potential Proceeds from Warrant Exercises Potential Proceeds from Warrant Exercises Potential proceeds from the exercise of warrants from February 2012 public offering Preferred Stock, Par or Stated Value Per Share Undesignated preferred stock, par value Preferred Stock, Shares Authorized Undesignated preferred stock, shares authorized Preferred Stock, Shares Issued Undesignated preferred stock, shares issued Preferred Stock, Shares Outstanding Undesignated preferred stock, shares outstanding Preferred Stock, Value, Issued Undesignated preferred stock, $0.01 par value - 10,000,000 shares authorized; no shares issued or outstanding at September 30, 2015 and December 31, 2014 Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Principal amount per share. Principal Amount Per Share Principal amount per share Principal Owner [Member] Principal stockholder Proceeds from Issuance of Common Stock Proceeds from issuance of common stock pursuant to ATM issuance Issuance of common stock and warrants. Proceeds From Issuance Of Common Stock And Warrants Proceeds from issuance of common stock and warrants Proceeds from Issuance of Debt Proceeds from issuance of facility financing obligation & milestone rights Proceeds from Issuance of Long-term Debt Proceeds from issuance of Tranche B of the facility financing obligation Proceeds from (Payments for) Other Financing Activities Other Proceeds from Related Party Debt Secured loan facility, amount borrowed Proceeds from Sale of Intangible Assets Proceeds from sale of intellectual property Proceeds from Sale of Property, Plant, and Equipment Proceeds from sale of property and equipment Product [Member] AFREZZA product sales Products and Services [Axis] Products and Services [Axis] Products and Services [Domain] Products and Services [Domain] Profit Loss Sharing Agreement Allocation Percentage Profit Loss Sharing Agreement Allocation Percentage Profits and losses sharing percentage Property, Plant and Equipment [Abstract] Property, Plant and Equipment [Abstract] Property, Plant and Equipment, Type [Axis] Property, Plant and Equipment, Type [Axis] Property, Plant and Equipment Disclosure [Text Block] Property and equipment Property, Plant and Equipment, Gross Property and equipment - gross Property, Plant and Equipment [Line Items] Property, Plant and Equipment [Line Items] Property, Plant and Equipment, Net Property and equipment - net Property and equipment - net Property, Plant and Equipment [Table Text Block] Property and Equipment Property, Plant and Equipment, Type [Domain] Property, Plant and Equipment, Type [Domain] Property, Plant and Equipment, Useful Life Estimated Useful Life (Years) Purchase Obligation, Future Minimum Payments, Remainder of Fiscal Year Remaining purchase commitment obligation under Insulin Supply Agreement Range [Axis] Range [Axis] Range [Domain] Range [Domain] Recently issued accounting standards. Recently Issued Accounting Standards [Policy Text Block] Recently Issued Accounting Standards Reclassification of Share Based Awards to Liability Reclassification of Share Based Awards to Liability Reclassification of share-based awards to liability Related party debt. Related Party Debt [Member] Related Party Debt Related Party [Domain] Related Party [Domain] Related Party Transaction [Axis] Related Party Transaction [Axis] Related Party Transaction Debt Instrument Prepayment Related Party Transaction Debt Instrument Prepayment Amount prepaid for cancellation of indebtedness Related Party Transaction [Domain] Related Party Transaction [Domain] Related Party Transaction, Expenses from Transactions with Related Party Interest expense on note payable to principal stockholder Related Party Transaction [Line Items] Related Party Transaction [Line Items] Related party transaction prepayment period. Related Party Transaction Prepayment Period Related party transaction prepayment period Related Party Transactions [Abstract] Related Party Transactions [Abstract] Related Party [Axis] Related Party [Axis] Related Party Transactions Disclosure [Text Block] Related-party arrangements Repayments of Senior Debt Payments on senior notes Payment of 2015 notes Research and Development Expense (Excluding Acquired in Process Cost) Research and development Research and Development Expense [Member] Research and development Restricted Stock Units (RSUs) [Member] Restricted Stock Units (RSUs) Restructuring and Related Activities [Abstract] Restructuring and Related Activities [Abstract] Restructuring and Related Activities Disclosure [Text Block] Restructuring charges Restructuring and Related Cost, Number of Positions Eliminated Number of employees eliminated Restructuring and Related Cost, Number of Positions Eliminated, Period Percent Percentage of workforce reduction Restructuring Charges Restructuring charges Restructuring Cost and Reserve [Line Items] Restructuring Cost and Reserve [Line