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Document and Entity Information - shares	6 Months Ended
Document and Entity Information - shares	Jun. 30, 2012	Aug. 06, 2012
Document and Entity Information [Abstract]
Entity Registrant Name	MANNKIND CORP
Entity Central Index Key	0000899460
Document Type	10-Q
Document Period End Date	Jun. 30, 2012
Amendment Flag	false
Document Fiscal Year Focus	2012
Document Fiscal Period Focus	Q2
Current Fiscal Year End Date	--12-31
Entity Filer Category	Accelerated Filer
Entity Common Stock, Shares Outstanding		199,384,118

Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands	Jun. 30, 2012	Dec. 31, 2011
Current assets:
Cash and cash equivalents	$ 31,639	$ 2,681
Available for sale securities and certificate of deposit	350	515
Prepaid expenses and other current assets	18,356	2,625
Total current assets	50,345	5,821
Property and equipment - net	189,159	193,029
State research and development credit exchange receivable	658	473
Other assets	230	230
Total	240,392	199,553
Current liabilities:
Accounts payable	5,817	4,624
Accrued expenses and other current liabilities	49,624	20,736
Total current liabilities	55,441	25,360
Senior convertible notes	211,184	210,642
Note payable to related party	218,142	277,203
Total liabilities	484,767	513,205
Commitments and contingencies
Stockholders' deficit:
Undesignated preferred stock, $0.01 par value - 10,000,000 shares authorized; no shares issued or outstanding at June 30, 2012 and December 31, 2011
Common stock, $0.01 par value 350,000,000 and 250,000,000 shares authorized at June 30, 2012 and December 31, 2011, respectively; 199,300,833 and 131,522,945 shares issued and outstanding at June 30, 2012 and December 31, 2011, respectively	1,993	1,315
Additional paid-in capital	1,763,939	1,620,535
Accumulated other comprehensive income (loss)	(9)	44
Deficit accumulated during the development stage	(2,010,298)	(1,935,546)
Total stockholders' deficit	(244,375)	(313,652)
Total	$ 240,392	$ 199,553

Condensed Consolidated Balance Sheets (Unaudited) (Parenthetical) - $ / shares	Jun. 30, 2012	Dec. 31, 2011
Stockholders' deficit:
Undesignated preferred stock, par value	$ 0.01	$ 0.01
Undesignated preferred stock, shares authorized	10,000,000	10,000,000
Undesignated preferred stock, shares issued
Undesignated preferred stock, shares outstanding
Common stock, par value	$ 0.01	$ 0.01
Common stock, shares authorized	350,000,000	250,000,000
Common stock, shares issued	199,300,833	199,300,833
Common stock, shares outstanding	131,522,945	131,522,945

Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended		257 Months Ended
	Jun. 30, 2012	Jun. 30, 2011	Jun. 30, 2012	Jun. 30, 2011	Jun. 30, 2012
Condensed Consolidated Statements of Operations [Abstract]
Revenue				$ 50	$ 3,131
Operating expenses:
Research and development	$ 26,638	$ 30,296	$ 50,794	56,585	1,416,845
General and administrative	17,416	8,890	27,193	20,652	407,424
In-process research and development costs					19,726
Goodwill impairment					151,428
Total operating expenses	44,054	39,186	77,987	77,237	1,995,423
Loss from operations	(44,054)	(39,186)	(77,987)	(77,187)	(1,992,292)
Other income	13,347	47	14,729	1,397	13,653
Interest expense on note payable to related party	(3,028)	(2,509)	(6,076)	(4,985)	(34,410)
Interest expense on senior convertible notes	(2,844)	(2,834)	(5,419)	(5,247)	(34,213)
Interest income	1	2	2	17	36,990
Loss before provision for income taxes	(36,578)	(44,480)	(74,751)	(86,005)	(2,010,272)
Income taxes					(26)
Net loss	(36,578)	(44,480)	(74,751)	(86,005)	(2,010,298)
Deemed dividend related to beneficial conversion feature of convertible preferred stock					(22,260)
Accretion on redeemable convertible preferred stock					(952)
Net loss applicable to common stockholders	$ (36,578)	$ (44,480)	$ (74,751)	$ (86,005)	$ (2,033,510)
Net loss per share applicable to common stockholders - basic and diluted	$ (0.23)	$ (0.37)	$ (0.49)	$ (0.71)
Shares used to compute basic and diluted net loss per share applicable to common stockholders	159,859	121,708	151,506	121,385

Condensed Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended		257 Months Ended
	Jun. 30, 2012	Jun. 30, 2011	Jun. 30, 2012	Jun. 30, 2011	Jun. 30, 2012
Condensed Consolidated Statements of Comprehensive Loss [Abstract]
Net Loss	$ (36,578)	$ (44,480)	$ (74,751)	$ (86,005)	$ (2,010,298)
Other comprehensive loss:
Cumulative translation (loss) gain	6	4	5	9	1
Unrealized gain (loss) on investments:
Unrealized holding gain (loss) during the period		(52)		(45)	(48)
Less: reclassification adjustment for gains (losses) included in net loss			48		48
Net unrealized (loss) gain on investments		(52)	48	(45)
Comprehensive loss	$ (36,572)	$ (44,528)	$ (74,698)	$ (86,041)	$ (2,010,297)

- Definition

The change in equity [net assets] of a business enterprise during a period from transactions and other events and circumstances from non-owner sources which are attributable to the reporting entity. It includes all changes in equity during a period except those resulting from investments by owners and distributions to owners, but excludes any and all transactions which are directly or indirectly attributable to that ownership interest in subsidiary equity which is not attributable to the parent.

+ References + Details

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

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- Definition

Amount after tax, before reclassification adjustments, resulting from the process of expressing in the reporting currency of the reporting entity those amounts that are denominated or measured in a different currency, and from transactions whose terms are denominated in a currency other than the entity's functional currency.

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- Definition

Net of tax amount of the income statement impact of the reclassification adjustment for unrealized gain (loss) realized upon the sale of available-for-sale securities.

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- Definition

Net of tax amount of unrealized holding gain (loss) before reclassification adjustments and transfers on available-for-sale securities.

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+ Details

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended		257 Months Ended
	Jun. 30, 2012	Jun. 30, 2011	Jun. 30, 2012
CASH FLOWS FROM OPERATING ACTIVITIES:
Net Loss	$ (74,751)	$ (86,005)	$ (2,010,298)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	7,343	8,023	119,718
Stock-based compensation expense	5,951	4,701	130,577
Stock expense for shares issued pursuant to research agreement			3,018
(Gain) loss on sale, abandonment/disposal or impairment of property and equipment	(73)	(63)	23,498
Accrued interest on investments, net of amortization of discounts			(191)
In-process research and development			19,726
Goodwill impairment			151,428
Loss on available-for-sale securities	117		990
Fair value adjustment of warrant liability	(2,709)		(2,709)
Fair value of forward purchase contract	(12,011)		(12,011)
Other, net	(7)	9	1,095
Changes in assets and liabilities:
State research and development credit exchange receivable	(185)	418	(658)
Prepaid expenses and other current assets	(15,731)	1,256	(16,756)
Other assets		87	(230)
Accounts payable	1,244	(447)	5,618
Accrued expenses and other current liabilities	33,308	4,574	53,282
Other liabilities			(2)
Net cash used in operating activities	(57,504)	(67,447)	(1,533,905)
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchase of marketable securities			(796,779)
Sales and maturities of marketable securities		3,828	796,393
Purchase of property and equipment	(448)	(6,109)	(327,557)
Proceeds from sale of property and equipment	73	63	450
Net cash (used in) provided by investing activities	(375)	(2,218)	(327,493)
CASH FLOWS FROM FINANCING ACTIVITIES:
Issuance of common stock and warrants, net of issuance costs	80,992	10,424	1,311,013
Collection of Series C convertible preferred stock subscriptions receivable			50,000
Issuance of Series B convertible preferred stock for cash			15,000
Cash received for common stock to be issued			3,900
Repurchase of common stock			(1,028)
Put shares sold to majority stockholder			623
Borrowings under lines of credit			4,220
Proceeds from notes receivables			1,742
Borrowings on notes payable to related party	6,250	18,000	381,250
Principal payments on notes payable to principal stockholder			(70,000)
Borrowings on notes payable			3,460
Principal payments on notes payable			(1,667)
Proceeds from senior convertible notes			207,050
Payment of employment taxes related to vested restricted stock units	(405)	(50)	(12,526)
Net cash provided by financing activities	86,837	28,374	1,893,037
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS	28,958	(41,291)	31,639
CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD	2,681	66,061
CASH AND CASH EQUIVALENTS, END OF PERIOD	31,639	24,770	31,639
SUPPLEMENTAL CASH FLOWS DISCLOSURES:
Cash paid for income taxes			26
Interest paid in cash, net of amounts capitalized	4,751	10,136	54,148
Accretion on redeemable convertible preferred stock			(952)
Issuance of common stock upon conversion of notes payable			3,331
Increase in additional paid-in capital resulting from merger			171,154
Issuance of common stock for notes receivable			2,758
Issuance of put option by stockholder			(2,949)
Put option redemption by stockholder			1,921
Issuance of Series C convertible preferred stock subscriptions			50,000
Issuance of Series A redeemable convertible preferred stock			4,296
Conversion of Series A redeemable convertible preferred stock			(5,248)
Non-cash construction in progress and property and equipment	2,343	1,039	2,343
Capitalization of interest on note payable to related party	11,876		11,876
Cancellation of principal on note payable to related party	77,187	$ 11,116	104,984
Warrant liability	7,632		7,632
Forward purchase contract contribution to additional paid-in capital	1,080		1,080
Reclassification of forward purchase contract to additional paid-in capital	$ 13,091		$ 13,091

Condensed Consolidated Statements of Cash Flows (Unaudited) (Parenthetical) - shares shares in Millions	6 Months Ended
	Jun. 30, 2012	Jun. 30, 2011
Series B Preferred Stock [Member]
SUPPLEMENTAL CASH FLOWS DISCLOSURE:
Conversion of convertible preferred stock amount converted	15.0
Series C Preferred Stock [Member]
SUPPLEMENTAL CASH FLOWS DISCLOSURE:
Conversion of convertible preferred stock amount converted		50.0

Description of business and basis of presentation

6 Months Ended

Jun. 30, 2012

Description of business and basis of presentation [Abstract]

Description of business and basis of presentation

1. Description of business and basis of presentation

The accompanying unaudited condensed consolidated financial statements of MannKind Corporation and its subsidiaries (the “Company”), have been prepared in accordance with generally accepted accounting principles in the United States of America (“GAAP”) for interim financial information and with the instructions to Form 10-Q and Article 10 of Regulation S-X of the Securities and Exchange Commission (the “SEC”). Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. These statements should be read in conjunction with the financial statements and notes thereto included in the Company’s latest audited annual financial statements. The audited statements for the year ended December 31, 2011 (which includes disclosures regarding the Company’s ability to continue as a going concern) are included in the Company’s annual report on Form 10-K for the fiscal year ended December 31, 2011 filed with the SEC on March 15, 2012 (the “Annual Report”).

In the opinion of management, all adjustments, consisting only of normal, recurring adjustments, considered necessary for a fair presentation of the results of these interim periods have been included. The results of operations for the six months ended June 30, 2012 may not be indicative of the results that may be expected for the full year.

The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements, and the reported amounts of expenses during the reporting period. Actual results could differ from those estimates or assumptions. The more significant estimates reflected in these accompanying financial statements involve assessing long-lived assets for impairment, accrued expenses including the valuation of warrant liabilities, the valuation of stock-based compensation and the determination of the provision for income taxes and corresponding deferred tax assets and liabilities and any valuation allowance recorded against net deferred tax assets.

Business — The Company is a biopharmaceutical company focused on the discovery and development of therapeutic products for diseases such as diabetes and cancer. The Company’s lead product candidate, AFREZZA (insulin human [rDNA origin]) inhalation powder, is an ultra rapid-acting insulin therapy in late-stage clinical investigation for the treatment of adults with type 1 or type 2 diabetes for the control of hyperglycemia.

