MannKind Presents New Scientific Data at 12th International Conference on Advanced Technologies & Treatments for Diabetes (ATTD 2019)
“The data to be presented provide additional insight into the pharmacodynamic effects produced by the ultra-rapid pharmacokinetic profile of inhaled Afrezza insulin compared to those associated with subcutaneous rapid acting insulin,” stated Dr.
Other data presented at this meeting showed that the pulmonary function of patients with diabetes is more impacted by factors such as high body mass index, elevated HbA1c levels and the time since onset of diabetes than by the effect of inhaled insulin. Kendall added “we believe that these and other recently published data significantly advance our understanding of the treatment opportunity that Afrezza therapy can offer.”
|Oral Presentation Highlights|
|Title:|| Ultra-rapid profile of insulin human inhalation powder mimics time-action profile of physiologic absorption of glucose from mixed-meal tolerance tests in type 2 diabetes
ATTD 2019 Thursday, February 21st (Hall M4): 17:20-17:30
|Presenter:||Marshall Grant, Senior Director, Head of Pharmaceutical Research, MannKind Corporation|
|Description:||This analysis was based on a randomized cross-over mixed-meal tolerance test study in type 2 diabetes and conducted to determine how the ultra-rapid PK/PD profile of Afrezza affects various facets of glucose control|
|Highlights:||Compared to subcutaneous rapid-acting insulin, the ultra-rapid PK profile of Afrezza resulted in:
|Poster Presentation Highlights|
|Title:|| Diabetes Duration, BMI, and HbA1c Have Greater Effects on Pulmonary Function (PF) Than Inhaled Technosphere® Insulin (Encore, previously presented at EASD)
ATTD 2019 Wednesday, February 20th (poster presentation Friday, February 22nd 10:20-10:25 Exhibition Area)
|Presenter:||Frank Pompilio, PharmD, VP, Medical Affairs, MannKind Corporation|
|Description:||Data from a pulmonary function (PF) study of patients with type 1 and type 2 diabetes was utilized to compare the effects of diabetes duration, body mass index (BMI), and HbA1c on baseline PF and changes in PF during 24 months of treatment between patients receiving Afrezza and those receiving usual care.|
|Highlights:|| The magnitude of Afrezza’s effect on FEV1 was comparable to those normally associated with diabetes-related factors such as high BMI, elevated HbA1c and long-standing diabetes
About ATTD Annual Meeting
The ATTD is a scientific program that brings leading international experts together to discuss breakthroughs in diabetes treatments, technological innovations and showcase the latest developments in new insulin analogues, delivery systems, pumps, glucose sensors, closed-loop systems and much more.
Available by prescription, Afrezza® (insulin human) Inhalation Powder is a rapid-acting inhaled insulin indicated to improve glycemic control in adult patients with diabetes mellitus. Afrezza consists of a dry powder formulation of human insulin delivered from a small and portable inhaler. Administered at the beginning of a meal, Afrezza dissolves rapidly upon inhalation to the lung and passes quickly into the bloodstream (in less than one minute). This rapid absorption allows Afrezza to begin reducing blood sugar levels within about 12 minutes of administration. Afrezza is available in 4-unit, 8-unit and 12-unit single-dose cartridges of insulin powder that can be used, as prescribed by a health care professional, in combination with other diabetes medications to achieve target blood sugar levels. For Afrezza doses exceeding 12 units, patients may use a combination of existing cartridge strengths. For more information on Afrezza, please visit www.afrezza.com.
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