Items] Restructuring Reserve, Current Restructuring liability Retained Earnings (Accumulated Deficit) Accumulated deficit Revenue Recognition, Deferred Revenue [Policy Text Block] Deferred product costs from collaboration Revenue Recognition, Milestone Method, Revenue Recognized Milestone payments earned Revenue, Net Revenue Sanofi Aventis [Member] Sanofi Aventis [Member] Sanofi-Aventis Deutschland GmbH Schedule of Accrued Liabilities [Table Text Block] Accrued Expenses and Other Current Liabilities Schedule of amortization of debt issuance expense. Schedule Of Amortization Of Debt Issuance Expense Table [Text Block] Accretion of Debt Issuance Expense Schedule of Carrying Values and Estimated Fair Values of Debt Instruments [Table Text Block] Summary of Carrying Values Estimated Fair Values of Notes and Facility Financing Obligation Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] Schedule of Long-term Debt Instruments [Table Text Block] Summary of Senior Convertible Notes Schedule of Inventory, Current [Table Text Block] Components of Inventories Schedule of Other Assets and Other Liabilities [Table Text Block] Accretion of Debt Issuance Cost and Debt Discount Property, Plant and Equipment [Table] Property, Plant and Equipment [Table] Schedule of Related Party Transactions, by Related Party [Table] Schedule of Related Party Transactions, by Related Party [Table] Schedule of Restructuring and Related Costs [Table] Schedule of Restructuring and Related Costs [Table] Schedule of Share-based Compensation, Activity [Table Text Block] Stock-Based Compensation Expense Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Stock by Class [Table] Schedule of Stock by Class [Table] Senior Convertible Notes Due Two Thousand Eighteen [Member] Senior Convertible Notes Due Two Thousand Eighteen [Member] Senior convertible notes due August 15, 2018 Senior convertible notes due two thousand fifteen. Senior Convertible Notes Due Two Thousand Fifteen [Member] Senior convertible notes due August 15, 2015 Share-based Compensation Stock-based compensation expense Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period Share based payment award , vesting period Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Weighted average grant date fair value of the stock options granted Equity Award [Domain] Equity Award [Domain] Shares Returned Under Share Lending Agreement Shares Returned Under Share Lending Agreement Returned shares of common stock under share lending agreement Short-term Debt, Type [Axis] Short-term Debt, Type [Axis] Short-term Debt, Type [Domain] Short-term Debt, Type [Domain] Statement [Line Items] Statement [Line Items] Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Statement of Comprehensive Income [Abstract] Statement of Comprehensive Income [Abstract] Statement [Table] Statement [Table] Stockholders' Equity Attributable to Parent Stockholders' deficit Total stockholders' deficit Stockholders' Equity Attributable to Parent [Abstract] Stockholders' deficit: Stock Issued Payment of 2015 notes and interest through issuance of common stock Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Number of restricted stock units issued Stock Issued During Period, Shares, Share-based Compensation, Net of Forfeitures Number of stock options issued Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures Fair value of Restricted stock options granted , value Stock Issued During Period, Value, Share-based Compensation, Net of Forfeitures Fair value of the stock options granted , value Subsequent Event [Line Items] Subsequent Event [Line Items] Subsequent Event [Member] Subsequent Event Subsequent Events [Abstract] Subsequent Events [Abstract] Subsequent Events [Text Block] Subsequent events Subsequent Event [Table] Subsequent Event [Table] Subsequent Event Type [Axis] Subsequent Event Type [Axis] Subsequent Event Type [Domain] Subsequent Event Type [Domain] Supplemental Cash Flow Information [Abstract] SUPPLEMENTAL CASH FLOWS DISCLOSURES: Text Block [Abstract] Text Block [Abstract] Trading Symbol Trading Symbol Tranche B [Member] Tranche B [Member] Less portion of commitment asset Two Thousand Nineteen Notes [Member] Two Thousand Nineteen Notes [Member] Senior convertible notes due December 31, 2019 Type of Arrangement and Non-arrangement Transactions [Axis] Type of Arrangement and Non-arrangement Transactions [Axis] Unamortized Debt Issuance Expense Unaccreted debt issuance costs Upfront Fee Upfront Fee Up-front fee Valuation Technique [Axis] Valuation Technique [Axis] Valuation Technique [Domain] Valuation Technique [Domain] Variable Rate [Axis] Variable Rate [Axis] Variable Rate [Domain] Variable Rate [Domain] Weighted Average Number of Shares Outstanding, Basic and Diluted Shares used to compute basic and diluted net loss per share Write Off of Derivative Liability Write Off of Derivative Liability Write off of derivative liability