AFREZZA consists of the Company’s proprietary Technosphere particles onto which insulin molecules are loaded. These loaded particles are then aerosolized and inhaled deep into the lung using the Company’s AFREZZA inhaler.

Basis of Presentation — The Company is considered to be in the development stage as its primary activities since incorporation have been establishing its facilities, recruiting personnel, conducting research and development, business development, business and financial planning, and raising capital. It is costly to develop therapeutic products and conduct clinical trials for these products. Since its inception through June 30, 2012 the Company has reported accumulated net losses of $2.0 billion, which include a goodwill impairment charge of $151.4 million, and cumulative negative cash flow from operations of $1.5 billion. At June 30, 2012, the Company’s capital resources consisted of cash, cash equivalents, and a certificate of deposit of $32.0 million and $26.9 million of available borrowings under the loan agreement with an entity controlled by the Company’s principal stockholder (see Note 11 — Related-party arrangements). Based upon the Company’s current expectations, management believes the Company’s existing capital resources will enable it to continue planned operations into the fourth quarter of 2012. However, the Company cannot provide assurances that its plans will not change or that changed circumstances will not result in the depletion of its capital resources more rapidly than it currently anticipates. The Company will need to raise additional capital, whether through the sale of equity or debt securities, a strategic business collaboration with a pharmaceutical company, the establishment of other funding facilities, licensing arrangements, assets sales or other means, or an increase in the borrowings available under the loan arrangement with its related party, in order to continue the development and commercialization of AFREZZA and other product candidates and to support its other ongoing activities. This raises substantial doubt about the Company’s ability to continue as a going concern. The financial statements do not include any adjustments that might result from the outcome of these uncertainties.

Fair Value of Financial Instruments — The carrying amounts of financial instruments, which include cash equivalents, available for sale securities, a certificate of deposit, and accounts payable, approximate their fair values due to their relatively short maturities. The fair value of the note payable to related party cannot be reasonably estimated as the Company would not be able to obtain a similar credit arrangement in the current economic environment.

Cash equivalents consist of highly liquid investments, with original or remaining maturities of 90 days or less at the time of purchase, that are readily convertible into cash. As of June 30, 2012 and December 31, 2011, the Company held $31.6 million and $2.7 million, respectively of cash and cash equivalents, consisting primarily of money market funds and the remaining funds in non-interest bearing checking accounts. The fair value of these investments was determined by using quoted prices for identical investments in an active market (Level 1 in the fair value hierarchy).

The Company’s available for sale securities consisted a common stock investment which the Company had determined to be other than temporarily impaired and had recorded a $117,000 realized loss in the quarter ended March 31, 2012. The certificate of deposit, having a maturity greater than 90 days, is held as collateral for the Company’s commercial credit card programs. The carrying value of the certificate of deposit approximates fair value based on quoted prices for similar instruments in an active market (Level 2 in the fair value hierarchy) and the common stock investment is stated at fair value based on quoted prices in an active market (Level 1 in the fair value hierarchy). As of June 30, 2012 and December 31, 2011, there were available for sale securities and a certificate of deposit of $350,000 and $515,000, respectively.

The following is a summary of the carrying values and estimated fair values of the Company’s senior convertible notes due in 2013 and 2015 (in millions).


	June 30, 2012				December 31, 2011
	Carrying value		Estimated fair value		Carrying value		Estimated fair value
Notes due 2013	$	114.1	$	60.4	$	113.9	$	61.0
Notes due 2015	$	97.1	$	56.8	$	96.8	$	60.8

The estimated fair value of the senior convertible notes due 2013 was calculated based on quoted prices in an active market (Level 1 in the fair value hierarchy). The estimated fair value of the senior convertible notes due 2015 was calculated based on model derived valuations whose inputs were observable, such as the Company’s stock price, and non-observable, such as the Company’s long-term historical volatility (Level 3 in the fair value hierarchy). As there is no current observable market for the senior convertible notes due 2015, the Company determined the estimated fair value using a convertible bond valuation model within a lattice framework. The convertible bond valuation model combined expected cash outflows with market-based assumptions regarding risk-adjusted yields, stock price volatility and recent price quotes and trading information regarding Company issued debt instruments and shares of common stock into which the notes are convertible.

The estimated fair value of the warrant liability was calculated based on the Black-Scholes option pricing model (Level 3 in the fair value hierarchy). See Note 9 – Warrant Liability for further discussion.

The estimated fair value of Mann Purchase Agreement was based on a forward purchase contract valuation (Level 3 in the fair value hierarchy). See Note 8- Common and Preferred Stock for further discussion.

The following roll-forward provides a summary of changes in fair value of the Company’s Level 3 financial assets and liabilities (in thousands):


	Three months ended June 30, 2012						Six months ended June 30, 2012
	Forward Purchase Contract			Warrant Liability			Forward Purchase Contract			Warrant Liability
Beginning Balance	$	744		$	(7,915	)	$	—		$	—
Issuance		—			—			1,080			(7,631	)
Adjustments to fair value		12,347			2,993			12,011			2,709
Transfers to additional paid-in-capital		(13,091	)		—			(13,091	)		—

Ending Balance	$	—		$	(4,922	)	$	—		$	(4,922	)

Recently Issued Accounting Standards — In June 2011, the FASB issued Accounting Standards Update No. 2011-05 (“ASU 2011-05”) for Comprehensive Income (Topic 220): “Presentation of Comprehensive Income”. This update improves the comparability, consistency and transparency of financial reporting and increases the prominence of items reported in other comprehensive income. This update is effective for interim and annual periods beginning after December 15, 2011. The Company has adopted all current required provisions of ASU 2011-05 on a retrospective basis.

In May 2011, the FASB issued Accounting Standards Update No. 2011-04 (“ASU 2011-04”) for Fair Value Measurement (Topic 820): “Amendments to Achieve Common Fair Value Measurement and Disclosure Requirements in U.S. GAAP and IFRSs”. This update addresses how to measure fair value and requires new disclosures about fair value measurements. The amendments in this update are effective for interim and annual periods beginning after December 15, 2011. The Company has adopted all current required provisions of ASU 2011-04.

- Definition

The entire disclosure for organization, consolidation and basis of presentation of financial statements disclosure.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 275
-SubTopic 10
-URI http://asc.fasb.org/subtopic&trid=2134480

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 852
-SubTopic 10
-URI http://asc.fasb.org/subtopic&trid=2209116

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 205
-SubTopic 10
-URI http://asc.fasb.org/subtopic&trid=2122150

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 810
-SubTopic 10
-URI http://asc.fasb.org/subtopic&trid=2197480

Reference 5: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
-Topic 810
-SubTopic 10
-Section 50
-Paragraph 8
-URI http://asc.fasb.org/extlink&oid=7880789&loc=SL6228881-111685

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 272
-SubTopic 10
-Section 50
-Paragraph 3
-URI http://asc.fasb.org/extlink&oid=6373374&loc=d3e70478-108055

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 720
-SubTopic 15
-URI http://asc.fasb.org/subtopic&trid=2122524

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 205
-SubTopic 10
-Section 45
-Paragraph 3
-URI http://asc.fasb.org/extlink&oid=7668296&loc=d3e288-107754

Reference 9: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 915
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-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6472506&loc=d3e38932-110933

Reference 10: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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-SubTopic 10
-Section 50
-Paragraph 3
-URI http://asc.fasb.org/extlink&oid=6367646&loc=d3e18780-107790

Reference 11: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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Reference 12: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
-Topic 205
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-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6359566&loc=d3e326-107755

Reference 13: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
-Name Statement of Position (SOP)
-Number 94-6
-Paragraph 10
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 14: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
-Name Accounting Research Bulletin (ARB)
-Number 51
-Paragraph 2-6
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 15: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name FASB Interpretation (FIN)
-Number 46R
-Paragraph 4, 14, 15
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 16: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name FASB Staff Position (FSP)
-Number FAS140-4/FIN46(R)-8
-Paragraph 8, C1, C7
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details

Available for Sale Securities and Certificate of Deposit

6 Months Ended

Jun. 30, 2012

Available for Sale Securities and Certificate of Deposit [Abstract]

Available for Sale Securities and Certificate of Deposit

2. Available for sale securities and certificate of deposit

The following is a summary of the available-for-sale securities classified as current assets (in thousands).


	June 30, 2012						December 31, 2011
	Cost Basis		Gross Unrealized Gain		Fair Value		Cost Basis		Gross Unrealized Gain		Fair Value
Common stock investment	$	—	$	—	$	—	$	117	$	48	$	165

During the three months ended March 31, 2012, the Company determined its common stock investment to be other than temporarily impaired and recorded the $117,000 realized loss for available-for-sale securities as “Other income (expense)” in the condensed consolidated statements of operations. Gross unrealized gains and losses are included in “Other comprehensive gain (loss).”

The Company’s $350,000 certificate of deposit, having a maturity greater than 90 days, is held as collateral for the Company’s commercial credit card programs.

- Definition

The entire disclosure for investments in certain debt and equity securities.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
-Glossary Debt Security
-URI http://asc.fasb.org/extlink&oid=6509901

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 310
-SubTopic 30
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=6379141&loc=d3e15032-111544

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
-SubTopic 10
-Section 50
-Paragraph 6
-URI http://asc.fasb.org/extlink&oid=6872113&loc=d3e27290-111563

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
-Glossary Equity Security
-URI http://asc.fasb.org/extlink&oid=6511694

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
-SubTopic 10
-Section 50
-Paragraph 5
-URI http://asc.fasb.org/extlink&oid=6872113&loc=d3e27232-111563

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 942
-SubTopic 320
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=6957658&loc=d3e62557-112803

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
-SubTopic 10
-Section 50
-Paragraph 9
-URI http://asc.fasb.org/extlink&oid=6872113&loc=d3e27357-111563

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=6872113&loc=d3e27161-111563

Reference 9: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
-SubTopic 10
-Section 50
-Paragraph 10
-URI http://asc.fasb.org/extlink&oid=6872113&loc=d3e27405-111563

Reference 10: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 115
-Paragraph 3, 19, 20, 21, 22, 137
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details

Accrued expenses and other current liabilities

6 Months Ended

Jun. 30, 2012

Accrued expenses and other current liabilities [Abstract]

Accrued expenses and other current liabilities

3. Accrued expenses and other current liabilities

Accrued expenses and other current liabilities are comprised of the following (in thousands):


	June 30, 2012		December 31, 2011
Salary and related expenses	$	6,791	$	8,997
Research and clinical trial costs		7,087		2,383
Accrued interest		2,461		8,262
Construction in progress		2,100		—
Warrant liability		4,922		—
Accrued litigation settlement liability		24,547		—
Other		1,716		1,094

Accrued expenses and other current liabilities	$	49,624	$	20,736

Accounting for stock-based compensation

6 Months Ended

Jun. 30, 2012

Accounting for stock-based compensation [Abstract]

Accounting for stock-based compensation

4. Accounting for stock-based compensation

Total stock-based compensation expense recognized in the accompanying condensed consolidated statements of operations for the three and six months ended June 30, 2012 and 2011 was as follows (in thousands):


	Three months ended June 30,				Six months ended June 30,
	2012		2011		2012		2011
Stock-based compensation	$	3,072	$	1,993	$	5,951	$	4,701

On May 17, 2012, the Compensation Committee approved a management proposal designed to encourage employee retention. The proposal involved the grant of stock options and restricted stock units to employees, including executive officers of the Company. 3,942,500 options were granted with vesting terms subject to the achievement of certain performance milestones. 3,942,500 options were granted with time-based vesting terms of 25% every 6 months beginning November 1, 2012, to be fully vested on May 1, 2014. 50,600 options were granted with time-based vesting terms of 25% after one year and ratably on a monthly basis over a period of 36 months thereafter. 62,700 restricted stock units were granted with terms time-based vesting of 25% after one year and ratably on a monthly basis over a period of 36 months thereafter. The performance-based options, time-based stock options, and restricted stock units had a grant date per share fair value of $1.12, $1.12 and $0.60, respectively.

