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Disclosure - Net loss per common share link:calculationLink link:presentationLink link:definitionLink 121 - Disclosure - Stock award plans link:calculationLink link:presentationLink link:definitionLink 122 - Disclosure - Commitments and contingencies link:calculationLink link:presentationLink link:definitionLink 123 - Disclosure - Employee benefit plans link:calculationLink link:presentationLink link:definitionLink 124 - Disclosure - Income taxes link:calculationLink link:presentationLink link:definitionLink 125 - Disclosure - Facility Agreement link:calculationLink link:presentationLink link:definitionLink 126 - Disclosure - Restructuring Charges link:calculationLink link:presentationLink link:definitionLink 127 - Disclosure - Selected quarterly financial data (unaudited) link:calculationLink link:presentationLink link:definitionLink 128 - Disclosure - Subsequent Events link:calculationLink link:presentationLink link:definitionLink 129 - Disclosure - Description of business and basis of presentation (Policies) link:calculationLink link:presentationLink link:definitionLink 130 - 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Disclosure - Effective Income Tax Rate (Detail) link:calculationLink link:presentationLink link:definitionLink 169 - Disclosure - Facility Agreement - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 170 - Disclosure - Accretion of Debt Issuance Cost and Debt Discount in Connection with Deerfield Financing (Detail) link:calculationLink link:presentationLink link:definitionLink 171 - Disclosure - Restructuring Charges - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 172 - Disclosure - Selected Quarterly Financial Data (Detail) link:calculationLink link:presentationLink link:definitionLink 173 - Disclosure - Selected Quarterly Financial Data - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 174 - Disclosure - Subsequent Events - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink