MannKind Presents Scientific Data at 28th Annual Scientific and Clinical Congress of the American Association of Clinical Endocrinologists (AACE 2019)
“These data demonstrate that Afrezza’s ultra-rapid onset uniquely affects early post-prandial glucose levels and other measures of mealtime glycemic control,” stated Dr.
Poster Presentation Highlights
Title: Ultra-rapid Profile of Technosphere® Insulin Inhalation Powder Mimics Time-Action Profile of Physiologic Absorption of Glucose From Mixed-Meal Tolerance Tests in Type 2 Diabetes AACE 2019
- Compared to insulin lispro, the ultra-rapid absorption of Afrezza provides significantly better control of early post-prandial glucose levels due to an earlier increase in glucose disposal and a faster suppression of endogenous glucose production. The duration of this effect is dose dependent.
- Compared to insulin lispro, Afrezza was associated with lower postprandial glucagon and C-peptide levels and produced a faster decrease in free fatty acid levels.
- The ultra-rapid profile of Afrezza closely approximates the time-action profile of physiologic insulin needs after a meal in patients with Type 2 Diabetes.
About AACE Annual Meeting
The AACE 2019 conference is an opportunity for healthcare professionals specializing in endocrinology, diabetes, and metabolism to gather to discuss the latest scientific advancements and best practices for enhancing patient care, and enjoy educational sessions led by the world's most respected endocrine clinicians.
Available by prescription, Afrezza® (insulin human) Inhalation Powder is a rapid-acting inhaled insulin indicated to improve glycemic control in adult patients with diabetes mellitus. Afrezza consists of a dry powder formulation of human insulin delivered from a small and portable inhaler. Administered at the beginning of a meal, Afrezza dissolves rapidly upon inhalation to the lung and passes quickly into the bloodstream (in less than one minute). This rapid absorption allows Afrezza to begin reducing blood sugar levels within about 12 minutes of administration. Afrezza is available in 4-unit, 8-unit and 12-unit single-dose cartridges of insulin powder that can be used, as prescribed by a health care professional, in combination with other diabetes medications to achieve target blood sugar levels. For Afrezza doses exceeding 12 units, patients may use a combination of existing cartridge strengths. For more information on Afrezza, please visit www.afrezza.com.
SVP, Investor Relations