The Company uses the Black-Scholes option valuation model to estimate the grant date fair value of employee stock options. Restricted stock units are valued based on the market price on the grant date. The Company calculated the fair value of employee stock options for the three months ended June 30, 2012 using the following assumptions:


	Performance-based	Time-based
Risk-free interest rate	0.20% — 0.32%	0.74% —1.16%
Expected lives	1.2 — 2.1 years	5.6 — 6.1 years
Volatility	35% — 70%	81% — 83%
Dividends	—	—

As of June 30, 2012, there was $14.0 million and $11.5 million of unrecognized compensation cost related to options and restricted stock units, respectively, which are expected to be recognized over the remaining weighted average vesting period of 1.9 years. The Company evaluates stock awards with performance conditions as to the probability that the performance conditions will be met and estimates the date at which the performance conditions will be met in order to properly recognize stock-based compensation expense over the requisite service period. As of June 30, 2012, there was $128,000 and $3.7 million of unrecognized expenses related to performance options and restricted stock units, respectively, for milestones not considered probable of achievement.

- Definition

The entire disclosure for compensation-related costs for equity-based compensation, which may include disclosure of policies, compensation plan details, allocation of equity compensation, incentive distributions, equity-based arrangements to obtain goods and services, deferred compensation arrangements, employee stock ownership plan details and employee stock purchase plan details.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 50
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6406099&loc=d3e25284-112666

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 40
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6418621&loc=d3e17540-113929

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 4
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5444-113901

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Staff Accounting Bulletin (SAB)
-Number Topic 14

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 123R
-Paragraph 64, 65, A240
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
-Name Statement of Position (SOP)
-Number 93-6
-Paragraph 53
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details

Net loss per common share

6 Months Ended

Jun. 30, 2012

Net loss per common share [Abstract]

Net loss per common share

5. Net loss per common share

Basic net loss per share excludes dilution for potentially dilutive securities and is computed by dividing net loss applicable to common stockholders by the weighted average number of common shares outstanding during the period excluding the shares loaned under the share lending arrangement (see Note 8 — Common and preferred stock). As of June 30, 2012, 9,000,000 shares of the Company’s common stock, which were loaned to a share borrower pursuant to the terms of a share lending agreement as described in Note 12, were issued and are outstanding, and holders of the borrowed shares have all the rights of a holder of the Company’s common stock. However, because the share borrower must return all borrowed shares to the Company (or, in certain circumstances, the cash value thereof), the borrowed shares are not considered outstanding for the purpose of computing and reporting basic or diluted earnings (loss) per share. Diluted net loss per share reflects the potential dilution that could occur if securities or other contracts to issue common stock were exercised or converted into common stock. Potentially dilutive securities are excluded from the computation of diluted net loss per share for all of the periods presented in the accompanying condensed consolidated statements of operations because the reported net loss in each of these periods results in their inclusion being antidilutive. Antidilutive securities, which consist of stock options, restricted stock units, warrants, and shares that could be issued upon conversion of the senior convertible notes, that are not included in the diluted net loss per share calculation consisted of an aggregate of 61,741,900 shares and 32,048,936 shares as of June 30, 2012 and 2011, respectively, and exclude the 9,000,000 shares loaned under the share lending arrangement.

State research and development credit exchange receivable

6 Months Ended

Jun. 30, 2012

State research and development credit exchange receivable [Abstract]

State research and development credit exchange receivable

6. State research and development credit exchange receivable

The State of Connecticut provides certain companies with the opportunity to exchange certain research and development income tax credit carryforwards for cash in exchange for forgoing the carryforward of the research and development income tax credits. The program provides for an exchange of research and development income tax credits for cash equal to 65% of the value of corporation tax credit available for exchange. Estimated amounts receivable under the program are recorded as a reduction of research and development expenses. At June 30, 2012 and December 31, 2011, the estimated amounts receivable under the program were $658,000 and $473,000, respectively.

Property and equipment - net

6 Months Ended

Jun. 30, 2012

Property and equipment - net [Abstract]

Property and equipment - net

7. Property and equipment — net

Property and equipment — net consist of the following (dollar amounts in thousands):


	Estimated Useful Life (Years)	June 30, 2012			December 31, 2011
Land	—	$	5,273		$	5,273
Buildings	39-40		54,948			54,948
Building improvements	5-40		114,225			114,247
Machinery and equipment	3-15		82,402			83,476
Furniture, fixtures and office equipment	5-10		5,135			5,249
Computer equipment and software	3		12,177			13,049
Leasehold improvements			48			53
Construction in progress			11,187			8,498

			285,395			284,793
Less accumulated depreciation and amortization			(96,236	)		(91,764	)

Property and equipment — net		$	189,159		$	193,029

Leasehold improvements are amortized over four years which is the shorter of the term of the lease or the service lives of the improvements.

Depreciation and amortization expense related to property and equipment for the three and six months ended June 30, 2012 and 2011 was as follows (in thousands):


	Three months ended June 30,				Six months ended June 30,
	2012		2011		2012		2011
Depreciation and amortization expense	$	3,304	$	3,580	$	6,661	$	7,379

- Definition

The entire disclosure for long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. Examples include land, buildings, machinery and equipment, and other types of furniture and equipment including, but not limited to, office equipment, furniture and fixtures, and computer equipment and software. This disclosure may include property plant and equipment accounting policies and methodology, a schedule of property, plant and equipment gross, additions, deletions, transfers and other changes, depreciation, depletion and amortization expense, net, accumulated depreciation, depletion and amortization expense and useful lives, income statement disclosures, assets held for sale and public utility disclosures.

+ References + Details

Common and preferred stock

6 Months Ended

Jun. 30, 2012

Common and preferred stock [Abstract]

Common and preferred stock

8. Common and preferred stock

On February 8, 2012, the Company sold 35,937,500 units in an underwritten public offering, including 4,687,500 units, sold pursuant to the full exercise of an over-allotment option granted to the underwriters, with each unit consisting of one share of common stock and a warrant to purchase 0.6 of a share of common stock. All of the securities were offered by the Company at a combined price to the public of $2.40 per unit and the underwriters purchased the units at a price of $2.256 per unit. Net proceeds from this offering were approximately $80.6 million, excluding any warrant exercises. The 21,562,500 warrants are exercisable at $2.40 per share and expire four years from the date of the issuance (See Note 9 – Warrant liability). The shares of common stock and warrants are immediately separable and were issued separately. Concurrent with the underwritten public offering, The Mann Group LLC (“The Mann Group”) agreed to purchase $77.2 million worth of restricted shares of common stock which will be paid, at the discretion of the Company, by cash or by cancellation of principal indebtedness under the amended loan arrangement, subject to stockholder approval to increase the number of our authorized shares (see Note 11 — Related-party arrangements).

The Company concluded that the Mann Group common stock purchase agreement represented a contingent forward purchase contract that met the definition of a derivative instrument in accordance with ASC 815 Derivatives and Hedging. Of the 31,250,000 shares pursuant to the common stock purchase agreement, the portion of the derivative instrument representing 14.7 million shares were recorded as equity (“Equity Portion”) as they met the criteria for equity classification under ASC 815-40 Derivatives and Hedging, Contracts in an Entity’s Own Stock. The remaining 16.7 million shares (“Non-Equity Portion”) required classification outside of equity as the Company did not have sufficient available shares at the time of issuance and at March 31, 2012. The Company revalues the forward purchase contract at each reporting date and records a fair value adjustment within “Other income”. At the time of issuance, the fair value of the forward purchase contract was $2.0 million. The Equity Portion of $0.9 million was classified as equity, and the Non-Equity Portion of $1.1 million was initially recorded to “Prepaid expenses and other current assets.

On May 17, 2012, the Company’s stockholders approved an increase in its authorized shares of common stock from 250,000,000 to 350,000,000. Accordingly, the shares of common stock needed to consummate the Mann Group common stock purchase agreement became available. As of May 17, 2012, the fair value of the Non-Equity Portion was $13.1 million. As of result of receiving stockholder approval of the increase in authorized shares, the Non-Equity Portion met the criteria for equity classification. Consequently, the Company reclassified the $13.1 million from “Prepaid expenses and other current assets” to “Additional paid-in capital.”

The fair value of the forward purchase contract is highly sensitive to the discount applied for lack of marketability and the stock price, and changes in this discount and/or the stock price caused the value of the forward purchase contract to change significantly. As of and for the six months ended June 30, 2012, the Company recognized the change in fair value of $12.0 million in “Other income.” The Company revalued the Non-Equity Portion using a forward contract valuation formula, in which the forward contract is estimated to be equal to the valuation date stock price of $2.40 at issuance and $1.69 at May 17, 2012 minus the strike price discounted to the valuation date using a risk-free rate of 0.08% at issuance and 0.18% at May 17, 2012. As the shares which would be received upon settlement are currently unregistered, the Company applied a discount for lack of marketability of 10.27% at issuance and 1.67% at May 17, 2012 based on quantitative put models, adjusted to take into account qualitative factors, including the fact that the Company’s stock is publicly traded and the fact that there is no contractual restriction on the unregistered shares being registered.

The Company is authorized to issue 350,000,000 shares of common stock, par value $0.01 per share, and 10,000,000 shares of undesignated preferred stock, par value $0.01 per share, issuable in one or more series designated by the Company’s board of directors. No other class of capital stock is authorized. As of June 30, 2012 and December 31, 2011, 199,300,833 and 131,522,945 shares of common stock, respectively, were issued and outstanding. Included in the common stock outstanding as of June 30, 2012 are 9,000,000 shares of common stock loaned to Bank of America under a share lending agreement in connection with the offering of the $100.0 million aggregate principal amount of 5.75% Senior Convertible Notes due 2015 (see Note 12 — Senior convertible notes). Bank of America is obligated to return the borrowed shares (or, in certain circumstances, the cash value thereof) to the Company on or about the 45th business day following the date as of which the entire principal amount of the notes ceases to be outstanding, subject to extension or acceleration in certain circumstances or early termination at Bank of America’s option. The Company did not receive any proceeds from the sale of the borrowed shares by Bank of America, but the Company did receive a nominal lending fee of $0.01 per share from Bank of America for the use of borrowed shares. As of June 30, 2012 the Company had not issued any shares of undesignated preferred stock.

Warrant Liability

6 Months Ended

Jun. 30, 2012

Warrant liability [Abstract]

Warrant liability

9. Warrant liability

In connection with the sale of units in February 2012, the Company issued separable warrants representing 21,562,500 shares of common stock which are exercisable at $2.40 per share and are exercisable any time prior to February 8, 2016. Warrants representing 60 shares of common stock have been exercised as of June 30, 2012.

Of the 21,562,500 shares represented by warrants, 16,145,833 shares were recorded as equity as they met the criteria for equity classification under ASC 815-40 Derivatives and Hedging, Contracts in an Entity’s Own Stock. The remaining warrants representing 5,416,667 shares require liability classification in accordance with ASC 480, Distinguishing Liabilities from Equity, as the Company did not have sufficient registered shares available at the time of issuance. The fair value of these shares was recorded in accrued expenses and other current liabilities in the condensed consolidated balance sheet. The warrants will be reported as a liability until they are exercised, or at the time that the Company has sufficient registered shares available, at which time the warrants will be adjusted to fair value and reclassified from liabilities to stockholders’ equity.

The warrants requiring liability classification were recorded at fair value at issuance and will be adjusted to fair value at each reporting period until exercised or expiration. The fair value of the warrant liability at the date of issuance was $7.6 million and was estimated using the Black-Scholes option pricing model, based on the following assumptions: expected dividend yield of 0%; expected volatility of 93%; risk free interest rate of 0.59%; and contractual term of 4.0 years.

As of March 31, 2012, the fair value of the warrant liability was $7.9 million and was estimated using the Black-Scholes option pricing model based on the following assumptions: expected dividend yield of 0%; expected volatility of 93%; risk-free interest rate of 0.59%; and contractual term of 4 years. Any change in fair value between reporting periods is recorded as other income (expense) in the condensed consolidated statements of operations. During the quarter ended March 31, 2012, a loss of $284,000 was recognized from the fair value adjustment of the warrant liability.

