MannKind Presents Poster at 15th International Conference on Advanced Technologies & Treatments for Diabetes (ATTD 2022) to Be Held April 27-30
- Simplified 2x dose of Technosphere® Insulin (TI) produced a statistically significant improvement in PPGE between Dose 1 & 2 from 45-120 minutes
- Higher dose of TI resulted in a mean difference of 52 mg/dL in PPGE at 120 minutes, with no new safety concerns
The proof-of-concept study demonstrated that a simplified 2x dose of Technosphere® Insulin (TI) provided significant reductions in post-prandial glucose excursions (PPGE) versus the current label dosage guidelines, with no new safety concerns. PPGE was tracked from 0 to 120 minutes following a standardized meal that was preceded by a dose of TI calculated in one of two ways: either based on the guidelines set forth in the current Afrezza® packaging (Dose 1) or by doubling the subject’s injectable insulin dose and rounding down to the nearest available TI dose (Dose 2). A statistically significant improvement in PPGE was observed between Dose 1 and Dose 2 from 45-120 minutes, and the higher dose of TI resulted in a mean difference of 52 mg/dL at 120 minutes.
“We continue to explore new ways to help patients living with diabetes achieve better glycemic control and address potential underdosing with this therapy,” said Dr.
“The perceived effect of the first dose of a medication greatly impacts the likelihood of a person taking a second dose of that medication,” said Dr.
Twenty adult participants (≥ 18 years) with type 1 diabetes (T1D) or type 2 diabetes (T2D) who were on subcutaneous basal-bolus insulin therapy were enrolled in the DOS study. On the first study visit, each subject received a standard meal that was preceded by Dose 1 of TI. At the next visit (2-3 days later), each subject received an identical meal that was preceded by Dose 2 of TI. Capillary blood glucose (SMBG) was measured immediately prior to the dose of TI and then afterward at 15, 30, 45, 60, 90 and 120 minutes.
The poster was authored by
This press release contains forward-looking statements about future clinical studies and the implications of clinical data that involve risks and uncertainties. Words such as “believes”, “anticipates”, “plans”, “expects”, “intends”, “will”, “goal”, “potential” and similar expressions are intended to identify forward-looking statements. These forward-looking statements are based upon MannKind’s current expectations. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, which include, without limitation, the risk that continued testing of Afrezza may not yield successful results or results that are consistent with earlier testing, and other risks detailed in MannKind’s filings with the Securities and Exchange Commission, including its Annual Report on Form 10-K for the year ended December 31, 2021 and subsequent periodic reports on Form 10-Q and current reports on Form 8-K. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. All forward-looking statements are qualified in their entirety by this cautionary statement, and MannKind undertakes no obligation to revise or update any forward-looking statements to reflect events or circumstances after the date of this press release.
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