As of June 30, 2012, the fair value of the warrant liability was $4.9 million and was estimated using the Black-Scholes option pricing model based on the following assumptions: expected dividend yield of 0%; expected volatility of 75.7%; risk-free interest rate of 0.41%; and contractual term of 3.6 years. Any change in fair value between reporting periods is recorded as other income (expense) in the condensed consolidated statements of operations. During the quarter ended June 30, 2012, a gain of $3.0 million was recognized from the fair value adjustment of the warrant liability. The fair value of the warrant liability is highly sensitive to the volatility rate used in the option pricing model and an increase in the volatility rate would cause an increase in the warrant liability. The volatility assumption is calculated based on historical activity.

Commitments and contingencies

6 Months Ended

Jun. 30, 2012

Commitments and contingencies [Abstract]

Commitments and contingencies

10. Commitments and contingencies

Guarantees and Indemnifications — In the ordinary course of its business, the Company makes certain indemnities, commitments and guarantees under which it may be required to make payments in relation to certain transactions. The Company, as permitted under Delaware law and in accordance with its Bylaws, indemnifies its officers and directors for certain events or occurrences, subject to certain limits, while the officer or director is or was serving at the Company’s request in such capacity. The term of the indemnification period is for the officer’s or director’s lifetime. The maximum amount of potential future indemnification is unlimited; however, the Company has a director and officer insurance policy that may enable it to recover a portion of any future amounts paid. The Company believes the fair value of these indemnification agreements is minimal. The Company has not recorded any liability for these indemnities in the accompanying condensed consolidated balance sheets. However, the Company accrues for losses for any known contingent liability, including those that may arise from indemnification provisions, when future payment is probable and the amount can be reasonably estimated. No such losses have been recorded to date.

Litigation — The Company is involved in various legal proceedings and other matters. In accordance with ASC 450 Contingencies, the Company records a provision for a liability when it is both probable that a liability has been incurred and the amount of the loss can be reasonably estimated.

The Securities Action. Beginning January 31, 2011, several complaints were filed in the U.S. District Court for the Central District of California against us and four of our officers – Alfred E. Mann, Hakan S. Edstrom, Dr. Peter C. Richardson and Matthew J. Pfeffer – on behalf of certain purchasers of our common stock. The complaints include claims asserted under Sections 10(b) and 20(a) of the Exchange Act and have been brought as purported shareholder class actions. In general, the complaints allege that the defendants violated federal securities laws by making materially false and misleading statements regarding our business and prospects for AFREZZA, thereby artificially inflating the price of the Company’s common stock. The U.S. District Court for the Central District of California has consolidated the pending actions for all purposes and appointed lead counsel.

On July 23, 2012, the Company, while continuing to deny all allegations of wrongdoing or liability whatsoever arising out of the Securities Action, and without in any way admitting fault or liability, entered into a stipulation of settlement to resolve the Securities Action. Subject to preliminary and final approval of the settlement by the U.S. District Court and notice to potential class members, and in exchange for a release of all claims by the class members, among others, and a dismissal of the consolidated lawsuits, the Company has agreed (i) to cause the Company’s insurers to pay class members and their attorneys a total of $16 million; and (ii) to issue class members and their attorneys 2,777,778 shares of the Company’s common stock. The Company has also agreed that if the consolidated closing bid price for the Company’s common stock is below $1.00 per share on the date the U.S. District Court enters an order of final judgment, then the Company will issue class members and their attorneys an additional one million shares of its common stock. Following final approval of the settlement by the U.S. District Court, the shares will be issued pursuant to an exemption from registration provided by Section 3(a)(10) of the Securities Act of 1933, as amended.

The Derivative Action. In February 2011, shareholder derivative complaints were filed in the Superior Court of California for the County of Los Angeles and in the U.S. District Court for the Central District of California against all of the Company’s directors and certain of its officers. The complaints in the shareholder derivative actions allege breaches of fiduciary duties by the defendants and other violations of law. In general, the complaints allege that the defendants caused or allowed for the dissemination of materially false and misleading statements regarding its business and prospects for AFREZZA, thereby artificially inflating the price of its common stock. The Superior Court of California for the County of Los Angeles has consolidated the actions pending before it and appointed lead counsel. The U.S. District Court for the Central District of California has also consolidated the derivative actions pending before it.

On August 3, 2012, the Company, while continuing to deny all allegations of wrongdoing or liability whatsoever arising out of the Derivative Actions and without in any way admitting fault or liability, entered into a stipulation of settlement to resolve the Derivative Action. Subject to preliminary and final approval of the settlement by the U.S. District Court and notice to shareholders, and in an exchange for a release of all claims by the plaintiffs, among others, and a dismissal of the Derivative Actions, the Company has agreed (i) to adopt certain corporate governance measures, (ii) to cause the Company’s insurers to pay the plaintiffs’ attorneys a total of $800,000, and (iii) to issue plaintiffs’ attorneys 225,000 shares of the Company’s common stock. Following final approval of the settlement by the U.S. District Court, the shares will be issued pursuant to an exemption from registration provided by Section 3(a)(10) of the Securities Act of 1933, as amended.

As a result of settlement discussions with the plaintiffs taking place in the latter part of the quarter ended June 30, 2012 and entering into the stipulation of settlement for the Securities Action on July 23, 2012 and for the Derivative Action on August 3, 2012, the Company determined that the liabilities pertaining to both the securities and derivative lawsuits were probable as of June 30, 2012. The Company’s financial statements as of and for the three months ended June 30, 2012 reflect the following accruals:

(i)

Cash consideration. The Company recorded a current liability of $16.8 million under “Accrued expense and other current liabilities” and a corresponding current asset under “Prepaid expenses and other current asset” to reflect a receivable from the Company’s insurers. The Company has determined that the collectability of the receivable from the insurers is probable. The cash obligation resulted in no charge to the Company’s Condensed Consolidated Statements of Operations for the period.

(ii)

Stock consideration. The Company recorded a charge to “General and administrative” expenses and an estimated current liability under “Accrued expense and other current liabilities” of $7.7 million representing the estimated fair value of the 3,002,778 common shares to be issued in the aggregate subject to court approval.

(iii)

Additional stock consideration. The Company concluded that the contingent obligation to issue an additional one million shares of its common stock, as defined in the stipulation of settlement agreement, met the definition of a derivative instrument in accordance with ASC 815 Derivatives and Hedging. The Company estimated the fair value of the derivative instrument using the Monte Carlo simulation model to forecast the contingent obligation applying probabilities that the stock price will be lower than $1.00 based on the following assumptions: expected volatility of 60%, risk free interest rate of 0.16% and final judgment dates ranging from four to six months. As a result, the Company estimated the fair value of this contingent obligation to be immaterial.

- Definition

The entire disclosure for commitments and contingencies.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
-SubTopic 20
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6449706&loc=d3e16207-108621

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 460
-SubTopic 10
-Section 50
-Paragraph 8
-URI http://asc.fasb.org/extlink&oid=6398077&loc=d3e12565-110249

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 450
-SubTopic 20
-Section 50
-Paragraph 4
-URI http://asc.fasb.org/extlink&oid=6952336&loc=d3e14435-108349

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.25)
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 440
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=6394976&loc=d3e25287-109308

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name FASB Interpretation (FIN)
-Number 14
-Paragraph 3
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 5
-Paragraph 9, 10, 11, 12
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details

Related-party arrangements

6 Months Ended

Jun. 30, 2012

Related-party arrangements

11. Related-party arrangements

In October 2007, the Company entered into a $350.0 million loan arrangement with its principal stockholder. In February 2009, the promissory note underlying the loan arrangement was revised as a result of the principal stockholder being licensed as a finance lender under the California Finance Lenders Law. Accordingly, the lender was revised to The Mann Group. Interest accrues on each outstanding advance at a fixed rate equal to the one-year LIBOR rate as reported by the Wall Street Journal on the date of such advance plus 3% per annum and is payable quarterly in arrears. The borrowing rate was 4.5% at both June 30, 2012 and December 31, 2011, respectively. In August 2010, the Company amended and restated the promissory note to extend the maturity date from December 31, 2011 to December 31, 2012. In January 2012, the Company amended the note with The Mann Group to extend the maturity date from December 31, 2012 to March 31, 2013 and to extend the date through which the Company can continue to borrow under the amended terms of the note until June 30, 2012. In addition, interest is payable on the first day of the calendar quarter following the calendar quarter in which an advance is made, or such other time as the Company and The Mann Group mutually agree. On May 9, 2012, the Company amended the note with The Mann Group to extend the maturity date of the $350.0 million loan arrangement from March 31, 2013 to July 1, 2013. Under the amended and restated promissory note The Mann Group may require the Company to prepay up to $200.0 million in advances that have been outstanding for at least 12 months. If The Mann Group exercises this right, the Company will have 90 days after The Mann Group provides written notice (or the number of days to maturity of the note if less than 90 days) to prepay such advances. On June 27, 2012, the Company amended the note with the Mann Group to allow accrued and unpaid interest that becomes due and payable under the note to be paid-in-kind and capitalized into new principal indebtedness upon agreement of the parties. In addition, the Company and The Mann Group agreed that the cancelled principal amount related to the common stock purchase agreement (see Note 6 – Common and preferred stock) would be permanently retired and not available for re-borrowing under the note. The amendment also extends the date through which the Company can borrow under the note to December 31, 2012.

In August 2010, the Company entered into a letter agreement confirming a previous commitment by The Mann Group to not require the Company to prepay amounts outstanding under the amended and restated promissory note if the prepayment would require the Company to use its working capital resources. In the event of a default, all unpaid principal and interest either becomes immediately due and payable or may be accelerated at The Mann Group’s option, and the interest rate will increase to the one-year LIBOR rate calculated on the date of the initial advance or in effect on the date of default, whichever is greater, plus 5% per annum. All borrowings under the loan arrangement are unsecured. The loan arrangement contains no financial covenants. There are no warrants associated with the loan arrangement.

The principal amount outstanding under the loan arrangement as of June 30, 2012, subsequent to the completion of the common stock purchase agreement was as follows (in thousands):


Principal amount outstanding at December 31, 2011	$	277,216
Borrowings		6,250
Capitalization of accrued and unpaid interest due and payable as of June 27, 2012		11,876
Cancellation of principal indebtedness related to the common stock purchase agreement completed on June 27, 2012		(77,200	)

Principal amount outstanding at June 30, 2012	$	218,142

As of June 30, 2012, the Company had accrued interest of $97,500 related to the remaining principal outstanding and $26.9 million of available borrowings remained under the loan arrangement.

On February 8, 2012, the Company sold $86.3 million worth of units in an underwritten public offering, with each unit consisting of one share of common stock and a warrant to purchase 0.6 of a share of common stock. Concurrent with this public offering, The Mann Group LLC purchased $77.2 million worth of restricted shares of common stock and on June 27, 2012, the Company completed the closing of the sale of 31,250,000 share of its common stock (see Note 8 – Common and preferred stock and Note 11 – Related-party arrangements).

- Definition

The entire disclosure for related party transactions. Examples of related party transactions include transactions between (a) a parent company and its subsidiary; (b) subsidiaries of a common parent; (c) and entity and its principal owners; and (d) affiliates.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 850
-SubTopic 10
-Section 50
-Paragraph 3
-URI http://asc.fasb.org/extlink&oid=6457730&loc=d3e39603-107864

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 850
-SubTopic 10
-Section 50
-Paragraph 4
-URI http://asc.fasb.org/extlink&oid=6457730&loc=d3e39622-107864

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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-URI http://asc.fasb.org/extlink&oid=6457730&loc=d3e39549-107864

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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-URI http://asc.fasb.org/extlink&oid=6457730&loc=d3e39678-107864

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(k))
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Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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-Paragraph 6
-URI http://asc.fasb.org/extlink&oid=6457730&loc=d3e39691-107864

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Regulation S-X (SX)
-Number 210
-Section 04
-Paragraph b
-Article 3A

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Regulation S-X (SX)
-Number 210
-Section 08
-Paragraph k
-Article 4

Reference 9: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 57
-Paragraph 1-4
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details

Senior convertible notes

6 Months Ended

Jun. 30, 2012

Senior convertible notes [Abstract]

Senior convertible notes

12. Senior convertible notes

Senior convertible notes consist of the following (in thousands):


	June 30 2012			December 31 2011
Notes due 2013
Principal amount	$	115,000		$	115,000
Unaccreted debt issuance expense		(852	)		(1,140	)

Net carrying amount		114,148			113,860

Notes due 2015
Principal amount	$	100,000		$	100,000
Unaccreted debt issuance expense		(2,964	)		(3,218	)

Net carrying amount		97, 036			96,782

Senior convertible notes	$	211,184		$	210,642

In August 2010, the Company completed a Rule 144A offering of $100.0 million aggregate principal amount of 5.75% Senior Convertible Notes due 2015. The Notes due 2015 are governed by the terms of an indenture dated as of August 24, 2010 (the “2015 Note Indenture”). The Notes due 2015 bear interest at the rate of 5.75% per year on the principal amount, payable in cash semi-annually in arrears on February 15 and August 15 of each year, beginning February 15, 2011. As of June 30, 2012 and December 31, 2011, the Company had accrued interest of $2.2 million related to the Notes due 2015. The Notes due 2015 are general, unsecured, senior obligations of the Company and effectively rank junior in right of payment to all of the Company’s secured debt, to the extent of the value of the assets securing such debt, and to the debt and all other liabilities of the Company’s subsidiaries. The maturity date of the Notes due 2015 is August 15, 2015 and payment is due in full on that date for unconverted securities. Holders of the Notes due 2015 may convert, at any time prior to the close of business on the business day immediately preceding the stated maturity date, any outstanding principal into shares of the Company’s common stock at an initial conversion rate of 147.0859 shares per $1,000 principal amount, which is equal to a conversion price of approximately $6.80 per share, subject to adjustment. Except in certain circumstances, if the Company undergoes a fundamental change: (1) the Company will pay a make-whole premium on the Notes due 2015 converted in connection with a fundamental change by increasing the conversion rate on such Notes due 2015, which amount, if any, will be based on the Company’s common stock price and the effective date of the fundamental change, and (2) each holder of Notes due 2015 will have the option to require the Company to repurchase all or any portion of such holder’s Notes due 2015 at a repurchase price of 100% of the principal amount of the Notes due 2015 to be repurchased plus accrued and unpaid interest, if any. The Company may elect to redeem some or all of the Notes due 2015 if the closing stock price has equaled 150% of the conversion price for at least 20 of the 30 consecutive trading days ending on the trading day before the Company’s redemption notice. The redemption price will equal 100% of the principal amount of the Notes due 2015 to be redeemed, plus accrued and unpaid interest, if any, to, but excluding, the redemption date, plus a make-whole payment equal to the sum of the present values of the remaining scheduled interest payments through and including August 15, 2015 (other than interest accrued up to, but excluding, the redemption date). The Company will be obligated to make the make-whole payment on all the Notes due 2015 called for redemption and converted during the period from the date the Company mailed the notice of redemption to and including the redemption date. The Company may elect to make the make-whole payment in cash or shares of its common stock, subject to certain limitations. Under the terms of the 2015 Note Indenture, the conversion option can be net-share settled and the maximum number of shares that could be required to be delivered under the contract, including the make-whole shares, is fixed and less than the number of authorized and unissued shares less the maximum number of shares that could be required to be delivered during the contract period under existing commitments. The Company performed an analysis at the time of the offering of the Notes due 2015 and each reporting date since and has concluded that the number of available authorized shares at the time of the offering and each subsequent reporting date was in excess of the maximum number of shares that could be required to be delivered during the contract period under existing commitments, including the outstanding convertible notes, stock options, restricted stock units, warrants, and other potential common stock issuances. The Company incurred approximately $4.2 million in issuance costs which are recorded as an offset to the Notes due 2015 in the accompanying condensed consolidated balance sheets. These costs are being amortized to interest expense using the effective interest method over the term of the Notes due 2015.

In December 2006, the Company completed a registered offering of $115.0 million aggregate principal amount of 3.75% Senior Convertible Notes due 2013. The Notes due 2013 are governed by the terms of an indenture dated as of November 1, 2006 and a First Supplemental Indenture, dated as of December 12, 2006 (the “2013 Note Indenture”). The Notes due 2013 bear interest at the rate of 3.75% per year on the principal amount, payable in cash semi-annually in arrears on June 15 and December 15 of each year, beginning June 15, 2007. As of June 30, 2012 and December 31, 2011, the Company had accrued interest of $192,000 related to the Notes due 2013. The Notes due 2013 are general, unsecured, senior obligations of the Company and effectively rank junior in right of payment to all of the Company’s secured debt, to the extent of the value of the assets securing such debt, and to the debt and all other liabilities of the Company’s subsidiaries. The maturity date of the Notes due 2013 is December 15, 2013 and payment is due in full on that date for unconverted securities. Holders of the Notes due 2013 may convert, at any time prior to the close of business on the business day immediately preceding the stated maturity date, any outstanding principal into shares of the Company’s common stock at an initial conversion rate of 44.5002 shares per $1,000 principal amount, which is equal to a conversion price of approximately $22.47 per share, subject to adjustment. Except in certain circumstances, if the Company undergoes a fundamental change: (1) the Company will pay a make-whole premium on the Notes due 2013 converted in connection with a fundamental change by increasing the conversion rate on such Notes, which amount, if any, will be based on the Company’s common stock price and the effective date of the fundamental change, and (2) each holder of Notes due 2013 will have the option to require the Company to repurchase all or any portion of such holder’s Notes at a repurchase price of 100% of the principal amount of the Notes to be repurchased plus accrued and unpaid interest, if any. Under the terms of the 2013 Note Indenture, the conversion option can be net-share settled and the maximum number of shares that could be required to be delivered under the contract, including the make-whole shares, is fixed and less than the number of authorized and unissued shares less the maximum number of shares that could be required to be delivered during the contract period under existing commitments. The Company performed an analysis at the time of the offering of the Notes due 2013 and each reporting date since and has concluded that the number of available authorized shares at the time of the offering and each subsequent reporting date was in excess of the maximum number of shares that could be required to be delivered during the contract period under existing commitments, including the outstanding convertible notes, stock options, restricted stock units, warrants, and other potential common stock issuances.

The Company incurred approximately $3.7 million in issuance costs which are recorded as an offset to the Notes due 2013 in the accompanying condensed consolidated balance sheets. These costs are being amortized to interest expense using the effective interest method over the term of the Notes due 2013.

Amortization of debt issuance expense in connection with the offerings of the Notes due 2015 and the Notes due 2013 during the three and six months ended June 30, 2012 and 2011 was as follows (in thousands):


	Three months ended June 30,				Six months ended June 30,
	2012		2011		2012		2011
Amortization expense	$	343	$	324	$	682	$	644

Income taxes

6 Months Ended

Jun. 30, 2012

Income taxes [Abstract]

Income taxes

13. Income taxes

As required by ASC 740 Income Taxes (“ASC 740”), management of the Company has evaluated the positive and negative evidence bearing upon the realizability of its deferred tax assets. Management has concluded, in accordance with the applicable accounting standards, that it is more likely than not that the Company may not realize the benefit of its deferred tax assets due to its history of operating losses. Accordingly, the net deferred tax assets have been fully reserved.

ASC 740-10-25 Income Taxes Recognition clarifies the accounting and disclosure for uncertainty in tax positions, as defined. This guidance seeks to reduce the diversity in practice associated with certain aspects of the recognition and measurement related to accounting for income taxes. The Company believes that its income tax filing positions and deductions will be sustained on audit and does not anticipate any adjustments that will result in a material change to its financial position. Therefore, no reserves for uncertain income tax positions have been recorded pursuant to this guidance. Tax years since 1993 remain subject to examination by the major tax jurisdictions in which the Company is subject to tax.

- Definition

The entire disclosure for income taxes. Disclosures may include net deferred tax liability or asset recognized in an enterprise's statement of financial position, net change during the year in the total valuation allowance, approximate tax effect of each type of temporary difference and carryforward that gives rise to a significant portion of deferred tax liabilities and deferred tax assets, utilization of a tax carryback, and tax uncertainties information.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(h))
-URI http://asc.fasb.org/extlink&oid=6881521&loc=d3e23780-122690

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 3
-URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32559-109319

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 15
-URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32718-109319

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 9
-URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32639-109319

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32537-109319

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 109
-Paragraph 136, 172
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Regulation S-X (SX)
-Number 210
-Section 08
-Paragraph h
-Article 4

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 109
-Paragraph 43, 44, 45, 46, 47, 48, 49
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details

Subsequent event

6 Months Ended

Jun. 30, 2012

Subsequent Events [Abstract]

Subsequent events

14. Subsequent event

On July 23, 2012, the Company entered into a stipulation of settlement to resolve the consolidated class action securities lawsuits. The current and former officers and directors named as individual defendants in the consolidated lawsuits have also entered into the stipulation of settlement which remains subject to preliminary and final approval by the U.S. District Court.

Subject to preliminary and final approval of the settlement by the U.S. District Court, and in exchange for a release of all claims by the class members, among others, and a dismissal of the consolidated lawsuits, the Company has agreed (i) to cause its insurers to pay class members and their attorneys a total of $16 million; and (ii) to issue to class members and their attorneys 2,777,778 shares of the Company’s common stock. The Company has also agreed that if the consolidated closing bid price for its common stock is below $1.00 per share on the date the U.S. District Court enters an order of final judgment, then the Company will issue class members and their attorneys an additional one million shares of its common stock.

On August 3, 2012, the Company, while continuing to deny all allegations of wrongdoing or liability whatsoever arising out of the Derivative Actions, and without in any way admitting fault or liability, entered into a stipulation of settlement to resolve the Derivative Actions. Subject to preliminary and final approval of the settlement by the U.S. District Court and notice to shareholders, and in an exchange for a release of all claims by the plaintiffs, among others, and a dismissal of the Derivative Actions, the Company has agreed (i) to adopt certain corporate governance measures, (ii) to cause the Company’s insurers to pay the plaintiffs’ attorneys a total of $800,000, and (iii) to issue plaintiffs’ attorneys 225,000 shares of the Company’s common stock. Following final approval of the settlement by the U.S. District Court, the shares will be issued pursuant to an exemption from registration provided by Section 3(a)(10) of the Securities Act of 1933, as amended.

As a result of settlement discussions with the plaintiff taking place in the latter part of the quarter ended June 30, 2012 and entering into the stipulation of settlement for Securities Action on July 23, 2012 and for the Derivative Action on August 3, 2012, the Company determined that the liabilities pertaining to both the securities and derivative lawsuits were probable as of June 30, 2012. Accordingly, the Company recorded a litigation settlement accrual in its financial statements as of and for the three months ended June 30, 2012 (see Note 10 — Commitments and contingencies).

Description of business and basis of presentation (Policies)	6 Months Ended
	Jun. 30, 2012
Description of business and basis of presentation [Abstract]
Business	*Business —* The Company is a biopharmaceutical company focused on the discovery and development of therapeutic products for diseases such as diabetes and cancer. The Company’s lead product candidate, AFREZZA (insulin human [rDNA origin]) inhalation powder, is an ultra rapid-acting insulin therapy in late-stage clinical investigation for the treatment of adults with type 1 or type 2 diabetes for the control of hyperglycemia. AFREZZA consists of the Company’s proprietary Technosphere particles onto which insulin molecules are loaded. These loaded particles are then aerosolized and inhaled deep into the lung using the Company’s AFREZZA inhaler.
Basis of Presentation	*Basis of Presentation —* The Company is considered to be in the development stage as its primary activities since incorporation have been establishing its facilities, recruiting personnel, conducting research and development, business development, business and financial planning, and raising capital. It is costly to develop therapeutic products and conduct clinical trials for these products. Since its inception through June 30, 2012 the Company has reported accumulated net losses of $2.0 billion, which include a goodwill impairment charge of $151.4 million, and cumulative negative cash flow from operations of $1.5 billion. At June 30, 2012, the Company’s capital resources consisted of cash, cash equivalents, and a certificate of deposit of $32.0 million and $26.9 million of available borrowings under the loan agreement with an entity controlled by the Company’s principal stockholder (see Note 11 — Related-party arrangements). Based upon the Company’s current expectations, management believes the Company’s existing capital resources will enable it to continue planned operations into the fourth quarter of 2012. However, the Company cannot provide assurances that its plans will not change or that changed circumstances will not result in the depletion of its capital resources more rapidly than it currently anticipates. The Company will need to raise additional capital, whether through the sale of equity or debt securities, a strategic business collaboration with a pharmaceutical company, the establishment of other funding facilities, licensing arrangements, assets sales or other means, or an increase in the borrowings available under the loan arrangement with its related party, in order to continue the development and commercialization of AFREZZA and other product candidates and to support its other ongoing activities. This raises substantial doubt about the Company’s ability to continue as a going concern. The financial statements do not include any adjustments that might result from the outcome of these uncertainties.
Fair Value of Financial Instruments	*Fair Value of Financial Instruments —* The carrying amounts of financial instruments, which include cash equivalents, available for sale securities, a certificate of deposit, and accounts payable, approximate their fair values due to their relatively short maturities. The fair value of the note payable to related party cannot be reasonably estimated as the Company would not be able to obtain a similar credit arrangement in the current economic environment.
Recently Issued Accounting Standards	Recently Issued Accounting Standards — In June 2011, the FASB issued Accounting Standards Update No. 2011-05 (“ASU 2011-05”) for Comprehensive Income (Topic 220): “Presentation of Comprehensive Income”. This update improves the comparability, consistency and transparency of financial reporting and increases the prominence of items reported in other comprehensive income. This update is effective for interim and annual periods beginning after December 15, 2011. The Company has adopted all current required provisions of ASU 2011-05 on a retrospective basis. In May 2011, the FASB issued Accounting Standards Update No. 2011-04 (“ASU 2011-04”) for Fair Value Measurement (Topic 820): “Amendments to Achieve Common Fair Value Measurement and Disclosure Requirements in U.S. GAAP and IFRSs”. This update addresses how to measure fair value and requires new disclosures about fair value measurements. The amendments in this update are effective for interim and annual periods beginning after December 15, 2011. The Company has adopted all current required provisions of ASU 2011-04.
Comprehensive Income Other Presentation	In June 2011, the FASB issued Accounting Standards Update No. 2011-05 (“ASU 2011-05”) for Comprehensive Income (Topic 220): “Presentation of Comprehensive Income”. This update improves the comparability, consistency and transparency of financial reporting and increases the prominence of items reported in other comprehensive income. This update is effective for interim and annual periods beginning after December 15, 2011. The Company has adopted all current required provisions of ASU 2011-05 on a retrospective basis.
Income taxes Recognition	As required by ASC 740 Income Taxes (“ASC 740”), management of the Company has evaluated the positive and negative evidence bearing upon the realizability of its deferred tax assets. Management has concluded, in accordance with the applicable accounting standards, that it is more likely than not that the Company may not realize the benefit of its deferred tax assets due to its history of operating losses. Accordingly, the net deferred tax assets have been fully reserved. ASC 740-10-25 Income Taxes Recognition clarifies the accounting and disclosure for uncertainty in tax positions, as defined. This guidance seeks to reduce the diversity in practice associated with certain aspects of the recognition and measurement related to accounting for income taxes. The Company believes that its income tax filing positions and deductions will be sustained on audit and does not anticipate any adjustments that will result in a material change to its financial position. Therefore, no reserves for uncertain income tax positions have been recorded pursuant to this guidance. Tax years since 1993 remain subject to examination by the major tax jurisdictions in which the Company is subject to tax.

Description of business and basis of presentation (Tables)

6 Months Ended

Jun. 30, 2012

Description of business and basis of presentation [Abstract]

Summary of the carrying values and estimated fair values of the Company's senior convertible notes due


	June 30, 2012				December 31, 2011
	Carrying value		Estimated fair value		Carrying value		Estimated fair value
Notes due 2013	$	114.1	$	60.4	$	113.9	$	61.0
Notes due 2015	$	97.1	$	56.8	$	96.8	$	60.8

Changes in fair value of the Company's Level 3 financial assets and liabilities


	Three months ended June 30, 2012						Six months ended June 30, 2012
	Forward Purchase Contract			Warrant Liability			Forward Purchase Contract			Warrant Liability
Beginning Balance	$	744		$	(7,915	)	$	—		$	—
Issuance		—			—			1,080			(7,631	)
Adjustments to fair value		12,347			2,993			12,011			2,709
Transfers to additional paid-in-capital		(13,091	)		—			(13,091	)		—

Ending Balance	$	—		$	(4,922	)	$	—		$	(4,922	)

Available for Sale Securities and Certificate of Deposit (Tables)

6 Months Ended

Jun. 30, 2012

Available for Sale Securities and Certificate of Deposit [Abstract]

Summary of available-for-sale securities classified as current assets


	June 30, 2012						December 31, 2011
	Cost Basis		Gross Unrealized Gain		Fair Value		Cost Basis		Gross Unrealized Gain		Fair Value
Common stock investment	$	—	$	—	$	—	$	117	$	48	$	165

- Definition

Tabular disclosure of available-for-sale securities which includes, but is not limited to, changes in the cost basis and fair value, fair value and gross unrealized gain (loss), fair values by type of security, contractual maturity and classification, amortized cost basis, contracts to acquire securities to be accounted for as available-for-sale, debt maturities, transfers to trading, change in net unrealized holding gain (loss) net of tax, continuous unrealized loss position fair value, aggregate losses qualitative disclosures, other than temporary impairment (OTTI) losses or other disclosures related to available for sale securities.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 942
-SubTopic 320
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=6957658&loc=d3e62557-112803

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
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-Section 50
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Reference 3: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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Reference 4: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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-URI http://asc.fasb.org/extlink&oid=6957658&loc=d3e62586-112803

Reference 5: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=6872113&loc=d3e27161-111563

Reference 6: http://www.xbrl.org/2003/role/presentationRef
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Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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-Paragraph 6
-URI http://asc.fasb.org/extlink&oid=6872113&loc=d3e27290-111563

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 115
-Paragraph 19, 20, 21
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 9: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name FASB Staff Position (FSP)
-Number FAS115-1/124-1
-Paragraph 17
-Subparagraph a, b
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 10: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Emerging Issues Task Force (EITF)
-Number 03-1
-Paragraph 21
-Subparagraph a, b
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details

Accrued Expenses and Other Current Liabilities (Tables)

6 Months Ended

Jun. 30, 2012

Accrued expenses and other current liabilities [Abstract]

Accrued expenses and other current liabilities


	June 30, 2012		December 31, 2011
Salary and related expenses	$	6,791	$	8,997
Research and clinical trial costs		7,087		2,383
Accrued interest		2,461		8,262
Construction in progress		2,100		—
Warrant liability		4,922		—
Accrued litigation settlement liability		24,547		—
Other		1,716		1,094

Accrued expenses and other current liabilities	$	49,624	$	20,736

Accounting for Stock- Based Compensation (Tables)

6 Months Ended

Jun. 30, 2012

Accounting for stock-based compensation [Abstract]

Summarized details of stock-based compensation expense recognized in the accompanying condensed consolidated statements of operations


	Three months ended June 30,				Six months ended June 30,
	2012		2011		2012		2011
Stock-based compensation	$	3,072	$	1,993	$	5,951	$	4,701

Assumptions used to calculate fair of employee stock options

The Company calculated the fair value of employee stock options for the three months ended June 30, 2012 using the following assumptions:


	Performance-based	Time-based
Risk-free interest rate	0.20% — 0.32%	0.74% —1.16%
Expected lives	1.2 — 2.1 years	5.6 — 6.1 years
Volatility	35% — 70%	81% — 83%
Dividends	—	—

Property and equipment net (Tables)

6 Months Ended

Jun. 30, 2012

Property and equipment - net [Abstract]

Property and equipment - net


	Estimated Useful Life (Years)	June 30, 2012			December 31, 2011
Land	—	$	5,273		$	5,273
Buildings	39-40		54,948			54,948
Building improvements	5-40		114,225			114,247
Machinery and equipment	3-15		82,402			83,476
Furniture, fixtures and office equipment	5-10		5,135			5,249
Computer equipment and software	3		12,177			13,049
Leasehold improvements			48			53
Construction in progress			11,187			8,498

			285,395			284,793
Less accumulated depreciation and amortization			(96,236	)		(91,764	)

Property and equipment — net		$	189,159		$	193,029

Depreciation and amortization expense


	Three months ended June 30,				Six months ended June 30,
	2012		2011		2012		2011
Depreciation and amortization expense	$	3,304	$	3,580	$	6,661	$	7,379

Related-party arrangements (Tables)

6 Months Ended

Jun. 30, 2012

Schedule of principal amount outstanding under loan arrangement


Principal amount outstanding at December 31, 2011	$	277,216
Borrowings		6,250
Capitalization of accrued and unpaid interest due and payable as of June 27, 2012		11,876
Cancellation of principal indebtedness related to the common stock purchase agreement completed on June 27, 2012		(77,200	)

Principal amount outstanding at June 30, 2012	$	218,142

Senior convertible notes (Tables)

6 Months Ended

Jun. 30, 2012

Senior convertible notes [Abstract]

Summary of senior convertible notes


	June 30 2012			December 31 2011
Notes due 2013
Principal amount	$	115,000		$	115,000
Unaccreted debt issuance expense		(852	)		(1,140	)

Net carrying amount		114,148			113,860

Notes due 2015
Principal amount	$	100,000		$	100,000
Unaccreted debt issuance expense		(2,964	)		(3,218	)

Net carrying amount		97, 036			96,782

Senior convertible notes	$	211,184		$	210,642

Summary of amortization of debt issuance expense


	Three months ended June 30,				Six months ended June 30,
	2012		2011		2012		2011
Amortization expense	$	343	$	324	$	682	$	644

- Definition

Tabular disclosure of long-debt instruments or arrangements, including identification, terms, features, collateral requirements and other information necessary to a fair presentation. These are debt arrangements that originally required repayment more than twelve months after issuance or greater than the normal operating cycle of the entity, if longer.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.22)
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 942
-SubTopic 470
-Section 50
-Paragraph 3
-URI http://asc.fasb.org/extlink&oid=6479336&loc=d3e64711-112823

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 3
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21475-112644

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(e),(f))
-URI http://asc.fasb.org/extlink&oid=6881521&loc=d3e23780-122690

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 835
-SubTopic 30
-Section 55
-Paragraph 8
-URI http://asc.fasb.org/extlink&oid=6584090&loc=d3e28878-108400

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 8
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21538-112644

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 835
-SubTopic 30
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-Paragraph 1A
-URI http://asc.fasb.org/extlink&oid=6451184&loc=d3e28541-108399

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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Reference 9: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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-URI http://asc.fasb.org/extlink&oid=6451184&loc=d3e28551-108399

Reference 10: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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-Paragraph 7
-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21521-112644

Reference 11: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Regulation S-X (SX)
-Number 210
-Section 02
-Paragraph 22
-Article 5

+ Details

Description of business and basis of presentation (Details) - USD ($) $ in Millions	Jun. 30, 2012	Dec. 31, 2011
Senior convertible notes due 2013 [Member]
Summary of the carrying values and estimated fair values of the Company's senior convertible notes due
Carrying value	$ 114.1	$ 113.9
Estimated fair value	60.4	61.0
Senior convertible notes due 2015 [Member]
Summary of the carrying values and estimated fair values of the Company's senior convertible notes due
Carrying value	97.1	96.8
Estimated fair value	$ 56.8	$ 60.8

Description of business and basis of presentation (Details 1) - USD ($) $ in Thousands	3 Months Ended	6 Months Ended
	Jun. 30, 2012	Jun. 30, 2012
Forward Purchase Contracts [Member]
Changes in fair value of Level 3 financial assets and liabilities
Beginning Balance	$ 744
Issuance		$ 1,080
Adjustments to fair value included in other income	12,347	12,011
Transfers to additional paid-in-capital	(13,091)	(13,091)
Warrant Liability [Member]
Changes in fair value of Level 3 financial assets and liabilities
Beginning Balance	(7,915)
Issuance		(7,631)
Adjustments to fair value included in other income	2,993	2,709
Ending Balance	$ (4,922)	$ (4,922)

Description of business and basis of presentation (Details Textual) - USD ($) $ in Thousands	3 Months Ended	6 Months Ended		257 Months Ended
	Mar. 31, 2012	Jun. 30, 2012	Jun. 30, 2011	Jun. 30, 2012	Dec. 31, 2011
Description of business and basis of presentation (Textual) [Abstract]
Deficit accumulated during the development stage		$ (2,010,298)		$ (2,010,298)	$ (1,935,546)
Goodwill impairment				151,428
Negative cash flow from operation since inception		57,504	$ 67,447	1,533,905
Cash, cash equivalents and marketable securities		32,000		32,000
Borrowings under loan agreement		$ 26,900		26,900
Maturity period of cash equivalents		90 days or less at the time of purchase
Available for sale securities, maturity period		greater than 90 days
Cash equivalents		$ 31,600		31,600	2,700
Available for sale securities and certificate of deposit		350		350	$ 515
Loss on available-for-sale securities	$ 117	$ 117		$ 990

Available for Sale Securities and Certificate of Deposit (Details) - USD ($) $ in Thousands	Jun. 30, 2012	Dec. 31, 2011
Summary of available-for-sale securities classified as current assets
Cost Basis		$ 117
Gross Unrealized Gain		48
Fair value		$ 165

- Definition

This element represents the portion of the balance sheet assertion valued at fair value by the entity whether such amount is presented as a separate caption or as a parenthetical disclosure. Additionally, this element may be used in connection with the fair value disclosures required in the footnote disclosures to the financial statements. The element may be used in both the balance sheet and disclosure in the same submission. This item represents Available-for-sale Securities which consist of all investments in certain debt and equity securities neither classified as trading or held-to-maturity securities. A debt security represents a creditor relationship with an enterprise. Debt securities include, among other items, US Treasury securities, US government securities, municipal securities, corporate bonds, convertible debt, commercial paper, and all securitized debt instruments. An equity security represents an ownership interest in an enterprise or the right to acquire or dispose of an ownership interest in an enterprise at fixed or determinable prices. Equity securities include, among other things, common stock, certain preferred stock, warrant rights, call options, and put options, but do not include convertible debt. An entity may opt to provide the reader with additional narrative text to better understand the nature of investments in debt and equity securities which are categorized as Available-for-sale.

+ References + Details

Available for Sale Securities and Certificate of Deposit (Details Textual) - USD ($) $ in Thousands	6 Months Ended	12 Months Ended
	Jun. 30, 2012	Dec. 31, 2011
Schedule of Investment Income, Reported Amounts, by Category [Line Items]
Available for sale securities, maturity period	greater than 90 days
Available for Sale Securities and Certificate of Deposit (Textual) [Abstract]
Available for sale securities, certificate of deposit		$ 117
Available for sale securities and certificate of deposit	$ 350	$ 515
Certificates of Deposit [Member]
Schedule of Investment Income, Reported Amounts, by Category [Line Items]
Available for sale securities, maturity period	greater than 90 days	greater than 90 days

- Definition

Amount of investment in debt and equity securities categorized neither as trading securities nor held-to-maturity securities and intended be sold or mature one year or operating cycle, if longer.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
-SubTopic 10
-Section 25
-Paragraph 1
-Subparagraph (b)
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Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
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Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 115
-Paragraph 12
-Subparagraph b
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 115
-Paragraph 13, 17
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 133
-Paragraph 22
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name FASB Staff Position (FSP)
-Number FAS115-1/124-1
-Paragraph 15C
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher AICPA
-Name Accounting Research Bulletin (ARB)
-Number 43
-Section A
-Paragraph 4, 5
-Chapter 3
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 115
-Paragraph 16
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 9: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name FASB Staff Position (FSP)
-Number FAS115-1/124-1
-Paragraph 15D
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details

Accrued Expenses and Other Current Liabilities (Details) - USD ($) $ in Thousands	Jun. 30, 2012	Dec. 31, 2011
Accrued expenses and other current liabilities
Salary and related expenses	$ 6,791	$ 8,997
Research and clinical trial costs	7,087	2,383
Accrued interest	2,461	8,262
Construction in progress	2,100
Warrant liability	4,922
Accrued litigation settlement liability	24,547
Other	1,716	1,094
Accrued expenses and other current liabilities	$ 49,624	$ 20,736

- Definition

Carrying value as of the balance sheet date of [accrued] interest payable on all forms of debt, including trade payables, that has been incurred and is unpaid. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

+ References + Details

- Definition

Carrying value as of the balance sheet date of obligations incurred through that date and payable arising from transactions not otherwise specified in the taxonomy. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

+ References + Details

Accounting for Stock- based Compensation (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2012	Jun. 30, 2011	Jun. 30, 2012	Jun. 30, 2011
Summarized details of stock-based compensation expense recognized in the accompanying condensed consolidated statements of operations
Stock-based compensation expense	$ 3,072	$ 1,993	$ 5,951	$ 4,701

- Definition

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

+ References + Details

Accounting for Stock- based Compensation (Details 1)	3 Months Ended
Accounting for Stock- based Compensation (Details 1)	Jun. 30, 2012
Performance-based [Member] \| Maximum [Member]
Assumptions used to calculate fair of employee stock options
Risk-free interest rate	0.32%
Expected lives	2 years 1 month 6 days
Volatility	70.00%
Dividends
Performance-based [Member] \| Minimum [Member]
Assumptions used to calculate fair of employee stock options
Risk-free interest rate	0.20%
Expected lives	1 year 2 months 12 days
Volatility	35.00%
Time-based [Member] \| Maximum [Member]
Assumptions used to calculate fair of employee stock options
Risk-free interest rate	1.16%
Expected lives	6 years 1 month 6 days
Volatility	83.00%
Dividends
Time-based [Member] \| Minimum [Member]
Assumptions used to calculate fair of employee stock options
Risk-free interest rate	0.74%
Expected lives	5 years 7 months 6 days
Volatility	81.00%

Accounting for Stock-based Compensation (Details Textual) $ / shares in Units, $ in Thousands	3 Months Ended	6 Months Ended
	Jun. 30, 2012 USD ($)	Jun. 30, 2012 USD ($) $ / shares shares
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Fair value per share of stock options \| $ / shares		$ 1.12
Options granted with vesting terms \| shares		3,942,500
Accounting for Stock Based Compensation (Textual) [Abstract]
Number of restricted stock units \| shares		50,600
Fair value of restricted stock units	$ 230,000
Number of restricted stock options \| shares		62,700
Weighted average vesting period for unrecognized compensation cost		1 year 10 months 24 days
Stock Options [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Unrecognized compensation cost related to non vested stock options	14,000	$ 14,000
Restricted Stock Units (RSUs) [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Unrecognized compensation cost related to non vested stock options	11,500	11,500
Unrecognized expenses milestones not considered probable of achievement	3,700	$ 3,700
Fair value per share of stock options \| $ / shares		$ 1.69
Vesting percentage of unvest		25.00%
Performance Options [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Unrecognized expenses milestones not considered probable of achievement	$ 128,000	$ 128,000
Fair value per share of stock options \| $ / shares		$ 0.60
Vesting percentage of unvest		25.00%

Net loss per common share (Details) - shares	6 Months Ended
Net loss per common share (Details) - shares	Jun. 30, 2012	Jun. 30, 2011
Net Loss Per Common Share (Textual) [Abstract]
Companies common stock share outstanding	9,000,000
Antidilutive securities	61,741,900	32,048,936
Shares loaned under the share lending arrangement	9,000,000

- Definition

Securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Antidilution
-URI http://asc.fasb.org/extlink&oid=6505113

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Diluted Earnings Per Share
-URI http://asc.fasb.org/extlink&oid=6510752

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Contingent Stock Agreement
-URI http://asc.fasb.org/extlink&oid=6508534

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 128
-Paragraph 40
-Subparagraph c
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 6: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 128
-Paragraph 13, 14
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 7: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Emerging Issues Task Force (EITF)
-Number 07-4
-Paragraph 4
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 8: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Statement of Financial Accounting Standard (FAS)
-Number 128
-Paragraph 171
-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

+ Details

State research and development credit exchange receivable (Details) - USD ($)	6 Months Ended
	Jun. 30, 2012	Dec. 31, 2011
State Research and Development Credit Exchange Receivable (Textual) [Abstract]
Percentage of credit exchange receivable	65.00%
Estimated amounts receivable under program	$ 658,000	$ 473,000

Property and equipment net (Details) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2012	Dec. 31, 2011
Property and equipment - net
Property, Plant and Equipment, Gross	$ 285,395	$ 284,793
Less accumulated depreciation and amortization	(96,236)	(91,764)
Property and equipment - net	189,159	193,029
Land [Member]
Property and equipment - net
Property, Plant and Equipment, Gross	5,273	5,273
Building [Member]
Property and equipment - net
Property, Plant and Equipment, Gross	$ 54,948	54,948
Building [Member] \| Maximum [Member]
Property and equipment - net
Estimated Useful Life	40 years
Building [Member] \| Minimum [Member]
Property and equipment - net
Estimated Useful Life	39 years
Building Improvements [Member]
Property and equipment - net
Property, Plant and Equipment, Gross	$ 114,225	114,247
Building Improvements [Member] \| Maximum [Member]
Property and equipment - net
Estimated Useful Life	40 years
Building Improvements [Member] \| Minimum [Member]
Property and equipment - net
Estimated Useful Life	5 years
Machinery and Equipment [Member]
Property and equipment - net
Property, Plant and Equipment, Gross	$ 82,402	83,476
Machinery and Equipment [Member] \| Maximum [Member]
Property and equipment - net
Estimated Useful Life	15 years
Machinery and Equipment [Member] \| Minimum [Member]
Property and equipment - net
Estimated Useful Life	3 years
Furniture, fixtures and office equipment [Member]
Property and equipment - net
Property, Plant and Equipment, Gross	$ 5,135	5,249
Furniture, fixtures and office equipment [Member] \| Maximum [Member]
Property and equipment - net
Estimated Useful Life	10 years
Furniture, fixtures and office equipment [Member] \| Minimum [Member]
Property and equipment - net
Estimated Useful Life	5 years
Computer equipment and software [Member]
Property and equipment - net
Property, Plant and Equipment, Gross	$ 12,177	13,049
Computer equipment and software [Member] \| Maximum [Member]
Property and equipment - net
Estimated Useful Life	3 years
Leasehold Improvements [Member]
Property and equipment - net
Property, Plant and Equipment, Gross	$ 48	53
Construction in Progress [Member]
Property and equipment - net
Property, Plant and Equipment, Gross	$ 11,187	$ 8,498

Property and Equipment net (Details 1) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2012	Jun. 30, 2011	Jun. 30, 2012	Jun. 30, 2011
Depreciation and amortization expense
Depreciation and amortization expense	$ 3,304	$ 3,580	$ 6,661	$ 7,379

Property and equipment net (Details Textual)	6 Months Ended
Property and equipment net (Details Textual)	Jun. 30, 2012
Property and Equipment Net (Textual) [Abstract]
Amortization period of lease hold improvements	4 years

Common and preferred stock (Details Textual) $ / shares in Units, $ in Thousands	3 Months Ended	6 Months Ended		257 Months Ended
	Mar. 31, 2012 USD ($) shares	Jun. 30, 2012 USD ($) $ / shares shares	Jun. 30, 2011 USD ($)	Jun. 30, 2012 USD ($) $ / shares shares	Jun. 27, 2012 shares	May 17, 2012 USD ($) $ / shares	Feb. 08, 2012 USD ($) $ / shares $ / Units shares	Dec. 31, 2011 USD ($) $ / shares shares	Aug. 31, 2010 USD ($)
Class of Stock [Line Items]
Number of Unit Sold in an Underwritten public offering							35,937,500
Number of warrants are exercisable							21,562,500
Rate at which warrants are exercisable \| $ / Units							2.40
Proposal to increase the authorized share		350,000,000		350,000,000				250,000,000
Risk Free Interest Rate	0.0059					0.0018
Discount for lack of marketability						0.0167
Capital stock authorized		131,522,945		131,522,945	31,250,000			131,522,945
Related Party Transaction [Line Items]
Common stock, shares issued		199,300,833		199,300,833				199,300,833
Common and Preferred Stock (Textual) [Abstract]
Units sold composition Description							each unit consisting of one share of common stock and a warrant to purchase 0.6 of a share of common stock
Warrant to purchase of a share of common stock \| $ / Units							0.6
Net proceeds from offering \| $		$ 80,992	$ 10,424	$ 1,311,013
Restricted Stock Agreed to be Purchased by Lender \| $							$ 77,200
Undesignated preferred stock, par value \| $ / shares		$ 0.01		$ 0.01				$ 0.01
Capital stock authorized		0		0
Capital stock authorized		131,522,945		131,522,945	31,250,000			131,522,945
Common stock loaned under share lending agreement, shares		9,000,000		9,000,000
Time required for returning shares after payment of entire debt		45 days
Nominal lending fee \| $ / shares		$ 0.01
Derivative Portion Balance in Current Assets \| $	$ 800
change in fair value recongized in other income \| $		$ 12,000		$ 12,000
Number of Shares that recorded the portion of the derivative instrument representing outside of equity	16,700,000
Valuation of non-equity portion of forward contract \| $ / shares						$ 1.69	$ 2.40
Senior convertible notes due 2015 [Member]
Class of Stock [Line Items]
Principal amount \| $		$ 100,000		$ 100,000				$ 100,000	$ 100,000
Senior notes, effective interest rate		5.75%		5.75%					5.75%
Other Than Equity [Member]
Class of Stock [Line Items]
Fair value of Non-Equity Portion \| $						$ 13,100
Warrant Liability [Member]
Class of Stock [Line Items]
Number of warrants are exercisable							21,562,500
Rate at which warrants are exercisable \| $ / Units							2.40
Duration for Expiration of warrants		4 years
Mann Group [Member]
Class of Stock [Line Items]
Authorized shares under common stock purchase agreement		250,000,000
Proposal to increase the authorized share		350,000,000		350,000,000
Capital stock authorized		31,250,000		31,250,000
Common and Preferred Stock (Textual) [Abstract]
Capital stock authorized		31,250,000		31,250,000
Mann Group [Member] \| Forward Purchase Contracts [Member]
Class of Stock [Line Items]
Fair value of the forward purchase contract	2,000,000
Other Expenses \| $	$ 300
Risk Free Interest Rate
Discount for lack of marketability						0.1027
Mann Group [Member] \| Forward Purchase Contracts [Member] \| Equity Component [Member]
Class of Stock [Line Items]
Number of Shares that recorded the portion of the derivative instrument representing equity		14,700,000		14,700,000
Fair value of the forward purchase contract		900,000		900,000
Mann Group [Member] \| Forward Purchase Contracts [Member] \| Other Than Equity [Member]
Class of Stock [Line Items]
Fair value of the forward purchase contract		1,100,000		1,100,000
Risk Free Interest Rate	0.0008
Underwriters [Member]
Class of Stock [Line Items]
Number of Unit Sold in an Underwritten public offering							4,687,500
Purchased Price of the units by underwriters \| $ / Units							2.256
Public [Member]
Class of Stock [Line Items]
Purchased Price of the units by underwriters \| $ / Units							2.40

Warrant liability (Details Textual)	1 Months Ended	3 Months Ended	6 Months Ended
Warrant liability (Details Textual)	Feb. 28, 2012	Mar. 31, 2012 USD ($)	Jun. 30, 2012 USD ($) shares	May 17, 2012	Feb. 08, 2012 USD ($) $ / Units shares
Warrant Liability (Textual) [Abstract]
Warrants Issued \| shares					21,562,500
Fair Value Adjustment (loss) of Warrant Liability \| $			$ 3,000,000
Fair Value of Warrant Liability \| $		$ 7,900,000
Fair Value Assumption Expected Dividend Rate		0.00
Fair Value Assumption Risk Free Interest Rate		0.0059		0.0018
Fair value assumption expected volatility rate		93.00%
Fair value assumption contractual term		4 years
Warrant Liability (Additional Textual) [Abstract]
Rate at which warrants are exercisable \| $ / Units					2.40
Warrants representing common stock \| shares			60
Warrant Equity Component [Member]
Warrant Liability (Textual) [Abstract]
Warrants Issued \| shares					16,145,833
Warrant Liability Component [Member]
Warrant Liability (Textual) [Abstract]
Warrants Issued \| shares					5,416,667
Fair Value Adjustment (loss) of Warrant Liability \| $		$ 284,000
Fair Value of Warrant Liability \| $			$ 4,900,000		$ 7,600,000
Fair Value Assumption Expected Dividend Rate			0.00		0.00
Fair Value Assumption Risk Free Interest Rate			0.0041		0.0059
Fair value assumption expected volatility rate			75.70%		93.00%
Fair value assumption contractual term	4 years		3 years 7 months 6 days

Commitments and Contingencies (Details)	6 Months Ended
Commitments and Contingencies (Details)	Jun. 30, 2012 USD ($) $ / shares shares	Aug. 03, 2012 USD ($)	May 17, 2012	Mar. 31, 2012
Commitments and Contingencies (Additional Textual) [Abstract]
Fair value assumption expected volatility rate				93.00%
Fair Value Assumption Risk Free Interest Rate			0.0018	0.0059
Derivative Actions [Member]
Commitments and Contingencies (Additional Textual) [Abstract]
Required payment by insurer to plaintiff \| $		$ 800,000
Additional Number of common stock to be issued to Plaintiff attorneys \| shares	225,000
Securities Action [Member]
Commitments and Contingencies (Additional Textual) [Abstract]
Required payment to class members and attorneys \| $	$ 16,000,000
Number of common stock to be issued to class members and attorneys \| shares	2,777,778
Closing bid price of Common Stock \| $ / shares	$ 1.00
Additional number of common stock to be issued to class members and attorneys \| shares	1,000,000
Securities and Derivative Lawsuits [Member]
Commitments and Contingencies (Additional Textual) [Abstract]
Loss Contingency settlement agreement cash consideration \| $	$ 16,800,000
Loss contingency settlement agreement stock consideration \| $	$ 7,700,000
Loss contingency settlement agreement stock issuable \| shares	3,002,778
Stock price used to forecast future liability \| $ / shares	$ 1.00
Fair value assumption expected volatility rate	60.00%
Fair Value Assumption Risk Free Interest Rate	0.0016
Maximum [Member] \| Securities and Derivative Lawsuits [Member]
Commitments and Contingencies (Additional Textual) [Abstract]
Range of final judgment	6 months
Minimum [Member] \| Securities and Derivative Lawsuits [Member]
Commitments and Contingencies (Additional Textual) [Abstract]
Range of final judgment	4 months

Related-party arrangements (Details) - USD ($) $ in Thousands	1 Months Ended	6 Months Ended
	May 31, 2012	Jun. 30, 2012
Principal amount outstanding under loan arrangement sequent to completion of common stock purchase agreement
Principal amount outstanding at December 31, 2011		$ 277,216
Borrowings		6,250
Principal amount outstanding at June 30, 2012		218,142
Capitalization of accrued and unpaid interest due and payable as of June 27, 2012		11,876
Cancellation of principal indebtedness related to the common stock purchase agreement completed on June 27, 2012	$ 200,000	$ (77,200)

Related-party arrangements (Details Textual) $ in Thousands	1 Months Ended			6 Months Ended
Related-party arrangements (Details Textual) $ in Thousands	May 31, 2012 USD ($)	Aug. 31, 2010	Oct. 31, 2007 USD ($)	Jun. 30, 2012 USD ($) shares	Dec. 31, 2011 shares	Jun. 27, 2012 shares	Feb. 08, 2012 USD ($) $ / Units
Related-party arrangements (Textual) [Abstract]
Loan agreement with related party			$ 350,000
Amount prepaid for cancellation of indebtedness	$ 200,000			$ (77,200)
Related party transaction prepayment period				90 days
Limit of borrowings				$ 350,000
Accrued interest of related party debt				11,876
Available borrowings under loan agreement				$ 6,250
Increased interest rate		5.00%
Underwritten public offering							$ 86,300
Units sold composition Description							each unit consisting of one share of common stock and a warrant to purchase 0.6 of a share of common stock
Common stock warrant to purchase of Share \| $ / Units							0.6
Company purchased restricted shares of common stock							$ 77,200
Common stock, shares outstanding \| shares				131,522,945	131,522,945	31,250,000
Maximum [Member]
Related Party Transaction [Line Items]
Borrowing rate					4.50%
Minimum [Member]
Related Party Transaction [Line Items]
Borrowing rate				4.50%
Number of Months Advances Outstanding				12 months
Related Party Debt [Member]
Related Party Transaction [Line Items]
Related party debt description of variable rate				one-year LIBOR
Interest rate variable rate on borrowings				3.00%

Senior convertible notes (Details) - USD ($) $ in Thousands	Jun. 30, 2012	Dec. 31, 2011	Aug. 31, 2010	Dec. 31, 2006
Summary of Senior convertible notes
Senior convertible notes	$ 211,184	$ 210,642
Senior convertible notes due 2013 [Member]
Summary of Senior convertible notes
Principal amount	115,000	115,000		$ 115,000
Unaccreted debt issuance expense	(852)	(1,140)
Net carrying amount	114,148	113,860
Senior convertible notes due 2015 [Member]
Summary of Senior convertible notes
Principal amount	100,000	100,000	$ 100,000
Unaccreted debt issuance expense	(2,964)	(3,218)
Net carrying amount	$ 97,036	$ 96,782

Senior convertible notes (Details 1) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2012	Jun. 30, 2011	Jun. 30, 2012	Jun. 30, 2011
Summary of amortization of debt issuance expense
Amortization expense	$ 343	$ 324	$ 682	$ 644

Senior convertible notes (Details Textual) - USD ($)	1 Months Ended
Senior convertible notes (Details Textual) - USD ($)	Aug. 31, 2010	Dec. 31, 2006	Jun. 30, 2012	Dec. 31, 2011
Senior convertible notes due 2015 [Member]
Senior Convertible Notes (Textual) [Abstract]
Principal amount	$ 100,000,000		$ 100,000,000	$ 100,000,000
Senior notes, effective interest rate	5.75%		5.75%
Accrued interest			$ 2,200,000	2,200,000
No of convertible shares	147.0859
Principal amount per share	$ 1,000
Conversion price of shares			$ 6.80
Issuance cost	$ 4,200,000
Percentage of repurchase price	100.00%
Percentage of redemption price	100.00%
Percentage of conversion price equaling stock price	150.00%
Consecutive trading days	Least 20 of the 30
Senior convertible notes due 2013 [Member]
Senior Convertible Notes (Textual) [Abstract]
Principal amount		$ 115,000,000	$ 115,000,000	115,000,000
Senior notes, effective interest rate		3.75%
Accrued interest			$ 192,000	$ 192,000
No of convertible shares		44.5002
Principal amount per share		$ 1,000
Conversion price of shares			$ 22.47
Issuance cost		$ 3,700,000
Percentage of repurchase price		100.00%

Subsequent event (Details) - USD ($)	6 Months Ended
Subsequent event (Details) - USD ($)	Jun. 30, 2012	Aug. 03, 2012
Securities Action [Member]
Subsequent Event (Textual) [Abstract]
Required payment to class members and attorneys	$ 16,000,000
Number of common stock to be issued to class members and attorneys	2,777,778
Closing bid price of Common Stock	$ 1.00
Derivative Actions [Member]
Subsequent Event (Textual) [Abstract]
Required payment by insurer to plaintiff		$ 800,000
Additional Number of common stock to be issued to Plaintiff attorneys	225,000